Erschienen in:
15.10.2018 | ASO Author Reflections
ASO Author Reflections: Regulation of Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma by Vitamin D Supplementation
verfasst von:
Yosuke Mukai, MD, Hidetoshi Eguchi, MD, PhD
Erschienen in:
Annals of Surgical Oncology
|
Sonderheft 3/2018
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Excerpt
Pancreatic ductal adenocarcinoma (PDAC), in particular, is defined by a dense stromal compartment
1 containing cancer-associated fibroblasts (CAFs) that express α-smooth muscle actin (SMA).
2 In addition, CAFs are known to have a profound influence on tumor progression.
3 Through the secretion of various cytokines, CAFs affect cancer growth, survival, metastasis, angiogenesis, and immunosurveillance.
4 Therefore, targeting CAFs can improve therapeutic effects. To date, preoperative chemoradiation therapy (CRT) has been administered to PDAC patients. Some patients experience recurrence after curative surgery with preoperative CRT. A clinical question was raised as to whether chemoradiation therapies reduce (inactivate) or increase (activate) CAFs. However, the effect of current CRT on CAFs still is unclear. If current CRT activates CAFs, a therapy that inactivates CAFs needs to be administered with CRT. …
