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24.09.2016 | Review

ASIA syndrome, calcinosis cutis and chronic kidney disease following silicone injections. A case-based review

verfasst von: Giuseppe Barilaro, Claudia Spaziani Testa, Antonella Cacciani, Giuseppe Donato, Mira Dimko, Amalia Mariotti

Erschienen in: Immunologic Research | Ausgabe 5-6/2016

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Abstract

An immunologic adjuvant is a substance that enhances the antigen-specific immune response preferably without triggering one on its own. Silicone, a synthetic polymer used for reconstructive and cosmetic purposes, can cause, once injected, local and/or systemic reactions and trigger manifestations of autoimmunity, occasionally leading to an overt autoimmune disease. Siliconosis, calcinosis cutis with hypercalcemia and chronic kidney disease have all been reported in association with silicone injection. Here, we describe a case of autoimmune/auto-inflammatory syndrome induced by adjuvants, calcinosis cutis and chronic kidney disease after liquid silicone multiple injections in a young man who underwent a sex reassignment surgery, followed by a review of the literature. To our knowledge, this is the first report describing the concomitance of the three clinical conditions in the same patients. The link between silicone and the immune system is not completely understood yet and requires further reports and investigations with long-term data, in order to identify the main individual and genetical risk factors predisposing to the wide spectrum of the adjuvant-induced responses.

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Titel: ASIA syndrome, calcinosis cutis and chronic kidney disease following silicone injections. A case-based review
verfasst von: Giuseppe Barilaro
Claudia Spaziani Testa
Antonella Cacciani
Giuseppe Donato
Mira Dimko
Amalia Mariotti
Publikationsdatum: 24.09.2016
Verlag: Springer US
Erschienen in: Immunologic Research / Ausgabe 5-6/2016
Print ISSN: 0257-277X
Elektronische ISSN: 1559-0755
DOI: https://doi.org/10.1007/s12026-016-8871-1

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ASIA syndrome, calcinosis cutis and chronic kidney disease following silicone injections. A case-based review

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