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02.11.2015 | Original Contribution | Ausgabe 1/2017

European Journal of Nutrition 1/2017

Association between body weight and composition and plasma 25-hydroxyvitamin D level in the Diabetes Prevention Program

European Journal of Nutrition > Ausgabe 1/2017
Lisa Ceglia, Jason Nelson, James Ware, Konstantinos-Dionysios Alysandratos, George A. Bray, Cheryl Garganta, David M. Nathan, Frank B. Hu, Bess Dawson-Hughes, Anastassios G. Pittas, Diabetes Prevention Program Research Group
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Electronic supplementary material

The online version of this article (doi:10.​1007/​s00394-015-1066-z) contains supplementary material, which is available to authorized users.


The authors of this report are responsible for its content. Statements in the report should not be construed as endorsement by the National Institutes of Health, the US Department of Health and Human Services.
The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH, the US Department of Health and Human Services or the above-listed institutions.



We examined associations between body weight and plasma 25-hydroxyvitamin D concentration (25OHD) in prediabetes and sought to estimate the impact of adiposity on these associations.


The study was conducted in the placebo (n = 1082) and intensive lifestyle (n = 1079) groups of the Diabetes Prevention Program (DPP), a multicenter trial to prevent type 2 diabetes in adults with prediabetes. Weight and 25OHD were measured at baseline, month 6, years 1 and 2. In a subset (n = 584), visceral (VAT) and subcutaneous (SAT) adiposity were assessed by computed tomography at baseline and year 1.


In cross-sectional analyses, baseline body weight, total fat, VAT, and SAT were inversely associated with plasma 25OHD concentration after multivariable adjustment. VAT accounted for 40 % [95 % CI 11, 69] of the association of body weight with plasma 25OHD concentration. There was no significant contribution by total fat or SAT. Two-year changes in plasma 25OHD concentration varied inversely with changes in body weight (p < 0.0001). One-year changes in total fat, VAT, or SAT were not significant mediators of the association between change in plasma 25OHD concentration and body weight.


Our study found an inverse association between body weight and plasma 25OHD concentration at baseline and over a 2-year period in adults with prediabetes. These findings in the DPP, a weight loss intervention study, raise the possibility that weight loss increases plasma 25OHD concentration. Whether adiposity mediates this association remains inconclusive.

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