ASO Author Reflections: TRPV2 and Gastric Cancer

Excerpt

Gastric cancer (GC) is one of the most common cancers worldwide and is the fifth most frequent cancer and third main cause of cancer mortality. Although surgical treatments, perioperative therapies, and adjuvant therapies for GC have been developed, its prognosis remains poor, especially in the more advanced stages. Accordingly, additional studies are required on the pathogenesis of GC and the development of innovative therapeutic targets for its treatment. The transient receptor potential (TRP) family are ligand-gated cation-permeable ion channels. The TRP families that are stimulated by vanilloid-like molecules are classified into the TRP vanilloid (TRPV) channels group. Six types of calcium-permeable channels are now categorized into this group and have various channel properties.¹ TRPV2 is a highly Ca²⁺-permeable ion channel that is stimulated by changes in osmolarity and membrane stretch.² Recently, some reports showed the clinical significance of TRPV2 in a variety of cancers; however, the process of action of TRPV2 has not yet been clarified in vitro and the clinical significance of TRPV2 in GC remains unknown. …