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International Journal of Clinical Pharmacy

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01.02.2014 | Review Article

Assessing medication adherence: options to consider

verfasst von: Audrey Lehmann, Parisa Aslani, Rana Ahmed, Jennifer Celio, Aurelie Gauchet, Pierrick Bedouch, Olivier Bugnon, Benoît Allenet, Marie Paule Schneider

Erschienen in: International Journal of Clinical Pharmacy | Ausgabe 1/2014

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Abstract

Background Adherence to chronic therapy is a key determinant of patient health outcomes in chronic disease. However, only about 50 % of patients adhere to chronic therapy. One of the challenges in promoting adherence is having an accurate understanding of adherence rates and the factors that contribute to non-adherence. There are many measures available to assess patient medication adherence. Aim of the review This review aims to present the commonly used indirect methods available for measuring medication adherence in routine healthcare and research studies. Method A literature review on medication adherence measures in patient populations with chronic conditions taking chronic medications was conducted through Medline (2003–2013). A complementary manual search of references cited in the retrieved studies was performed in order to identify any additional studies. Results Of the 238 initial Medline search results, 57 full texts were retrieved. Forty-seven articles were included as a result of the manual search. Adherence measures identified were: self-report (reported in 50 publications), electronic measures (33), pharmacy refills and claims data (26) and pill counts (25). Patient self-report, electronic measures, pharmacy refill and claims data were the most commonly used measures of adherence in research, routine practice, epidemiological and intervention studies. These methods, and their strengths and limitations have been described in this paper. Conclusion A multitude of indirect measures of adherence exist in the literature, however, there is no “gold” standard for measuring adherence to medications. Triangulation of methods increases the validity and reliability of the adherence data collected. To strengthen the adherence data collected and allow for comparison of data, future research and practice interventions should use an internationally accepted, operational standardized definition of medication adherence and clearly describe the medication adherence methods used.

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Nunes V, Neilson J, O’Flynn N, Calvert N, Kuntze S, Smithson H, et al. Clinical Guidelines and Evidence Review for Medicines Adherence: involving patients in decisions about prescribed medicines and supporting adherence [Internet]. London, National Collaborating Centre for Primary Care and Royal College of General Practitioners; 2009. 364p. [cited 2013 Jul 16]. Available from: http://www.nice.org.uk/nicemedia/pdf/CG76FullGuideline.pdf.

Haynes RB, Ackloo E, Sahota N, McDonald HP, Yao X. Interventions for enhancing medication adherence. Cochrane Database Syst Rev. 2008(2):Cd000011.

Golay A. Pharmacoeconomic aspects of poor adherence: can better adherence reduce healthcare costs? J Med Econ. 2011;14(5):594–608.PubMed

Gadkari AS, McHorney CA. Medication nonfulfillment rates and reasons: narrative systematic review. Curr Med Res Opin. 2010;26(3):683–705.PubMed

Haynes RB, McDonald HP, Garg AX. Helping patients follow prescribed treatment: clinical applications. JAMA. 2002;288(22):2880–3.PubMed

Sabate E. Adherence to long-term therapies: Evidence for action [Internet]. Geneva: World Health Organisation; 2003. 196 p. [cited 2013 Jul 16]. Available from: http://whqlibdoc.who.int/publications/2003/9241545992.pdf.

Vrijens B, De Geest S, Hughes DA, Przemyslaw K, Demonceau J, Ruppar T, et al. A new taxonomy for describing and defining adherence to medications. Br J Clin Pharmacol. 2012;73(5):691–705.PubMed

Burrell A, Wong P, Ollendorf D, Fuldeore M, Roy A, Fairchild C, et al. Defining compliance/adherence and persistence. ISPOR Special Interest Working Group. Value Health. 2005;8:A194–5.

Baudrant-Boga M, Lehmann A, Allenet B. Thinking differently the patient medication compliance: from an injunctive posture to a working alliance between the patient and the healthcare provider: concepts and determinants. Ann Pharm Fr. 2012;70(1):15–25 French.PubMed

10.

Schneider MP, Herzig L, Hampai DH, Bugnon O. Medication adherence in chronic patients: from its concepts to its management in primary care. Rev Med Suisse. 2013;9(386):1032–6 French.PubMed

11.

Allenet B, Baudrant M, Lehmann A, Gauchet A, Roustit M, Bedouch P, et al. How can we evaluate medication adherence? What are the methods? Ann Pharm Fr. 2013;71(2):135–41 French.PubMed

12.

Horne R, Weinman J, Barber N, Elliot R, Morgan M. Concordance, adherence and compliance in medicine taking. London: Report for the National Co-ordinating Centre for NHS Service Delivery and Organisation R & D; 2005.

13.

Dunbar-Jacob J, Sereika SM, Houze M, Luyster FS, Callan JA. Accuracy of measures of medication adherence in a cholesterol-lowering regimen. West J Nurs Res. 2012;34(5):578–97.PubMedCentralPubMed

14.

Vollmer WM, Xu M, Feldstein A, Smith D, Waterbury A, Rand C. Comparison of pharmacy-based measures of medication adherence. BMC Health Serv Res. 2012;12:155.PubMedCentralPubMed

15.

McCarberg BH. A critical assessment of opioid treatment adherence using urine drug testing in chronic pain management. Postgrad Med. 2011;123(6):124–31.PubMed

16.

Cook P, Schmiege S, McClean M, Aagaard L, Kahook M. Practical and analytic issues in the electronic assessment of adherence. West J Nurs Res. 2012;34(5):598–620.PubMed

17.

Garfield S, Clifford S, Eliasson L, Barber N, Willson A. Suitability of measures of self-reported medication adherence for routine clinical use: a systematic review. BMC Med Res Methodol. 2011;11:149.PubMedCentralPubMed

18.

Spoelstra SL, Given CW. Assessment and measurement of adherence to oral antineoplastic agents. Semin Oncol Nurs. 2011;27(2):116–32.PubMed

19.

Mora PA, Berkowitz A, Contrada RJ, Wisnivesky J, Horne R, Leventhal H, et al. Factor structure and longitudinal invariance of the Medical Adherence Report Scale-Asthma. Psychol Health. 2011;26(6):713–27.PubMed

20.

Vervloet M, van Dijk L, Santen-Reestman J, van Vlijmen B, Bouvy ML, de Bakker DH. Improving medication adherence in diabetes type 2 patients through Real Time Medication Monitoring: a randomised controlled trial to evaluate the effect of monitoring patients’ medication use combined with short message service (SMS) reminders. BMC Health Serv Res. 2011;11:5.PubMedCentralPubMed

21.

Devulapalli KK, Ignacio RV, Weiden P, Cassidy KA, Williams TD, Safavi R, et al. Why do persons with bipolar disorder stop their medication? Psychopharmacol Bull. 2010;43(3):5–14.PubMed

22.

Sajatovic M, Velligan DI, Weiden PJ, Valenstein MA, Ogedegbe G. Measurement of psychiatric treatment adherence. J Psychosom Res. 2010;69(6):591–9.PubMed

23.

Shi L, Liu J, Koleva Y, Fonseca V, Kalsekar A, Pawaskar M. Concordance of adherence measurement using self-reported adherence questionnaires and medication monitoring devices. Pharmacoeconomics. 2010;28(12):1097–107.PubMed

24.

Nakonezny PA, Hughes CW, Mayes TL, Sternweis-Yang KH, Kennard BD, Byerly MJ, et al. A comparison of various methods of measuring antidepressant medication adherence among children and adolescents with major depressive disorder in a 12-week open trial of fluoxetine. J Child Adolesc Psychopharmacol. 2010;20(5):431–9.PubMed

25.

Shi L, Liu J, Fonseca V, Walker P, Kalsekar A, Pawaskar M. Correlation between adherence rates measured by MEMS and self-reported questionnaires: a meta-analysis. Health Qual Life Outcomes. 2010;8:99.PubMedCentralPubMed

26.

Carter BL, van Mil JWF. Comparative effectiveness research: evaluating pharmacist interventions and strategies to improve medication adherence. Am J Hypertens. 2010;23(9):949–55.PubMed

27.

Velligan D, Sajatovic M, Valenstein M, Riley WT, Safren S, Lewis-Fernandez R, et al. Methodological challenges in psychiatric treatment adherence research. Clin Schizophr Relat Psychoses. 2010;4(1):74–91.PubMed

28.

Cohen HW, Shmukler C, Ullman R, Rivera CM, Walker EA. Measurements of medication adherence in diabetic patients with poorly controlled HbA(1c). Diabet Med. 2010;27(2):210–6.PubMed

29.

Dobbels F, Berben L, De Geest S, Drent G, Lennerling A, Whittaker C, et al. The psychometric properties and practicability of self-report instruments to identify medication nonadherence in adult transplant patients: a systematic review. Transplantation. 2010;90(2):205–19.PubMed

30.

Greenlaw SM, Yentzer BA, O’Neill JL, Balkrishnan R, Feldman SR. Assessing adherence to dermatology treatments: a review of self-report and electronic measures. Skin Res Technol. 2010;16(2):253–8.PubMed

31.

Muzzarelli S, Brunner-La Rocca H, Pfister O, Foglia P, Moschovitis G, Mombelli G, et al. Adherence to the medical regime in patients with heart failure. Eur J Heart Fail. 2010;12(4):389–96.PubMed

32.

Berk L, Hallam KT, Colom F, Vieta E, Hasty M, Macneil C, et al. Enhancing medication adherence in patients with bipolar disorder. Hum Psychopharmacol. 2010;25(1):1–16.PubMed

33.

Cohen JL, Mann DM, Wisnivesky JP, Home R, Leventhal H, Musumeci-Szabo TJ, et al. Assessing the validity of self-reported medication adherence among inner-city asthmatic adults: the Medication Adherence Report Scale for Asthma. Ann Allergy Asthma Immunol. 2009;103(4):325–31.PubMed

34.

Bell DJ, Wootton D, Mukaka M, Montgomery J, Kayange N, Chimpeni P, et al. Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi. Malar J. 2009;8:204.PubMedCentralPubMed

35.

Velligan DI, Weiden PJ, Sajatovic M, Scott J, Carpenter D, Ross R, et al. The expert consensus guideline series: adherence problems in patients with serious and persistent mental illness. J Clin Psychiatry. 2009;70(Suppl 4):1–46 quiz 7–8.PubMed

36.

Hansen RA, Kim MM, Song L, Tu W, Wu J, Murray MD. Comparison of methods to assess medication adherence and classify nonadherence. Ann Pharmacother. 2009;43(3):413–22.PubMed

37.

Vreeman RC, Wiehe SE, Pearce EC, Nyandiko WM. A systematic review of pediatric adherence to antiretroviral therapy in low- and middle-income countries. Pediatr Infect Dis J. 2008;27(8):686–91.PubMed

38.

Zelikovsky N, Schast AP. Eliciting accurate reports of adherence in a clinical interview: development of the Medical Adherence Measure. Pediatr Nurs. 2008;34(2):141–6.PubMed

39.

Morisky DE, Ang A, Krousel-Wood M, Ward HJ. Predictive validity of a medication adherence measure in an outpatient setting. J Clin Hypertens (Greenwich). 2008;10(5):348–54.

40.

Tzeng JI, Chang CC, Chang HJ, Lin CC. Assessing analgesic regimen adherence with the Morisky Medication Adherence Measure for Taiwanese patients with cancer pain. J Pain Symptom Manage. 2008;36(2):157–66.PubMed

41.

Zeller A, Schroeder K, Peters TJ. An adherence self-report questionnaire facilitated the differentiation between nonadherence and nonresponse to antihypertensive treatment. J Clin Epidemiol. 2008;61(3):282–8.PubMed

42.

Reynolds NR, Sun J, Nagaraja HN, Gifford AL, Wu AW, Chesney MA. Optimizing measurement of self-reported adherence with the ACTG Adherence Questionnaire: a cross-protocol analysis. J Acquir Immune Defic Syndr. 2007;46(4):402–9.PubMed

43.

Gossec L, Tubach F, Dougados M, Ravaud P. Reporting of adherence to medication in recent randomized controlled trials of 6 chronic diseases: a systematic literature review. Am J Med Sci. 2007;334(4):248–54.PubMed

44.

Cramer JA, Benedict A, Muszbek N, Keskinaslan A, Khan ZM. The significance of compliance and persistence in the treatment of diabetes, hypertension and dyslipidaemia: a review. Int J Clin Pract. 2008;62(1):76–87.PubMedCentralPubMed

45.

Gehi AK, Ali S, Na B, Whooley MA. Self-reported medication adherence and cardiovascular events in patients with stable coronary heart disease: the heart and soul study. Arch Intern Med. 2007;167(16):1798–803.PubMedCentralPubMed

46.

Bender BG, Bartlett SJ, Rand CS, Turner C, Wamboldt FS, Zhang L. Impact of interview mode on accuracy of child and parent report of adherence with asthma-controller medication. Pediatrics. 2007;120(3):e471–7.PubMed

47.

Parker CS, Chen Z, Price M, Gross R, Metlay JP, Christie JD, et al. Adherence to warfarin assessed by electronic pill caps, clinician assessment, and patient reports: results from the IN-RANGE study. J Gen Intern Med. 2007;22(9):1254–9.PubMedCentralPubMed

48.

Bryson CL, Au DH, Young B, McDonell MB, Fihn SD. A refill adherence algorithm for multiple short intervals to estimate refill compliance (ReComp). Med Care. 2007;45(6):497–504.PubMed

49.

Elm JJ, Kamp C, Tilley BC, Guimaraes P, Fraser D, Deppen P, et al. Self-reported adherence versus pill count in Parkinson’s disease: the NET-PD experience. Mov Disord. 2007;22(6):822–7.PubMed

50.

Wetzels GE, Nelemans PJ, Schouten JS, Dirksen CD, van der Weijden T, Stoffers HE, et al. Electronic monitoring of adherence as a tool to improve blood pressure control. A randomized controlled trial. Am J Hypertens. 2007;20(2):119–25.PubMed

51.

Safren SA, Duran P, Yovel I, Perlman CA, Sprich S. Medication adherence in psychopharmacologically treated adults with ADHD. J Atten Disord. 2007;10(3):257–60.PubMed

52.

Escalada P, Griffiths P. Do people with cancer comply with oral chemotherapy treatments? Br J Commun Nurs. 2006;11(12):532–6.

53.

Berg KM, Arnsten JH. Practical and conceptual challenges in measuring antiretroviral adherence. J Acquir Immune Defic Syndr. 2006;43(Suppl 1):S79–87.PubMedCentralPubMed

54.

Hearnshaw H, Lindenmeyer A. What do we mean by adherence to treatment and advice for living with diabetes? A review of the literature on definitions and measurements. Diabet Med. 2006;23(7):720–8.PubMed

55.

Velligan DI, Lam YW, Glahn DC, Barrett JA, Maples NJ, Ereshefsky L, et al. Defining and assessing adherence to oral antipsychotics: a review of the literature. Schizophr Bull. 2006;32(4):724–42.PubMed

56.

Pratt SI, Mueser KT, Driscoll M, Wolfe R, Bartels SJ. Medication nonadherence in older people with serious mental illness: prevalence and correlates. Psychiatr Rehabil J. 2006;29(4):299–310.PubMed

57.

Chia LR, Schlenk EA, Dunbar-Jacob J. Effect of personal and cultural beliefs on medication adherence in the elderly. Drugs Aging. 2006;23(3):191–202.PubMed

58.

Andrade SE, Kahler KH, Frech F, Chan KA. Methods for evaluation of medication adherence and persistence using automated databases. Pharmacoepidemiol Drug Saf. 2006;15(8):565–74.PubMed

59.

Kerr T, Walsh J, Lloyd-Smith E, Wood E. Measuring adherence to highly active antiretroviral therapy: implications for research and practice. Curr HIV/AIDS Rep. 2005;2(4):200–5.PubMed

60.

Hess LM, Saboda K, Malone DC, Salasche S, Warneke J, Alberts DS. Adherence assessment using medication weight in a phase IIb clinical trial of difluoromethylornithine for the chemoprevention of skin cancer. Cancer Epidemiol Biomarkers Prev. 2005;14(11 Pt 1):2579–83.PubMed

61.

Sikka R, Xia F, Aubert RE. Estimating medication persistency using administrative claims data. Am J Manag Care. 2005;11(7):449–57.PubMed

62.

MacLaughlin E, Raehl C, Treadway A, Sterling T, Zoller D, Bond C. Assessing medication adherence in the elderly: which tools to use in clinical practice? Drugs Aging. 2005;22(3):231–55.PubMed

63.

Nieuwkerk PT, Oort FJ. Self-reported adherence to antiretroviral therapy for HIV-1 infection and virologic treatment response: a meta-analysis. J Acquir Immune Defic Syndr. 2005;38(4):445–8.PubMed

64.

Dolder CR, Lacro JP, Warren KA, Golshan S, Perkins DO, Jeste DV. Brief evaluation of medication influences and beliefs: development and testing of a brief scale for medication adherence. J Clin Psychopharmacol. 2004;24(4):404–9.PubMed

65.

Garber MC, Nau DP, Erickson SR, Aikens JE, Lawrence JB. The concordance of self-report with other measures of medication adherence: a summary of the literature. Med Care. 2004;42(7):649–52.PubMed

66.

DiMatteo MR. Variations in patients’ adherence to medical recommendations: a quantitative review of 50 years of research. Med Care. 2004;42(3):200–9 Epub 2004/04/13.PubMed

67.

Butler JA, Peveler RC, Roderick P, Horne R, Mason JC. Measuring compliance with drug regimens after renal transplantation: comparison of self-report and clinician rating with electronic monitoring. Transplantation. 2004;77(5):786–9.PubMed

68.

Vik SA, Maxwell CJ, Hogan DB. Measurement, correlates, and health outcomes of medication adherence among seniors. Ann Pharmacother. 2004;38(2):303–12.PubMed

69.

Feinn R, Tennen H, Cramer J, Kranzler HR. Measurement and prediction of medication compliance in problem drinkers. Alcohol Clin Exp Res. 2003;27(8):1286–92.PubMed

70.

Loayza N, Crettol S, Riquier F, Eap CB. Adherence to antidepressant treatment: what the doctor thinks and what the patient says. Pharmacopsychiatry. 2012;45(5):204–7.PubMed

71.

Jay MS, DuRant RH, Shoffitt T, Linder CW, Litt IF. Effect of peer counselors on adolescent compliance in use of oral contraceptives. Pediatrics. 1984;73(2):126–31.PubMed

72.

Choo PW, Rand CS, Inui TS, Lee ML, Cain E, Cordeiro-Breault M, et al. Validation of patient reports, automated pharmacy records, and pill counts with electronic monitoring of adherence to antihypertensive therapy. Med Care. 1999;37(9):846–57.PubMed

73.

Simoni JM, Kurth AE, Pearson CR, Pantalone DW, Merrill JO, Frick PA. Self-report measures of antiretroviral therapy adherence: a review with recommendations for HIV research and clinical management. AIDS Behav. 2006;10(3):227–45.PubMed

74.

Williams AB, Amico KR, Bova C, Womack JA. A proposal for quality standards for measuring medication adherence in research. AIDS Behav. 2013;17(1):284–97.PubMedCentralPubMed

75.

George J, Mackinnon A, Kong DC, Stewart K. Development and validation of the Beliefs and Behaviour Questionnaire (BBQ). Patient Educ Couns. 2006;64(1–3):50–60.PubMed

76.

Gadkari AS, McHorney CA. Unintentional non-adherence to chronic prescription medications: how unintentional is it really? BMC Health Serv Res. 2012;12:98.PubMedCentralPubMed

77.

Paterson C, Britten N. A narrative review shows the unvalidated use of self-report questionnaires for individual medication as outcome measures. J Clin Epidemiol. 2005;58(10):967–73.PubMed

78.

Kimberlin CL, Winterstein AG. Validity and reliability of measurement instruments used in research. Am J Health Syst Pharm. 2008;65(23):2276–84.PubMed

79.

Zogg JB, Woods SP, Sauceda JA, Wiebe JS, Simoni JM. The role of prospective memory in medication adherence: a review of an emerging literature. J Behav Med. 2012;35(1):47–62.PubMedCentralPubMed

80.

LaFleur J, Oderda GM. Methods to measure patient compliance with medication regimens. J Pain Palliat Care Pharmacother. 2004;18(3):81–7.PubMed

81.

Lu M, Safren SA, Skolnik PR, Rogers WH, Coady W, Hardy H, et al. Optimal recall period and response task for self-reported HIV medication adherence. AIDS Behav. 2008;12(1):86–94.PubMed

82.

Doro P, Benko R, Czako A, Matuz M, Thurzo F, Soos G. Optimal recall period in assessing the adherence to antihypertensive therapy: a pilot study. Int J Clin Pharm. 2011;33(4):690–5.PubMed

83.

Matza LS, Yu-Isenberg KS, Coyne KS, Park J, Wakefield J, Skinner EP, et al. Further testing of the reliability and validity of the ASK-20 adherence barrier questionnaire in a medical center outpatient population. Curr Med Res Opin. 2008;24(11):3197–206.PubMed

84.

Krummenacher I, Cavassini M, Bugnon O, Schneider MP. An interdisciplinary HIV-adherence program combining motivational interviewing and electronic antiretroviral drug monitoring. AIDS Care. 2011;23(5):550–61.PubMed

85.

Gertsch A, Michel O, Locatelli I, Bugnon O, Rickenbach M, Cavassini M, et al. Adherence to antiretroviral treatment decreases during postpartum compared to pregnancy: a longitudinal electronic monitoring study. AIDS Patient Care STDS. 2013;27(4):208–10.PubMed

86.

Burnier M, Schneider MP, Chiolero A, Stubi CL, Brunner HR. Electronic compliance monitoring in resistant hypertension: the basis for rational therapeutic decisions. J Hypertens. 2001;19(2):335–41.PubMed

87.

de Bruin M, Hospers HJ, van den Borne HW, Kok G, Prins JM. Theory- and evidence-based intervention to improve adherence to antiretroviral therapy among HIV-infected patients in the Netherlands: a pilot study. AIDS Patient Care STDS. 2005;19(6):384–94.PubMed

88.

Dayer L, Heldenbrand S, Anderson P, Gubbins PO, Martin BC. Smartphone medication adherence apps: potential benefits to patients and providers. J Am Pharm Assoc (2003). 2013;53(2):172–81.

89.

Broomhead S, Mars M. Retrospective return on investment analysis of an electronic treatment adherence device piloted in the Northern Cape Province. Telemed J E Health. 2012;18(1):24–31.PubMed

90.

Haberer JE, Kahane J, Kigozi I, Emenyonu N, Hunt P, Martin J, et al. Real-time adherence monitoring for HIV antiretroviral therapy. AIDS Behav. 2010;14(6):1340–6.PubMedCentralPubMed

91.

Ingerski LM, Hente EA, Modi AC, Hommel KA. Electronic measurement of medication adherence in pediatric chronic illness: a review of measures. J Pediatr. 2011;159(4):528–34.PubMedCentralPubMed

92.

Daniels T, Goodacre L, Sutton C, Pollard K, Conway S, Peckham D. Accurate assessment of adherence: self-report and clinician report vs electronic monitoring of nebulizers. Chest. 2011;140(2):425–32.PubMed

93.

Hermann MM, Ustundag C, Diestelhorst M. Electronic compliance monitoring of topical treatment after ophthalmic surgery. Int Ophthalmol. 2010;30(4):385–90.PubMed

94.

Haberer JE, Robbins GK, Ybarra M, Monk A, Ragland K, Weiser SD, et al. Real-time electronic adherence monitoring is feasible, comparable to unannounced pill counts, and acceptable. AIDS Behav. 2012;16(2):375–82.PubMedCentralPubMed

95.

Arnet I, Walter PN, Hersberger KE. Polymedication Electronic Monitoring System (POEMS)—a new technology for measuring adherence. Front Pharmacol. 2013;4:26.PubMedCentralPubMed

96.

Santschi V, Wuerzner G, Schneider MP, Bugnon O, Burnier M. Clinical evaluation of IDAS II, a new electronic device enabling drug adherence monitoring. Eur J Clin Pharmacol. 2007;63(12):1179–84.PubMed

97.

De Bleser L, Vincke B, Dobbels F, Happ MB, Maes B, Vanhaecke J, et al. A new electronic monitoring device to measure medication adherence: usability of the Helping Hand. Sensors (Basel). 2010;10(3):1535–52.

98.

Schmidt S, Sheikzadeh S, Beil B, Patten M, Stettin J. Acceptance of telemonitoring to enhance medication compliance in patients with chronic heart failure. Telemed J E Health. 2008;14(5):426–33.PubMed

99.

Osterberg L, Blaschke T. Adherence to medication. N Engl J Med. 2005;353(5):487–97.PubMed

100.

Steiner JF, Prochazka AV. The assessment of refill compliance using pharmacy records: methods, validity, and applications. J Clin Epidemiol. 1997;50(1):105–16.PubMed

101.

Vink NM, Klungel OH, Stolk RP, Denig P. Comparison of various measures for assessing medication refill adherence using prescription data. Pharmacoepidemiol Drug Saf. 2009;18(2):159–65.PubMed

102.

Watanabe JH, Bounthavong M, Chen T. Revisiting the medication possession ratio threshold for adherence in lipid management. Curr Med Res Opin. 2013;29(3):175–80.PubMed

103.

McKenzie MC, Lenz TL, Gillespie ND, Skradski JJ. Medication Adherence Improvements in Employees Participating in a Pharmacist-Run Risk Reduction Program [Internet]. Innov Pharm. 2012;3(4):article 94. [cited 2013 Jul 16]. Available from: http://www.pharmacy.umn.edu/innovations/prod/groups/cop/@pub/@cop/@innov/documents/article/cop_article_421024.pdf.

104.

Karve S, Cleves MA, Helm M, Hudson TJ, West DS, Martin BC. Good and poor adherence: optimal cut-point for adherence measures using administrative claims data. Curr Med Res Opin. 2009;25(9):2303–10.PubMed

105.

Cramer JA, Roy A, Burrell A, Fairchild CJ, Fuldeore MJ, Ollendorf DA, et al. Medication compliance and persistence: terminology and definitions. Value Health. 2008;11(1):44–7.PubMed

106.

Peterson AM, Nau DP, Cramer JA, Benner J, Gwadry-Sridhar F, Nichol M. A checklist for medication compliance and persistence studies using retrospective databases. Value Health. 2007;10(1):3–12.PubMed

107.

Blaschke TF, Osterberg L, Vrijens B, Urquhart J. Adherence to medications: insights arising from studies on the unreliable link between prescribed and actual drug dosing histories. Annu Rev Pharmacol Toxicol. 2012;52:275–301.PubMed

108.

Lachaine J, Beauchemin C, Sasane R, Hodgkins PS. Treatment patterns, adherence, and persistence in ADHD: a Canadian perspective. Postgrad Med. 2012;124(3):139–48.PubMed

109.

Krueger KP, Berger BA, Felkey B. Medication adherence and persistence: a comprehensive review. Adv Ther. 2005;22(4):313–56.PubMed

110.

Marcum ZA, Gellad WF. Medication adherence to multidrug regimens. Clin Geriatr Med. 2012;28(2):287–300.PubMedCentralPubMed

111.

Murray MD, Morrow DG, Weiner M, Clark DO, Tu W, Deer MM, et al. A conceptual framework to study medication adherence in older adults. Am J Geriatr Pharmacother. 2004;2(1):36–43.PubMed

112.

Jonikas MA, Mandl KD. Surveillance of medication use: early identification of poor adherence. J Am Med Inf Assoc. 2012;19(4):649–54.

113.

Palli SR, Kamble PS, Chen H, Aparasu RR. Persistence of stimulants in children and adolescents with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol. 2012;22(2):139–48.PubMed

114.

Digital Health Feedback System. Proteus Digital Health 2013. [cited 2013 Jul 16]. Available from: http://www.proteusdigitalhealth.com/technology/digital-health-feedback-system/.

115.

Haynes RB, Sackett DL. Compliance with therapeutic regimens. Baltimore: John Hopkins Univ. Press; 1976 293 p.

Titel: Assessing medication adherence: options to consider
verfasst von: Audrey Lehmann
Parisa Aslani
Rana Ahmed
Jennifer Celio
Aurelie Gauchet
Pierrick Bedouch
Olivier Bugnon
Benoît Allenet
Marie Paule Schneider
Publikationsdatum: 01.02.2014
Verlag: Springer Netherlands
Erschienen in: International Journal of Clinical Pharmacy / Ausgabe 1/2014
Print ISSN: 2210-7703
Elektronische ISSN: 2210-7711
DOI: https://doi.org/10.1007/s11096-013-9865-x

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