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07.10.2016 | Original Research | Ausgabe 4/2016 Open Access

Infectious Diseases and Therapy 4/2016

Assessment of Minimum Inhibitory Concentrations of Telavancin by Revised Broth Microdilution Method in Phase 3 Hospital-Acquired Pneumonia/Ventilator-Associated Pneumonia Clinical Isolates

Zeitschrift:
Infectious Diseases and Therapy > Ausgabe 4/2016
Autoren:
Jennifer I. Smart, Gordon Ralph Corey, Martin E. Stryjewski, Whedy Wang, Steven L. Barriere
Wichtige Hinweise

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Abstract

Introduction

The broth microdilution method (BMD) for testing telavancin minimum inhibitory concentrations (MICs) was revised (rBMD) in 2014 to improve the accuracy, precision, and reproducibility of the testing method. The aim of this study was to determine the effect of the revised method on telavancin MIC values for Staphylococcus aureus (S. aureus) clinical isolates obtained from hospital-acquired pneumonia (HAP) patients.

Methods

Isolates from patients who participated in the phase 3 Assessment of Telavancin for Treatment of HAP Studies were retested using the rBMD method.

Results

Retesting of 647 isolates produced a range of telavancin MIC values from 0.015 µg/mL to 0.12 µg/mL with MIC50/90 values of 0.06/0.06 µg/mL for the total pool of samples. For methicillin-resistant S. aureus (MRSA), MIC50/90 values were 0.06/0.12 µg/mL. These values are up to 4-fold lower than MIC50/90 values obtained using the original method. These results were used in part to justify lowering the telavancin breakpoints. All tested isolates remained susceptible to telavancin at the revised susceptibility breakpoint of ≤0.12 µg/mL. Overall, the clinical cure rate for microbiologically evaluable telavancin-treated patients was 78% for S. aureus, 76% for patients with MRSA, and 79% for patients with isolates with reduced susceptibility to vancomycin (MIC ≥1 µg/mL).

Conclusion

Results from the rBMD method support the in vitro potency of telavancin against S. aureus.

Trial registration

ATTAIN (NCT00107952 and NCT00124020).

Funding

Theravance Biopharma Antibiotics, Inc.
Literatur
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