Erschienen in:
17.10.2018 | ASO Author Reflections
ASO Author Reflections: Primary Tumor Location and Long-Term Survival After Hepatic Resection for Metastatic Colon Cancer
verfasst von:
John M. Creasy, MD, Michael I. D’Angelica, MD, FACS
Erschienen in:
Annals of Surgical Oncology
|
Sonderheft 3/2018
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Excerpt
In colorectal cancer (CRC), primary tumor location is classified as proximal (right) or distal (left) based on the relationship to the splenic flexure. This distinction occurs because the right colon develops from the midgut, and the left colon develops from the hindgut. Tumors within these unique regions are known to vary in regard to clinicopathologic factors, such as microsatellite instability (MSI) and KRAS and BRAF mutation rates.
1 In recent prospective trials of metastatic and unresectable CRC, improved progression-free survival (PFS) and overall survival (OS) were observed for patients with left-sided primary tumors.
2‐
4 However, patients with limited colorectal liver metastases (CRLM) are candidates for surgery, with the potential for long-term survival and cure. The impact of primary tumor location has not been well-examined in patients with resectable CRLM and long-term follow-up. …
