Background
Methods
Subjects
H. pylori infection test
Screening for SNPs
Genotyping assay
Statistical analysis
Results
General description of the samples
Variable | Group | Statistics | P | ||
---|---|---|---|---|---|
Case (n = 381) | Control (n = 427) | ||||
Age (median (IQR)) | 60 (52–69) | 57 (50–65) | W = 65,012 | < 0.001 | |
Age group | < 65 | 237 (62.2%) | 313 (73.3%) | χ2 = 11.408 | < 0.001 |
≥65 | 144 (37.8%) | 114 (26.7%) | |||
Gender | female | 95 (24.9%) | 107 (25.1%) | χ2 = 0.002 | 0.968 |
male | 286 (75.1%) | 320 (74.9%) |
Association between LATS1 and LATS2 SNPs and risk of H. pylori infection in normal control
Variable | H. pylori infection of the control group | Statistics | P | ||
---|---|---|---|---|---|
negative (n = 225) | positive (n = 202) | ||||
Age (median (IQR)) | 54 (50–66) | 53 (49–64) | W = 24,220 | 0.240 | |
Age group | < 65 | 160 (71.1%) | 153 (75.7%) | χ2 = 1.167 | 0.280 |
≥65 | 65 (28.9%) | 49 (24.3%) | |||
Gender | female | 56 (24.9%) | 51 (25.2%) | χ2 = 0.007 | 0.932 |
male | 169 (75.1%) | 151 (74.8%) |
Locus | Model | Genotype | Control [n(%)] | Case [n(%)] | OR (95%CI)a | P | AIC | BIC |
---|---|---|---|---|---|---|---|---|
LATS1 rs9393175 | codominant | G/G | 125 (55.56) | 128 (64.00) | 1 | – | 1092.330 | 1115.760 |
A/G | 88 (39.11) | 61 (30.50) | 0.671 (0.443–1.010) | 0.057 | ||||
A/A | 12 (5.33) | 11 (5.50) | 0.916 (0.383–2.175) | 0.842 | ||||
dominant | G/G | 125 (55.56) | 128 (64.00) | 1 | – | 591.691 | 607.899 | |
A/A + A/G | 100 (44.44) | 72 (36.00) | 0.700 (0.472–1.035) | 0.074 | ||||
recessive | G/G + A/G | 213 (94.67) | 189 (94.50) | 1 | – | 594.873 | 611.081 | |
A/A | 12 (5.33) | 11 (5.50) | 1.062 (0.449–2.487) | 0.889 | ||||
overdominant | G/G + A/A | 137 (60.89) | 139 (69.50) | – | 591.254 | 607.462 | ||
A/G | 88 (39.11) | 61 (30.50) | 0.675 (0.449–1.011) | 0.058 | ||||
log-additive | – | – | – | 0.792 (0.570–1.093) | 0.158 | 592.876 | 609.084 | |
LATS2 rs558614 | codominant | T/T | 63 (29.30) | 60 (30.46) | 1 | – | 579.405 | 599.511 |
C/T | 106 (49.30) | 91 (46.19) | 0.900 (0.572–1.416) | 0.648 | ||||
C/C | 46 (21.40) | 46 (23.35) | 1.042 (0.606–1.794) | 0.881 | ||||
dominant | T/T | 63 (29.30) | 60 (30.46) | 1 | – | 577.742 | 593.826 | |
C/C + C/T | 152 (70.70) | 137 (69.54) | 0.943 (0.617–1.442) | 0.787 | ||||
recessive | T/T + C/T | 169 (78.60) | 151 (76.65) | 1 | – | 577.614 | 593.698 | |
C/C | 46 (21.40) | 46 (23.35) | 1.112 (0.698–1.772) | 0.654 | ||||
overdominant | T/T + C/C | 109 (50.70) | 106 (53.81) | 1 | – | 577.428 | 593.512 | |
C/T | 106 (49.30) | 91 (46.19) | 0.884 (0.599–1.303) | 0.534 | ||||
log-additive | – | – | – | 1.012 (0.773–1.326) | 0.930 | 577.807 | 593.891 | |
LATS2 rs9552315 | codominant | T/T | 45 (20.18) | 60 (30.00) | 1 | – | 588.160 | 608.397 |
C/T | 119 (53.36) | 88 (44.00) | 0.549 (0.339–0.881) | 0.014 | ||||
C/C | 59 (26.46) | 52 (26.00) | 0.650 (0.377–1.114) | 0.118 | ||||
dominant | T/T | 45 (20.18) | 60 (30.00) | 1 | – | 586.672 | 602.862 | |
C/C + C/T | 178 (79.82) | 140 (70.00) | 0.582 (0.370–0.909) | 0.018 | ||||
recessive | T/T + C/T | 164 (73.54) | 148 (74.00) | 1 | – | 592.331 | 608.521 | |
C/C | 59 (26.46) | 52 (26.00) | 0.970 (0.626–1.499) | 0.891 | ||||
overdominant | T/T + C/C | 104 (46.64) | 112 (56.00) | 1 | – | 588.616 | 604.805 | |
C/T | 119 (53.36) | 88 (44.00) | 0.685 (0.466–1.005) | 0.054 | ||||
log-additive | – | – | – | 0.811 (0.618–1.061) | 0.128 | 590.018 | 606.207 | |
LATS2 rs7317471 | codominant | C/C | 177 (80.09) | 173 (85.64) | 1 | – | 590.953 | 611.190 |
C/T | 39 (17.65) | 28 (13.86) | 0.746 (0.435–1.266) | 0.281 | ||||
T/T | 5 (2.26) | 1 (0.50) | 0.206 (0.011–1.230) | 0.152 | ||||
dominant | C/C | 177 (80.09) | 173 (85.64) | 1 | – | 590.590 | 606.780 | |
C/T + T/T | 44 (19.91) | 29 (14.36) | 0.684 (0.405–1.143) | 0.151 | ||||
recessive | C/C + C/T | 216 (97.74) | 201 (99.50) | 1 | – | 590.126 | 606.316 | |
T/T | 5 (2.26) | 1 (0.50) | 0.217 (0.011–1.362) | 0.165 | ||||
overdominant | C/C + T/T | 182 (82.35) | 174 (86.14) | 1 | – | 591.689 | 607.879 | |
C/T | 39 (17.65) | 28 (13.86) | 0.764 (0.446–1.295) | 0.320 | ||||
log-additive | – | – | – | 0.667 (0.413–1.057) | 0.090 | 589.722 | 609.912 | |
LATS2 rs9509492 | codominant | A/A | 87 (39.01) | 74 (36.82) | 1 | – | 595.106 | 615.355 |
A/G | 98 (43.95) | 96 (47.76) | 1.147 (0.754–1.746) | 0.522 | ||||
G/G | 38 (17.04) | 31 (15.42) | 0.964 (0.544–1.699) | 0.898 | ||||
dominant | A/A | 87 (39.01) | 74 (36.82) | 1 | – | 593.488 | 609.687 | |
A/G + G/G | 136 (60.99) | 127 (63.18) | 1.096 (0.739–1.627) | 0.649 | ||||
recessive | A/A + A/G | 185 (82.96) | 170 (84.58) | 1 | – | 593.516 | 609.715 | |
G/G | 38 (17.04) | 31 (15.42) | 0.894 (0.529–1.500) | 0.672 | ||||
overdominant | A/A + G/G | 125 (56.05) | 105 (52.24) | 1 | – | 593.123 | 609.322 | |
A/G | 98 (43.95) | 96 (47.76) | 1.160 (0.790–1.702) | 0.449 | ||||
log-additive | – | – | – | 1.013 (0.772–1.329) | 0.927 | 593.687 | 609.886 |
Association between LATS1 and LATS2 SNPs and risk of non-cardia GC
Locus | Model | Genotype | Control [n(%)] | Case [n(%)] | OR (95%CI)a | P | AIC | BIC |
---|---|---|---|---|---|---|---|---|
LATS1 rs9393175 | codominant | G/G | 253 (59.53) | 253 (67.29) | 1 | – | 1092.330 | 1115.760 |
A/G | 149 (35.06) | 101 (26.86) | 0.696 (0.509–0.949) | 0.022 | ||||
A/A | 23 (5.41) | 22 (11.26) | 0.906 (0.486–1.683) | 0.753 | ||||
dominant | G/G | 253 (59.53) | 253 (67.29) | 1 | – | 1090.969 | 1109.713 | |
A/A + A/G | 172 (40.47) | 123 (32.71) | 0.725 (0.540–0.972) | 0.032 | ||||
recessive | G/G + A/G | 402 (94.59) | 354 (94.15) | 1 | – | 1095.593 | 1114.337 | |
A/A | 23 (5.41) | 22 (5.85) | 1.018 (0.551–1.877) | 0.954 | ||||
overdominant | G/G + A/A | 276 (64.94) | 275 (73.14) | 1 | – | 1090.429 | 1109.173 | |
A/G | 149 (35.06) | 101 (26.86) | 0.702 (0.516–0.952) | 0.024 | ||||
log-additive | – | – | – | 0.814 (0.641–1.030) | 0.088 | 1092.663 | 1111.406 | |
LATS2 rs558614 | codominant | T/T | 123 (29.85) | 90 (23.81) | 1 | – | 1081.499 | 1104.859 |
C/T | 197 (47.82) | 192 (50.79) | 1.287 (0.916–1.812) | 0.147 | ||||
C/C | 92 (22.33) | 96 (25.40) | 1.375 (0.923–2.052) | 0.118 | ||||
dominant | T/T | 123 (29.85) | 90 (23.81) | 1 | – | 1079.635 | 1098.323 | |
C/C + C/T | 289 (70.15) | 288 (76.19) | 1.315 (0.955–1.815) | 0.094 | ||||
recessive | T/T + C/T | 320 (77.67) | 282 (74.60) | 1 | – | 1081.613 | 1100.301 | |
C/C | 92 (22.33) | 96 (25.40) | 1.168 (0.838–1.628) | 0.360 | ||||
overdominant | T/T + C/C | 215 (52.18) | 186 (49.21) | – | – | 1081.954 | 1100.642 | |
C/T | 197 (47.82) | 192 (50.79) | 1.107 (0.834–1.470) | 0.480 | ||||
log-additive | – | – | – | 1.176 (0.964–1.436) | 0.111 | 1079.912 | 1098.600 | |
LATS2 rs9552315 | codominant | T/T | 105 (24.82) | 100 (26.46) | 1 | – | 1096.314 | 1119.743 |
C/T | 207 (48.94) | 195 (51.59) | 1.034 (0.735–1.456) | 0.848 | ||||
C/C | 111 (26.24) | 83 (21.96) | 0.812 (0.544–1.212) | 0.309 | ||||
dominant | T/T | 105 (24.82) | 100 (26.46) | 1 | – | 1096.153 | 1114.896 | |
C/C + C/T | 318 (75.18) | 278 (73.54) | 0.956 (0.693–1.321) | 0.785 | ||||
recessive | T/T + C/T | 312 (73.76) | 295 (78.04) | 1 | – | 1094.350 | 1113.094 | |
C/C | 111 (26.24) | 83 (21.96) | 0.795 (0.570–1.104) | 0.172 | ||||
overdominant | T/T + C/C | 216 (51.06) | 183 (48.41) | 1 | – | 1095.351 | 1114.095 | |
C/T | 207 (48.94) | 195 (51.59) | 1.144 (0.863–1.516) | 0.350 | ||||
log-additive | – | – | – | 0.903 (0.740–1.102) | 0.317 | 1095.226 | 1113.970 | |
LATS2 rs7317471 | codominant | C/C | 350 (82.74) | 302 (79.89) | 1 | – | 1097.992 | 1121.421 |
C/T | 67 (15.84) | 69 (18.25) | 1.188 (0.816–1.729) | 0.368 | ||||
T/T | 6 (1.42) | 7 (1.85) | 1.386 (0.449–4.402) | 0.566 | ||||
dominant | C/C | 350 (82.74) | 302 (79.89) | 1 | – | 1096.061 | 1114.804 | |
C/T + T/T | 73 (17.26) | 76 (20.11) | 1.204 (0.839–1.729) | 0.314 | ||||
recessive | C/C + C/T | 417 (98.58) | 371 (98.15) | 1 | – | 1096.804 | 1115.547 | |
T/T | 6 (1.42) | 7 (1.85) | 1.345 (0.437–4.264) | 0.602 | ||||
overdominant | C/C + T/T | 356 (84.17) | 309 (81.75) | 1 | – | 1096.322 | 1115.065 | |
C/T | 67 (15.84) | 69 (18.25) | 1.180 (0.812–1.717) | 0.385 | ||||
log-additive | – | – | – | 1.185 (0.861–1.633) | 0.298 | 1095.993 | 1114.736 | |
LATS2 rs9509492 | codominant | A/A | 161 (37.97) | 180 (47.24) | 1 | – | 1094.648 | 1118.102 |
A/G | 194 (45.75) | 161 (42.26) | 0.747 (0.552–1.010) | 0.058 | ||||
G/G | 69 (16.27) | 40 (10.50) | 0.525 (0.333–0.818) | 0.005 | ||||
dominant | A/A | 161 (37.97) | 180 (47.24) | 1 | – | 1095.087 | 1113.850 | |
A/G + G/G | 263 (62.03) | 201 (52.76) | 0.688 (0.518–0.915) | 0.010 | ||||
recessive | A/A + A/G | 355 (83.73) | 341 (89.50) | 1 | – | 1096.241 | 1115.004 | |
G/G | 69 (16.27) | 40 (10.50) | 0.609 (0.397–0.923) | 0.021 | ||||
overdominant | A/A + G/G | 230 (54.25) | 220 (57.74) | 1 | – | 1100.815 | 1119.578 | |
A/G | 194 (45.75) | 161 (42.26) | 0.871 (0.657–1.156) | 0.339 | ||||
log-additive | – | – | – | 0.731 (0.594–0.897) | 0.003 | 1092.686 | 1111.449 |
Association between five SNPs and expression of LATS1 and LATS2 proteins in non-cardia GC tissues
Locus | Model | Genotype | Positive expression N(%) | Negative expression N(%) | OR (95% CI)a | P | AIC | BIC |
---|---|---|---|---|---|---|---|---|
LATS1 rs9393175 | codominant | G/G | 30 (62.50) | 40 (65.57) | 1 | – | 157.896 | 171.353 |
A/G | 15 (31.25) | 16 (26.23) | 1.208 (0.508–2.869) | 0.667 | ||||
A/A | 3 (6.25%) | 5 (8.20) | 0.795 (0.152–3.535) | 0.767 | ||||
dominant | G/G | 30 (62.50) | 40 (65.57) | 1 | – | 156.162 | 166.927 | |
A/A + A/G | 18 (37.50) | 21 (34.43) | 1.110 (0.497–2.467) | 0.798 | ||||
recessive | G/G + A/G | 45 (93.75) | 56 (91.80) | 1 | – | 156.082 | 166.847 | |
A/A | 3 (6.25) | 5 (8.20) | 0.750 (0.146–3.258) | 0.706 | ||||
overdominant | G/G + A/A | 33 (68.75) | 45 (73.77) | 1 | – | 155.985 | 166.751 | |
A/G | 15 (31.25) | 16 (26.23) | 1.237 (0.527–2.897) | 0.623 | ||||
log-additive | – | – | – | 1.012 (0.544–1.863) | 0.970 | 156.225 | 166.991 | |
LATS2 rs558614 | codominant | T/T | 20 (26.67) | 6 (17.14) | 1 | – | 144.846 | 158.348 |
C/T | 35 (46.67) | 21 (60.00) | 0.505 (0.163–1.407) | 0.208 | ||||
C/C | 20 (26.67) | 8 (22.86) | 0.739 (0.208–2.522) | 0.630 | ||||
dominant | T/T | 20 (26.67) | 6 (17.14) | 1 | – | 143.431 | 154.233 | |
T/C + C/C | 55 (73.33) | 29 (82.86) | 0.570 (0.190–1.513) | 0.280 | ||||
recessive | T/T + C/T | 55 (73.33) | 27 (77.14) | 1 | – | 144.519 | 155.321 | |
C/C | 20 (26.67) | 8 (22.86) | 1.200 (0.478–3.229) | 0.705 | ||||
overdominant | C/C + T/T | 40 (53.33) | 14 (40.00) | 1 | – | 143.079 | 153.881 | |
C/T | 35 (46.67) | 21 (60.00) | 0.593 (0.258–1.336) | 0.211 | ||||
log-additive | – | – | – | 0.882 (0.491–1.572) | 0.670 | 144.483 | 155.285 | |
LATS2 rs9552315 | codominant | T/T | 25 (33.33) | 7 (20.59) | 1 | – | 141.158 | 154.615 |
C/T | 31 (41.33) | 20 (58.82) | 0.409 (0.139–1.100) | 0.087 | ||||
C/C | 19 (25.33) | 7 (20.59) | 0.716 (0.207–2.451) | 0.591 | ||||
dominant | T/T | 25 (33.33) | 7 (20.59) | 1 | – | 140.308 | 151.073 | |
T/C + C/C | 50 (66.67) | 27 (79.41) | 0.489 (0.174–1.244) | 0.149 | ||||
recessive | T/T + C/T | 56 (74.67) | 27 (79.41) | 1 | – | 142.279 | 153.044 | |
C/C | 19 (25.33) | 7 (20.59) | 1.283 (0.493–3.632) | 0.621 | ||||
overdominant | C/C + T/T | 44 (58.67) | 14 (41.18) | 1 | – | 139.447 | 150.213 | |
C/T | 31 (41.33) | 20 (58.82) | 0.478 (0.205–1.089) | 0.082 | ||||
log-additive | – | – | – | 0.836 (0.473–1.468) | 0.533 | 142.140 | 152.905 | |
LATS2 rs7317471 | C/C | 63 (85.14) | 26 (74.29) | 1 | – | 142.226 | 152.992 | |
C/T | 11 (14.86) | 9 (25.71) | 0.509 (0.186–1.413) | 0.187 | ||||
LATS2 rs9509492 | codominant | A/A | 34 (45.33) | 16 (44.44) | 1 | – | 147.894 | 161.441 |
A/G | 32 (42.67) | 18 (50.00) | 0.842 (0.364–1.936) | 0.686 | ||||
G/G | 9 (12.00) | 2 (5.56) | 2.138 (0.478–15.146) | 0.366 | ||||
dominant | A/A | 34 (45.33) | 16 (44.44) | 1 | – | 147.305 | 158.143 | |
A/G + G/G | 41 (54.67) | 20 (55.56) | 0.972 (0.433–2.167) | 0.945 | ||||
recessive | A/A + A/G | 66 (88.00) | 34 (94.44) | – | 146.058 | 156.896 | ||
G/G | 9 (12.00) | 2 (5.56) | 2.332 (0.559–15.911) | 0.297 | ||||
overdominant | A/A + G/G | 43 (57.33) | 18 (50.00) | 1 | – | 146.805 | 157.644 | |
A/G | 32 (42.67) | 18 (50.00) | 0.748 (0.334–1.670) | 0.478 | ||||
log-additive | – | – | – | 1.147 (0.623–2.160) | 0.662 | 147.118 | 157.956 |