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Zeitschrift

Arthritis Research & Therapy

Arthritis Research & Therapy 1/2017

Ausgabe 1/2017

Inhaltsverzeichnis ( 288 Artikel )

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Advanced Knee Structure Analysis (AKSA): a comparison of bone mineral density and trabecular texture measurements using computed tomography and high-resolution peripheral quantitative computed tomography of human knee cadavers

Torsten Lowitz, Oleg Museyko, Valérie Bousson, Christine Chappard, Liess Laouisset, Jean-Denis Laredo, Klaus Engelke

01.12.2017 | Letter | Ausgabe 1/2017 Open Access

High body mass index in rheumatoid arthritis: why we should promote physical activity

M. Hugo, N. Mehsen-Cetre, A. Pierreisnard, E. Pupier, B. Cherifi, T. Schaeverbeke, V. Rigalleau

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Calprotectin (S100A8/A9) has the strongest association with ultrasound-detected synovitis and predicts response to biologic treatment: results from a longitudinal study of patients with established rheumatoid arthritis

Hilde Haugedal Nordal, Karl Albert Brokstad, Magne Solheim, Anne-Kristine Halse, Tore K. Kvien, Hilde Berner Hammer

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Lack of partial renal response by 12 weeks after induction therapy predicts poor renal response and systemic damage accrual in lupus nephritis class III or IV

Hironari Hanaoka, Hidehiro Yamada, Tomofumi Kiyokawa, Harunobu Iida, Takeshi Suzuki, Yoshioki Yamasaki, Seido Ooka, Hiroko Nagafuchi, Takahiro Okazaki, Daisuke Ichikawa, Sayuri Shirai, Yugo Shibagaki, Junki Koike, Shoichi Ozaki

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The relationship between synovitis quantified by an ultrasound 7-joint inflammation score and physical disability in rheumatoid arthritis – a cohort study

Jakub Závada, Petra Hánová, Jana Hurňáková, Lenka Szczuková, Michal Uher, Šárka Forejtová, Martin Klein, Herman Mann, Marta Olejárová, Olga Růžičková, Olga Šléglová, Karel Hejduk, Karel Pavelka

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Factors associated with initiation and persistence of urate-lowering therapy

Mats Dehlin, Emin Hoxha Ekström, Max Petzold, Ulf Strömberg, Gunilla Telg, Lennart T. H. Jacobsson

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Optimal regimens of sulfamethoxazole-trimethoprim for chemoprophylaxis of Pneumocystis pneumonia in patients with systemic rheumatic diseases: results from a non-blinded, randomized controlled trial

Masako Utsunomiya, Hiroaki Dobashi, Toshio Odani, Kazuyoshi Saito, Naoto Yokogawa, Kenji Nagasaka, Kenchi Takenaka, Makoto Soejima, Takahiko Sugihara, Hiroyuki Hagiyama, Shinya Hirata, Kazuo Matsui, Yoshinori Nonomura, Masahiro Kondo, Fumihito Suzuki, Makoto Tomita, Mari Kihara, Waka Yokoyama, Fumio Hirano, Hayato Yamazaki, Ryoko Sakai, Toshihiro Nanki, Ryuji Koike, Hitoshi Kohsaka, Nobuyuki Miyasaka, Masayoshi Harigai

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

TIM-1 defines a human regulatory B cell population that is altered in frequency and function in systemic sclerosis patients

Octavio Aravena, Ashley Ferrier, Madhvi Menon, Claudia Mauri, Juan Carlos Aguillón, Lilian Soto, Diego Catalán

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Clinical significance of soluble CD163 in polymyositis-related or dermatomyositis-related interstitial lung disease

Yasunori Enomoto, Yuzo Suzuki, Hironao Hozumi, Kazutaka Mori, Masato Kono, Masato Karayama, Kazuki Furuhashi, Tomoyuki Fujisawa, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui, Daisuke Suzuki, Noriyoshi Ogawa, Ran Nakashima, Tsuneyo Mimori, Toshihide Iwashita, Takafumi Suda

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Semaphorin 7A as a potential immune regulator and promising therapeutic target in rheumatoid arthritis

Jianmin Xie, Hao Wang

01.12.2017 | Erratum | Ausgabe 1/2017 Open Access

Erratum to: Serum IL-33, a new marker predicting response to rituximab in rheumatoid arthritis

Jérémie Sellam, Elodie Rivière, Alice Courties, Paul-Olivier Rouzaire, Barbara Tolusso, Edward M. Vital, Paul Emery, Gianfranco Ferraccioli, Martin Soubrier, Bineta Ly, Houria Hendel Chavez, Yassine Taoufik, Maxime Dougados, Xavier Mariette

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability

Kim M. Huffman, Ryan Jessee, Brian Andonian, Brittany N. Davis, Rachel Narowski, Janet L. Huebner, Virginia B. Kraus, Julie McCracken, Brian F. Gilmore, K. Noelle Tune, Milton Campbell, Timothy R. Koves, Deborah M. Muoio, Monica J. Hubal, William E. Kraus

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Early changes in gene expression and inflammatory proteins in systemic juvenile idiopathic arthritis patients on canakinumab therapy

Arndt H. Brachat, Alexei A. Grom, Nico Wulffraat, Hermine I. Brunner, Pierre Quartier, Riva Brik, Liza McCann, Huri Ozdogan, Lidia Rutkowska-Sak, Rayfel Schneider, Valeria Gerloni, Liora Harel, Maria Terreri, Kristin Houghton, Rik Joos, Daniel Kingsbury, Jorge M. Lopez-Benitez, Stephan Bek, Martin Schumacher, Marie-Anne Valentin, Hermann Gram, Ken Abrams, Alberto Martini, Daniel J. Lovell, Nanguneri R. Nirmala, Nicolino Ruperto, for the Pediatric Rheumatology International Trials Organization (PRINTO) and the Pediatric Rheumatology Collaborative Study Group (PRCSG)

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Identification of potential saliva and tear biomarkers in primary Sjögren’s syndrome, utilising the extraction of extracellular vesicles and proteomics analysis

Lara A. Aqrawi, Hilde Kanli Galtung, Beate Vestad, Reidun Øvstebø, Bernd Thiede, Shermin Rusthen, Alix Young, Eduarda M. Guerreiro, Tor Paaske Utheim, Xiangjun Chen, Øygunn Aass Utheim, Øyvind Palm, Janicke Liaaen Jensen

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The 23-valent pneumococcal polysaccharide vaccine in patients with rheumatoid arthritis: a double-blinded, randomized, placebo-controlled trial

Yasumori Izumi, Manabu Akazawa, Yukihiro Akeda, Shigeto Tohma, Fuminori Hirano, Haruko Ideguchi, Ryutaro Matsumura, Tomoya Miyamura, Shunsuke Mori, Takahiro Fukui, Nozomi Iwanaga, Yuka Jiuchi, Hideko Kozuru, Hiroshi Tsutani, Kouichirou Saisyo, Takao Sugiyama, Yasuo Suenaga, Yasumasa Okada, Masao Katayama, Kenji Ichikawa, Hiroshi Furukawa, Kenji Kawakami, Kazunori Oishi, Kiyoshi Migita

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Persistent stromal fibroblast activation is present in chronic tendinopathy

Stephanie G. Dakin, Christopher D. Buckley, Mohammad Hussein Al-Mossawi, Robert Hedley, Fernando O. Martinez, Kim Wheway, Bridget Watkins, Andrew J. Carr

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Comparative analyses of muscle MRI and muscular function in anti-synthetase syndrome patients and matched controls: a cross-sectional study

Helena Andersson, Eva Kirkhus, Torhild Garen, Ragnhild Walle-Hansen, Else Merckoll, Øyvind Molberg

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Synovitis in osteoarthritis: current understanding with therapeutic implications

Alexander Mathiessen, Philip G. Conaghan

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Discovery of new candidate genes for rheumatoid arthritis through integration of genetic association data with expression pathway analysis

Klementy Shchetynsky, Lina-Marcella Diaz-Gallo, Lasse Folkersen, Aase Haj Hensvold, Anca Irinel Catrina, Louise Berg, Lars Klareskog, Leonid Padyukov

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Blood chemokine profile in untreated early rheumatoid arthritis: CXCL10 as a disease activity marker

Jayesh M. Pandya, Anna-Carin Lundell, Kerstin Andersson, Inger Nordström, Elke Theander, Anna Rudin

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

A longitudinal study of fecal calprotectin and the development of inflammatory bowel disease in ankylosing spondylitis

Eva Klingberg, Hans Strid, Arne Ståhl, Anna Deminger, Hans Carlsten, Lena Öhman, Helena Forsblad-d’Elia

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

α2AP regulates vascular alteration by inhibiting VEGF signaling in systemic sclerosis: the roles of α2AP in vascular dysfunction in systemic sclerosis

Yosuke Kanno, En Shu, Hiroyuki Kanoh, Ayaka Matsuda, Mariko Seishima

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Osteoarthritis-associated basic calcium phosphate crystals activate membrane proximal kinases in human innate immune cells

Emma M. Corr, Clare C. Cunningham, Laura Helbert, Geraldine M. McCarthy, Aisling Dunne

01.12.2017 | Commentary | Ausgabe 1/2017 Open Access

Rheumatology around the world: perspectives from Australia and New Zealand

Fiona M. F. McQueen

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Circulating plasmablasts/plasma cells: a potential biomarker for IgG4-related disease

Wei Lin, Panpan Zhang, Hua Chen, Yu Chen, Hongxian Yang, Wenjie Zheng, Xuan Zhang, Fengxiao Zhang, Wen Zhang, Peter E. Lipsky

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Fat mass and fat distribution are associated with low back pain intensity and disability: results from a cohort study

Sultana Monira Hussain, Donna M. Urquhart, Yuanyuan Wang, Jonathan E. Shaw, Dianna J. Magliano, Anita E. Wluka, Flavia M. Cicuttini

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Proangiogenic effects of soluble α-Klotho on systemic sclerosis dermal microvascular endothelial cells

Celestina Mazzotta, Mirko Manetti, Irene Rosa, Eloisa Romano, Jelena Blagojevic, Silvia Bellando-Randone, Cosimo Bruni, Gemma Lepri, Serena Guiducci, Lidia Ibba-Manneschi, Marco Matucci-Cerinic

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

CD14brightCD16+ intermediate monocytes are induced by interleukin-10 and positively correlate with disease activity in rheumatoid arthritis

Masako Tsukamoto, Noriyuki Seta, Keiko Yoshimoto, Katsuya Suzuki, Kunihiro Yamaoka, Tsutomu Takeuchi

01.12.2017 | Commentary | Ausgabe 1/2017 Open Access

Latin-American challenges and opportunities in rheumatology

Francisco Airton Castro Rocha

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Ultrasound-detected pathologies cluster into groups with different clinical outcomes: data from 3000 community referrals for shoulder pain

Gui Tran, Elizabeth M. A. Hensor, Aaron Ray, Sarah R. Kingsbury, Philip O’Connor, Philip G. Conaghan

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Prevalence and associated factors of resting electrocardiogram abnormalities among systemic lupus erythematosus patients without cardiovascular disease

Hanan Al Rayes, Paula J. Harvey, Dafna D. Gladman, Jiandong Su, Arthy Sabapathy, Murray B. Urowitz, Zahi Touma

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Endothelial injury in rheumatoid arthritis: a crosstalk between dimethylarginines and systemic inflammation

Theodoros Dimitroulas, James Hodson, Aamer Sandoo, Jacqueline Smith, George D. Kitas

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Th17 and CD24hiCD27+ regulatory B lymphocytes are biomarkers of response to biologics in rheumatoid arthritis

Sarah Salomon, Caroline Guignant, Pierre Morel, Gauthier Flahaut, Clément Brault, Clément Gourguechon, Patrice Fardellone, Jean-Pierre Marolleau, Brigitte Gubler, Vincent Goëb

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Development of three-dimensional prints of arthritic joints for supporting patients’ awareness to structural damage

Arnd Kleyer, Laura Beyer, Christoph Simon, Fabian Stemmler, Matthias Englbrecht, Christian Beyer, Jürgen Rech, Bernhard Manger, Gerhard Krönke, Georg Schett, Axel J. Hueber

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Priming in response to pro-inflammatory cytokines is a feature of adult synovial but not dermal fibroblasts

Thomas Crowley, John D. O’Neil, Holly Adams, Andrew M. Thomas, Andrew Filer, Christopher D. Buckley, Andrew R. Clark

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Sex differences in the association of skin advanced glycation endproducts with knee osteoarthritis progression

Charles B. Eaton, Maria Sayeed, Syeda Ameernaz, Mary B. Roberts, John D. Maynard, Jeffrey B. Driban, Timothy E. McAlindon

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Acupuncture decreased the risk of coronary heart disease in patients with fibromyalgia in Taiwan: a nationwide matched cohort study

Mei-Yao Wu, Ming-Cheng Huang, Jen-Huai Chiang, Mao-Feng Sun, Yu-Chen Lee, Hung-Rong Yen

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The impact of arthritis and joint pain on individual healthcare expenditures: findings from the Medical Expenditure Panel Survey (MEPS), 2011

Edith M. Williams, Rebekah J. Walker, Trevor Faith, Leonard E. Egede

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Epstein-Barr virus lytic infection promotes activation of Toll-like receptor 8 innate immune response in systemic sclerosis monocytes

Antonella Farina, Giovanna Peruzzi, Valentina Lacconi, Stefania Lenna, Silvia Quarta, Edoardo Rosato, Anna Rita Vestri, Michael York, David H. Dreyfus, Alberto Faggioni, Stefania Morrone, Maria Trojanowska, G. Alessandra Farina

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Structural cartilage damage attracts circulating rheumatoid arthritis synovial fibroblasts into affected joints

Jan Hillen, Christiane Geyer, Marianne Heitzmann, Denise Beckmann, Annika Krause, Ina Winkler, Hermann Pavenstädt, Christoph Bremer, Thomas Pap, Adelheid Korb-Pap

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Presence of an interferon signature in individuals who are anti-nuclear antibody positive lacking a systemic autoimmune rheumatic disease diagnosis

Joan Wither, Sindhu R. Johnson, Tony Liu, Babak Noamani, Dennisse Bonilla, Larissa Lisnevskaia, Earl Silverman, Arthur Bookman, Carolina Landolt-Marticorena

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Epidemiology and disease characteristics of systemic sclerosis-related pulmonary arterial hypertension: results from a real-life screening programme

Kathleen Morrisroe, Wendy Stevens, Joanne Sahhar, Candice Rabusa, Mandana Nikpour, Susanna Proudman, the Australian Scleroderma Interest Group (ASIG)

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Population-specific association between ABCG2 variants and tophaceous disease in people with gout

Wendy He, Amanda Phipps-Green, Lisa K. Stamp, Tony R. Merriman, Nicola Dalbeth

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Effect of FCGR polymorphism on the occurrence of late-onset neutropenia and flare-free survival in rheumatic patients treated with rituximab

Sofia Ajeganova, Daniel Tesfa, Hans Hägglund, Bengt Fadeel, Inger Vedin, Anna Linda Zignego, Jan Palmblad

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Multiplex serum protein analysis reveals potential mechanisms and markers of response to hyperimmune caprine serum in systemic sclerosis

Niamh Quillinan, Kristina E. N. Clark, Bryan Youl, Jeffrey Vernes, Deirdre McIntosh, Syed Haq, Christopher P. Denton

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Characterization of the HLA-DRβ1 third hypervariable region amino acid sequence according to charge and parental inheritance in systemic sclerosis

Coline A. Gentil, Hilary S. Gammill, Christine T. Luu, Maureen D. Mayes, Dan E. Furst, J. Lee Nelson

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis

Raphael S. Peres, Gabriela B. Santos, Nerry T. Cecilio, Valquíria A. P. Jabor, Michael Niehues, Bruna G. S. Torres, Gabriela Buqui, Carlos H. T. P. Silva, Teresa Dalla Costa, Norberto P. Lopes, Maria C. Nonato, Fernando S. Ramalho, Paulo Louzada-Júnior, Thiago M. Cunha, Fernando Q. Cunha, Flavio S. Emery, Jose C. Alves-Filho

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Social media for arthritis-related comparative effectiveness and safety research and the impact of direct-to-consumer advertising

Jeffrey R. Curtis, Lang Chen, Phillip Higginbotham, W. Benjamin Nowell, Ronit Gal-Levy, James Willig, Monika Safford, Joseph Coe, Kaitlin O’Hara, Roee Sa’adon

01.12.2017 | Commentary | Ausgabe 1/2017 Open Access

Rheumatology in Africa—challenges and opportunities

Girish M. Mody

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Cigarette smoking and the risk of primary Sjögren’s syndrome: a nested case control study

Peter Olsson, Carl Turesson, Thomas Mandl, Lennart Jacobsson, Elke Theander

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Mechanistic rationales for targeting interleukin-17A in spondyloarthritis

Siba P. Raychaudhuri, Smriti K. Raychaudhuri

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Elevated serum autoantibodies against co-inhibitory PD-1 facilitate T cell proliferation and correlate with disease activity in new-onset systemic lupus erythematosus patients

Hui Shi, Junna Ye, Jialin Teng, Yufeng Yin, Qiongyi Hu, Xinyao Wu, Honglei Liu, Xiaobing Cheng, Yutong Su, Mengru Liu, Juanfang Gu, Ting Lu, HaoJie Chen, Hui Zheng, Yue Sun, Chengde Yang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Phase 1b randomized, double-blind study of namilumab, an anti-granulocyte macrophage colony-stimulating factor monoclonal antibody, in mild-to-moderate rheumatoid arthritis

T. W. J. Huizinga, A. Batalov, R. Stoilov, E. Lloyd, T. Wagner, D. Saurigny, B. Souberbielle, E. Esfandiari

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Support for phosphoinositol 3 kinase and mTOR inhibitors as treatment for lupus using in-silico drug-repurposing analysis

Daniel Toro-Domínguez, Pedro Carmona-Sáez, Marta E. Alarcón-Riquelme

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Accuracy of magnetic resonance imaging to detect cartilage loss in severe osteoarthritis of the first carpometacarpal joint: comparison with histological evaluation

Michael S. Saltzherr, J. Henk Coert, Ruud W. Selles, Johan W. van Neck, Jean-Bart Jaquet, Gerjo J. V. M. van Osch, Edwin H. G. Oei, Jolanda J. Luime, Galied S. R. Muradin

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Low disease activity for up to 3 years after adalimumab discontinuation in patients with early rheumatoid arthritis: 2-year results of the HOPEFUL-3 Study

Yoshiya Tanaka, Hisashi Yamanaka, Naoki Ishiguro, Nobuyuki Miyasaka, Katsuyoshi Kawana, Junko Kimura, Naoki Agata, Tsutomu Takeuchi

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Chromatin landscapes and genetic risk for juvenile idiopathic arthritis

Lisha Zhu, Kaiyu Jiang, Karstin Webber, Laiping Wong, Tao Liu, Yanmin Chen, James N. Jarvis

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Activation status of mucosal-associated invariant T cells reflects disease activity and pathology of systemic lupus erythematosus

Asako Chiba, Naoto Tamura, Kazunori Yoshikiyo, Goh Murayama, Mie Kitagaichi, Ken Yamaji, Yoshinari Takasaki, Sachiko Miyake

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Risk prediction model for knee pain in the Nottingham community: a Bayesian modelling approach

G. S. Fernandes, A. Bhattacharya, D. F. McWilliams, S. L. Ingham, M. Doherty, W. Zhang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Increased serum levels of fractalkine and mobilisation of CD34+CD45− endothelial progenitor cells in systemic sclerosis

Audrey Benyamine, Jérémy Magalon, Sylvie Cointe, Romaric Lacroix, Laurent Arnaud, Nathalie Bardin, Pascal Rossi, Yves Francès, Fanny Bernard-Guervilly, Gilles Kaplanski, Jean-Robert Harlé, Pierre-Jean Weiller, Philippe Berbis, David Braunstein, Elisabeth Jouve, Nathalie Lesavre, Françoise Couranjou, Françoise Dignat-George, Florence Sabatier, Pascale Paul, Brigitte Granel

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Subclinical dermal involvement is detectable by high frequency ultrasound even in patients with limited cutaneous systemic sclerosis

A. Sulli, B. Ruaro, V. Smith, S. Paolino, C. Pizzorni, G. Pesce, M. Cutolo

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Association of the lupus low disease activity state (LLDAS) with health-related quality of life in a multinational prospective study

Vera Golder, Rangi Kandane-Rathnayake, Alberta Yik-Bun Hoi, Molla Huq, Worawit Louthrenoo, Yuan An, Zhan Guo Li, Shue Fen Luo, Sargunan Sockalingam, Chak Sing Lau, Mo Yin Mok, Aisha Lateef, Kate Franklyn, Susan Morton, Sandra Teresa V. Navarra, Leonid Zamora, Yeong-Jian Wu, Laniyati Hamijoyo, Madelynn Chan, Sean O’Neill, Fiona Goldblatt, Mandana Nikpour, Eric Francis Morand, for the Asia-Pacific Lupus Collaboration

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Mitigation of disease- and treatment-related risks in patients with psoriatic arthritis

Martin Bergman, Amy Lundholm

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Risk factors for flare and treatment of disease flares during pregnancy in rheumatoid arthritis and axial spondyloarthritis patients

Stephanie van den Brandt, Astrid Zbinden, Dominique Baeten, Peter M. Villiger, Monika Østensen, Frauke Förger

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

B cell epitope of human cytomegalovirus phosphoprotein 65 (HCMV pp65) induced anti-dsDNA antibody in BALB/c mice

Ao HoHsieh, Chin Man Wang, Yeong-Jian Jan Wu, Albert Chen, Ming-I Chang, Ji-Yih Chen

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Varying the item format improved the range of measurement in patient-reported outcome measures assessing physical function

Gregor Liegl, Barbara Gandek, H. Felix Fischer, Jakob B. Bjorner, John E. Ware Jr., Matthias Rose, James F. Fries, Sandra Nolte

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

OX40 signaling is involved in the autoactivation of CD4+CD28− T cells and contributes to the pathogenesis of autoimmune arthritis

Juean Jiang, Cuiping Liu, Mi Liu, Yu Shen, Xiaohan Hu, Qin Wang, Jian Wu, Min Wu, Qi Fang, Xueguang Zhang

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Poor prognostic factors guiding treatment decisions in rheumatoid arthritis patients: a review of data from randomized clinical trials and cohort studies

Katinka Albrecht, Angela Zink

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Treatment of mucocutaneous manifestations in Behçet’s disease with anakinra: a pilot open-label study

Peter C. Grayson, Yusuf Yazici, Melissa Merideth, H. Nida Sen, Michael Davis, Elaine Novakovich, Elizabeth Joyal, Raphaela Goldbach-Mansky, Cailin H. Sibley

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Excessive activation of the TLR9/TGF-β1/PDGF-B pathway in the peripheral blood of patients with systemic lupus erythematosus

Yi Yuan, Mingyue Yang, Kuo Wang, Jing Sun, Lili Song, Xue Diao, Zhenyu Jiang, Genhong Cheng, Xiaosong Wang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

DNA methylation mediates genotype and smoking interaction in the development of anti-citrullinated peptide antibody-positive rheumatoid arthritis

Weida Meng, Zaihua Zhu, Xia Jiang, Chun Lai Too, Steffen Uebe, Maja Jagodic, Ingrid Kockum, Shahnaz Murad, Luigi Ferrucci, Lars Alfredsson, Hejian Zou, Lars Klareskog, Andrew P. Feinberg, Tomas J. Ekström, Leonid Padyukov, Yun Liu

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Minimal disease activity and impact of disease in psoriatic arthritis: a Spanish cross-sectional multicenter study

Rubén Queiro, Juan D. Cañete, Carlos Montilla, Miguel Abad, María Montoro, Susana Gómez, Ana Cábez, on behalf of the MAAPS study group

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Diagnostic value of a 3-day course of prednisolone in patients with possible rheumatoid arthritis – the TryCort study

Uta Kiltz, Christine von Zabern, Xenofon Baraliakos, Frank Heldmann, Bernd Mintrop, Michael Sarholz, Dietmar Krause, Friedrich Dybowski, Ludwig Kalthoff, Jürgen Braun

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Direct-acting antiviral agents in the therapy of hepatitis C virus-related mixed cryoglobulinaemia: a single-centre experience

Gianfranco Lauletta, Sabino Russi, Fabio Pavone, Angelo Vacca, Franco Dammacco

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Baseline JAK phosphorylation profile of peripheral blood leukocytes, studied by whole blood phosphospecific flow cytometry, is associated with 1-year treatment response in early rheumatoid arthritis

Krista Kuuliala, Antti Kuuliala, Riitta Koivuniemi, Hannu Kautiainen, Heikki Repo, Marjatta Leirisalo-Repo

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Glutaminase 1 plays a key role in the cell growth of fibroblast-like synoviocytes in rheumatoid arthritis

Soshi Takahashi, Jun Saegusa, Sho Sendo, Takaichi Okano, Kengo Akashi, Yasuhiro Irino, Akio Morinobu

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Incorporating assessment of the cervical facet joints in the modified Stoke ankylosing spondylitis spine score is of additional value in the evaluation of spinal radiographic outcome in ankylosing spondylitis

Fiona Maas, Suzanne Arends, Elisabeth Brouwer, Hendrika Bootsma, Reinhard Bos, Freke R. Wink, Anneke Spoorenberg

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Doctors’ preferences in de-escalating DMARDs in rheumatoid arthritis: a discrete choice experiment

T. Martijn Kuijper, Riëtte Folmer, Elly A. Stolk, Johanna M. W. Hazes, Jolanda J. Luime

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Calgizzarin (S100A11): a novel inflammatory mediator associated with disease activity of rheumatoid arthritis

Lucie Andrés Cerezo, Barbora Šumová, Klára Prajzlerová, David Veigl, Dres Damgaard, Claus Henrik Nielsen, Karel Pavelka, Jiří Vencovský, Ladislav Šenolt

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Increased galectin-3 may serve as a serologic signature of pre-rheumatoid arthritis while markers of synovitis and cartilage do not differ between early undifferentiated arthritis subsets

Saida Farah Issa, Anne Duer, Mikkel Østergaard, Kim Hørslev-Petersen, Merete L. Hetland, Michael Sejer Hansen, Kirsten Junker, Hanne M. Lindegaard, Jakob M. Møller, Peter Junker

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Clinical and demographic factors associated with change and maintenance of disease severity in a large registry of patients with rheumatoid arthritis

George W. Reed, David H. Collier, Andrew S. Koenig, Katherine C. Saunders, Dimitrios A. Pappas, Heather J. Litman, Joel M. Kremer, Sameer Kotak

01.12.2017 | Erratum | Ausgabe 1/2017 Open Access

Erratum to: Plasma complement factor H is associated with disease activity of patients with ANCA-associated vasculitis

Su-Fang Chen, Feng-Mei Wang, Zhi-Ying Li, Feng Yu, Ming-Hui Zhao, Min Chen

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Monosodium urate crystal deposition associated with the progress of radiographic grade at the sacroiliac joint in axial SpA: a dual-energy CT study

Junqing Zhu, Aiwu Li, Ertao Jia, Yi Zhou, Juan Xu, Shixian Chen, Yinger Huang, Xiang Xiao, Juan Li

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Multicenter inception cohort of enthesitis-related arthritis: variation in disease characteristics and treatment approaches

Sabrina Gmuca, Rui Xiao, Timothy G. Brandon, Ilaria Pagnini, Tracey B. Wright, Timothy Beukelman, Esi M. Morgan, Pamela F. Weiss

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Circulating DNA in rheumatoid arthritis: pathological changes and association with clinically used serological markers

Elena Rykova, Aleksey Sizikov, Dirk Roggenbuck, Oksana Antonenko, Leonid Bryzgalov, Evgeniy Morozkin, Kseniya Skvortsova, Valentin Vlassov, Pavel Laktionov, Vladimir Kozlov

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Models solely using claims-based administrative data are poor predictors of rheumatoid arthritis disease activity

Brian C. Sauer, Chia-Chen Teng, Neil A. Accortt, Zachary Burningham, David Collier, Mona Trivedi, Grant W. Cannon

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Disturbed microcirculation in the hands of patients with systemic sclerosis detected by fluorescence optical imaging: a pilot study

Stefanie Friedrich, Susanne Lüders, Stephanie Gabriele Werner, Anne-Marie Glimm, Gerd-Rüdiger Burmester, Gabriela Riemekasten, Marina Backhaus, Sarah Ohrndorf

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Structural predictors of response to intra-articular steroid injection in symptomatic knee osteoarthritis

Nasimah Maricar, Matthew J. Parkes, Michael J. Callaghan, Charles E. Hutchinson, Andrew D. Gait, Richard Hodgson, David T. Felson, Terence W. O’Neill

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The autocrine role of proteoglycan-4 (PRG4) in modulating osteoarthritic synoviocyte proliferation and expression of matrix degrading enzymes

Ali Alquraini, Maha Jamal, Ling Zhang, Tannin Schmidt, Gregory D. Jay, Khaled A. Elsaid

01.12.2017 | Research Article | Ausgabe 1/2017 Open Access

Comprehensive analysis of treatment response phenotypes in rheumatoid arthritis for pharmacogenetic studies

Kristopher A. Standish, C. Chris Huang, Mark E. Curran, Nicholas J. Schork

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Targeting CD22 with the monoclonal antibody epratuzumab modulates human B-cell maturation and cytokine production in response to Toll-like receptor 7 (TLR7) and B-cell receptor (BCR) signaling

Natalia V. Giltiay, Geraldine L. Shu, Anthony Shock, Edward A. Clark

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Prolactin blocks the expression of receptor activator of nuclear factor κB ligand and reduces osteoclastogenesis and bone loss in murine inflammatory arthritis

Maria G. Ledesma-Colunga, Norma Adán, Georgina Ortiz, Mariana Solís-Gutiérrez, Fernando López-Barrera, Gonzalo Martínez de la Escalera, Carmen Clapp

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Costs associated with failure to respond to treatment among patients with rheumatoid arthritis initiating TNFi therapy: a retrospective claims analysis

Michael Grabner, Natalie N. Boytsov, Qing Huang, Xiang Zhang, Tingjian Yan, Jeffrey R. Curtis

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Molecular mechanisms underlying osteoarthritis development: Notch and NF-κB

Taku Saito, Sakae Tanaka

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Development of a clinical prediction algorithm for knee osteoarthritis structural progression in a cohort study: value of adding measurement of subchondral bone density

Michael P. LaValley, Grace H. Lo, Lori Lyn Price, Jeffrey B. Driban, Charles B. Eaton, Timothy E. McAlindon

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The performance of different classification criteria sets for spondyloarthritis in the worldwide ASAS-COMOSPA study

Pauline Bakker, Anna Moltó, Adrien Etcheto, Filip Van den Bosch, Robert Landewé, Floris van Gaalen, Maxime Dougados, Désirée van der Heijde

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Interleukin-10-producing LAG3+ regulatory T cells are associated with disease activity and abatacept treatment in rheumatoid arthritis

Shinichiro Nakachi, Shuji Sumitomo, Yumi Tsuchida, Haruka Tsuchiya, Masanori Kono, Rika Kato, Keiichi Sakurai, Norio Hanata, Yasuo Nagafuchi, Shoko Tateishi, Hiroko Kanda, Tomohisa Okamura, Kazuhiko Yamamoto, Keishi Fujio

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Associations between systemic bone mineral density and early knee cartilage changes in middle-aged adults without clinical knee disease: a prospective cohort study

Andrew J. Teichtahl, Yuanyuan Wang, Anita E. Wluka, Boyd J. Strauss, Joseph Proietto, John B. Dixon, Graeme Jones, Flavia M. Cicuttini

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

TNF inhibitors appear to inhibit disease progression and improve outcome in Takayasu arteritis; an observational, population-based time trend study

Birgir Gudbrandsson, Øyvind Molberg, Øyvind Palm

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

M2 macrophage is the predominant phenotype in airways inflammatory lesions in patients with granulomatosis with polyangiitis

Alexandre Wagner Silva de Souza, Mirjan van Timmeren, Jan-Stephan Sanders, Coen Stegeman, Peter Heeringa, Cees G. M. Kallenberg, Johanna Westra

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

B cell repopulation kinetics after rituximab treatment in ANCA-associated vasculitides compared to rheumatoid arthritis, and connective tissue diseases: a longitudinal observational study on 120 patients

Jens Thiel, Marta Rizzi, Marie Engesser, Ann-Kathrin Dufner, Arianna Troilo, Raquel Lorenzetti, Reinhard E. Voll, Nils Venhoff

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Are ankylosing spondylitis, psoriatic arthritis and undifferentiated spondyloarthritis associated with an increased risk of cardiovascular events? A prospective nationwide population-based cohort study

Karin Bengtsson, Helena Forsblad-d’Elia, Elisabeth Lie, Eva Klingberg, Mats Dehlin, Sofia Exarchou, Ulf Lindström, Johan Askling, Lennart T. H. Jacobsson

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Differences in serum and synovial CD4+ T cells and cytokine profiles to stratify patients with inflammatory osteoarthritis and rheumatoid arthritis

Alessandra Penatti, Federica Facciotti, Roberta De Matteis, Paola Larghi, Moira Paroni, Antonella Murgo, Orazio De Lucia, Massimiliano Pagani, Luca Pierannunzii, Marcello Truzzi, Andreea Ioan-Facsinay, Sergio Abrignani, Jens Geginat, Pier Luigi Meroni

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Pregnancy-induced gene expression changes in vivo among women with rheumatoid arthritis: a pilot study

Dana E. Goin, Mette Kiel Smed, Lior Pachter, Elizabeth Purdom, J. Lee Nelson, Hanne Kjærgaard, Jørn Olsen, Merete Lund Hetland, Vibeke Zoffmann, Bent Ottesen, Damini Jawaheer

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Tie2 as a novel key factor of microangiopathy in systemic sclerosis

Falk Moritz, Janine Schniering, Jörg H. W. Distler, Renate E. Gay, Steffen Gay, Oliver Distler, Britta Maurer

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Early blockade of joint inflammation with a fatty acid amide hydrolase inhibitor decreases end-stage osteoarthritis pain and peripheral neuropathy in mice

Jason J. McDougall, Milind M. Muley, Holly T. Philpott, Allison Reid, Eugene Krustev

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The clinical characteristics of Chinese Takayasu’s arteritis patients: a retrospective study of 411 patients over 24 years

Jing Li, Fei Sun, Zhe Chen, Yunjiao Yang, Jiuliang Zhao, Mengtao Li, Xinping Tian, Xiaofeng Zeng

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Ultrasound-detected bone erosion is a relapse risk factor after discontinuation of biologic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis whose ultrasound power Doppler synovitis activity and clinical disease activity are well controlled

Shin-ya Kawashiri, Keita Fujikawa, Ayako Nishino, Akitomo Okada, Toshiyuki Aramaki, Toshimasa Shimizu, Masataka Umeda, Shoichi Fukui, Takahisa Suzuki, Tomohiro Koga, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Akinari Mizokami, Hideki Nakamura, Tomoki Origuchi, Yukitaka Ueki, Kiyoshi Aoyagi, Takahiro Maeda, Atsushi Kawakami

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Pre-silencing of genes involved in the electron transport chain (ETC) pathway is associated with responsiveness to abatacept in rheumatoid arthritis

C. Derambure, G. Dzangue-Tchoupou, C. Berard, N. Vergne, M. Hiron, M. A. D’Agostino, P. Musette, O. Vittecoq, T. Lequerré

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Fibroblast-like synoviocyte metabolism in the pathogenesis of rheumatoid arthritis

Marta F. Bustamante, Ricard Garcia-Carbonell, Katrijn D. Whisenant, Monica Guma

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Increased serum concentrations of IL-1 beta, IL-21 and Th17 cells in overweight patients with rheumatoid arthritis

Hirofumi Shoda, Yasuo Nagafuchi, Yumi Tsuchida, Keiichi Sakurai, Shuji Sumitomo, Keishi Fujio, Kazuhiko Yamamoto

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

TGFβ1-induced SMAD2/3 and SMAD1/5 phosphorylation are both ALK5-kinase-dependent in primary chondrocytes and mediated by TAK1 kinase activity

Arjan van Caam, Wojciech Madej, Amaya Garcia de Vinuesa, Marie-José Goumans, Peter ten Dijke, Esmeralda Blaney Davidson, Peter van der Kraan

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

HDL cholesterol efflux capacity in rheumatoid arthritis patients: contributing factors and relationship with subclinical atherosclerosis

Beatriz Tejera-Segura, María Macía-Díaz, José David Machado, Antonia de Vera-González, Jose A. García-Dopico, José M. Olmos, José L. Hernández, Federico Díaz-González, Miguel A. González-Gay, Iván Ferraz-Amaro

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

In-vivo monitoring of anti-folate therapy in arthritic rats using [18F]fluoro-PEG-folate and positron emission tomography

Durga M. S. H. Chandrupatla, Gerrit Jansen, Ricardo Vos, Mariska Verlaan, Qingshou Chen, Philip S. Low, Albert D. Windhorst, Adriaan A. Lammertsma, Conny J. van der Laken, Carla F. M. Molthoff

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The prevalence of ACPA is lower in rheumatoid arthritis patients with an older age of onset but the composition of the ACPA response appears identical

Debbie M. Boeters, Lukas Mangnus, Sofia Ajeganova, Elisabet Lindqvist, Björn Svensson, René E. M. Toes, Leendert A. Trouw, Tom W. J. Huizinga, Francis Berenbaum, Jacques Morel, Solbritt Rantapää-Dahlqvist, Annette H. M. van der Helm-van Mil

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Lymphatic delivery of etanercept via nanotopography improves response to collagen-induced arthritis

Melissa B. Aldrich, Fred C. Velasquez, Sunkuk Kwon, Ali Azhdarinia, Kenneth Pinkston, Barrett R. Harvey, Wenyaw Chan, John C. Rasmussen, Russell F. Ross, Caroline E. Fife, E. M. Sevick-Muraca

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Prediction of response to remission induction therapy by gene expression profiling of peripheral blood in Japanese patients with microscopic polyangiitis

Akihiro Ishizu, Utano Tomaru, Sakiko Masuda, Ken-ei Sada, Koichi Amano, Masayoshi Harigai, Yasushi Kawaguchi, Yoshihiro Arimura, Kunihiro Yamagata, Shoichi Ozaki, Hiroaki Dobashi, Sakae Homma, Yasunori Okada, Hitoshi Sugiyama, Joichi Usui, Naotake Tsuboi, Seiichi Matsuo, Hirofumi Makino, for the Research Committee of the Intractable Vasculitis Syndrome and the Research Committee of the Intractable Renal Disease of the Ministry of Health, Labour, and Welfare of Japan

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Is the current ASAS expert definition of a positive family history useful in identifying axial spondyloarthritis? Results from the SPACE and DESIR cohorts

Zineb Ez-Zaitouni, Andrea Hilkens, Laure Gossec, Inger Jorid Berg, Robert Landewé, Roberta Ramonda, Maxime Dougados, Désirée van der Heijde, Floris van Gaalen

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Exosomal amyloid A and lymphatic vessel endothelial hyaluronic acid receptor-1 proteins are associated with disease activity in rheumatoid arthritis

Jihyung Yoo, Sang Kwang Lee, Mikyung Lim, Donghyuk Sheen, Eun-Hye Choi, Soon Ae Kim

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Ectopic germinal center and megalin defect in primary Sjogren syndrome with renal Fanconi syndrome

Jing Wang, Yubing Wen, Mengyu Zhou, Xiaoxiao Shi, Lanping Jiang, Mingxi Li, Yang Yu, Xuemei Li, Xuewang Li, Wen Zhang, Andrew L. Lundquist, Limeng Chen

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

RANK/RANKL/OPG system in the intervertebral disc

Norihiko Takegami, Koji Akeda, Junichi Yamada, Tomohiko Sano, Koichiro Murata, Jenny Huang, Koichi Masuda, Akihiro Sudo

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Survival and quality of life in incident systemic sclerosis-related pulmonary arterial hypertension

Kathleen Morrisroe, Wendy Stevens, Molla Huq, David Prior, Jo Sahhar, Gene-Siew Ngian, David Celermajer, Jane Zochling, Susanna Proudman, Mandana Nikpour, the Australian Scleroderma Interest Group (ASIG)

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Gout and subsequent erectile dysfunction: a population-based cohort study from England

Alyshah Abdul Sultan, Christian Mallen, Richard Hayward, Sara Muller, Rebecca Whittle, Matthew Hotston, Edward Roddy

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Effect of tryptase inhibition on joint inflammation: a pharmacological and lentivirus-mediated gene transfer study

Alexandre Denadai-Souza, Camilla Moreira Ribeiro, Corinne Rolland, Anne Thouard, Céline Deraison, Cristoforo Scavone, Daniel Gonzalez-Dunia, Nathalie Vergnolle, Maria Christina Werneck Avellar

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

High mobility group box-1 contributes to anti-myeloperoxidase antibody-induced glomerular endothelial cell injury through a moesin-dependent route

Hui Deng, Chen Wang, Dong-Yuan Chang, Nan Hu, Min Chen, Ming-Hui Zhao

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

MRI evidence of structural changes in the sacroiliac joints of patients with non-radiographic axial spondyloarthritis even in the absence of MRI inflammation

Walter P. Maksymowych, Stephanie Wichuk, Maxime Dougados, Heather Jones, Annette Szumski, Jack F. Bukowski, Lisa Marshall, Robert G. Lambert

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Anti-nuclear autoantibodies in the general German population: prevalence and lack of association with selected cardiovascular and metabolic disorders—findings of a multicenter population-based study

Manas K. Akmatov, Nadja Röber, Wolfgang Ahrens, Dieter Flesch-Janys, Julia Fricke, Halina Greiser, Kathrin Günther, Rudolf Kaaks, Yvonne Kemmling, Bastian Krone, Jakob Linseisen, Christa Meisinger, Susanne Moebus, Nadia Obi, Carlos A. Guzman, Karsten Conrad, Frank Pessler

01.12.2017 | Editorial | Ausgabe 1/2017 Open Access

Pulmonary arterial hypertension in scleroderma: care gaps in screening

Janet E. Pope

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Negative anti-neutrophil cytoplasm antibody at switch to maintenance therapy is associated with a reduced risk of relapse

Matthew David Morgan, Matthew Szeto, Michael Walsh, David Jayne, Kerstin Westman, Niels Rasmussen, Thomas F. Hiemstra, Oliver Flossmann, Annelies Berden, Peter Höglund, Lorraine Harper, on behalf of the European Vasculitis Society

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Drug safety analyses in a rheumatoid arthritis registry: application of different approaches regarding timing of exposure and confounder measurement

Daniel H. Solomon, Nancy A. Shadick, Michael E. Weinblatt, Agnes Zak, Michelle Frits, Jessica M. Franklin

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The effects of resistance training on muscle strength, joint pain, and hand function in individuals with hand osteoarthritis: a systematic review and meta-analysis

Nicoló Edoardo Magni, Peter John McNair, David Andrew Rice

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

High-sensitivity cardiac troponin T is a biomarker for atherosclerosis in systemic lupus erythematous patients: a cross-sectional controlled study

Gillian Divard, Rachid Abbas, Camille Chenevier-Gobeaux, Noémie Chanson, Brigitte Escoubet, Marie-Paule Chauveheid, Antoine Dossier, Thomas Papo, Monique Dehoux, Karim Sacre

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The cumulative number of micro-haemorrhages and micro-thromboses in nailfold videocapillaroscopy is a good indicator of disease activity in systemic sclerosis: a validation study of the NEMO score

Romina Andracco, Rosaria Irace, Eleonora Zaccara, Serena Vettori, Wanda Maglione, Antonella Riccardi, Francesca Pignataro, Roberta Ferrara, Domenico Sambataro, Gianluca Sambataro, Claudio Vitali, Gabriele Valentini, Nicoletta Del Papa

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Anti-connective tissue growth factor (CTGF/CCN2) monoclonal antibody attenuates skin fibrosis in mice models of systemic sclerosis

Katsunari Makino, Tomoko Makino, Lukasz Stawski, Kenneth E. Lipson, Andrew Leask, Maria Trojanowska

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

High sensitivity and negative predictive value of the DETECT algorithm for an early diagnosis of pulmonary arterial hypertension in systemic sclerosis: application in a single center

Alfredo Guillén-Del Castillo, Eduardo L. Callejas-Moraga, Gabriela García, José F. Rodríguez-Palomares, Antonio Román, Cristina Berastegui, Manuel López-Meseguer, Enric Domingo, Vicente Fonollosa-Plá, Carmen Pilar Simeón-Aznar

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Chemokine receptor co-expression reveals aberrantly distributed TH effector memory cells in GPA patients

Lucas L. Lintermans, Abraham Rutgers, Coen A. Stegeman, Peter Heeringa, Wayel H. Abdulahad

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Leucine-rich alpha 2 glycoprotein promotes Th17 differentiation and collagen-induced arthritis in mice through enhancement of TGF-β-Smad2 signaling in naïve helper T cells

Hayato Urushima, Minoru Fujimoto, Takashi Mishima, Tomoharu Ohkawara, Hiromi Honda, Hyun Lee, Hirohisa Kawahata, Satoshi Serada, Tetsuji Naka

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Genome-wide pathway analysis identifies VEGF pathway association with oral ulceration in systemic lupus erythematosus

Adrià Aterido, Antonio Julià, Patricia Carreira, Ricardo Blanco, José Javier López-Longo, José Javier Pérez Venegas, Àlex Olivé, José Luís Andreu, Maria Ángeles Aguirre-Zamorano, Paloma Vela, Joan M. Nolla, José Luís Marenco-de la Fuente, Antonio Zea, José María Pego, Mercedes Freire, Elvira Díez, María López-Lasanta, Mireia López-Corbeto, Núria Palau, Raül Tortosa, Josep Lluís Gelpí, Devin Absher, Richard M Myers, Antonio Fernández-Nebro, Sara Marsal

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

IFN-λ1 with Th17 axis cytokines and IFN-α define different subsets in systemic lupus erythematosus (SLE)

Vilija Oke, Susanna Brauner, Anders Larsson, Johanna Gustafsson, Agneta Zickert, Iva Gunnarsson, Elisabet Svenungsson

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Serum levels of leptin and high molecular weight adiponectin are inversely associated with radiographic spinal progression in patients with ankylosing spondylitis: results from the ENRADAS trial

Agnes Hartl, Joachim Sieper, Uta Syrbe, Joachim Listing, Kay-Geert Hermann, Martin Rudwaleit, Denis Poddubnyy

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Differing specificities and isotypes of anti-citrullinated peptide/protein antibodies in palindromic rheumatism and rheumatoid arthritis

Sonia Cabrera-Villalba, María José Gomara, Juan D. Cañete, Julio Ramírez, Georgina Salvador, Virginia Ruiz-Esquide, Maria Victoria Hernández, José Inciarte-Mundo, Isabel Haro, Raimon Sanmartí

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Chemokine signals are crucial for enhanced homing and differentiation of circulating osteoclast progenitor cells

Alan Sucur, Zrinka Jajic, Marinko Artukovic, Marina Ikic Matijasevic, Branimir Anic, Darja Flegar, Antonio Markotic, Tomislav Kelava, Sanja Ivcevic, Natasa Kovacic, Vedran Katavic, Danka Grcevic

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Work outcome in yet undiagnosed patients with non-radiographic axial spondyloarthritis and ankylosing spondylitis; results of a cross-sectional study among patients with chronic low back pain

Lonneke van Hoeven, Annelies E. R. C. H. Boonen, Johanna M. W. Hazes, Angelique E. A. M. Weel

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Mir-155 is overexpressed in systemic sclerosis fibroblasts and is required for NLRP3 inflammasome-mediated collagen synthesis during fibrosis

Carol M. Artlett, Sihem Sassi-Gaha, Jennifer L. Hope, Carol A. Feghali-Bostwick, Peter D. Katsikis

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Preliminary safety and efficacy profile of prucalopride in the treatment of systemic sclerosis (SSc)-related intestinal involvement: results from the open label cross-over PROGASS study

Barbara Vigone, Monica Caronni, Adriana Severino, Chiara Bellocchi, Anna Rita Baldassarri, Mirella Fraquelli, Gaia Montanelli, Alessandro Santaniello, Lorenzo Beretta

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Animal models of rheumatoid pain: experimental systems and insights

Bradford D. Fischer, Adeshina Adeyemo, Michael E. O’Leary, Andrea Bottaro

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Fluorescence optical imaging and musculoskeletal ultrasonography in juvenile idiopathic polyarticular disease before and during antirheumatic treatment - a multicenter non-interventional diagnostic evaluation

Ariane Klein, Georg Werner Just, Stephanie Gabriele Werner, Prasad T. Oommen, Kirsten Minden, Ingrid Becker, Hans-Eckhard Langer, Dirk Klee, Gerd Horneff

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Cardiovascular risk factors predate the onset of symptoms of rheumatoid arthritis: a nested case–control study

Heidi Kokkonen, Hans Stenlund, Solbritt Rantapää-Dahlqvist

01.12.2017 | Commentary | Ausgabe 1/2017 Open Access

Rheumatology in the Middle East in 2017: clinical challenges and research

Abdulla Watad, Jamal Al-Saleh, Merav Lidar, Howard Amital, Yehuda Shoenfeld

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Autologous chondrocyte implantation-derived synovial fluids display distinct responder and non-responder proteomic profiles

Charlotte H. Hulme, Emma L. Wilson, Mandy J. Peffers, Sally Roberts, Deborah M. Simpson, James B. Richardson, Pete Gallacher, Karina T. Wright

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Beneficial effect of resveratrol on phenotypic features and activity of osteoarthritic osteoblasts

Élie Abed, Aline Delalandre, Daniel Lajeunesse

01.12.2017 | Letter | Ausgabe 1/2017 Open Access

Anti-citrullinated protein antibodies and bone loss in patients with early arthritis: comment on the article “Anti-citrullinated protein antibodies and high levels of rheumatoid factor are associated with systemic bone loss in patients with early untreated rheumatoid arthritis” by Bugatti et al.

Santos Castañeda, Irene Llorente, Rosario García-Vicuña, Isidoro González-Álvaro

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Cardiovascular disease risk profiles in inflammatory joint disease entities

Grunde Wibetoe, Eirik Ikdahl, Silvia Rollefstad, Inge C. Olsen, Kjetil Bergsmark, Tore K. Kvien, Anne Salberg, Dag Magnar Soldal, Gunnstein Bakland, Åse Lexberg, Bjørg-Tilde Fevang, Hans Christian Gulseth, Glenn Haugeberg, Anne Grete Semb

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Therapeutic effect of a novel histone deacetylase 6 inhibitor, CKD-L, on collagen-induced arthritis in vivo and regulatory T cells in rheumatoid arthritis in vitro

Bo Ram Oh, Dong-hyeon Suh, Daekwon Bae, Nina Ha, Young Il Choi, Hyun Jung Yoo, Jin Kyun Park, Eun Young Lee, Eun Bong Lee, Yeong Wook Song

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Evaluation of newly proposed remission cut-points for disease activity score in 28 joints (DAS28) in rheumatoid arthritis patients upon IL-6 pathway inhibition

M. Schoels, F. Alasti, J. S. Smolen, D. Aletaha

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Limited cutaneous systemic sclerosis skin demonstrates distinct molecular subsets separated by a cardiovascular development gene expression signature

Emma C. Derrett-Smith, Viktor Martyanov, Cecilia B. Chighizola, Pia Moinzadeh, Corrado Campochiaro, Korsa Khan, Tammara A. Wood, Pier Luigi Meroni, David J. Abraham, Voon H. Ong, Robert Lafyatis, Michael L. Whitfield, Christopher P. Denton

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Coculture of bovine cartilage with synovium and fibrous joint capsule increases aggrecanase and matrix metalloproteinase activity

Per Swärd, Yang Wang, Maria Hansson, L. Stefan Lohmander, Alan J. Grodzinsky, André Struglics

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Abatacept reduces synovial regulatory T-cell expression in patients with psoriatic arthritis

Agnes Szentpetery, Eric Heffernan, Martina Gogarty, Lisa Mellerick, Janet McCormack, Muhammad Haroon, Musaab Elmamoun, Phil Gallagher, Genevieve Kelly, Aurelie Fabre, Brian Kirby, Oliver FitzGerald

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Factors associated with initial or subsequent choice of biologic disease-modifying antirheumatic drugs for treatment of rheumatoid arthritis

Yinzhu Jin, Rishi J. Desai, Jun Liu, Nam-Kyong Choi, Seoyoung C. Kim

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

IgA N- and O-glycosylation profiling reveals no association with the pregnancy-related improvement in rheumatoid arthritis

Albert Bondt, Simone Nicolardi, Bas C. Jansen, T. Martijn Kuijper, Johanna M. W. Hazes, Yuri E. M. van der Burgt, Manfred Wuhrer, Radboud J. E. M. Dolhain

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Interaction of the GCKR and A1CF loci with alcohol consumption to influence the risk of gout

Humaira Rasheed, Lisa K. Stamp, Nicola Dalbeth, Tony R. Merriman

01.12.2017 | Commentary | Ausgabe 1/2017 Open Access

The “myth” of loss of angiogenesis in systemic sclerosis: a pivotal early pathogenetic process or just a late unavoidable event?

Marco Matucci-Cerinic, Mirko Manetti, Cosimo Bruni, Ines Chora, Silvia Bellando-Randone, Gemma Lepri, Amato De Paulis, Serena Guiducci

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Pathogenic roles of CXCL10 signaling through CXCR3 and TLR4 in macrophages and T cells: relevance for arthritis

Jong-Ho Lee, Bongjun Kim, Won Jong Jin, Hong-Hee Kim, Hyunil Ha, Zang Hee Lee

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Impact of obesity on the response to tumor necrosis factor inhibitors in axial spondyloarthritis

Raphael Micheroli, Monika Hebeisen, Lukas M. Wildi, Pascale Exer, Giorgio Tamborrini, Jürg Bernhard, Burkhard Möller, Pascal Zufferey, Michael J. Nissen, Almut Scherer, Adrian Ciurea, on behalf of the Rheumatologists of the Swiss Clinical Quality Management Program

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Sustained benefit from combined plasmapheresis and allogeneic mesenchymal stem cells transplantation therapy in systemic sclerosis

Huayong Zhang, Jun Liang, Xiaojun Tang, Dandan Wang, Xuebing Feng, Fan Wang, Bingzhu Hua, Hong Wang, Lingyun Sun

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Genetic deficiency of Wnt5a diminishes disease severity in a murine model of rheumatoid arthritis

Susan MacLauchlan, Maria A. Zuriaga, José J. Fuster, Carla M. Cuda, Jennifer Jonason, Fernanda Behzadi, Jennifer Parker Duffen, G. Kenneth Haines III, Tamar Aprahamian, Harris Perlman, Kenneth Walsh

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Settings and artefacts relevant for Doppler ultrasound in large vessel vasculitis

L. Terslev, A. P. Diamantopoulos, U. Møller Døhn, W. A. Schmidt, S. Torp-Pedersen

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

A phase III, randomized, two-armed, double-blind, parallel, active controlled, and non-inferiority clinical trial to compare efficacy and safety of biosimilar adalimumab (CinnoRA®) to the reference product (Humira®) in patients with active rheumatoid arthritis

Ahmadreza Jamshidi, Farhad Gharibdoost, Mahdi Vojdanian, Soosan G. Soroosh, Mohsen Soroush, Arman Ahmadzadeh, Mohammad Ali Nazarinia, Mohammad Mousavi, Hadi Karimzadeh, Mohammad Reza Shakibi, Zahra Rezaieyazdi, Maryam Sahebari, Asghar Hajiabbasi, Ali Asghar Ebrahimi, Najmeh Mahjourian, Amin Mohammadinejad Rashti

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Levels of serum biomarkers from a two-year multicentre trial are associated with treatment response on knee osteoarthritis cartilage loss as assessed by magnetic resonance imaging: an exploratory study

Johanne Martel-Pelletier, Jean-Pierre Raynauld, François Mineau, François Abram, Patrice Paiement, Philippe Delorme, Jean-Pierre Pelletier

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Identification of differential co-expressed gene networks in early rheumatoid arthritis achieving sustained drug-free remission after treatment with a tocilizumab-based or methotrexate-based strategy

Xavier M. Teitsma, Johannes W. G. Jacobs, Michal Mokry, Michelle E. A. Borm, Attila Pethö-Schramm, Jacob M. van Laar, Johannes W. J. Bijlsma, Floris P. J. Lafeber

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Ultrasonography and dual-energy computed tomography provide different quantification of urate burden in gout: results from a cross-sectional study

Tristan Pascart, Agathe Grandjean, Laurène Norberciak, Vincent Ducoulombier, Marguerite Motte, Hélène Luraschi, Marie Vandecandelaere, Catherine Godart, Eric Houvenagel, Nasser Namane, Jean-François Budzik

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Emerging technologies in autoantibody testing for rheumatic diseases

Nancy J. Olsen, May Y. Choi, Marvin J. Fritzler

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Incidence of and risk factors for nephrolithiasis in patients with gout and the general population, a cohort study

A. J. Landgren, L. T. H. Jacobsson, U. Lindström, T. Z. S. Sandström, P. Drivelegka, L. Björkman, E. Fjellstedt, M. Dehlin

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

RIG-I expression in perifascicular myofibers is a reliable biomarker of dermatomyositis

Xavier Suárez-Calvet, Eduard Gallardo, Iago Pinal-Fernandez, Noemi De Luna, Cinta Lleixà, Jordi Díaz-Manera, Ricardo Rojas-García, Ivan Castellví, M. Angeles Martínez, Josep M. Grau, Albert Selva-O’Callaghan, Isabel Illa

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Targeted designed variants of alpha-2-macroglobulin (A2M) attenuate cartilage degeneration in a rat model of osteoarthritis induced by anterior cruciate ligament transection

Yang Zhang, Xiaochun Wei, Shawn Browning, Gaetano Scuderi, Lewis S. Hanna, Lei Wei

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Inhibition of T cell-mediated inflammation in uveitis by a novel anti-CD3 antibody

Sunao Sugita, Jun Shimizu, Kenichi Makabe, Hiroshi Keino, Takeshi Watanabe, Masayo Takahashi

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Genome-wide DNA methylation profile analysis identifies differentially methylated loci associated with ankylosis spondylitis

Jiangcan Hao, Yang Liu, Jiawen Xu, Wenyu Wang, Yan Wen, Awen He, Qianrui Fan, Xiong Guo, Feng Zhang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

CD4 T lymphocyte autophagy is upregulated in the salivary glands of primary Sjögren’s syndrome patients and correlates with focus score and disease activity

Cristiano Alessandri, Francesco Ciccia, Roberta Priori, Elisa Astorri, Giuliana Guggino, Riccardo Alessandro, Aroldo Rizzo, Fabrizio Conti, Antonina Minniti, Cristiana Barbati, Marta Vomero, Monica Pendolino, Annacarla Finucci, Elena Ortona, Tania Colasanti, Marina Pierdominici, Walter Malorni, Giovanni Triolo, Guido Valesini

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Anabolic role of lysyl oxidase like-2 in cartilage of knee and temporomandibular joints with osteoarthritis

Weam Alshenibr, Mustafa M. Tashkandi, Saqer F. Alsaqer, Yazeed Alkheriji, Amelia Wise, Sadanand Fulzele, Pushkar Mehra, Mary B. Goldring, Louis C. Gerstenfeld, Manish V. Bais

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Safety, tolerability, clinical, and joint structural outcomes of a single intra-articular injection of allogeneic mesenchymal precursor cells in patients following anterior cruciate ligament reconstruction: a controlled double-blind randomised trial

Yuanyuan Wang, Andrew Shimmin, Peter Ghosh, Paul Marks, James Linklater, David Connell, Stephen Hall, Donna Skerrett, Silviu Itescu, Flavia M. Cicuttini

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Performance of gout definitions for genetic epidemiological studies: analysis of UK Biobank

Murray Cadzow, Tony R. Merriman, Nicola Dalbeth

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

IgG Fc galactosylation predicts response to methotrexate in early rheumatoid arthritis

Susanna L. Lundström, Aase H. Hensvold, Dorothea Rutishauser, Lars Klareskog, A. Jimmy Ytterberg, Roman A. Zubarev, Anca I. Catrina

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Hydroxychloroquine inhibits CD154 expression in CD4+ T lymphocytes of systemic lupus erythematosus through NFAT, but not STAT5, signaling

Shu-Fen Wu, Chia-Bin Chang, Jui-Mei Hsu, Ming-Chi Lu, Ning-Sheng Lai, Chin Li, Chien-Hsueh Tung

01.12.2017 | Editorial | Ausgabe 1/2017 Open Access

Incident gout and erectile dysfunction: is hyperuricaemia the elephant in the room?

Abhishek Abhishek, Michael Doherty

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

A novel scoring system based on common laboratory tests predicts the efficacy of TNF-inhibitor and IL-6 targeted therapy in patients with rheumatoid arthritis: a retrospective, multicenter observational study

Jin Nakagawa, Yoshinobu Koyama, Atsushi Kawakami, Yukitaka Ueki, Hiroshi Tsukamoto, Takahiko Horiuchi, Shuji Nagano, Ayumi Uchino, Toshiyuki Ota, Mitsuteru Akahoshi, Koichi Akashi

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Lack of high BMI-related features in adipocytes and inflammatory cells in the infrapatellar fat pad (IFP)

Anja J. de Jong, Inge R. Klein-Wieringa, Stefan N. Andersen, Joanneke C. Kwekkeboom, Linda Herb-van Toorn, Badelog J. E. de Lange-Brokaar, Danny van Delft, John Garcia, Wu Wei, Huub J. L. van der Heide, Yvonne M. Bastiaansen-Jenniskens, Gerjo J. V. M. van Osch, Annemarie M. Zuurmond, Vedrana Stojanovic-Susulic, Rob G. H. H. Nelissen, René E. M. Toes, Margreet Kloppenburg, Andreea Ioan-Facsinay

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Bortezomib treatment induces a higher mortality rate in lupus model mice with a higher disease activity

Tomoko Ikeda, Hiroshi Fujii, Masato Nose, Yukiko Kamogawa, Tsuyoshi Shirai, Yuko Shirota, Tomonori Ishii, Hideo Harigae

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The impact of age and gut microbiota on Th17 and Tfh cells in K/BxN autoimmune arthritis

Fei Teng, Krysta M. Felix, C. Pierce Bradley, Debdut Naskar, Heqing Ma, Walid A. Raslan, Hsin-Jung Joyce Wu

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The association between sonographic enthesitis and radiographic damage in psoriatic arthritis

Ari Polachek, Richard Cook, Vinod Chandran, Dafna D. Gladman, Lihi Eder

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The isotype and IgG subclass distribution of anti-carbamylated protein antibodies in rheumatoid arthritis patients

Myrthe A. M. van Delft, Marije K. Verheul, Leonie E. Burgers, Veerle F. A. M. Derksen, Annette H. M. van der Helm-van Mil, Diane van der Woude, Tom W. J. Huizinga, René E. M. Toes, Leendert A. Trouw

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Frequency, distribution and immunologic nature of infusion reactions in subjects receiving pegloticase for chronic refractory gout

Leonard H. Calabrese, Arthur Kavanaugh, Anthony E. Yeo, Peter E. Lipsky

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Biosemantics guided gene expression profiling of Sjögren’s syndrome: a comparative analysis with systemic lupus erythematosus and rheumatoid arthritis

Nirav R. Shah, Braxton D. Noll, Craig B. Stevens, Michael T. Brennan, Farah B. Mougeot, Jean-Luc C. Mougeot

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Decreased ex vivo production of interferon-gamma is associated with severity and poor prognosis in patients with lupus

Sung Soo Ahn, Eun Seong Park, Joo Sung Shim, Sang-Jun Ha, Beom Seok Kim, Seung Min Jung, Sang-Won Lee, Yong-Beom Park, Jason Jungsik Song

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

High titers of both rheumatoid factor and anti-CCP antibodies at baseline in patients with rheumatoid arthritis are associated with increased circulating baseline TNF level, low drug levels, and reduced clinical responses: a post hoc analysis of the RISING study

Tsutomu Takeuchi, Nobuyuki Miyasaka, Takashi Inui, Toshiro Yano, Toru Yoshinari, Tohru Abe, Takao Koike

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Decrease in bone mineral density during three months after diagnosis of early rheumatoid arthritis measured by digital X-ray radiogrammetry predicts radiographic joint damage after one year

Michael Ziegelasch, Kristina Forslind, Thomas Skogh, Katrine Riklund, Alf Kastbom, Ewa Berglin

01.12.2017 | Commentary | Ausgabe 1/2017 Open Access

Opportunities and challenges in rheumatology research in Central Europe

Zoltán Szekanecz, Branimir Anic, Gábor Héjj, Iztok Holc, Aniella Hunka, Eugene Kucharz, Klaus Machold, Miroslav Mayer, Artur Pahor, Rudolf Puchner, Jozef Rovensky, Ladislav Senolt, Alena Tuchynova, Jiri Vencovsky, Josef S. Smolen

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

A novel susceptibility locus in the IL12B region is associated with the pathophysiology of Takayasu arteritis through IL-12p40 and IL-12p70 production

Toshiki Nakajima, Hajime Yoshifuji, Masakazu Shimizu, Koji Kitagori, Kosaku Murakami, Ran Nakashima, Yoshitaka Imura, Masao Tanaka, Koichiro Ohmura, Fumihiko Matsuda, Chikashi Terao, Tsuneyo Mimori

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Estrogen attenuates the spondyloarthritis manifestations of the SKG arthritis model

Hyemin Jeong, Eun-Kyung Bae, Hunnyun Kim, Yeong Hee Eun, In Young Kim, Hyungjin Kim, Jaejoon Lee, Chan Hong Jeon, Eun-Mi Koh, Hoon-Suk Cha

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Effects of HLA-DRB1 alleles on susceptibility and clinical manifestations in Japanese patients with adult onset Still’s disease

Tomoyuki Asano, Hiroshi Furukawa, Shuzo Sato, Makiko Yashiro, Hiroko Kobayashi, Hiroshi Watanabe, Eiji Suzuki, Tomoyuki Ito, Yoshifumi Ubara, Daisuke Kobayashi, Nozomi Iwanaga, Yasumori Izumi, Keita Fujikawa, Satoshi Yamasaki, Tadashi Nakamura, Tomohiro Koga, Toshimasa Shimizu, Masataka Umeda, Fumiaki Nonaka, Michio Yasunami, Yukitaka Ueki, Katsumi Eguchi, Naoyuki Tsuchiya, Shigeto Tohma, Koh-ichiro Yoshiura, Hiromasa Ohira, Atsushi Kawakami, Kiyoshi Migita

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Proximal tibial trabecular bone mineral density is related to pain in patients with osteoarthritis

Wadena D. Burnett, Saija A. Kontulainen, Christine E. McLennan, Diane Hazel, Carl Talmo, David R. Wilson, David J. Hunter, James D. Johnston

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Association of medial meniscal extrusion with medial tibial osteophyte distance detected by T2 mapping MRI in patients with early-stage knee osteoarthritis

Shinnosuke Hada, Muneaki Ishijima, Haruka Kaneko, Mayuko Kinoshita, Lizu Liu, Ryo Sadatsuki, Ippei Futami, Anwajan Yusup, Tomohiro Takamura, Hitoshi Arita, Jun Shiozawa, Takako Aoki, Yuji Takazawa, Hiroshi Ikeda, Shigeki Aoki, Hisashi Kurosawa, Yasunori Okada, Kazuo Kaneko

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Absence of ultrasound inflammation in patients presenting with arthralgia rules out the development of arthritis

Myrthe van der Ven, M. van der Veer-Meerkerk, D. F. Ten Cate, N. Rasappu, M. R. Kok, D. Csakvari, J. M. W. Hazes, A. H. Gerards, J. J. Luime

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

MicroRNA-488 and -920 regulate the production of proinflammatory cytokines in acute gouty arthritis

Weidong Zhou, Ying Wang, Rongfeng Wu, Yan He, Qun Su, Guixiu Shi

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Gout and comorbidity: a nominal group study of people with gout

Jasvinder A. Singh

01.12.2017 | Editorial | Ausgabe 1/2017 Open Access

Inflammasome lights up in systemic sclerosis

John Henderson, Steven O’Reilly

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Usefulness of lung ultrasound B-lines in connective tissue disease-associated interstitial lung disease: a literature review

YuKai Wang, Luna Gargani, Tatiana Barskova, Dan E. Furst, Marco Matucci Cerinic

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Endoplasmic reticulum stress cooperates with Toll-like receptor ligation in driving activation of rheumatoid arthritis fibroblast-like synoviocytes

Pawel A. Kabala, Chiara Angiolilli, Nataliya Yeremenko, Aleksander M. Grabiec, Barbara Giovannone, Desiree Pots, Timothy R. Radstake, Dominique Baeten, Kris A. Reedquist

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Patient-reported outcomes of baricitinib in patients with rheumatoid arthritis and no or limited prior disease-modifying antirheumatic drug treatment

Michael Schiff, Tsutomu Takeuchi, Roy Fleischmann, Carol L. Gaich, Amy M. DeLozier, Douglas Schlichting, Wen-Ling Kuo, Ji-Eon Won, Tara Carmack, Terence Rooney, Patrick Durez, Saeed Shaikh, Rodolfo Pardo Hidalgo, Ronald van Vollenhoven, Cristiano A. F. Zerbini

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

High-magnitude compression accelerates the premature senescence of nucleus pulposus cells via the p38 MAPK-ROS pathway

Pei Li, Gang Hou, Ruijie Zhang, Yibo Gan, Yuan Xu, Lei Song, Qiang Zhou

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Serum bone-turnover biomarkers are associated with the occurrence of peripheral and axial arthritis in psoriatic disease: a prospective cross-sectional comparative study

Deepak R. Jadon, Raj Sengupta, Alison Nightingale, Hui Lu, Juliet Dunphy, Amelia Green, James T. Elder, Rajan P. Nair, Eleanor Korendowych, Mark A. Lindsay, Neil J. McHugh

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

HM71224, a selective Bruton’s tyrosine kinase inhibitor, attenuates the development of murine lupus

Yu-Yon Kim, Ki Tae Park, Sun Young Jang, Kyu Hang Lee, Joo-Yun Byun, Kwee Hyun Suh, Young-Mi Lee, Young Hoon Kim, Kwang Woo Hwang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Patient-provider discordance between global assessments of disease activity in rheumatoid arthritis: a comprehensive clinical evaluation

Divya N. Challa, Zoran Kvrgic, Andrea L. Cheville, Cynthia S. Crowson, Tim Bongartz, Thomas G. Mason II, Eric L. Matteson, Clement J. Michet Jr, Scott T. Persellin, Daniel E. Schaffer, Theresa L. Wampler Muskardin, Kerry Wright, John M. Davis III

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Assessment of intracranial vessels in association with carotid atherosclerosis and brain vascular lesions in rheumatoid arthritis

Csaba Oláh, Zsófia Kardos, Mariann Sepsi, Attila Sas, László Kostyál, Harjit Pal Bhattoa, Katalin Hodosi, György Kerekes, László Tamási, Attila Valikovics, Dániel Bereczki, Zoltán Szekanecz

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Assessing risk of liver enzyme elevation in patients with immune-mediated diseases and different hepatitis B virus serostatus receiving anti-TNF agents: a nested case-control study

Ying-Ming Chiu, Mei-Shu Lai, K. Arnold Chan

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

A somatization comorbidity phenotype impacts response to therapy in rheumatoid arthritis: post-hoc results from the certolizumab pegol phase 4 PREDICT trial

Jeffrey R. Curtis, Christopher Herrem, ’Matladi N. Ndlovu, Cathy O’Brien, Yusuf Yazici

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Large country differences in work outcomes in patients with RA – an analysis in the multinational study COMORA

Antje van der Zee-Neuen, Polina Putrik, Sofia Ramiro, Andras P. Keszei, Ihsane Hmamouchi, Maxime Dougados, Annelies Boonen

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

S100A8/A9 increases the mobilization of pro-inflammatory Ly6Chigh monocytes to the synovium during experimental osteoarthritis

Niels A. J. Cremers, Martijn H. J. van den Bosch, Stephanie van Dalen, Irene Di Ceglie, Giuliana Ascone, Fons van de Loo, Marije Koenders, Peter van der Kraan, Annet Sloetjes, Thomas Vogl, Johannes Roth, Edwin J. W. Geven, Arjen B. Blom, Peter L. E. M. van Lent

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Targeted proteomics reveals promising biomarkers of disease activity and organ involvement in antineutrophil cytoplasmic antibody-associated vasculitis

Jun Ishizaki, Ayako Takemori, Koichiro Suemori, Takuya Matsumoto, Yoko Akita, Ken-ei Sada, Yukio Yuzawa, Koichi Amano, Yoshinari Takasaki, Masayoshi Harigai, Yoshihiro Arimura, Hirofumi Makino, Masaki Yasukawa, Nobuaki Takemori, Hitoshi Hasegawa, for the Research Committee of Intractable Vasculitis Syndrome and the Research Committee of Intractable Renal Disease of the Ministry of Health, Labour and Welfare of Japan

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Low levels of antibodies against common viruses associate with anti-citrullinated protein antibody-positive rheumatoid arthritis; implications for disease aetiology

Natalia Sherina, Hulda S. Hreggvidsdottir, Camilla Bengtsson, Monika Hansson, Lena Israelsson, Lars Alfredsson, Karin Lundberg

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Further Treatment Intensification in Undifferentiated and Rheumatoid Arthritis Patients Already in Low Disease Activity has Limited Benefit towards Physical Functioning

Sytske Anne Bergstra, Otto Olivas, Gülşah Akdemir, Naghmeh Riyazi, Gerard Collée, Johannes H. L. M. van Groenendael, Robert B. M. Landewé, Cornelia F. Allaart

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Ultrasound of the hand is sufficient to detect subclinical inflammation in rheumatoid arthritis remission: a post hoc longitudinal study

Hilde Berner Hammer, Tore K. Kvien, Lene Terslev

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Assessment of 3-month changes in bone microstructure under anti-TNFα therapy in patients with rheumatoid arthritis using high-resolution peripheral quantitative computed tomography (HR-pQCT)

Tomohiro Shimizu, Hyo Jin Choi, Ursula Heilmeier, Matthew Tanaka, Andrew J. Burghardt, Jingshan Gong, Nattagan Chanchek, Thomas M. Link, Jonathan Graf, John B. Imboden, Xiaojuan Li

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Clinical features of IgG4-related periaortitis/periarteritis based on the analysis of 179 patients with IgG4-related disease: a case–control study

Makiko Ozawa, Yasunari Fujinaga, Junpei Asano, Akira Nakamura, Takayuki Watanabe, Tetsuya Ito, Takashi Muraki, Hideaki Hamano, Shigeyuki Kawa

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The caspase-8/RIPK3 signaling axis in antigen presenting cells controls the inflammatory arthritic response

Salina Dominguez, Anna B. Montgomery, G. Kenneth Haines III, Christina L. Bloomfield, Carla M. Cuda

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

T-bet+CD11c+ B cells are critical for antichromatin immunoglobulin G production in the development of lupus

Ya Liu, Shiyu Zhou, Jie Qian, Yan Wang, Xiang Yu, Dai Dai, Min Dai, Lingling Wu, Zhuojun Liao, Zhixin Xue, Jiehua Wang, Goujun Hou, Jianyang Ma, John B. Harley, Yuanjia Tang, Nan Shen

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Residual disease activity and treatment adjustments in psoriatic arthritis in current clinical practice

Leonieke J. J. van Mens, Marleen G. H. van de Sande, Inka A. Fluri, Sadaf Atiqi, Arno W. R. van Kuijk, Dominique L. P. Baeten

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Behçet’s disease risk association fine-mapped on the IL23R–IL12RB2 intergenic region in Koreans

Eun Ha Kang, Sewon Kim, Min Young Park, Ji Yong Choi, In Ah Choi, Min Jung Kim, You-Jung Ha, Eun Young Lee, Yun Jong Lee, Eun Bong Lee, Changwon Kang, Yeong Wook Song

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Is gout a risk equivalent to diabetes for stroke and myocardial infarction? A retrospective claims database study

Jasvinder A. Singh, Rekha Ramachandaran, Shaohua Yu, Shuo Yang, Fenglong Xie, Huifeng Yun, Jie Zhang, Jeffrey R. Curtis

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Incretins in patients with rheumatoid arthritis

Beatriz Tejera-Segura, Raquel López-Mejías, María Jesús Domínguez-Luis, Antonia M. de Vera-González, Alejandra González-Delgado, Begoña Ubilla, José M. Olmos, José L. Hernández, Miguel A. González-Gay, Iván Ferraz-Amaro

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Microparticles from patients with systemic lupus erythematosus induce production of reactive oxygen species and degranulation of polymorphonuclear leukocytes

Line Kjær Winberg, Søren Jacobsen, Claus H. Nielsen

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

A new bioassay for measuring the strength of IL-6/STAT3 signal inhibition by tocilizumab in patients with rheumatoid arthritis

Shuntaro Saito, Katsuya Suzuki, Keiko Yoshimoto, Yuko Kaneko, Yoshihiro Matsumoto, Kunihiro Yamaoka, Tsutomu Takeuchi

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Methotrexate and anti-tumor necrosis factor treatment improves endothelial function in patients with inflammatory arthritis

Gia Deyab, Ingrid Hokstad, Jon Elling Whist, Milada Cvancarova Smastuen, Stefan Agewall, Torstein Lyberg, Nicoletta Ronda, Knut Mikkelsen, Gunnbjorg Hjeltnes, Ivana Hollan

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Fluorescence optical imaging in pediatric patients with inflammatory and non-inflammatory joint diseases: a comparative study with ultrasonography

Marisa Christin Beck, Anne-Marie Glimm, Sarah Ohrndorf, Kirsten Minden, Ralf Trauzeddel, Stephanie Gabriele Werner, Gerd Horneff, Marina Backhaus, Gerd Rüdiger Burmester, Tilmann Kallinich, Hermann Girschick, Jens Klotsche

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Enhanced IFN-α production is associated with increased TLR7 retention in the lysosomes of palasmacytoid dendritic cells in systemic lupus erythematosus

Goh Murayama, Nanako Furusawa, Asako Chiba, Ken Yamaji, Naoto Tamura, Sachiko Miyake

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Soluble CD40L is associated with increased oxidative burst and neutrophil extracellular trap release in Behçet’s disease

Sandro Félix Perazzio, Paulo Vitor Soeiro-Pereira, Viviane Cardoso dos Santos, Marlon Vilela de Brito, Bruno Salu, Maria Luiza Vilela Oliva, Anne Margherite Stevens, Alexandre Wagner Silva de Souza, Hans D. Ochs, Troy R. Torgerson, Antonio Condino-Neto, Luis Eduardo Coelho Andrade

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Dose-response relationship between lower serum magnesium level and higher prevalence of knee chondrocalcinosis

Chao Zeng, Jie Wei, Robert Terkeltaub, Tuo Yang, Hyon K. Choi, Yi-lun Wang, Dong-xing Xie, David J. Hunter, Yuqing Zhang, Hui Li, Yang Cui, Liang-jun Li, Guang-hua Lei

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Severe intestinal dysbiosis is prevalent in primary Sjögren’s syndrome and is associated with systemic disease activity

Thomas Mandl, Jan Marsal, Peter Olsson, Bodil Ohlsson, Kristofer Andréasson

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Predictive biological markers of systemic lupus erythematosus flares: a systematic literature review

Noémie Gensous, Aurélie Marti, Thomas Barnetche, Patrick Blanco, Estibaliz Lazaro, Julien Seneschal, Marie-Elise Truchetet, Pierre Duffau, Christophe Richez, on behalf of the FHU ACRONIM

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Right drug, right patient, right time: aspiration or future promise for biologics in rheumatoid arthritis?

Vasco C. Romão, Edward M. Vital, João Eurico Fonseca, Maya H. Buch

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Relevance of structural damage in the sacroiliac joints for the functional status and spinal mobility in patients with axial spondyloarthritis: results from the German Spondyloarthritis Inception Cohort

Mikhail Protopopov, Joachim Sieper, Hildrun Haibel, Joachim Listing, Martin Rudwaleit, Denis Poddubnyy

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Changes in clinical disease activity are weakly linked to changes in MRI inflammation on treat-to-target escalation of therapy in rheumatoid arthritis

Fiona M. McQueen, Peter Chapman, Terina Pollock, Dena D’Souza, Arier C. Lee, Nicola Dalbeth, Lisa Stamp, Karen Lindsay, Anthony Doyle

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Urine S100 proteins as potential biomarkers of lupus nephritis activity

Jessica L. Turnier, Ndate Fall, Sherry Thornton, David Witte, Michael R. Bennett, Simone Appenzeller, Marisa S. Klein-Gitelman, Alexei A. Grom, Hermine I. Brunner

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Ultrasound verified inflammation and structural damage in patients with hereditary haemochromatosis-related arthropathy

Christian Dejaco, Andreas Stadlmayr, Christina Duftner, Viktoria Trimmel, Rusmir Husic, Elisabeth Krones, Shahin Zandieh, Emma Husar-Memmer, Gernot Zollner, Josef Hermann, Judith Gretler, Angelika Lackner, Anja Ficjan, Christian Datz, Roland Axman, Jochen Zwerina

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Biological function integrated prediction of severe radiographic progression in rheumatoid arthritis: a nested case control study

Young Bin Joo, Yul Kim, Youngho Park, Kwangwoo Kim, Jeong Ah Ryu, Seunghun Lee, So-Young Bang, Hye-Soon Lee, Gwan-Su Yi, Sang-Cheol Bae

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

TLR2 stimulation impairs anti-inflammatory activity of M2-like macrophages, generating a chimeric M1/M2 phenotype

Lilian Quero, Edveena Hanser, Tobias Manigold, André N. Tiaden, Diego Kyburz

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Anti-carbamylated protein antibodies precede disease onset in monkeys with collagen-induced arthritis

Marije K. Verheul, Michel P. M. Vierboom, Bert A. ’t Hart, Rene E. M. Toes, Leendert A. Trouw

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Failure to achieve lupus low disease activity state (LLDAS) six months after diagnosis is associated with early damage accrual in Caucasian patients with systemic lupus erythematosus

Matteo Piga, Alberto Floris, Giulia Cappellazzo, Elisabetta Chessa, Mattia Congia, Alessandro Mathieu, Alberto Cauli

01.12.2017 | Review | Ausgabe 1/2017 Open Access

New insights on the MMP-13 regulatory network in the pathogenesis of early osteoarthritis

Heng Li, Dan Wang, Yongjian Yuan, Jikang Min

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Whole blood microRNA expression pattern differentiates patients with rheumatoid arthritis, their seropositive first-degree relatives, and healthy unrelated control subjects

Vidyanand Anaparti, Irene Smolik, Xiaobo Meng, Victor Spicer, Neeloffer Mookherjee, Hani El-Gabalawy

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Matrix metalloproteinase-3 and the 7-joint ultrasound score in the assessment of disease activity and therapeutic efficacy in patients with moderate to severe rheumatoid arthritis

Ling Zhou, Geng Wang, Xin Liu, Jing Song, Ling Chen, Huji Xu

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Chinese Registry of rheumatoid arthritis (CREDIT): II. prevalence and risk factors of major comorbidities in Chinese patients with rheumatoid arthritis

Shangyi Jin, Mengtao Li, Yongfei Fang, Qin Li, Ju Liu, Xinwang Duan, Yi Liu, Rui Wu, Xiaofei Shi, Yongfu Wang, Zhenyu Jiang, Yanhong Wang, Chen Yu, Qian Wang, Xinping Tian, Yan Zhao, Xiaofeng Zeng, CREDIT Co-authors

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Platelets are activated in ANCA-associated vasculitis via thrombin-PARs pathway and can activate the alternative complement pathway

Di Miao, Dan-Yang Li, Min Chen, Ming-Hui Zhao

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Factors associated with oral glucocorticoid use in patients with rheumatoid arthritis: a drug use study from a prospective national biologics registry

Rachel J. Black, Susan Lester, Rachelle Buchbinder, Claire Barrett, Marissa Lassere, Lyn March, Samuel Whittle, Catherine L. Hill

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Targeting of vascular adhesion protein-1 by positron emission tomography visualizes sites of inflammation in Borrelia burgdorferi-infected mice

Riikka Siitonen, Annukka Pietikäinen, Heidi Liljenbäck, Meeri Käkelä, Mirva Söderström, Sirpa Jalkanen, Jukka Hytönen, Anne Roivainen

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Childhood Takayasu arteritis: disease course and response to therapy

Florence A. Aeschlimann, Simon W. M. Eng, Shehla Sheikh, Ronald M. Laxer, Diane Hebert, Damien Noone, Marinka Twilt, Christian Pagnoux, Susanne M. Benseler, Rae S. M. Yeung

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Experience with etanercept, tocilizumab and interleukin-1 inhibitors in systemic onset juvenile idiopathic arthritis patients from the BIKER registry

Gerd Horneff, Anna Carina Schulz, Jens Klotsche, Anton Hospach, Kirsten Minden, Ivan Foeldvari, Ralf Trauzeddel, Gerd Ganser, Frank Weller-Heinemann, Johannes Perter Haas

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Serum connective tissue growth factor is a highly discriminatory biomarker for the diagnosis of rheumatoid arthritis

Xinyu Yang, Ke Lin, Shanmin Ni, Jianmin Wang, Qingqing Tian, Huaijun Chen, Matthew A. Brown, Kaidi Zheng, Weitao Zhai, Li Sun, Shengwei Jin, Jianguang Wang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Similar short-term clinical response to high-dose versus low-dose methotrexate in monotherapy and combination therapy in patients with rheumatoid arthritis

Sytske Anne Bergstra, Cornelia F. Allaart, Rosaline van den Berg, Arvind Chopra, Nimmisha Govind, Tom W. J. Huizinga, Robert B. M. Landewe

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Identification of multiple cancer-associated myositis-specific autoantibodies in idiopathic inflammatory myopathies: a large longitudinal cohort study

Hanbo Yang, Qinglin Peng, Liguo Yin, Shanshan Li, Jingli Shi, Yamei Zhang, Xin Lu, Xiaoming Shu, Sigong Zhang, Guochun Wang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The immediate effect of a soft knee brace on pain, activity limitations, self-reported knee instability, and self-reported knee confidence in patients with knee osteoarthritis

Tomasz Cudejko, Martin van der Esch, Marike van der Leeden, Josien C. van den Noort, Leo D. Roorda, Willem Lems, Jos Twisk, Martijn Steultjens, James Woodburn, Jaap Harlaar, Joost Dekker

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The role of aberrant expression of T cell miRNAs affected by TNF-α in the immunopathogenesis of rheumatoid arthritis

Ning-Sheng Lai, Hui-Chun Yu, Chien-Hsueh Tung, Kuang-Yung Huang, Hsien-Bin Huang, Ming-Chi Lu

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

New clues to the nature of immunoglobulin G4-related disease: a retrospective Japanese multicenter study of baseline clinical features of 334 cases

Kazunori Yamada, Motohisa Yamamoto, Takako Saeki, Ichiro Mizushima, Shoko Matsui, Yuhei Fujisawa, Satoshi Hara, Hiroki Takahashi, Hideki Nomura, Shigeyuki Kawa, Mitsuhiro Kawano

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Resistin upregulates chemokine production by fibroblast-like synoviocytes from patients with rheumatoid arthritis

Hiroshi Sato, Sei Muraoka, Natsuko Kusunoki, Shotaro Masuoka, Soichi Yamada, Hideaki Ogasawara, Toshio Imai, Yoshikiyo Akasaka, Naobumi Tochigi, Hiroshi Takahashi, Kazuaki Tsuchiya, Shinichi Kawai, Toshihiro Nanki

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Increased synovial lipodystrophy induced by high fat diet aggravates synovitis in experimental osteoarthritis

Ane Larrañaga-Vera, Ana Lamuedra, Sandra Pérez-Baos, Ivan Prieto-Potin, Leticia Peña, Gabriel Herrero-Beaumont, Raquel Largo

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Prediction of progression of damage to articular cartilage 2 years after anterior cruciate ligament reconstruction: use of aggrecan and type II collagen biomarkers in a retrospective observational study

Yasumori Sobue, Toshihisa Kojima, Kazutoshi Kurokouchi, Shigeo Takahashi, Hiroaki Yoshida, Robin Poole, Naoki Ishiguro

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Plasma C4d as marker for lupus nephritis in systemic lupus erythematosus

Myriam Martin, Karolina I. Smoląg, Albin Björk, Birgitta Gullstrand, Marcin Okrój, Jonatan Leffler, Andreas Jönsen, Anders A. Bengtsson, Anna M. Blom

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Patients and surgeons provide endorsement of core domains for total joint replacement clinical trials

Anh Hoang, Susan M. Goodman, Iris Y. Navarro-Millán, Lisa A. Mandl, Mark P. Figgie, Mathias P. Bostrom, Douglas E. Padgett, Peter K. Sculco, Alexander S. McLawhorn, Jasvinder A. Singh

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Role of endoplasmic reticulum stress in the protective effects of PPARβ/δ activation on endothelial dysfunction induced by plasma from patients with lupus

Marta Toral, Rosario Jiménez, Miguel Romero, Iñaki Robles-Vera, Manuel Sánchez, Mercedes Salaices, José Mario Sabio, Juan Duarte

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Comparison of 2002 AECG and 2016 ACR/EULAR classification criteria and added value of salivary gland ultrasonography in a patient cohort with suspected primary Sjögren’s syndrome

Maëlle Le Goff, Divi Cornec, Sandrine Jousse-Joulin, Dewi Guellec, Sebastian Costa, Thierry Marhadour, Rozenn Le Berre, Steeve Genestet, Béatrice Cochener, Sylvie Boisrame-Gastrin, Yves Renaudineau, Jacques-Olivier Pers, Alain Saraux, Valérie Devauchelle-Pensec

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

VISTA deficiency attenuates antibody-induced arthritis and alters macrophage gene expression in response to simulated immune complexes

Sabrina Ceeraz, Susan K. Eszterhas, Petra A. Sergent, David A. Armstrong, Alix Ashare, Thomas Broughton, Li Wang, Dov Pechenick, Christopher M. Burns, Randolph J. Noelle, Matthew P. Vincenti, Roy A. Fava

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Is the relationship between increased knee muscle strength and improved physical function following exercise dependent on baseline physical function status?

Michelle Hall, Rana S. Hinman, Martin van der Esch, Marike van der Leeden, Jessica Kasza, Tim V. Wrigley, Ben R. Metcalf, Fiona Dobson, Kim L. Bennell

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Angiogenesis and VEGF-expressing cells are identified predominantly in the fascia rather than in the muscle during the early phase of dermatomyositis

Ken Yoshida, Haruyasu Ito, Kazuhiro Furuya, Taro Ukichi, Kentaro Noda, Daitaro Kurosaka

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Which measuring site in ankylosing spondylitis is best to detect bone loss and what predicts the decline: results from a 5-year prospective study

Anna Deminger, Eva Klingberg, Mattias Lorentzon, Mats Geijer, Jan Göthlin, Martin Hedberg, Eva Rehnberg, Hans Carlsten, Lennart T. Jacobsson, Helena Forsblad-d’Elia

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Rheumatoid arthritis bone marrow environment supports Th17 response

Ewa Kuca-Warnawin, Weronika Kurowska, Monika Prochorec-Sobieszek, Anna Radzikowska, Tomasz Burakowski, Urszula Skalska, Magdalena Massalska, Magdalena Plebańczyk, Barbara Małdyk-Nowakowska, Iwona Słowińska, Robert Gasik, Włodzimierz Maśliński

01.12.2017 | Editorial | Ausgabe 1/2017 Open Access

The biological functions of DNA: from the sublime to the slime

David S. Pisetsky

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Use of a baseline risk score to identify the risk of serious infectious events in patients with rheumatoid arthritis during certolizumab pegol treatment

Jeffrey R. Curtis, Kevin Winthrop, Cathy O’Brien, Matladi N. Ndlovu, Marc de Longueville, Boulos Haraoui

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The risk of malignancy and its incidence in early rheumatoid arthritis patients treated with biologic DMARDs

Soo-Kyung Cho, Jiyoung Lee, Minkyung Han, Sang-Cheol Bae, Yoon-Kyoung Sung

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Incidence of giant cell arteritis in Western Norway 1972–2012: a retrospective cohort study

L. K. Brekke, A. P. Diamantopoulos, B-T. Fevang, J. Aβmus, E. Esperø, C. G. Gjesdal

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Factors associated with the 6-minute walk distance in patients with systemic sclerosis

Sébastien Sanges, Jonathan Giovannelli, Vincent Sobanski, Sandrine Morell-Dubois, Hélène Maillard, Marc Lambert, Céline Podevin, Nicolas Lamblin, Pascal De Groote, Jean-François Bervar, Thierry Perez, Régis Matran, Martine Rémy-Jardin, Pierre-Yves Hatron, Éric Hachulla, David Launay

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Progranulin derivative Atsttrin protects against early osteoarthritis in mouse and rat models

Jian-lu Wei, Wenyu Fu, Yuan-jing Ding, Aubryanna Hettinghouse, Matin Lendhey, Ran Schwarzkopf, Oran D. Kennedy, Chuan-ju Liu

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Association between ultrasound-detected synovitis and knee pain: a population-based case–control study with both cross-sectional and follow-up data

Aliya Sarmanova, Michelle Hall, Gwen S. Fernandes, Archan Bhattacharya, Ana M. Valdes, David A. Walsh, Michael Doherty, Weiya Zhang

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

CX3CL1 promotes MMP-3 production via the CX3CR1, c-Raf, MEK, ERK, and NF-κB signaling pathway in osteoarthritis synovial fibroblasts

Sheng-Mou Hou, Chun-Han Hou, Ju-Fang Liu

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

The effect of kidney function on the urate lowering effect and safety of increasing allopurinol above doses based on creatinine clearance: a post hoc analysis of a randomized controlled trial

Lisa K. Stamp, Peter T. Chapman, Murray Barclay, Anne Horne, Christopher Frampton, Paul Tan, Jill Drake, Nicola Dalbeth

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Disease evolution in mixed connective tissue disease: results from a long-term nationwide prospective cohort study

Silje Reiseter, Ragnar Gunnarsson, Jukka Corander, Joanna Haydon, May Brit Lund, Trond Mogens Aaløkken, Eli Taraldsrud, Siri Opsahl Hetlevik, Øyvind Molberg

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Efficacy, safety, and tolerability of secukinumab in patients with active ankylosing spondylitis: a randomized, double-blind phase 3 study, MEASURE 3

Karel Pavelka, Alan Kivitz, Eva Dokoupilova, Ricardo Blanco, Marco Maradiaga, Hasan Tahir, Luminita Pricop, Mats Andersson, Aimee Readie, Brian Porter

01.12.2017 | Review | Ausgabe 1/2017 Open Access

Nonradiographic axial spondyloarthritis: clinical and therapeutic relevance

Nilasha Ghosh, Eric M. Ruderman

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Nitrated nucleosome levels and neuropsychiatric events in systemic lupus erythematosus; a multi-center retrospective case-control study

Isabel Ferreira, Sara Croca, Maria Gabriella Raimondo, Manjit Matharu, Sarah Miller, Ian Giles, David Isenberg, Yiannis Ioannou, John G. Hanly, Murray B. Urowitz, Nicole Anderson, Cynthia Aranow, Anca Askanase, Sang-Cheol Bae, Sasha Bernatsky, Ian N. Bruce, Jill Buyon, Ann E. Clarke, Mary Anne Dooley, Paul Fortin, Ellen Ginzler, Dafna Gladman, Caroline Gordon, Murat Inanc, Søren Jacobsen, Kenneth Kalunian, Diane Kamen, Munther Khamashta, Sam Lim, Susan Manzi, Joan Merrill, Ola Nived, Christine Peschken, Michelle Petri, Rosalind Ramsey-Goldman, Guillermo Ruiz-Irastorza, Jorge Sanchez-Guerrero, Kristjan Steinson, Gunnar K. Sturfelt, Ronald van Vollenhoven, Daniel J. Wallace, Asad Zoma, Anisur Rahman

01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Profiling microRNAs in individuals at risk of progression to rheumatoid arthritis

L. Ouboussad, L. Hunt, E. M. A. Hensor, J. L. Nam, N. A. Barnes, P. Emery, M. F. McDermott, M. H. Buch

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