Our group previously demonstrated that 75% of patients with pancreatic ductal adenocarcinoma (PDAC) experienced weight loss in the year preceding diagnosis, and greater prediagnosis weight loss was associated with poor postoperative outcomes.
1 Unfortunately, nearly all patients with PDAC experience disease recurrence after pancreatectomy.
2 Predictors of recurrence and survival outcomes have been investigated, but few have been validated. Prior studies have investigated postoperative weight change as a prognostic marker but often are limited by small sample sizes, weight measurements at standardized postoperative time points, or short follow-up. …