Erschienen in:
05.12.2018 | ASO Author Reflections
ASO Author Reflections: PTTG1 Protein Expression in Adrenocortical Carcinoma
verfasst von:
Minerva Angélica Romero Arenas, MD, MPH, Nancy D. Perrier, MD
Erschienen in:
Annals of Surgical Oncology
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Sonderheft 3/2019
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Excerpt
Adrenocortical carcinoma (ACC) is a rare malignancy with a poor prognosis owing to late diagnosis.
1 Histological parameters may not always distinguish benign adrenocortical adenomas (ACAs) from ACCs. Additional techniques like immunohistochemical markers could provide significant clinical utility. Pituitary-tumor transforming gene (PTTG1/securin) encodes securin, a protein that prevents separins from promoting sister chromatid separation.
2,
3 PTTG1 has been shown to modulate cancer-related angiogenesis, metastasis, and therapeutic response and is highly expressed across a number of tumor types.
3,
4 This study was designed to validate the potential role of PTTG1 protein levels in ACC by utilizing a tissue microarray (TMA)-based analysis of PTTG1 nuclear protein levels across normal adrenal tissue, ACA, and ACC.
5 Differential PTTG1 expression levels between ACC and ACA were validated using publicly available messenger RNA (mRNA) expression data. Lastly, PTTG1 protein levels in ACC were correlated with clinical features. …
