26.08.2020 | ASO Author Reflections
ASO Author Reflections: Salvage Total Laryngectomy, the Last Resort for Patients with Residual, Recurrent or Second Primary Laryngeal and Hypopharyngeal Cancer in Times of Nonsurgical Organ Preserving Treatment Strategies
verfasst von:
Jens Debacker, MD, Jeroen Meulemans, MD, Wouter Huvenne, MD, PhD, Vincent Vander Poorten, MD, MSc, PhD
Erschienen in:
Annals of Surgical Oncology
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Sonderheft 3/2020
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Excerpt
As a result of important landmark trials, the primary treatment for laryngeal and hypopharyngeal squamous cell carcinoma (SCC) shifted from surgery to nonsurgical organ-preserving strategies based on radiotherapy and chemotherapy.
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2 However, in 25–36% of patients undergoing these organ-preservation strategies, there is residual or recurrent cancer that requires salvage surgery.
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2 Consequently, salvage total laryngectomy (STL) proved a key element in increasing the patient’s survival when primary larynx-preserving strategies fail, with reported 5-year survival rates around 50%.
3 Unfortunately, predicting which patients will do well after STL remains troublesome. Multiple prognosticators were found associated with a decreased survival, but these often resulted from small sample-size series, lacking a valid multivariable analysis of the data. …