Skip to main content
Erschienen in: Der Urologe 12/2012

01.12.2012 | Leitthema

Aspekte der traditionellen indischen Medizin (Ayurveda) in der Urologie

verfasst von: Dr. J. Mani, S. Kumar, G.J. Dobos, A. Haferkamp

Erschienen in: Die Urologie | Ausgabe 12/2012

Einloggen, um Zugang zu erhalten

Zusammenfassung

Ayurveda ist global gesehen das älteste System und die zumeist angewandte Naturheilkunde in Indien. Der Unterschied zur westlichen Medizin besteht darin, dass diese Heilkunde auf jahrtausendealte Erfahrungswerte, Empirie und Intuition basiert. Diese wurden über Generationen sowohl mündlich als auch über Aufzeichnungen übermittelt. Ayurveda bezieht sich nicht nur auf den Körper, sondern auch auf den Geist. Demnach resultieren die meisten Krankheiten durch die psychophysiologischen und pathologischen Veränderungen im Körper. Letztendlich ist die ausgeglichene Balance zwischen Körper, Geist und Seele die ayurvedische Definition von Gesundheit. Ayurvedische Medizin wird im Rahmen der Behandlung der Urolithiasis zur Diurese, zur Litholyse, spasmoanalgetisch und antimikrobiell eingesetzt.
Literatur
1.
Zurück zum Zitat Sharma A, Chandraker S, Patel VK, Ramteke P (2009) Antibacterial activity of medicinal plants against pathogens causing complicated urinary tract infections. Indian J Pharm Sci 71:136–139PubMedCrossRef Sharma A, Chandraker S, Patel VK, Ramteke P (2009) Antibacterial activity of medicinal plants against pathogens causing complicated urinary tract infections. Indian J Pharm Sci 71:136–139PubMedCrossRef
2.
Zurück zum Zitat Pereira RS, Sumita TC, Furlan MR et al (2004) Antibacterial activity of essential oils on microorganisms isolated from urinary tract infection. Rev Saude Publica 38:326–328PubMedCrossRef Pereira RS, Sumita TC, Furlan MR et al (2004) Antibacterial activity of essential oils on microorganisms isolated from urinary tract infection. Rev Saude Publica 38:326–328PubMedCrossRef
3.
Zurück zum Zitat Bag A, Bhattacharyya SK, Chattopadhyay RR (2008) Medicinal plants and urinary tract infections: an update. Pharmacog Rev 4:277–284 Bag A, Bhattacharyya SK, Chattopadhyay RR (2008) Medicinal plants and urinary tract infections: an update. Pharmacog Rev 4:277–284
4.
Zurück zum Zitat Sharma A, Chandraker S, Patel VK, Ramteke P (2009) Antibacterial activity of medicinal plants against pathogens causing complicated urinary tract infections. Indian J Pharm Sci 71(2):136–139PubMedCrossRef Sharma A, Chandraker S, Patel VK, Ramteke P (2009) Antibacterial activity of medicinal plants against pathogens causing complicated urinary tract infections. Indian J Pharm Sci 71(2):136–139PubMedCrossRef
5.
Zurück zum Zitat Barros ME, Schor N, Boim MA (2003) Effects of an aqueous extract from Phyllantus niruri on calcium oxalate crystallization in vitro. Urol Res 30(6):374–379PubMed Barros ME, Schor N, Boim MA (2003) Effects of an aqueous extract from Phyllantus niruri on calcium oxalate crystallization in vitro. Urol Res 30(6):374–379PubMed
6.
Zurück zum Zitat Barros ME, Lima R, Mercuri LP et al (2006) Effect of extract of Phyllanthus niruri on crystal deposition in experimental urolithiasis. Urol Res 34(6):351–357PubMedCrossRef Barros ME, Lima R, Mercuri LP et al (2006) Effect of extract of Phyllanthus niruri on crystal deposition in experimental urolithiasis. Urol Res 34(6):351–357PubMedCrossRef
7.
Zurück zum Zitat Micali S, Sighinolfi MC, Celia A et al (2006) Can Phyllanthus niruri affect the efficacy of extracorporeal shock wave lithotripsy for renal stones? A randomized, prospective, long-term study. J Urol 176(3):1020–1022PubMedCrossRef Micali S, Sighinolfi MC, Celia A et al (2006) Can Phyllanthus niruri affect the efficacy of extracorporeal shock wave lithotripsy for renal stones? A randomized, prospective, long-term study. J Urol 176(3):1020–1022PubMedCrossRef
8.
Zurück zum Zitat Sangeeta D, Sidhu H, Thind SK, Nath R (1994) Effect of Tribulus terrestris on oxalate metabolism in rats. J Ethnopharmacol 44(2):61–66PubMedCrossRef Sangeeta D, Sidhu H, Thind SK, Nath R (1994) Effect of Tribulus terrestris on oxalate metabolism in rats. J Ethnopharmacol 44(2):61–66PubMedCrossRef
9.
Zurück zum Zitat Sangeeta D, Sidhu H, Thind SK, Nath R (1994) Effect of Tribulus terrestris on oxalate metabolism in rats. J Ethnopharmacol 44(2):61–66PubMedCrossRef Sangeeta D, Sidhu H, Thind SK, Nath R (1994) Effect of Tribulus terrestris on oxalate metabolism in rats. J Ethnopharmacol 44(2):61–66PubMedCrossRef
10.
Zurück zum Zitat Christina AJ, Packia Lakshmi M, Nagarajan M, Kurian S (2002) Modulatory effect of Cyclea peltata Lam. on stone formation induced by ethylene glycol treatment in rats. Methods Find Exp Clin Pharmacol 24(2):77–79PubMedCrossRef Christina AJ, Packia Lakshmi M, Nagarajan M, Kurian S (2002) Modulatory effect of Cyclea peltata Lam. on stone formation induced by ethylene glycol treatment in rats. Methods Find Exp Clin Pharmacol 24(2):77–79PubMedCrossRef
11.
Zurück zum Zitat Christina AJ, Priya Mole M, Moorthy P (2002) Studies on the antilithic effect of Rotula aquatica lour in male Wistar rats. Methods Find Exp Clin Pharmacol 24(6):357–359PubMedCrossRef Christina AJ, Priya Mole M, Moorthy P (2002) Studies on the antilithic effect of Rotula aquatica lour in male Wistar rats. Methods Find Exp Clin Pharmacol 24(6):357–359PubMedCrossRef
12.
Zurück zum Zitat Vasava YR, Bhuyan C, Rajagopala M et al (2010) Effect of Mahayavanala Roma Kshara and Dhanyaka Gokshura Ghrita in benign prostatic hyperplasia. Ayu 31(3):332–337PubMedCrossRef Vasava YR, Bhuyan C, Rajagopala M et al (2010) Effect of Mahayavanala Roma Kshara and Dhanyaka Gokshura Ghrita in benign prostatic hyperplasia. Ayu 31(3):332–337PubMedCrossRef
13.
Zurück zum Zitat Sengupta G, Hazra A, Kundu A, Ghosh A (2011) Comparison of Murraya koenigii- and Tribulus terrestris-based oral formulation versus tamsulosin in the treatment of benign prostatic hyperplasia in men aged > 50 years: a double-blind, double-dummy, randomized controlled trial. Clin Ther 33(12):1943–1952PubMedCrossRef Sengupta G, Hazra A, Kundu A, Ghosh A (2011) Comparison of Murraya koenigii- and Tribulus terrestris-based oral formulation versus tamsulosin in the treatment of benign prostatic hyperplasia in men aged > 50 years: a double-blind, double-dummy, randomized controlled trial. Clin Ther 33(12):1943–1952PubMedCrossRef
14.
Zurück zum Zitat Reddy S, Aggarwal BB (1994) Curcumin is a non-competitive and selective inhibitor of phosphorylase kinase. FEBS Lett 341:19–22PubMedCrossRef Reddy S, Aggarwal BB (1994) Curcumin is a non-competitive and selective inhibitor of phosphorylase kinase. FEBS Lett 341:19–22PubMedCrossRef
15.
Zurück zum Zitat Singh S, Aggarwal BB (1995) Activation of transcription factor NF kappa B is suppressed by curcumin (diferuloylmethane) (corrected). J Biol Chem 270:24995–25000PubMedCrossRef Singh S, Aggarwal BB (1995) Activation of transcription factor NF kappa B is suppressed by curcumin (diferuloylmethane) (corrected). J Biol Chem 270:24995–25000PubMedCrossRef
16.
Zurück zum Zitat Natarajan K, Singh S, Burke TR Jr et al (1996) Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc Natl Acad Sci USA 93:9090–9095PubMedCrossRef Natarajan K, Singh S, Burke TR Jr et al (1996) Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B. Proc Natl Acad Sci USA 93:9090–9095PubMedCrossRef
17.
Zurück zum Zitat Singh S, Natarajan K, Aggarwal BB (1996) Capsaicin (8-methyl-Nvanillyl-6-nonenamide) is a potent inhibitor of nuclear transcription factor-kappa B activation by diverse agents. J Immunol 157:4412–4420PubMed Singh S, Natarajan K, Aggarwal BB (1996) Capsaicin (8-methyl-Nvanillyl-6-nonenamide) is a potent inhibitor of nuclear transcription factor-kappa B activation by diverse agents. J Immunol 157:4412–4420PubMed
18.
Zurück zum Zitat Chaturvedi MM, Kumar A, Darnay BG et al (1997) Sanguinarine (pseudochelerythrine) is a potent inhibitor of NF-kappa B activation, Ikappa B alpha phosphorylation, and degradation. J Biol Chem 272:30129–30134PubMedCrossRef Chaturvedi MM, Kumar A, Darnay BG et al (1997) Sanguinarine (pseudochelerythrine) is a potent inhibitor of NF-kappa B activation, Ikappa B alpha phosphorylation, and degradation. J Biol Chem 272:30129–30134PubMedCrossRef
19.
Zurück zum Zitat Kumar A, Dhawan S, Aggarwal BB (1998) Emodin (3-methyl-1,6,8- trihydroxyanthraquinone) inhibits TNF-induced NF-kappa B activation, Ikappa B degradation, and expression of cell surface adhesion proteins in human vascular endothelial cells. Oncogene 17:913–918PubMedCrossRef Kumar A, Dhawan S, Aggarwal BB (1998) Emodin (3-methyl-1,6,8- trihydroxyanthraquinone) inhibits TNF-induced NF-kappa B activation, Ikappa B degradation, and expression of cell surface adhesion proteins in human vascular endothelial cells. Oncogene 17:913–918PubMedCrossRef
20.
Zurück zum Zitat Kumar A, Dhawan S, Hardegen NJ et al (1998) Curcumin (diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-kappa B activation. Biochem Pharmacol 55:775–783PubMedCrossRef Kumar A, Dhawan S, Hardegen NJ et al (1998) Curcumin (diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-kappa B activation. Biochem Pharmacol 55:775–783PubMedCrossRef
21.
Zurück zum Zitat Manna SK, Mukhopadhyay A, Van NT et al (1999) Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun Nterminal kinase, and apoptosis. J Immunol 163:6800–6809PubMed Manna SK, Mukhopadhyay A, Van NT et al (1999) Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun Nterminal kinase, and apoptosis. J Immunol 163:6800–6809PubMed
22.
Zurück zum Zitat Manna SK, Gad YP, Mukhopadhyay A et al (1999) Suppression of tumor necrosis factor-activated nuclear transcription factor kappa B, activator protein-1, c-Jun N-terminal kinase, and apoptosis by beta-lapachone. Biochem Pharmacol 57:763–774PubMedCrossRef Manna SK, Gad YP, Mukhopadhyay A et al (1999) Suppression of tumor necrosis factor-activated nuclear transcription factor kappa B, activator protein-1, c-Jun N-terminal kinase, and apoptosis by beta-lapachone. Biochem Pharmacol 57:763–774PubMedCrossRef
23.
Zurück zum Zitat Chainy GB, Manna SK, Chaturvedi MM et al (2000) Anethole blocksboth early and late cellular responses transduced by tumornecrosis factor: effect on NF-kappa B, AP-1, JNK, MAPKK and apoptosis. Oncogene 19:2943–2950PubMedCrossRef Chainy GB, Manna SK, Chaturvedi MM et al (2000) Anethole blocksboth early and late cellular responses transduced by tumornecrosis factor: effect on NF-kappa B, AP-1, JNK, MAPKK and apoptosis. Oncogene 19:2943–2950PubMedCrossRef
24.
Zurück zum Zitat Manna SK, Sah NK, Newman RA et al (2000) Oleandrin suppressesactivation of nuclear transcription factor-kappa B, activatorprotein-1, and c-Jun NH2-terminal kinase. Cancer Res 60:3838–3847PubMed Manna SK, Sah NK, Newman RA et al (2000) Oleandrin suppressesactivation of nuclear transcription factor-kappa B, activatorprotein-1, and c-Jun NH2-terminal kinase. Cancer Res 60:3838–3847PubMed
25.
Zurück zum Zitat Manna SK, Mukhopadhyay A, Aggarwal BB (2000) Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. J Immunol 164:6509–6519PubMed Manna SK, Mukhopadhyay A, Aggarwal BB (2000) Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation. J Immunol 164:6509–6519PubMed
26.
Zurück zum Zitat Mukhopadhyay A, Bueso-Ramos C, Chatterjee D et al (2001) Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines. Oncogene 20:7597–7609PubMedCrossRef Mukhopadhyay A, Bueso-Ramos C, Chatterjee D et al (2001) Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines. Oncogene 20:7597–7609PubMedCrossRef
27.
Zurück zum Zitat Anto RJ, Mukhopadhyay A, Denning K et al (2002) Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl. Carcinogenesis 23:143–150PubMedCrossRef Anto RJ, Mukhopadhyay A, Denning K et al (2002) Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl. Carcinogenesis 23:143–150PubMedCrossRef
28.
Zurück zum Zitat Ashikawa K, Majumdar S, Banerjee S et al (2002) Piceatannol inhibits TNF-induced NF-kappa B activation and NF-kappa B-mediated gene expression through suppression of kappa B alpha kinase and p65 phosphorylation. J Immunol 169:6490–6497PubMed Ashikawa K, Majumdar S, Banerjee S et al (2002) Piceatannol inhibits TNF-induced NF-kappa B activation and NF-kappa B-mediated gene expression through suppression of kappa B alpha kinase and p65 phosphorylation. J Immunol 169:6490–6497PubMed
29.
Zurück zum Zitat Banerjee S, Bueso-Ramos C, Aggarwal BB (2002) Suppression of 7,12-imethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappa B, cyclooxygenase 2, and matrix metalloprotease 9. Cancer Res 62:4945–4954PubMed Banerjee S, Bueso-Ramos C, Aggarwal BB (2002) Suppression of 7,12-imethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappa B, cyclooxygenase 2, and matrix metalloprotease 9. Cancer Res 62:4945–4954PubMed
30.
Zurück zum Zitat Mukhopadhyay A, Banerjee S, Stafford LJ et al (2002) Curcumininduced suppression of cell proliferation correlates with downregulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation. Oncogene 21:8852–8861PubMedCrossRef Mukhopadhyay A, Banerjee S, Stafford LJ et al (2002) Curcumininduced suppression of cell proliferation correlates with downregulation of cyclin D1 expression and CDK4-mediated retinoblastoma protein phosphorylation. Oncogene 21:8852–8861PubMedCrossRef
31.
Zurück zum Zitat Bharti AC, Donato N, Aggarwal BB (2003) Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells. J Immunol 171:3863–3871PubMed Bharti AC, Donato N, Aggarwal BB (2003) Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells. J Immunol 171:3863–3871PubMed
32.
Zurück zum Zitat Bharti AC, Donato N, Singh S et al (2003) Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and Ikappa B alpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis. Blood 101:1053–1062, 43PubMedCrossRef Bharti AC, Donato N, Singh S et al (2003) Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and Ikappa B alpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis. Blood 101:1053–1062, 43PubMedCrossRef
33.
Zurück zum Zitat Estrov Z, Shishodia S, Faderl S et al (2003) Resveratrol blocks interleukin-1 beta-induced activation of the nuclear transcription factor NF-kappa B, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells. Blood 102:987–995PubMedCrossRef Estrov Z, Shishodia S, Faderl S et al (2003) Resveratrol blocks interleukin-1 beta-induced activation of the nuclear transcription factor NF-kappa B, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells. Blood 102:987–995PubMedCrossRef
34.
Zurück zum Zitat Manna SK, Bueso-Ramos C, Alvarado F et al (2003) Calagualine inhibits nuclear transcription factors-kappa B activated by various inflammatory and tumor promoting agents. Cancer Lett 190:171–182PubMedCrossRef Manna SK, Bueso-Ramos C, Alvarado F et al (2003) Calagualine inhibits nuclear transcription factors-kappa B activated by various inflammatory and tumor promoting agents. Cancer Lett 190:171–182PubMedCrossRef
35.
Zurück zum Zitat Shishodia S, Majumdar S, Banerjee S et al (2003) Ursolic acid inhibits nuclear factor-kappa B activation induced by carcinogenic agents through suppression of Ikappa B alpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1. Cancer Res 63:4375–4383PubMed Shishodia S, Majumdar S, Banerjee S et al (2003) Ursolic acid inhibits nuclear factor-kappa B activation induced by carcinogenic agents through suppression of Ikappa B alpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1. Cancer Res 63:4375–4383PubMed
36.
Zurück zum Zitat Shishodia S, Potdar P, Gairola CG et al (2003) Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappa B activation through inhibition of Ikappa B alpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1. Carcinogenesis 24:1269–1279PubMedCrossRef Shishodia S, Potdar P, Gairola CG et al (2003) Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappa B activation through inhibition of Ikappa B alpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1. Carcinogenesis 24:1269–1279PubMedCrossRef
37.
Zurück zum Zitat Takada Y, Aggarwal BB (2003) Betulinic acid suppresses carcinogeninduced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase- 2 and matrix metalloprotease-9. J Immunol 171:3278–3286PubMed Takada Y, Aggarwal BB (2003) Betulinic acid suppresses carcinogeninduced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase- 2 and matrix metalloprotease-9. J Immunol 171:3278–3286PubMed
38.
Zurück zum Zitat Aggarwal S, Takada Y, Singh S et al (2004) Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappa B signaling. Int J Cancer 111:679–692PubMedCrossRef Aggarwal S, Takada Y, Singh S et al (2004) Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappa B signaling. Int J Cancer 111:679–692PubMedCrossRef
39.
Zurück zum Zitat Bharti AC, Takada Y, Aggarwal BB (2004) Curcumin (diferuloylmethane) inhibits receptor activator of NF-kappa B ligandinduced NF-kappa B activation in osteoclast precursors and suppresses osteoclastogenesis. J Immunol 172:5940–5947PubMed Bharti AC, Takada Y, Aggarwal BB (2004) Curcumin (diferuloylmethane) inhibits receptor activator of NF-kappa B ligandinduced NF-kappa B activation in osteoclast precursors and suppresses osteoclastogenesis. J Immunol 172:5940–5947PubMed
40.
Zurück zum Zitat Li L, Aggarwal BB, Shishodia S et al (2004) Nuclear factor-kappa B and Ikappa B kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis. Cancer 101:2351–2362PubMedCrossRef Li L, Aggarwal BB, Shishodia S et al (2004) Nuclear factor-kappa B and Ikappa B kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis. Cancer 101:2351–2362PubMedCrossRef
41.
Zurück zum Zitat Shishodia S, Aggarwal BB (2004) Guggulsterone inhibits NF-kappa B and Ikappa B alpha kinase activation, suppresses expression of antiapoptotic gene products, and enhances apoptosis. J Biol Chem 279:47148–47158PubMedCrossRef Shishodia S, Aggarwal BB (2004) Guggulsterone inhibits NF-kappa B and Ikappa B alpha kinase activation, suppresses expression of antiapoptotic gene products, and enhances apoptosis. J Biol Chem 279:47148–47158PubMedCrossRef
42.
Zurück zum Zitat Takada Y, Aggarwal BB (2004) Flavopiridol inhibits NF-kappa B activation induced by various carcinogens and inflammatory agents through inhibition of Ikappa B alpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9. J Biol Chem 279:4750–4759PubMedCrossRef Takada Y, Aggarwal BB (2004) Flavopiridol inhibits NF-kappa B activation induced by various carcinogens and inflammatory agents through inhibition of Ikappa B alpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9. J Biol Chem 279:4750–4759PubMedCrossRef
43.
Zurück zum Zitat Aggarwal BB, Shishodia S, Takada Y et al (2005) Curcumin suppresses the paclitaxel-induced nuclear factor-kappa B pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. Clin Cancer Res 11:7490–7498PubMedCrossRef Aggarwal BB, Shishodia S, Takada Y et al (2005) Curcumin suppresses the paclitaxel-induced nuclear factor-kappa B pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. Clin Cancer Res 11:7490–7498PubMedCrossRef
44.
Zurück zum Zitat Ichikawa H, Takada Y, Murakami A et al (2005) Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products. J Immunol 174:7383–7392PubMed Ichikawa H, Takada Y, Murakami A et al (2005) Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products. J Immunol 174:7383–7392PubMed
45.
Zurück zum Zitat Shishodia S, Amin HM, Lai R et al (2005) Curcumin (diferuloylmethane) inhibits constitutive NF-kappa B activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma. Biochem Pharmacol 70:700–713PubMedCrossRef Shishodia S, Amin HM, Lai R et al (2005) Curcumin (diferuloylmethane) inhibits constitutive NF-kappa B activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma. Biochem Pharmacol 70:700–713PubMedCrossRef
46.
Zurück zum Zitat Siwak DR, Shishodia S, Aggarwal BB et al (2005) Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of Ikappa B kinase and nuclear factor kappa B activity and are independent of the B-Raf/mitogenactivated/extracellular signal-regulated protein kinase pathway and the Akt pathway. Cancer 104:879–890PubMedCrossRef Siwak DR, Shishodia S, Aggarwal BB et al (2005) Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of Ikappa B kinase and nuclear factor kappa B activity and are independent of the B-Raf/mitogenactivated/extracellular signal-regulated protein kinase pathway and the Akt pathway. Cancer 104:879–890PubMedCrossRef
47.
Zurück zum Zitat Takada Y, Murakami A, Aggarwal BB (2005) Zerumbone abolishes NF kappa B and Ikappa B alpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion. Oncogene 24:6957–6969PubMedCrossRef Takada Y, Murakami A, Aggarwal BB (2005) Zerumbone abolishes NF kappa B and Ikappa B alpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion. Oncogene 24:6957–6969PubMedCrossRef
48.
Zurück zum Zitat Takada Y, Andreeff M, Aggarwal BB (2005) Indole-3-carbinol suppresses NF-kappa B and Ikappa B alpha kinase activation, causing inhibition of expression of NF-kappa B-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells. Blood 106:641–649PubMedCrossRef Takada Y, Andreeff M, Aggarwal BB (2005) Indole-3-carbinol suppresses NF-kappa B and Ikappa B alpha kinase activation, causing inhibition of expression of NF-kappa B-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells. Blood 106:641–649PubMedCrossRef
49.
Zurück zum Zitat Takada Y, Kobayashi Y, Aggarwal BB (2005) Evodiamine abolishes constitutive and inducible NF-kappa B activation by inhibiting Ikappa B alpha kinase activation, thereby suppressing NF-kappa B regulated antiapoptotic and metastatic gene expression, upregulating apoptosis, and inhibiting invasion. J Biol Chem 280:17203–17212PubMedCrossRef Takada Y, Kobayashi Y, Aggarwal BB (2005) Evodiamine abolishes constitutive and inducible NF-kappa B activation by inhibiting Ikappa B alpha kinase activation, thereby suppressing NF-kappa B regulated antiapoptotic and metastatic gene expression, upregulating apoptosis, and inhibiting invasion. J Biol Chem 280:17203–17212PubMedCrossRef
50.
Zurück zum Zitat Adams LS, Seeram NP, Aggarwal BB et al (2006) Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells. J Agric Food Chem 54:980–985PubMedCrossRef Adams LS, Seeram NP, Aggarwal BB et al (2006) Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells. J Agric Food Chem 54:980–985PubMedCrossRef
51.
Zurück zum Zitat Aggarwal S, Ichikawa H, Takada Y et al (2006) Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of Ikappa B alpha kinase and Akt activation. Mol Pharmacol 69:195–206PubMed Aggarwal S, Ichikawa H, Takada Y et al (2006) Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of Ikappa B alpha kinase and Akt activation. Mol Pharmacol 69:195–206PubMed
52.
Zurück zum Zitat Chakravarti N, Myers JN, Aggarwal BB (2006) Targeting constitutive and interleukin-6-inducible signal transducers and activators of transcription 3 pathway in head and neck squamous cell carcinoma carcinoma cells by curcumin (diferuloylmethane). Int J Cancer 119(6):1268–1275PubMedCrossRef Chakravarti N, Myers JN, Aggarwal BB (2006) Targeting constitutive and interleukin-6-inducible signal transducers and activators of transcription 3 pathway in head and neck squamous cell carcinoma carcinoma cells by curcumin (diferuloylmethane). Int J Cancer 119(6):1268–1275PubMedCrossRef
53.
Zurück zum Zitat Ichikawa H, Takada Y, Shishodia S et al (2006) Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-kappa B (NF-kappa B) activation and NF-kappa B-regulated gene expression. Mol Cancer Ther 5:1434–1445PubMedCrossRef Ichikawa H, Takada Y, Shishodia S et al (2006) Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-kappa B (NF-kappa B) activation and NF-kappa B-regulated gene expression. Mol Cancer Ther 5:1434–1445PubMedCrossRef
54.
Zurück zum Zitat Ichikawa H, Murakami A, Aggarwal BB (2006) 19-Acetoxychavicol acetate inhibits RANKL-induced osteoclastic differentiation of RAW 264.7 monocytic cells by suppressing nuclear factor-kappa B activation. Mol Cancer Res 4:275–281PubMedCrossRef Ichikawa H, Murakami A, Aggarwal BB (2006) 19-Acetoxychavicol acetate inhibits RANKL-induced osteoclastic differentiation of RAW 264.7 monocytic cells by suppressing nuclear factor-kappa B activation. Mol Cancer Res 4:275–281PubMedCrossRef
55.
Zurück zum Zitat Ichikawa H, Aggarwal BB (2006) Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kappa B ligand and by tumor cells by suppressing nuclear factor-kappa B activation. Clin Cancer Res 12:662–668PubMedCrossRef Ichikawa H, Aggarwal BB (2006) Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kappa B ligand and by tumor cells by suppressing nuclear factor-kappa B activation. Clin Cancer Res 12:662–668PubMedCrossRef
56.
Zurück zum Zitat Sandur SK, Ichikawa H, Sethi G et al (2006) Plumbagin (5-hydroxy-2- methyl-1,4-naphthoquinone) suppresses NF-kappa B activation and NF-kappa B-regulated gene products through modulation of p65 and Ikappa B alpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents. J Biol Chem 281:17023–17033PubMedCrossRef Sandur SK, Ichikawa H, Sethi G et al (2006) Plumbagin (5-hydroxy-2- methyl-1,4-naphthoquinone) suppresses NF-kappa B activation and NF-kappa B-regulated gene products through modulation of p65 and Ikappa B alpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents. J Biol Chem 281:17023–17033PubMedCrossRef
57.
Zurück zum Zitat Sethi G, Ahn KS, Sandur SK et al (2006) Indirubin enhances TNFinduced apoptosis through modulation of nuclear factor-kappa B signaling pathway. J Biol Chem Sethi G, Ahn KS, Sandur SK et al (2006) Indirubin enhances TNFinduced apoptosis through modulation of nuclear factor-kappa B signaling pathway. J Biol Chem
58.
Zurück zum Zitat Shishodia S, Aggarwal BB (2006) Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, I kappa B kinase activation and NF-kappa B-regulated gene expression. Oncogene 25:1463–1473PubMedCrossRef Shishodia S, Aggarwal BB (2006) Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, I kappa B kinase activation and NF-kappa B-regulated gene expression. Oncogene 25:1463–1473PubMedCrossRef
59.
Zurück zum Zitat Takada Y, Ichikawa H, Badmaev V et al (2006) Acetyl-11-keto-betaboswellic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing NF-kappa B and NF-kappa B-regulated gene expression. J Immunol 176:3127–3140PubMed Takada Y, Ichikawa H, Badmaev V et al (2006) Acetyl-11-keto-betaboswellic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing NF-kappa B and NF-kappa B-regulated gene expression. J Immunol 176:3127–3140PubMed
60.
Zurück zum Zitat Zambre AP, Kulkarni VM, Padhye S et al (2006) Novel curcumin analogs targeting TNF-induced NF-kappa B activation and proliferation in human leukemic KBM-5 cells. Bioorg Med Chem Zambre AP, Kulkarni VM, Padhye S et al (2006) Novel curcumin analogs targeting TNF-induced NF-kappa B activation and proliferation in human leukemic KBM-5 cells. Bioorg Med Chem
61.
Zurück zum Zitat Fukuda K, Hibiya Y, Mutoh M et al (1999) Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells. J Ethnopharmacol 66:227–233PubMedCrossRef Fukuda K, Hibiya Y, Mutoh M et al (1999) Inhibition by berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells. J Ethnopharmacol 66:227–233PubMedCrossRef
62.
Zurück zum Zitat Hong CH, Hur SK, Oh OJ et al (2002) Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells. J Ethnopharmacol 83:153–159PubMedCrossRef Hong CH, Hur SK, Oh OJ et al (2002) Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells. J Ethnopharmacol 83:153–159PubMedCrossRef
63.
Zurück zum Zitat Kiemer AK, Hartung T, Huber C et al (2003) Phyllanthus amarus has anti-inflammatory potential by inhibition of iNOS, COX-2, and cytokines via the NF-kappa B pathway. J Hepatol 38:289–297PubMedCrossRef Kiemer AK, Hartung T, Huber C et al (2003) Phyllanthus amarus has anti-inflammatory potential by inhibition of iNOS, COX-2, and cytokines via the NF-kappa B pathway. J Hepatol 38:289–297PubMedCrossRef
64.
Zurück zum Zitat Li RW, Leach DN, Myers SP et al (2004) Anti-inflammatory activity, cytotoxicity and active compounds of Tinospora smilacina Benth. Phytother Res 18:78–83PubMedCrossRef Li RW, Leach DN, Myers SP et al (2004) Anti-inflammatory activity, cytotoxicity and active compounds of Tinospora smilacina Benth. Phytother Res 18:78–83PubMedCrossRef
65.
Zurück zum Zitat Chun KS, Keum YS, Han SS et al (2003) Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kappa B activation. Carcinogenesis 24:1515–1524PubMedCrossRef Chun KS, Keum YS, Han SS et al (2003) Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kappa B activation. Carcinogenesis 24:1515–1524PubMedCrossRef
66.
Zurück zum Zitat Androulakis XM, Muga SJ, Chen F et al (2006) Chemopreventive effects of Khaya senegalensis bark extract on human colorectal cancer. Anticancer Res 26:2397–2405PubMed Androulakis XM, Muga SJ, Chen F et al (2006) Chemopreventive effects of Khaya senegalensis bark extract on human colorectal cancer. Anticancer Res 26:2397–2405PubMed
67.
Zurück zum Zitat Huss U, Ringbom T, Perera P et al (2002) Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay. J Nat Prod 65:1517–1521PubMedCrossRef Huss U, Ringbom T, Perera P et al (2002) Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay. J Nat Prod 65:1517–1521PubMedCrossRef
68.
Zurück zum Zitat Marsik P, Kokoska L, Landa P et al (2005) In vitro inhibitory effects of thymol and quinones of Nigella sativa seeds on cyclooxygenase-1- and -2-catalyzed prostaglandin E2 biosyntheses. Planta Med 71:739–742PubMedCrossRef Marsik P, Kokoska L, Landa P et al (2005) In vitro inhibitory effects of thymol and quinones of Nigella sativa seeds on cyclooxygenase-1- and -2-catalyzed prostaglandin E2 biosyntheses. Planta Med 71:739–742PubMedCrossRef
69.
Zurück zum Zitat Lev-Ari S, Maimon Y, Strier L et al (2006) Down-regulation of prostaglandin E2 by curcumin is correlated with inhibition of cell growth and induction of apoptosis in human colon carcinoma cell lines. J Soc Integr Oncol 4:21–26PubMed Lev-Ari S, Maimon Y, Strier L et al (2006) Down-regulation of prostaglandin E2 by curcumin is correlated with inhibition of cell growth and induction of apoptosis in human colon carcinoma cell lines. J Soc Integr Oncol 4:21–26PubMed
70.
Zurück zum Zitat Park C, Kim GY, Kim GD et al (2006) Induction of G2/M arrest and inhibition of cyclooxygenase-2 activity by curcumin in human bladder cancer T24 cells. Oncol Rep 15:1225–1231PubMed Park C, Kim GY, Kim GD et al (2006) Induction of G2/M arrest and inhibition of cyclooxygenase-2 activity by curcumin in human bladder cancer T24 cells. Oncol Rep 15:1225–1231PubMed
71.
Zurück zum Zitat Sharma MK, Kumar M, Kumar A (2002) Ocimum sanctum aqueous leaf extract provides protection against mercury induced toxicity in Swiss albino mice. Indian J Exp Biol 40:1079–1082PubMed Sharma MK, Kumar M, Kumar A (2002) Ocimum sanctum aqueous leaf extract provides protection against mercury induced toxicity in Swiss albino mice. Indian J Exp Biol 40:1079–1082PubMed
72.
Zurück zum Zitat Samudralwar DL, Garg AN (1996) Minor and trace elemental determination in the Indian herbal and other medicinal preparations. Biol Trace Elem Res 54:113–121PubMedCrossRef Samudralwar DL, Garg AN (1996) Minor and trace elemental determination in the Indian herbal and other medicinal preparations. Biol Trace Elem Res 54:113–121PubMedCrossRef
73.
Zurück zum Zitat Rekha PS, Kuttan G, Kuttan R (2001) Antioxidant activity of Brahma rasayana. Indian J Exp Biol 39:447–452PubMed Rekha PS, Kuttan G, Kuttan R (2001) Antioxidant activity of Brahma rasayana. Indian J Exp Biol 39:447–452PubMed
74.
Zurück zum Zitat Paranjpe P, Patki P, Patwardhan B (1990) Ayurvedic treatment of obesity: a randomised double-blind, placebo-controlled clinical trial. J Ethnopharmacol 29:1–11PubMedCrossRef Paranjpe P, Patki P, Patwardhan B (1990) Ayurvedic treatment of obesity: a randomised double-blind, placebo-controlled clinical trial. J Ethnopharmacol 29:1–11PubMedCrossRef
75.
Zurück zum Zitat Aggarwal BB, Bhatt ID, Ichikawa H et al (2007) Curcumin—biological and medicinal properties. In: Ravindran PN, Babu KN, Sivaraman K (Hrsg) Turmeric the Genus Curcuma. CRC Press, NY, S 297–368 Aggarwal BB, Bhatt ID, Ichikawa H et al (2007) Curcumin—biological and medicinal properties. In: Ravindran PN, Babu KN, Sivaraman K (Hrsg) Turmeric the Genus Curcuma. CRC Press, NY, S 297–368
76.
Zurück zum Zitat Shenouda NS, Zhou C, Browning JD et al (2004) Phytoestrogens in common herbs regulate prostate cancer cell growth in vitro. Nutr Cancer 49:200–208PubMedCrossRef Shenouda NS, Zhou C, Browning JD et al (2004) Phytoestrogens in common herbs regulate prostate cancer cell growth in vitro. Nutr Cancer 49:200–208PubMedCrossRef
77.
Zurück zum Zitat Shankar S, Chen Q, Sarva K et al (2007) Curcumin enhances the apoptosis-inducing potential of TRAIL in prostate cancer cells: molecular mechanisms of apoptosis, migration and angiogenesis. J Mol Signal 2:10PubMedCrossRef Shankar S, Chen Q, Sarva K et al (2007) Curcumin enhances the apoptosis-inducing potential of TRAIL in prostate cancer cells: molecular mechanisms of apoptosis, migration and angiogenesis. J Mol Signal 2:10PubMedCrossRef
78.
Zurück zum Zitat Goel A, Kunnumakkara AB, Aggarwal BB (2007) Curcumin as Curecumin: from kitchen to clinic. Biochem Pharmacol Goel A, Kunnumakkara AB, Aggarwal BB (2007) Curcumin as Curecumin: from kitchen to clinic. Biochem Pharmacol
79.
Zurück zum Zitat Pang X, Yi Z, Zhang X et al (2009) Acetyl-11-keto-beta-boswellic acid inhibits prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis. Cancer Res 69(14):5893–5900PubMedCrossRef Pang X, Yi Z, Zhang X et al (2009) Acetyl-11-keto-beta-boswellic acid inhibits prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis. Cancer Res 69(14):5893–5900PubMedCrossRef
80.
Zurück zum Zitat Singh SV, Choi S, Zeng Y et al (2007) Guggulsterone-induced apoptosis in human prostate cancer cells is caused by reactive oxygen intermediate dependent activation of c-Jun NH2-terminal kinase. Cancer Res 67(15):7439–7449PubMedCrossRef Singh SV, Choi S, Zeng Y et al (2007) Guggulsterone-induced apoptosis in human prostate cancer cells is caused by reactive oxygen intermediate dependent activation of c-Jun NH2-terminal kinase. Cancer Res 67(15):7439–7449PubMedCrossRef
81.
Zurück zum Zitat Singh SV, Zeng Y, Xiao D et al (2005) Caspase-dependent apoptosis induction by guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, in PC-3 human prostate cancer cells is mediated by Bax and Bak. Mol Cancer Ther 4(11):1747–1754PubMedCrossRef Singh SV, Zeng Y, Xiao D et al (2005) Caspase-dependent apoptosis induction by guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, in PC-3 human prostate cancer cells is mediated by Bax and Bak. Mol Cancer Ther 4(11):1747–1754PubMedCrossRef
82.
Zurück zum Zitat Xiao D, Singh SV (2008) z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. Mol Cancer Ther 7(1):171–180PubMedCrossRef Xiao D, Singh SV (2008) z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. Mol Cancer Ther 7(1):171–180PubMedCrossRef
83.
Zurück zum Zitat Ru P, Steele R, Nerurkar PV et al (2011) Bitter melon extract impairs prostate cancer cell-cycle progression and delays prostatic intraepithelial neoplasia in TRAMP model. Cancer Prev Res (Phila) 4(12):2122–2130CrossRef Ru P, Steele R, Nerurkar PV et al (2011) Bitter melon extract impairs prostate cancer cell-cycle progression and delays prostatic intraepithelial neoplasia in TRAMP model. Cancer Prev Res (Phila) 4(12):2122–2130CrossRef
84.
Zurück zum Zitat Tong QS, Zheng LD, Lu P et al (2006) Apoptosis-inducing effects of curcumin derivatives in human bladder cancer cells. Anticancer Drugs 17(3):279–287PubMedCrossRef Tong QS, Zheng LD, Lu P et al (2006) Apoptosis-inducing effects of curcumin derivatives in human bladder cancer cells. Anticancer Drugs 17(3):279–287PubMedCrossRef
85.
Zurück zum Zitat Watanabe FT, Chade DC, Reis ST et al (2011) Curcumin, but not Prima-1, decreased tumor cell proliferation in the syngeneic murine orthotopic bladder tumor model. Clinics (Sao Paulo) 66(12):2121–2124 Watanabe FT, Chade DC, Reis ST et al (2011) Curcumin, but not Prima-1, decreased tumor cell proliferation in the syngeneic murine orthotopic bladder tumor model. Clinics (Sao Paulo) 66(12):2121–2124
86.
Zurück zum Zitat Chadalapaka G, Jutooru I, Burghardt R, Safe S (2010) Drugs that target specificity proteins downregulate epidermal growth factor receptor in bladder cancer cells. Mol Cancer Res 8(5):739–750PubMedCrossRef Chadalapaka G, Jutooru I, Burghardt R, Safe S (2010) Drugs that target specificity proteins downregulate epidermal growth factor receptor in bladder cancer cells. Mol Cancer Res 8(5):739–750PubMedCrossRef
87.
Zurück zum Zitat Goel A, Aggarwal BB (2010) Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radiprotector for normal organs. Nutr Cancer 62(7):919–930 (Review)PubMedCrossRef Goel A, Aggarwal BB (2010) Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radiprotector for normal organs. Nutr Cancer 62(7):919–930 (Review)PubMedCrossRef
88.
Zurück zum Zitat Chen X, Hasuma T, Yano Y et al (1997) Inhibition of farnesyl protein transferase by monoterpene, curcumin derivatives and gallotannin. Anticancer Res 17:2555–2564PubMed Chen X, Hasuma T, Yano Y et al (1997) Inhibition of farnesyl protein transferase by monoterpene, curcumin derivatives and gallotannin. Anticancer Res 17:2555–2564PubMed
89.
Zurück zum Zitat Woo JH, Kim YH, Choi YJ et al (2003) Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt. Carcinogenesis 24(7):1199–1208PubMedCrossRef Woo JH, Kim YH, Choi YJ et al (2003) Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt. Carcinogenesis 24(7):1199–1208PubMedCrossRef
90.
Zurück zum Zitat Frank N, Knauft J, Amelung F et al (2003) No prevention of liver and kidney tumors in Long-Evans Cinnamon rats by dietary curcumin, but inhibition at other sites and of metastases. Mutat Res 523–524:127–135 Frank N, Knauft J, Amelung F et al (2003) No prevention of liver and kidney tumors in Long-Evans Cinnamon rats by dietary curcumin, but inhibition at other sites and of metastases. Mutat Res 523–524:127–135
91.
Zurück zum Zitat Garodia P, Ichikawa H, Malani N et al (2007) From ancient medicine to modern medicine: ayurvedic concepts of health and their role in inflammation and cancer. J Soc Integr Oncol Winter 5(1):25–37CrossRef Garodia P, Ichikawa H, Malani N et al (2007) From ancient medicine to modern medicine: ayurvedic concepts of health and their role in inflammation and cancer. J Soc Integr Oncol Winter 5(1):25–37CrossRef
92.
Zurück zum Zitat Anand P, Sundaram C, Jhurani S et al (2008) Curcumin and cancer: an „old-age“ disease with an „age-old“ solution. Cancer Lett 267(1):133–164PubMedCrossRef Anand P, Sundaram C, Jhurani S et al (2008) Curcumin and cancer: an „old-age“ disease with an „age-old“ solution. Cancer Lett 267(1):133–164PubMedCrossRef
Metadaten
Titel
Aspekte der traditionellen indischen Medizin (Ayurveda) in der Urologie
verfasst von
Dr. J. Mani
S. Kumar
G.J. Dobos
A. Haferkamp
Publikationsdatum
01.12.2012
Verlag
Springer-Verlag
Erschienen in
Die Urologie / Ausgabe 12/2012
Print ISSN: 2731-7064
Elektronische ISSN: 2731-7072
DOI
https://doi.org/10.1007/s00120-012-3063-7

Weitere Artikel der Ausgabe 12/2012

Der Urologe 12/2012 Zur Ausgabe

URO-Telegramm

URO-Telegramm

Update Urologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.