18.03.2021 | ASO Author Reflections
ASO Author Reflections: Ovarian Cystectomy for Apparent Early-Stage Pure Immature Ovarian Teratomas
verfasst von:
Dan Wang, MD, Yang Xiang, MD
Erschienen in:
Annals of Surgical Oncology
|
Ausgabe 11/2021
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Excerpt
Immature teratomas (IMTs) are a specific subgroup of malignant ovarian germ cell tumors (MOGCTs) involving tissues derived from the ectoderm, mesoderm, and endoderm.
1 IMTs present a distinct biological behavior, and patients may relapse with IMT or develop mature elements.
2 Most IMTs occur in young patients wishing to retain their fertility, and are diagnosed at an early stage with an excellent prognosis. Current management for early-stage IMTs, except stage IA grade 1 IMT, is unilateral salpingo-oophorectomy (USO) with complete staging surgery (CSS), followed by platinum-based chemotherapy;
3 however, the necessity and extent of CSS remains controversial.
4 Chemotherapy is less effective in IMTs compared with other histological subtypes of MOGCTs.
5 Many young patients with IMTs present with acute abdominal pain (tumor torsion, tumor rupture) requiring emergency surgery, and some patients might thus undergo ovarian cystectomy with incomplete staging due to a lack of frozen sections and/or a non-gynecologic oncologist surgeon.
6,
7 Management of these patients poses a clinical dilemma if a postoperative diagnosis of IMT is made; however, information on this topic is lacking because of the rarity of IMTs. …
