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01.12.2018 | Research article | Ausgabe 1/2018 Open Access

BMC Geriatrics 1/2018

Association among handgrip strength, body mass index and decline in cognitive function among the elderly women

Zeitschrift:
BMC Geriatrics > Ausgabe 1/2018
Autoren:
Su-min Jeong, Seulggie Choi, Kyuwoong Kim, Sung Min Kim, Sujin Kim, Sang Min Park
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1186/​s12877-018-0918-9) contains supplementary material, which is available to authorized users.
Su-min Jeong and Seulggie Choi contributed equally to this work.

Abstract

Background

The association between handgrip strength combined with body mass index (BMI) and cognitive impairment has not been thoroughly examined. We aimed to investigate whether the relationship between handgrip strength and risk of cognitive impairment is altered by the presence of obesity in older women.

Methods

A total of 544 older women aged over 65 years without cognitive impairment from the Korean Longitudinal Study of Aging (KLoSA) were included in the study. Handgrip strength was classified in a binary manner (weak or strong) or in tertiles and obesity was defined as a BMI ≥ 25 kg/m2, in accordance with the Asia-Pacific World Health Organization criteria. Incident cognitive impairment was defined as a Korean Mini-mental State Examination (K-MMSE) score of less than 24 after eight years of follow-up.

Results

Strong handgrip strength was associated with reduced likelihood of developing cognitive impairment compared to weak handgrip strength in obese women (adjusted odds ratio, aOR 0.23, 95% confidence interval, CI 0.08–0.66). The highest tertile of handgrip strength was associated with reduced risk of incident cognitive impairment (aOR 0.16, 95% CI 0.04–0.70), compared to the lowest tertile of handgrip strength in obese women, with a significant linear trend (p for trend = 0.016). Furthermore, the highest tertile of handgrip strength was significantly associated with smaller decline in K-MMSE scores compared to the lowest tertile of handgrip strength in obese women (p value = 0.009). There was no association between handgrip strength and incident cognitive impairment in non-obese women.

Conclusions

Strong handgrip strength was associated with reduced risk of cognitive impairment among obese women, but not in non-obese women. Handgrip strength may be a simple and useful marker for predicting future cognitive impairment among obese women.
Zusatzmaterial
Additional file 1: Table S1. Sensitivity analysis of the descriptive characteristics between study participants with non-participants. (DOCX 16 kb)
12877_2018_918_MOESM1_ESM.docx
Additional file 2: Figure S1. Predictive margins for cognitive impairment according to handgrip strength and obesity. Predictive margins calculated by logistic regression analysis after adjustments for age, marital status, education, income, insurance, area of residence, smoking status, drinking, physical activity, weight change, activities of daily living, depression, comorbidity, and baseline K-MMSE score. Obesity: non-obese, BMI < 25 kg/m2; obese, BMI ≥ 25 kg/m2. Handgrip strength: weak, lower half, < 18.5 kgF; strong, upper half, ≥18.5 kgF. (PNG 27 kb)
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