Skip to main content
Erschienen in:

13.09.2022 | Original Article–Physics & Engineering

Assessment of the frequency dependence of acoustic properties on material, composition, and scatterer size of the medium

verfasst von: Mai Ino, Kenji Yoshida, Shinnosuke Hirata, Kazuyo Ito, Tadashi Yamaguchi

Erschienen in: Journal of Medical Ultrasonics | Ausgabe 4/2022

Einloggen, um Zugang zu erhalten

Abstract

Purpose

The aim of this study was to elucidate the frequency dependence of the speed of sound (SoS) and attenuation coefficients in phantoms with controlled attenuation properties (scatterer density, scatterer size, absorption control material) and rat livers.

Methods

The frequency dependence of SoS and attenuation coefficients were evaluated with ultrasound (1–15 MHz) by observing multiple phantoms with different scatterer sizes, densities, and presence or absence of evaporated milk as absorbing media. Normal and fatty model rat livers were examined with the same protocol.

Results

The phantom results revealed that the scatterer density and SoS of the base media were the dominant factors causing the changes in SoS. Frequency dependence was not observed in SoS. Assessment of the attenuation coefficient showed that the frequency dependence was mainly affected by absorption attenuation when the scatterer was as small as a hepatocyte (i.e. ≤ 10 µm). Scattering attenuation was also observed to affect frequency dependence when the scatterer was as large as lipid droplets (i.e. ≤ 40 µm).

Conclusion

Assuming a consistent size of the main scatterers in the evaluation medium, the frequency dependence of the SoS and attenuation coefficients may provide insight into the scatterer density and the contribution of absorption and scattering attenuation. Further studies in the higher frequency band (up to about 50 MHz) are expected to advance the clinical application of high-frequency ultrasound.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Yamaguchi T. Basic concept and clinical applications of quantitative ultrasound (QUS) technologies. J Med Ultrason. 2021;48:391–402.CrossRef Yamaguchi T. Basic concept and clinical applications of quantitative ultrasound (QUS) technologies. J Med Ultrason. 2021;48:391–402.CrossRef
2.
Zurück zum Zitat Ophir J, Céspedes I, Ponnekanti H, et al. Elastography: A quantitative method for imaging the elasticity of biological tissues. Ultrason Imaging. 1991;13:111–34.CrossRefPubMed Ophir J, Céspedes I, Ponnekanti H, et al. Elastography: A quantitative method for imaging the elasticity of biological tissues. Ultrason Imaging. 1991;13:111–34.CrossRefPubMed
3.
Zurück zum Zitat Harada N, Shirabe K, Ijichi H, et al. Acoustic radiation force impulse imaging predicts postoperative ascites resulting from curative hepatic resection for hepatocellular carcinoma. Surgery. 2012;151:837–43.CrossRefPubMed Harada N, Shirabe K, Ijichi H, et al. Acoustic radiation force impulse imaging predicts postoperative ascites resulting from curative hepatic resection for hepatocellular carcinoma. Surgery. 2012;151:837–43.CrossRefPubMed
4.
Zurück zum Zitat Zhang P, Zhou P, Tian SM, et al. Application of acoustic radiation force impulse imaging for the evaluation of focal liver lesion elasticity. Hepatobiliary Pancreat Dis Int. 2013;12:165–70.CrossRefPubMed Zhang P, Zhou P, Tian SM, et al. Application of acoustic radiation force impulse imaging for the evaluation of focal liver lesion elasticity. Hepatobiliary Pancreat Dis Int. 2013;12:165–70.CrossRefPubMed
6.
Zurück zum Zitat Zhi H, Xiao XY, Ou B, et al. Could ultrasonic elastography help the diagnosis of small (≤2 cm) breast cancer with the usage of sonographic BI-RADS classification? Eur J Radiol. 2012;81:3216–21.CrossRefPubMed Zhi H, Xiao XY, Ou B, et al. Could ultrasonic elastography help the diagnosis of small (≤2 cm) breast cancer with the usage of sonographic BI-RADS classification? Eur J Radiol. 2012;81:3216–21.CrossRefPubMed
7.
Zurück zum Zitat Choi WJ, Kim HH, Cha JH, et al. Predicting prognostic factors of breast cancer using shear wave elastography. Ultrasound Med Biol. 2014;40:269–74.CrossRefPubMed Choi WJ, Kim HH, Cha JH, et al. Predicting prognostic factors of breast cancer using shear wave elastography. Ultrasound Med Biol. 2014;40:269–74.CrossRefPubMed
8.
Zurück zum Zitat Feleppa E, Kalisz A, Sokil-Melgar JB, et al. Typing of prostate tissue by ultrasonic spectrum analysis. IEEE Trans Ultrason Ferroelectr Freq Control. 1996;43:609–19.CrossRef Feleppa E, Kalisz A, Sokil-Melgar JB, et al. Typing of prostate tissue by ultrasonic spectrum analysis. IEEE Trans Ultrason Ferroelectr Freq Control. 1996;43:609–19.CrossRef
9.
Zurück zum Zitat Mamou J, Coron A, Oelze ML, et al. Three-dimensional high-frequency backscatter and envelope quantification of cancerous human lymph nodes. Ultrasound Med Biol. 2011;37:345–57.CrossRefPubMedPubMedCentral Mamou J, Coron A, Oelze ML, et al. Three-dimensional high-frequency backscatter and envelope quantification of cancerous human lymph nodes. Ultrasound Med Biol. 2011;37:345–57.CrossRefPubMedPubMedCentral
10.
Zurück zum Zitat Oelze ML, O’Brien WD, Blue JP, et al. Differentiation and characterization of rat mammary fibroadenomas and 4T1 mouse carcinomas using quantitative ultrasound imaging. IEEE Trans Med Imaging. 2004;23:764–71.CrossRefPubMed Oelze ML, O’Brien WD, Blue JP, et al. Differentiation and characterization of rat mammary fibroadenomas and 4T1 mouse carcinomas using quantitative ultrasound imaging. IEEE Trans Med Imaging. 2004;23:764–71.CrossRefPubMed
13.
Zurück zum Zitat Nakajima S, Shibuya K, Kamiyama N, et al. Comparison of ultrasound colored image views produced by application of statistical analysis of radio-frequency signals and histological findings in patients with chronic hepatitis C. J Med Ultrason. 2010;37:51–8.CrossRef Nakajima S, Shibuya K, Kamiyama N, et al. Comparison of ultrasound colored image views produced by application of statistical analysis of radio-frequency signals and histological findings in patients with chronic hepatitis C. J Med Ultrason. 2010;37:51–8.CrossRef
14.
Zurück zum Zitat Ricci P, Marigliano C, Cantisani V, et al. Valutazione ecografica della fibrosi epatica: esperienza preliminare con acoustic structure quantification (ASQ). Radiol Medica. 2013;118:995–1010.CrossRef Ricci P, Marigliano C, Cantisani V, et al. Valutazione ecografica della fibrosi epatica: esperienza preliminare con acoustic structure quantification (ASQ). Radiol Medica. 2013;118:995–1010.CrossRef
15.
Zurück zum Zitat Yamaguchi T, Hachiya H. Proposal of a parametric imaging method for quantitative diagnosis of liver fibrosis. J Med Ultrason. 2010;37:155–66.CrossRef Yamaguchi T, Hachiya H. Proposal of a parametric imaging method for quantitative diagnosis of liver fibrosis. J Med Ultrason. 2010;37:155–66.CrossRef
17.
Zurück zum Zitat Fujii Y, Taniguchi N, Takano R, et al. Texture analysis with a new method in which the region of interest is segmented into multiple layers for radiofrequency amplitude histogram analysis of fibrous rat livers. J Med Ultrason. 2004;31:13–20.CrossRef Fujii Y, Taniguchi N, Takano R, et al. Texture analysis with a new method in which the region of interest is segmented into multiple layers for radiofrequency amplitude histogram analysis of fibrous rat livers. J Med Ultrason. 2004;31:13–20.CrossRef
18.
Zurück zum Zitat Kaltenbach TEM, Gruener B, Akinli AS, et al. Acoustic structure quantification (ASQ): a new tool in sonographic examination of liver lesions in hepatic alveolar echinococcosis. J Med Ultrason. 2014;41:445–53.CrossRef Kaltenbach TEM, Gruener B, Akinli AS, et al. Acoustic structure quantification (ASQ): a new tool in sonographic examination of liver lesions in hepatic alveolar echinococcosis. J Med Ultrason. 2014;41:445–53.CrossRef
19.
Zurück zum Zitat Ghoshal G, Lavarello RJ, Kemmerer JP, et al. Ex vivo study of quantitative ultrasound parameters in fatty rabbit livers. Ultrasound Med Biol. 2012;38:2238–48.CrossRefPubMedPubMedCentral Ghoshal G, Lavarello RJ, Kemmerer JP, et al. Ex vivo study of quantitative ultrasound parameters in fatty rabbit livers. Ultrasound Med Biol. 2012;38:2238–48.CrossRefPubMedPubMedCentral
21.
Zurück zum Zitat Sasso M, Audière S, Kemgang A, et al. Liver steatosis assessed by controlled attenuation parameter (CAP) measured with the XL probe of the fibroscan: a pilot study assessing diagnostic accuracy. Ultrasound Med Biol. 2016;42:92–103.CrossRefPubMed Sasso M, Audière S, Kemgang A, et al. Liver steatosis assessed by controlled attenuation parameter (CAP) measured with the XL probe of the fibroscan: a pilot study assessing diagnostic accuracy. Ultrasound Med Biol. 2016;42:92–103.CrossRefPubMed
22.
Zurück zum Zitat Audière S, Labourdette A, Miette V, et al. Improved ultrasound attenuation measurement method for the non-invasive evaluation of hepatic steatosis using fibroscan. Ultrasound Med Biol. 2021;47:3181–95.CrossRefPubMed Audière S, Labourdette A, Miette V, et al. Improved ultrasound attenuation measurement method for the non-invasive evaluation of hepatic steatosis using fibroscan. Ultrasound Med Biol. 2021;47:3181–95.CrossRefPubMed
23.
Zurück zum Zitat Tamaki N, Koizumi Y, Hirooka M, et al. Novel quantitative assessment system of liver steatosis using a newly developed attenuation measurement method. Hepatol Res. 2018;48:821–8.CrossRefPubMed Tamaki N, Koizumi Y, Hirooka M, et al. Novel quantitative assessment system of liver steatosis using a newly developed attenuation measurement method. Hepatol Res. 2018;48:821–8.CrossRefPubMed
24.
Zurück zum Zitat Weijers G, Starke A, Thijssen JM, et al. Transcutaneous vs. intraoperative quantitative ultrasound for staging bovine hepatic steatosis. Ultrasound Med Biol. 2012;38:1404–13.CrossRefPubMed Weijers G, Starke A, Thijssen JM, et al. Transcutaneous vs. intraoperative quantitative ultrasound for staging bovine hepatic steatosis. Ultrasound Med Biol. 2012;38:1404–13.CrossRefPubMed
26.
Zurück zum Zitat Abe K, Arakawa M, Kanai H. Estimation method for sound velocity distribution for high-resolution ultrasonic tomographic imaging. J Med Ultrason. 2019;46:27–33.CrossRef Abe K, Arakawa M, Kanai H. Estimation method for sound velocity distribution for high-resolution ultrasonic tomographic imaging. J Med Ultrason. 2019;46:27–33.CrossRef
27.
Zurück zum Zitat Imbault M, Faccinetto A, Osmanski BF, et al. Robust sound speed estimation for ultrasound-based hepatic steatosis assessment. Phys Med Biol. 2017;62:3582–98.CrossRefPubMed Imbault M, Faccinetto A, Osmanski BF, et al. Robust sound speed estimation for ultrasound-based hepatic steatosis assessment. Phys Med Biol. 2017;62:3582–98.CrossRefPubMed
29.
Zurück zum Zitat Hasegawa H, Nagaoka R. Initial phantom study on estimation of speed of sound in medium using coherence among received echo signals. J Med Ultrason. 2019;46:297–307.CrossRef Hasegawa H, Nagaoka R. Initial phantom study on estimation of speed of sound in medium using coherence among received echo signals. J Med Ultrason. 2019;46:297–307.CrossRef
30.
Zurück zum Zitat Goss SA, Johnston RL, Dunn F. Comprehensive compilation of empirical ultrasonic properties of mammalian tissues. J Acoust Soc Am. 1978;64:423–57.CrossRefPubMed Goss SA, Johnston RL, Dunn F. Comprehensive compilation of empirical ultrasonic properties of mammalian tissues. J Acoust Soc Am. 1978;64:423–57.CrossRefPubMed
31.
Zurück zum Zitat Hachiya H, Ohtsuki S, Tanaka M. Relationship between speed of sound in and density of normal and diseased rat livers. Jpn J Appl Phys. 1994;33:3130–3.CrossRef Hachiya H, Ohtsuki S, Tanaka M. Relationship between speed of sound in and density of normal and diseased rat livers. Jpn J Appl Phys. 1994;33:3130–3.CrossRef
32.
Zurück zum Zitat Hachiya H, Yamaguchi T. Acoustic characteristics of the tissue and the ultrasonic B-mode Image. Med Imaging Technol. 2003;21:95–100 ([in japanese]). Hachiya H, Yamaguchi T. Acoustic characteristics of the tissue and the ultrasonic B-mode Image. Med Imaging Technol. 2003;21:95–100 ([in japanese]).
33.
Zurück zum Zitat Irie S, Inoue K, Yoshida K, et al. Speed of sound in diseased liver observed by scanning acoustic microscopy with 80 MHz and 250 MHz. J Acoust Soc Am. 2016;139:512–9.CrossRefPubMed Irie S, Inoue K, Yoshida K, et al. Speed of sound in diseased liver observed by scanning acoustic microscopy with 80 MHz and 250 MHz. J Acoust Soc Am. 2016;139:512–9.CrossRefPubMed
34.
Zurück zum Zitat Strohm EM, Moore MJ, Kolios MC. Single cell photoacoustic microscopy: a review. IEEE J Sel Top Quantum Electron. 2016;22:137–51.CrossRef Strohm EM, Moore MJ, Kolios MC. Single cell photoacoustic microscopy: a review. IEEE J Sel Top Quantum Electron. 2016;22:137–51.CrossRef
35.
Zurück zum Zitat Drakos T, Antoniou A, Evripidou N, et al. Ultrasonic attenuation of an agar, silicon dioxide, and evaporated milk gel phantom. J Med Ultrasound. 2021;29:239–49.CrossRefPubMedPubMedCentral Drakos T, Antoniou A, Evripidou N, et al. Ultrasonic attenuation of an agar, silicon dioxide, and evaporated milk gel phantom. J Med Ultrasound. 2021;29:239–49.CrossRefPubMedPubMedCentral
36.
Zurück zum Zitat Drakos T, Giannakou M, Menikou G, et al. An improved method to estimate ultrasonic absorption in agar-based gel phantom using thermocouples and MR thermometry. Ultrasonics. 2020;103: 106089.CrossRefPubMed Drakos T, Giannakou M, Menikou G, et al. An improved method to estimate ultrasonic absorption in agar-based gel phantom using thermocouples and MR thermometry. Ultrasonics. 2020;103: 106089.CrossRefPubMed
38.
Zurück zum Zitat Schwartz M. Estimating the acoustic attenuation coefficient slope for liver from reflected ultrasound signals. IEEE Trans Sonics Ultrason. 1979;26:353–61.CrossRef Schwartz M. Estimating the acoustic attenuation coefficient slope for liver from reflected ultrasound signals. IEEE Trans Sonics Ultrason. 1979;26:353–61.CrossRef
39.
Zurück zum Zitat Brewin MP, Pike LC, Rowland DE, et al. The acoustic properties, centered on 20 MHZ, of an IEC agar-based tissue-mimicking material and its temperature, frequency and age dependence. Ultrasound Med Biol. 2008;34:1292–306.CrossRefPubMed Brewin MP, Pike LC, Rowland DE, et al. The acoustic properties, centered on 20 MHZ, of an IEC agar-based tissue-mimicking material and its temperature, frequency and age dependence. Ultrasound Med Biol. 2008;34:1292–306.CrossRefPubMed
40.
Zurück zum Zitat Sun C, Pye SD, Browne JE, et al. The speed of sound and attenuation of an IEC agar-based tissue-mimicking material for high frequency ultrasound applications. Ultrasound Med Biol. 2012;38:1262–70.CrossRefPubMedPubMedCentral Sun C, Pye SD, Browne JE, et al. The speed of sound and attenuation of an IEC agar-based tissue-mimicking material for high frequency ultrasound applications. Ultrasound Med Biol. 2012;38:1262–70.CrossRefPubMedPubMedCentral
41.
Zurück zum Zitat Matsukawa M, Akimoto T, Ueba S, et al. Ultrasonic wave properties in the particle compounded agarose gels. Ultrasonics. 2002;40:323–7.CrossRefPubMed Matsukawa M, Akimoto T, Ueba S, et al. Ultrasonic wave properties in the particle compounded agarose gels. Ultrasonics. 2002;40:323–7.CrossRefPubMed
42.
Zurück zum Zitat Matsukawa M, Sasaki K, Akimoto T, et al. Application of a suspension theory to particle-dispersed agarose gels. Jpn J Appl Phys. 2002;41:3163–7.CrossRef Matsukawa M, Sasaki K, Akimoto T, et al. Application of a suspension theory to particle-dispersed agarose gels. Jpn J Appl Phys. 2002;41:3163–7.CrossRef
43.
Zurück zum Zitat Farrer AI, Odéen H, de Bever J, et al. Characterization and evaluation of tissue-mimicking gelatin phantoms for use with MRgFUS. J Ther Ultrasound. 2015;3:1–11.CrossRef Farrer AI, Odéen H, de Bever J, et al. Characterization and evaluation of tissue-mimicking gelatin phantoms for use with MRgFUS. J Ther Ultrasound. 2015;3:1–11.CrossRef
44.
Zurück zum Zitat Inglis S, Ramnarine KV, Plevris JN, et al. An anthropomorphic tissue-mimicking phantom of the oesophagus for endoscopic ultrasound. Ultrasound Med Biol. 2006;32:249–59.CrossRefPubMed Inglis S, Ramnarine KV, Plevris JN, et al. An anthropomorphic tissue-mimicking phantom of the oesophagus for endoscopic ultrasound. Ultrasound Med Biol. 2006;32:249–59.CrossRefPubMed
45.
Zurück zum Zitat Sato T, Watanabe Y. High sensitivity estimation of red blood cell aggregation with ultrasonic peak frequency. IEEE International Ultrasonics Symposium (IUS). 2013. pp 868–71. Sato T, Watanabe Y. High sensitivity estimation of red blood cell aggregation with ultrasonic peak frequency. IEEE International Ultrasonics Symposium (IUS). 2013. pp 868–71.
46.
Zurück zum Zitat Madsen EL, Frank GR, Dong F. Liquid or solid ultrasonically tissue-mimicking materials with very low scatter. Ultrasound Med Biol. 1998;24:535–42.CrossRefPubMed Madsen EL, Frank GR, Dong F. Liquid or solid ultrasonically tissue-mimicking materials with very low scatter. Ultrasound Med Biol. 1998;24:535–42.CrossRefPubMed
47.
Zurück zum Zitat Browne JE, Ramnarine KV, Watson AJ, et al. Assessment of the acoustic properties of common tissue-mimicking test phantoms. Ultrasound Med Biol. 2003;29:1053–60.CrossRefPubMed Browne JE, Ramnarine KV, Watson AJ, et al. Assessment of the acoustic properties of common tissue-mimicking test phantoms. Ultrasound Med Biol. 2003;29:1053–60.CrossRefPubMed
Metadaten
Titel
Assessment of the frequency dependence of acoustic properties on material, composition, and scatterer size of the medium
verfasst von
Mai Ino
Kenji Yoshida
Shinnosuke Hirata
Kazuyo Ito
Tadashi Yamaguchi
Publikationsdatum
13.09.2022
Verlag
Springer Nature Singapore
Erschienen in
Journal of Medical Ultrasonics / Ausgabe 4/2022
Print ISSN: 1346-4523
Elektronische ISSN: 1613-2254
DOI
https://doi.org/10.1007/s10396-022-01235-1

Neu im Fachgebiet Radiologie

Ringen um den richtigen Umgang mit Zufallsbefunden

Wenn 2026 in Deutschland das Lungenkrebsscreening mittels Low-Dose-Computertomografie (LDCT) eingeführt wird, wird es auch viele Zufallsbefunde ans Licht bringen. Das birgt Chancen und Risiken.

Bald 5% der Krebserkrankungen durch CT verursacht

Die jährlich rund 93 Millionen CTs in den USA könnten künftig zu über 100.000 zusätzlichen Krebserkrankungen führen, geht aus einer Modellrechnung hervor. Damit würde eine von 20 Krebserkrankungen auf die ionisierende Strahlung bei CT-Untersuchungen zurückgehen.

Röntgen-Thorax oder LDCT fürs Lungenscreening nach HNSCC?

Personen, die an einem Plattenepithelkarzinom im Kopf-Hals-Bereich erkrankt sind, haben ein erhöhtes Risiko für Metastasen oder zweite Primärmalignome der Lunge. Eine Studie hat untersucht, wie die radiologische Überwachung aussehen sollte.

Statine: Was der G-BA-Beschluss für Praxen bedeutet

Nach dem G-BA-Beschluss zur erweiterten Verordnungsfähigkeit von Lipidsenkern rechnet die DEGAM mit 200 bis 300 neuen Dauerpatienten pro Praxis. Im Interview erläutert Präsidiumsmitglied Erika Baum, wie Hausärztinnen und Hausärzte am besten vorgehen.

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.