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29.07.2024 | REVIEW

Assessing the Therapeutic Potential of Fecal Microbiota Transplantation in Steatotic Liver Disease: Current Insights and Future Pathways

verfasst von: Carolina Jiménez-González, Ignacio Vallejo, David Sordo, Juan Manuel Medina-Méndez, Marta Alonso-Peña, Javier Crespo

Erschienen in: Current Hepatology Reports | Ausgabe 4/2024

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Abstract

Purpose of Review

To explain the relevance of Fecal Microbiota Transplantation (FMT) for the treatment of MASLD, the scientific evidence supporting its usefulness, and the difficulties of its translation into effective treatments for use in routine clinical practice.

Recent Findings

FMT has been proven effective and safe in other indications and several procedures have been tested for delivery of fecal microbiota to the intestine. The field awaits results from ongoing clinical trials to better understand the role of FMT in the management of MASLD.

Summary

The pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is multifaceted, involving an intricate interaction among genetic predisposition, diet, environmental factors, lifestyle choices, and the gut microbiota (GM). The complexity of these interactions may explain the difficulties to obtain an effective pharmacological treatment for MASLD.

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Titel: Assessing the Therapeutic Potential of Fecal Microbiota Transplantation in Steatotic Liver Disease: Current Insights and Future Pathways
verfasst von: Carolina Jiménez-González
Ignacio Vallejo
David Sordo
Juan Manuel Medina-Méndez
Marta Alonso-Peña
Javier Crespo
Publikationsdatum: 29.07.2024
Verlag: Springer US
Erschienen in: Current Hepatology Reports / Ausgabe 4/2024
Elektronische ISSN: 2195-9595
DOI: https://doi.org/10.1007/s11901-024-00670-7

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Assessing the Therapeutic Potential of Fecal Microbiota Transplantation in Steatotic Liver Disease: Current Insights and Future Pathways