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Erschienen in: Osteoporosis International 12/2005

01.12.2005 | Original Article

Assessment of teeth as biomarkers for skeletal fluoride exposure

verfasst von: A. P. G. F. Vieira, M. Mousny, R. Maia, R. Hancock, E. T. Everett, M. D. Grynpas

Erschienen in: Osteoporosis International | Ausgabe 12/2005

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Abstract

Skeletal fluorosis and dental fluorosis are diseases related to fluoride (F) ingestion. Bone is the largest storage site of F in our body. Therefore, bone F concentrations are considered biomarkers for total F body burden (exposure). However, difficult accessibility limits its use as a biomarker. Thus, a more accessible tissue should be considered and analyzed as a biomarker for total F body burden. The objective of this study, which was divided into two parts, was to evaluate teeth as a biomarker for skeletal F exposure. In part 1 of the study, 70 mice of three different strains (SWR/J, A/J and 129P3/J) were exposed to different levels of water fluoridation (0, 25, 50 and 100 ppm). Bone (femora and vertebrae) and teeth from these mice were then analyzed for F concentration using Instrumental Neutron Activation Analysis (INAA). In part 2 of the study, human teeth (enamel and dentin) and bone from 30 study subjects were collected and analyzed for F concentration using INAA. Study subjects lived in areas with optimum levels of water fluoridation (0.7 and 1 ppm) and underwent therapeutic extraction of their unerupted third molars. The values of bone and teeth F concentration were correlated for parts 1 and 2 of this study. The results showed that in the animal model, where animals were exposed to a wide range of F in their drinking water, tooth [F] correlated with bone [F]. However, no correlation was seen between bone and enamel F concentrations or between bone and dentin F concentrations in the human samples. Therefore, teeth are not good biomarkers for skeletal F exposure in humans when exposure is confined to optimum levels of F in the drinking water.
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Metadaten
Titel
Assessment of teeth as biomarkers for skeletal fluoride exposure
verfasst von
A. P. G. F. Vieira
M. Mousny
R. Maia
R. Hancock
E. T. Everett
M. D. Grynpas
Publikationsdatum
01.12.2005
Verlag
Springer-Verlag
Erschienen in
Osteoporosis International / Ausgabe 12/2005
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-005-1870-z

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