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22.05.2015 | Original Article | Ausgabe 3/2016

Journal of Nuclear Cardiology 3/2016

Assessment of left ventricular ejection fraction using low radiation dose computed tomography

Zeitschrift:
Journal of Nuclear Cardiology > Ausgabe 3/2016
Autoren:
YiQi Yang, BSc Yeung Yam, MSc Li Chen, MD Ahmed Aljizeeri, MD Siamak Aliyary Ghraboghly, MBBS Ibraheem Al-Harbi, PhD Ally Pen, MD, FRCPC, FACC, FASNC Terrence D. Ruddy, MD, FRCPC, FACC, FASNC, FSCCT Benjamin J. W. Chow
Wichtige Hinweise
See related editorial, doi:10.​1007/​s12350-015-0183-7.
An erratum to this article can be found at http://​dx.​doi.​org/​10.​1007/​s12350-015-0211-7.

Abstract

Background

Cardiac CT is a non-invasive modality with the ability to estimate LVEF. However, given its limited temporal resolution and radiation, there has been initial resistance to use CT to measure LVEF. Developing an accurate, fast, low radiation dose protocol is desirable.

Objective

The objective of this study is to demonstrate that a ‘low radiation dose’ 64 slice cardiac computed tomography (CT) protocol is feasible and can accurately measure left ventricular ejection fraction (LVEF) while delivering a radiation dose lower than radionuclide angiography (RNA).

Methods

Patients undergoing RNA were prospectively screened and enrolled to undergo a ‘low-dose’ 64 slice CT LVEF protocol. LVEF measures, duration of each study and radiation dose between CT and RNA were compared.

Results

A total of 77 patients (mean age = 61.8 ± 12.2 years and 58 men) were analyzed. The mean LVEF measured by CT and RNA were 41.9 ± 15.2% and 39.4 ± 13.9%, respectively, (P = 0.154) with a good correlation (r = 0.863). Bland-Altman plot revealed a good agreement between the CT and RNA LVEF (mean difference of −2.4). There was good agreement between CT LVEF and RNA for identifying patients with LVEF ≤30% (kappa = 0.693) and LVEF ≥50% (kappa = 0.749). The mean dose estimated effective dose for CT and RNA were 4.7 ± 1.6 and 9.5 ± 1.0 mSv, respectively. The mean CT LVEF imaging duration (4:32 ± 3:05 minutes) was significantly shorter than the RNA image acquisition time (9:05 ± 2:36 minutes; p < 0.001).

Conclusion

The results of our study suggest that low-dose CT LVEF protocol is feasible, accurate, and fast while delivering a lower radiation dose than traditional RNA.

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