Skip to main content
main-content

28.07.2017 | Retinal Disorders | Ausgabe 11/2017

Graefe's Archive for Clinical and Experimental Ophthalmology 11/2017

Assessment of intravitreal ocriplasmin treatment for vitreomacular traction in clinical practice

Zeitschrift:
Graefe's Archive for Clinical and Experimental Ophthalmology > Ausgabe 11/2017
Autoren:
Ricarda G. Schumann, Julian Langer, Denise Compera, Katharina Luedtke, Markus M. Schaumberger, Thomas Kreutzer, Wolfgang J. Mayer, Armin Wolf, Siegfried G. Priglinger

Abstract

Purpose

To assess treatment effects following intravitreal injection of ocriplasmin for vitreomacular traction (VMT), with or without full-thickness macular hole (FTMH), in real-life setting.

Methods

This is a monocentric, retrospective, consecutive series of 82 eyes from 82 patients who underwent ocriplasmin treatment between July 2013 and December 2016. We included 57 eyes with pure VMT, 17 eyes with small FTMHs, and eight eyes with medium FTMHs. Primary outcome measures were VMT release and MH closure rates. Secondary outcomes were visual acuity (VA), morphological changes, and subjective visual impairment after 1, 3, and 6 months and at last follow-up.

Results

After a median follow-up of 10 months, VMT release was achieved by pharmacologic vitreolysis in 57% of all eyes, whereas the macular hole closure rate was 32%. In those presenting with five or more positive prognostic factors (PPF), eyes with pure VMT showed nonsurgical traction release in 88%, and FTMHs were released in 93%, with a closure rate of 20%. Small FTMHs closed in 41% and medium FTMHs in 13%. The mean change in VA (LogMAR) was −0.07 ± 0.24 (median − 0.10) in all eyes. Subretinal fluid accumulation and ellipsoid zone changes were seen in 31% and 37% of all eyes, respectively. They were more frequent in eyes with traction release, but were self-limited.

Conclusions

In a real-life setting, release of VMT by ocriplasmin injection can be achieved in the majority of eyes, relying on a strict patient selection. Closure of FTMHs rather correlates with hole diameter than with presence of PPF, and remains a rare finding in medium FTMHs.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de. Zusätzlich können Sie eine Zeitschrift Ihrer Wahl in gedruckter Form beziehen – ohne Aufpreis.

Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 11/2017

Graefe's Archive for Clinical and Experimental Ophthalmology 11/2017 Zur Ausgabe

Neu im Fachgebiet Augenheilkunde

01.03.2019 | Leitlinien, Stellungnahmen und Empfehlungen | Ausgabe 4/2019

Empfehlungen bei progredienter Myopie im Kindes- und Jugendalter

Stellungnahme von DOG und BVA. Stand Dezember 2018

19.02.2019 | Refraktionsfehler | CME | Ausgabe 3/2019 Open Access

Astigmatismus