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01.08.2012 | Oncology

Assessment of the metabolic flow phenotype of primary colorectal cancer: correlations with microvessel density are influenced by the histological scoring method

verfasst von: Vicky Goh, Manuel Rodriguez-Justo, Alec Engledow, Manu Shastry, Raymondo Endozo, Jacqui Peck, Marie Meagher, Stuart A. Taylor, Steve Halligan, Ashley M. Groves

Erschienen in: European Radiology | Ausgabe 8/2012

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Abstract

Objectives

To investigate how the histological scoring of microvessel density affects correlations between integrated ¹⁸F-FDG-PET/perfusion CT parameters and CD105 microvessel density.

Methods

A total of 53 patients were enrolled from 2007 to 2010. Integrated ¹⁸F-FDG-PET/perfusion CT was successful in 45 patients, 35 of whom underwent surgery without intervening treatment. Tumour SUV_max, SUV_mean and regional blood flow (BF) were derived. Immunohistochemical staining for CD105 expression and analysis were performed for two hot spots, four hot spots and the Chalkley method. Correlations between metabolic flow parameters and CD105 expression were assessed using Spearman’s rank correlation.

Results

Mean (SD) for tumour size was 38.5 (20.5) mm, for SUV_max, SUV_mean and BF it was 19.1 (4.5), 11.6 (2.5) and 85.4 (40.3) mL/min/100 g tissue, and for CD105 microvessel density it was 71.4 (23.6), 66.8 (22.9) and 6.18 (2.07) for two hot spots, four hot spots and the Chalkley method, respectively. Positive correlation between BF and CD105 expression was modest but higher for Chalkley than for four hot spots analysis (r = 0.38, P = 0.03; r = 0.33, P = 0.05, respectively). There were no significant correlations between metabolic parameters (SUV_max or SUV_mean) and CD105 expression (r = 0.08–0.22, P = 0.21–0.63).

Conclusions

The histological analysis method affects correlations between tumour CD105 expression and BF but not SUV_max or SUV_mean.

Key Points

• FDG-PET/perfusion CT offers new surrogate biomarkers of angiogenesis.

• Microvessel density scoring influences histopathological correlations with CT blood flow.

• Highest correlations were found with the Chalkley analysis method.

• Correlations between SUV and CD105 are not affected by the scoring method.

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Titel: Assessment of the metabolic flow phenotype of primary colorectal cancer: correlations with microvessel density are influenced by the histological scoring method
verfasst von: Vicky Goh
Manuel Rodriguez-Justo
Alec Engledow
Manu Shastry
Raymondo Endozo
Jacqui Peck
Marie Meagher
Stuart A. Taylor
Steve Halligan
Ashley M. Groves
Publikationsdatum: 01.08.2012
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 8/2012
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-012-2423-4

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Assessment of the metabolic flow phenotype of primary colorectal cancer: correlations with microvessel density are influenced by the histological scoring method

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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Abstract

Objectives

Methods

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