Skip to main content
Erschienen in: Journal of Neural Transmission 9/2009

01.09.2009 | Biological Psychiatry - Short Communication

Association analysis of serotonin receptor 1B (HTR1B) and brain-derived neurotrophic factor gene polymorphisms in borderline personality disorder

verfasst von: André Tadić, Amelie Elsäßer, Anja Victor, Robert von Cube, Ömür Başkaya, Stefanie Wagner, Klaus Lieb, Wolfgang Höppner, Norbert Dahmen

Erschienen in: Journal of Neural Transmission | Ausgabe 9/2009

Einloggen, um Zugang zu erhalten

Abstract

The purpose of this study was to test for association between Borderline personality disorder (BPD) and variants of the HTR1B and the brain-derived neurotrophic factor (BDNF) gene. We genotyped four HTR1B and the functional BDNF G196A marker in 161 Caucasian BPD patients and 156 healthy controls. There were no significant differences between groups in genotype or haplotype distribution of HTR1B markers or in genotype distribution of the BDNF marker. Logistic regression analyses revealed an over-representation of the BDNF 196A allele in HTR1B A-161 allele carrying BPD patients.
Literatur
Zurück zum Zitat Chen ZY, Patel PD, Sant G et al (2004) Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. J Neurosci 24:4401–4411PubMedCrossRef Chen ZY, Patel PD, Sant G et al (2004) Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. J Neurosci 24:4401–4411PubMedCrossRef
Zurück zum Zitat Duan J, Sanders AR, Vander Molen JE et al (2003) Polymorphisms in the 5′-untranslated region of the human serotonin receptor 1B (HTR1B) gene affect gene expression. Mol Psychiatry 8:901–910PubMedCrossRef Duan J, Sanders AR, Vander Molen JE et al (2003) Polymorphisms in the 5′-untranslated region of the human serotonin receptor 1B (HTR1B) gene affect gene expression. Mol Psychiatry 8:901–910PubMedCrossRef
Zurück zum Zitat Dwivedi Y, Rizavi HS, Conley RR et al (2003) Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. Arch Gen Psychiatry 60:804–815PubMedCrossRef Dwivedi Y, Rizavi HS, Conley RR et al (2003) Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. Arch Gen Psychiatry 60:804–815PubMedCrossRef
Zurück zum Zitat Iga J, Ueno S, Yamauchi K et al (2007) The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with psychotic feature and suicidal behavior in Japanese major depressive patients. Am J Med Genet B Neuropsychiatr Genet 144B:1003–1006PubMedCrossRef Iga J, Ueno S, Yamauchi K et al (2007) The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with psychotic feature and suicidal behavior in Japanese major depressive patients. Am J Med Genet B Neuropsychiatr Genet 144B:1003–1006PubMedCrossRef
Zurück zum Zitat Kim YK, Lee HP, Won SD et al (2007) Low plasma BDNF is associated with suicidal behavior in major depression. Prog Neuropsychopharmacol Biol Psychiatry 31:78–85PubMedCrossRef Kim YK, Lee HP, Won SD et al (2007) Low plasma BDNF is associated with suicidal behavior in major depression. Prog Neuropsychopharmacol Biol Psychiatry 31:78–85PubMedCrossRef
Zurück zum Zitat Kimata H (2005) Differential modulation of cerebrospinal fluid neurotrophins in patients with atopic dermatitis who attempted suicide. J Clin Psychiatry 66:1193–1194PubMedCrossRef Kimata H (2005) Differential modulation of cerebrospinal fluid neurotrophins in patients with atopic dermatitis who attempted suicide. J Clin Psychiatry 66:1193–1194PubMedCrossRef
Zurück zum Zitat Lieb K, Zanarini MC, Schmahl C et al (2004) Borderline personality disorder. Lancet 364:453–461PubMedCrossRef Lieb K, Zanarini MC, Schmahl C et al (2004) Borderline personality disorder. Lancet 364:453–461PubMedCrossRef
Zurück zum Zitat Martinowich K, Lu B (2008) Interaction between BDNF and serotonin: role in mood disorders. Neuropsychopharmacology 33:73–83PubMedCrossRef Martinowich K, Lu B (2008) Interaction between BDNF and serotonin: role in mood disorders. Neuropsychopharmacology 33:73–83PubMedCrossRef
Zurück zum Zitat Pezawas L, Verchinski BA, Mattay VS et al (2004) The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology. J Neurosci 24:10099–10102PubMedCrossRef Pezawas L, Verchinski BA, Mattay VS et al (2004) The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology. J Neurosci 24:10099–10102PubMedCrossRef
Zurück zum Zitat Sanders AR, Duan J, Gejman PV (2002) DNA variation and psychopharmacology of the human serotonin receptor 1B (HTR1B) gene. Pharmacogenomics 3:745–762PubMedCrossRef Sanders AR, Duan J, Gejman PV (2002) DNA variation and psychopharmacology of the human serotonin receptor 1B (HTR1B) gene. Pharmacogenomics 3:745–762PubMedCrossRef
Zurück zum Zitat Sari Y (2004) Serotonin 1B receptors: from protein to physiological function and behavior. Neurosci Biobehav Rev 28:565–582PubMedCrossRef Sari Y (2004) Serotonin 1B receptors: from protein to physiological function and behavior. Neurosci Biobehav Rev 28:565–582PubMedCrossRef
Zurück zum Zitat Sun HF, Chang YT, Fann CS et al (2002) Association study of novel human serotonin 5-HT(1B) polymorphisms with alcohol dependence in Taiwanese Han. Biol Psychiatry 51:896–901PubMedCrossRef Sun HF, Chang YT, Fann CS et al (2002) Association study of novel human serotonin 5-HT(1B) polymorphisms with alcohol dependence in Taiwanese Han. Biol Psychiatry 51:896–901PubMedCrossRef
Metadaten
Titel
Association analysis of serotonin receptor 1B (HTR1B) and brain-derived neurotrophic factor gene polymorphisms in borderline personality disorder
verfasst von
André Tadić
Amelie Elsäßer
Anja Victor
Robert von Cube
Ömür Başkaya
Stefanie Wagner
Klaus Lieb
Wolfgang Höppner
Norbert Dahmen
Publikationsdatum
01.09.2009
Verlag
Springer Vienna
Erschienen in
Journal of Neural Transmission / Ausgabe 9/2009
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI
https://doi.org/10.1007/s00702-009-0264-3

Weitere Artikel der Ausgabe 9/2009

Journal of Neural Transmission 9/2009 Zur Ausgabe

Basic Neurosciences, Genetics and Immunology - Short Communication

Hemispheric lateralization of the corticostriatal glutamatergic system in the rat

Basic Neurosciences, Genetics and Immunology - Short Communication

Role of the metabotropic glutamate receptor subtype 1 in the Harmaline-induced tremor in rats

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Neu im Fachgebiet Neurologie

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.