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Erschienen in: Inflammation 1/2013

01.02.2013

Assessment of Inflammatory and Oxidative Biomarkers in Obesity and Their Associations with Body Mass Index

verfasst von: Sílvia Juliane Piva, Etiane Tatsch, José Antonio Mainardi De Carvalho, Guilherme Vargas Bochi, Helena Kober, Thiago Duarte, Marta Maria Medeiros Frescura Duarte, Ivana Beatrice Mânica da Cruz, Maria Beatriz Moretto, Rafael Noal Moresco

Erschienen in: Inflammation | Ausgabe 1/2013

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Abstract

The aim of this study was to evaluate the inflammatory and oxidative biomarkers’ levels in obese subjects and their associations with body mass index (BMI), in order to investigate the role of these biomarkers in obesity. Fasting glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, apolipoprotein A, apolipoprotein B, albumin, urinary albumin, creatinine, glomerular filtration rate, interleukin-6 (IL-6), nitrate/nitrite (NOx), and ischemia-modified albumin (IMA) were measured in 93 subjects divided according to different BMI. IL-6, urinary albumin, and IMA levels were significantly higher in obese subjects. However, the levels of NOx were significantly lower in this population. Significant correlations between BMI and IL-6 (r = 0.326, P = 0.002), NOx (r = −0.249, P = 0.021), urinary albumin (r = 0.270, P = 0.008), and IMA (r = 0.286, P = 0.005) were reported. We have shown an increase of IL-6, urinary albumin, and IMA combined with lower levels of NOx in obese patients and an association between of these biomarkers with BMI, suggesting a possible interplay of oxidative stress, inflammation, and endothelial dysfunction state in obesity.
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Metadaten
Titel
Assessment of Inflammatory and Oxidative Biomarkers in Obesity and Their Associations with Body Mass Index
verfasst von
Sílvia Juliane Piva
Etiane Tatsch
José Antonio Mainardi De Carvalho
Guilherme Vargas Bochi
Helena Kober
Thiago Duarte
Marta Maria Medeiros Frescura Duarte
Ivana Beatrice Mânica da Cruz
Maria Beatriz Moretto
Rafael Noal Moresco
Publikationsdatum
01.02.2013
Verlag
Springer US
Erschienen in
Inflammation / Ausgabe 1/2013
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-012-9538-2

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