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Erschienen in: Journal of Anesthesia 1/2017

17.10.2016 | Letter to the Editor

Assessing interaction between dexmedetomidine and propofol

verfasst von: Gui-Zhen Yang, Fu-Shan Xue, Chao Sun

Erschienen in: Journal of Anesthesia | Ausgabe 1/2017

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Excerpt

In the recent article by Yoo et al. [1] assessing the effect of dexmedetomidine pretreatment on the median effective bolus dose of propofol for facilitating laryngeal mask airway insertion, dexmedetomidine 1 µg/kg was infused over 10 min, followed by propofol 2.5 mg/kg administration and the laryngeal mask airway was inserted. The main disadvantage of using dexmedetomidine as a drug of anesthesia induction is slow onset. Because intravenous administration of dexmedetomidine has an onset of action after approximately 15 min in healthy adults, it is recommended that a single dose dexmedetomidine should be given 15 min before anesthesia induction [2]. Moreover, in the methods, there was no mention of time to start the laryngeal mask airway insertion after completion of propofol administration. After intravenous injection of propofol, the time to reach peak effect is about 100–120 s [3]. …
Literatur
1.
Zurück zum Zitat Yoo JY, Kwak HJ, Kim YB, Park CK, Lee SY, Kim JY. The effect of dexmedetomidine pretreatment on the median effective bolus dose of propofol for facilitating laryngeal mask airway insertion. J Anesth. 2016. doi:10.1007/s00540-016-2245-7. Yoo JY, Kwak HJ, Kim YB, Park CK, Lee SY, Kim JY. The effect of dexmedetomidine pretreatment on the median effective bolus dose of propofol for facilitating laryngeal mask airway insertion. J Anesth. 2016. doi:10.​1007/​s00540-016-2245-7.
2.
Zurück zum Zitat Afonso J, Reis F. Dexmedetomidine: current role in anesthesia and intensive care. Rev Bras Anestesiol. 2012;62:118–33.CrossRefPubMed Afonso J, Reis F. Dexmedetomidine: current role in anesthesia and intensive care. Rev Bras Anestesiol. 2012;62:118–33.CrossRefPubMed
3.
Zurück zum Zitat Rolly G, Versichelen L, Huyghe L, Mungroop H. Effect of speed of injection on induction of anaesthesia using propofol. Br J Anaesth. 1985;57:743–6.CrossRefPubMed Rolly G, Versichelen L, Huyghe L, Mungroop H. Effect of speed of injection on induction of anaesthesia using propofol. Br J Anaesth. 1985;57:743–6.CrossRefPubMed
Metadaten
Titel
Assessing interaction between dexmedetomidine and propofol
verfasst von
Gui-Zhen Yang
Fu-Shan Xue
Chao Sun
Publikationsdatum
17.10.2016
Verlag
Springer Japan
Erschienen in
Journal of Anesthesia / Ausgabe 1/2017
Print ISSN: 0913-8668
Elektronische ISSN: 1438-8359
DOI
https://doi.org/10.1007/s00540-016-2258-2

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