Skip to main content
Erschienen in:

30.06.2022 | Original Article

Association between alanine aminotransferase as surrogate of fatty liver disease and physical activity and sedentary time in adolescents with obesity

verfasst von: Valérie Julian, Peter Bergsten, Gael Ennequin, Anders Forslund, Hakan Ahlstrom, Iris Ciba, Marie Dahlbom, Dieter Furthner, Julian Gomahr, Joel Kullberg, Katharina Maruszczak, Katharina Morwald, Roger Olsson, Thomas Pixner, Anna Schneider, Bruno Pereira, Suzanne Ring-Dimitriou, David Thivel, Daniel Weghuber

Erschienen in: European Journal of Pediatrics | Ausgabe 8/2022

Einloggen, um Zugang zu erhalten

Abstract

To compare patterns of sedentary (SED) time (more sedentary, SED + vs less sedentary, SED-), moderate to vigorous physical activity (MVPA) time (more active, MVPA + vs less active, MVPA-), and combinations of behaviors (SED-/MVPA + , SED-/MVPA-, SED + /MVPA + , SED + /MVPA-) regarding nonalcoholic fatty liver diseases (NAFLD) markers. This cross-sectional study included 134 subjects (13.4 ± 2.2 years, body mass index (BMI) 98.9 ± 0.7 percentile, 48.5% females) who underwent 24-h/7-day accelerometry, anthropometric, and biochemical markers (alanine aminotransferase (ALT) as first criterion, and aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), AST/ALT ratio as secondary criteria). A subgroup of 39 patients underwent magnetic resonance imaging-liver fat content (MRI-LFC). Hepatic health was better in SED- (lower ALT, GGT, and MRI-LFC (p < 0.05), higher AST/ALT (p < 0.01)) vs SED + and in MVPA + (lower ALT (p < 0.05), higher AST/ALT (p < 0.01)) vs MVPA- groups after adjustment for age, gender, and Tanner stages. SED-/MVPA + group had the best hepatic health. SED-/MVPA- group had lower ALT and GGT and higher AST/ALT (p < 0.05) in comparison with SED + /MVPA + group independently of BMI. SED time was positively associated with biochemical (high ALT, low AST/ALT ratio) and imaging (high MRI-LFC) markers independently of MVPA. MVPA time was associated with biochemical markers (low ALT, high AST/ALT) but these associations were no longer significant after adjustment for SED time.
Conclusion: Lower SED time is associated with better hepatic health independently of MVPA. Reducing SED time might be a first step in the management of pediatric obesity NAFLD when increasing MVPA is not possible.
What is Known:
• MVPA and SED times are associated with cardiometabolic risks in youths with obesity.
• The relationships between NAFLD markers and concomitant MVPA and SED times have not been studied in this population.
What is New:
• Low SED time is associated with healthier liver enzyme profiles and LFC independent of MVPA.
• While low SED/high MVPA is the more desirable pattern, low SED/low MVPA pattern would have healthier liver enzyme profile compared with high MVPA/high SED, independent of BMI, suggesting that reducing SED time irrespective of MVPA is needed to optimize liver health.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
6.
Zurück zum Zitat Albert Pérez E, Mateu Olivares V, Martínez-Espinosa RM et al (2018) New insights about how to make an intervention in children and adolescents with metabolic syndrome: diet, exercise vs. changes in body composition. A systematic review of RCT. Nutrients 10:E878. https://doi.org/10.3390/nu10070878 Albert Pérez E, Mateu Olivares V, Martínez-Espinosa RM et al (2018) New insights about how to make an intervention in children and adolescents with metabolic syndrome: diet, exercise vs. changes in body composition. A systematic review of RCT. Nutrients 10:E878. https://​doi.​org/​10.​3390/​nu10070878
7.
19.
Zurück zum Zitat Martins C, Aires L, Júnior IF et al (2015) Physical activity is related to fatty liver marker in obese youth, independently of central obesity or cardiorespiratory fitness. J Sports Sci Med 14:103–109PubMedPubMedCentral Martins C, Aires L, Júnior IF et al (2015) Physical activity is related to fatty liver marker in obese youth, independently of central obesity or cardiorespiratory fitness. J Sports Sci Med 14:103–109PubMedPubMedCentral
31.
Zurück zum Zitat Chalasani N, Younossi Z, Lavine JE et al (2012) The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Am J Gastroenterol 107:811–826. https://doi.org/10.1038/ajg.2012.128CrossRefPubMed Chalasani N, Younossi Z, Lavine JE et al (2012) The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Am J Gastroenterol 107:811–826. https://​doi.​org/​10.​1038/​ajg.​2012.​128CrossRefPubMed
41.
51.
Zurück zum Zitat Fridolfsson J, Buck C, Hunsberger M et al (2021) High-intensity activity is more strongly associated with metabolic health in children compared to sedentary time: a cross-sectional study of the I.Family cohort. Int J Behav Nutr Phys Act 18:90. https://doi.org/10.1186/s12966-021-01156-1 Fridolfsson J, Buck C, Hunsberger M et al (2021) High-intensity activity is more strongly associated with metabolic health in children compared to sedentary time: a cross-sectional study of the I.Family cohort. Int J Behav Nutr Phys Act 18:90. https://​doi.​org/​10.​1186/​s12966-021-01156-1
Metadaten
Titel
Association between alanine aminotransferase as surrogate of fatty liver disease and physical activity and sedentary time in adolescents with obesity
verfasst von
Valérie Julian
Peter Bergsten
Gael Ennequin
Anders Forslund
Hakan Ahlstrom
Iris Ciba
Marie Dahlbom
Dieter Furthner
Julian Gomahr
Joel Kullberg
Katharina Maruszczak
Katharina Morwald
Roger Olsson
Thomas Pixner
Anna Schneider
Bruno Pereira
Suzanne Ring-Dimitriou
David Thivel
Daniel Weghuber
Publikationsdatum
30.06.2022
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Pediatrics / Ausgabe 8/2022
Print ISSN: 0340-6199
Elektronische ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-022-04539-z

Neu im Fachgebiet Pädiatrie

Podcast

Magendarminfekte: Dos and Don'ts bei Kleinkindern

Die Leitlinie zur akuten infektiösen Gastroenteritis wurde 2024 umfassend überarbeitet. Cola und Saft zur oralen Hydratation und einige Antidiarrhoika sollten vermieden werden. Von einem standardmäßigen Erregerpanel wird abgeraten. Die Hintergründe zu diesen und weiteren Empfehlungen erläutert Leitlinienkoordinator Prof. Carsten Posovszky.

Ab sofort gelten die neuen Verordnungsausnahmen für Lipidsenker

Freie Fahrt für Lipidsenker? Das nicht, doch mit niedrigerem Schwellenwert fürs Infarktrisiko und neuen Indikationen hat der G-BA die Verordnungs-Handbremse ein gutes Stück weit gelockert.

ADHS-Kranke verlieren sieben Lebensjahre

  • 11.02.2025
  • ADHS
  • Nachrichten

Ein ADHS verkürzt die Lebenserwartung um rund sieben Jahre, bei Frauen sind es sogar fast neun Jahre. Ein Großteil der erhöhten Sterblichkeit lässt sich auf modifizierbare Risikofaktoren wie Alkohol, Rauchen und psychische Begleiterkrankungen zurückführen.

Abdominale CT bei Kindern: 40% mit Zufallsbefunden

Wird bei Kindern mit stumpfem Trauma eine CT des Bauchraums veranlasst, sind in rund 40% der Fälle Auffälligkeiten zu sehen, die nichts mit dem Trauma zu tun haben. Die allerwenigsten davon sind klinisch relevant.

Update Pädiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.