Assessment of the bidirectional causal association between allergic diseases and neuropsychiatric disorders
- 20.06.2025
- Original Paper
- Verfasst von
- Guo Zhen Fan
- Li Xin Hu
- Jie Guan
- Ren Zheng Guan
- Zheng Hai Qu
Abstract
Purpose
This study aimed to explore the causal associations between allergic diseases and neuropsychiatric disorders via bidirectional Mendelian randomization (MR) analysis.
Methods
This study employed three methodologies for MR analysis, primarily utilizing the inverse variance weighted approach, while supplementing with MR-Egger regression and the weighted median method. Sensitivity analyses encompassed Cochran’s Q test, MR-PRESSO test, MR-Egger regression intercept and leave-one-out analysis, all serving to validate the reliability of the reported findings.
Results
The forward MR analysis results indicated that bipolar disorder (BD) was positively correlated with allergic asthma (AA) (OR = 1.204) and allergic rhinitis (AR) (OR = 4.647), and depression was positively correlated with AA (OR = 1.141) and atopic dermatitis (AD) (OR = 1.103). The reverse MR analysis outcomes unveiled a negative association between allergic urticaria (AU) and autism spectrum disorder (ASD) (OR = 0.780), a positive correlation between allergic conjunctivitis (AC) and tic disorder (TD) (OR = 1.020). Sensitivity analysis indicated an absence of significant heterogeneity or potential horizontal pleiotropy.
Conclusions
AA and AD acted as risk factors for depression; AA and AR increased the risk of BD; ASD served as a protective factor for AU; TD was a risk factor for AC.
Anzeige
- Titel
- Assessment of the bidirectional causal association between allergic diseases and neuropsychiatric disorders
- Verfasst von
-
Guo Zhen Fan
Li Xin Hu
Jie Guan
Ren Zheng Guan
Zheng Hai Qu
- Publikationsdatum
- 20.06.2025
- Verlag
- Springer Berlin Heidelberg
- Erschienen in
-
European Archives of Psychiatry and Clinical Neuroscience / Ausgabe 1/2026
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491 - DOI
- https://doi.org/10.1007/s00406-025-02051-7
Dieser Inhalt ist nur sichtbar, wenn du eingeloggt bist und die entsprechende Berechtigung hast.
Dieser Inhalt ist nur sichtbar, wenn du eingeloggt bist und die entsprechende Berechtigung hast.