ASO Author Reflections: Rethinking Spleen Preservation in Patients with Body Pancreatic Ductal Adenocarcinoma
- 22.04.2024
- ASO Author Reflections
- Verfasst von
- Christian Hobeika, MD, PhD
- Alain Sauvanet, MD
- Erschienen in
- Annals of Surgical Oncology | Ausgabe 7/2024
Auszug
En bloc distal splenopancreatectomy (DSP) with optimal tangential margin clearance followed by systemic chemotherapy is the standard of care for distal pancreatic ductal adenocarcinoma (PDAC). However, there is no evidence supporting the oncological value of splenectomy in patients with PDAC localized in the body of the pancreas (i.e., ≥5 cm from the spleen hilum) in improving distal margins, nodal staging (i.e., station 10) or prognosis.1 Conversely, the innocuity of splenectomy is unlikely, especially considering vascular and infectious, possibly lethal (e.g., overwhelming post-splenectomy infection syndrome), complications, as well as its immune function correlations with cancer promotion. Patients having spleen-preserving distal pancreatectomy (SPDP) experienced better outcomes and quality of life compared with DSP patients, as demonstrated in benign diseases and, more recently, in intraductal papillary mucinous neoplasms (IPMNs).2 Furthermore, autologous splenic implantation in DSP for benign or premalignant lesions is under evaluation.3 …
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- Titel
- ASO Author Reflections: Rethinking Spleen Preservation in Patients with Body Pancreatic Ductal Adenocarcinoma
- Verfasst von
-
Christian Hobeika, MD, PhD
Alain Sauvanet, MD
- Publikationsdatum
- 22.04.2024
- Verlag
- Springer International Publishing
- Erschienen in
-
Annals of Surgical Oncology / Ausgabe 7/2024
Print ISSN: 1068-9265
Elektronische ISSN: 1534-4681 - DOI
- https://doi.org/10.1245/s10434-024-15273-1
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