Erschienen in:
16.05.2019 | ASO Author Reflections
ASO Author Reflections: Precise p53 Analysis in Formalin-Fixed Paraffin-Embedded Specimens Can Predict Head and Neck Squamous Cell Carcinoma Outcomes
verfasst von:
Taisuke Mori, DMD, PhD, Kenya Kobayashi, MD, Seiichi Yoshimoto, MD, PhD
Erschienen in:
Annals of Surgical Oncology
|
Sonderheft 3/2019
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Excerpt
Head and neck squamous cell carcinomas (HNSCCs) arise in the mucosal linings of the upper aerodigestive tract and are unexpectedly heterogeneous in nature. HNSCC is a heterogeneous disease with various etiologies, such as smoking, alcohol consumption, and human papilloma virus (HPV) infection. Recently, The Cancer Genome Atlas consortium published a comprehensive genomic characterization of 279 HNSCCs, which found no frequent druggable mutations, and observed the most frequent altered gene to be TP53 (72%) without HPV associated cases.
1 Other comprehensive analyzes were almost similar.
2,
3 The TP53 gene and its corresponding protein are frequently inactivated or partially disabled by mutations that lead to increased risks of developing cancer. However, detailed analysis of p53 molecule and analysis of tumor malignancy has not been done in HNSCC based on sufficient case number. …
