20.11.2021 | ASO Author Reflections
ASO Author Reflections: An Evolving Skeletal Muscle Profiling—Towards Precise Host Phenotype and Prognostic Stratification in Non-small Cell Lung Cancer
verfasst von:
Changbo Sun, MD, Masaki Anraku, MD, PhD, Jun Nakajima, MD, PhD
Erschienen in:
Annals of Surgical Oncology
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Ausgabe 3/2022
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Excerpt
Prognostic heterogeneity after surgery for non-small cell lung cancer is related to multiple factors, including tumor-specific factors and host-derived characteristics. The tumor-node-metastasis staging system provides the current guideline for the tumor-specific features. However, there are large variations in the clinical outcomes within each stage. Skeletal muscle depletion, which is associated with the loss of muscle quantity (sarcopenia) and reduced muscle quality, is a potential host-derived unfavorable factor for cancer prognosis.
1 Recently, there have been accumulating studies that simply concentrate on a single measure of either skeletal muscle area or density.
2 Nonetheless, little is known regarding the degree and impact of skeletal muscle depletion, including morphometric mass and componential density, on computed tomography within the context of non-small cell lung cancer, although chest computed tomography is routinely performed at diagnosis before surgery. …