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Environmental Health and Preventive Medicine

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01.11.2009 | Regular Article

Association between bone mineral density and lifestyle factors or vitamin D receptor gene polymorphism in adult male workers: a cross-sectional study

verfasst von: Yayoi Funakoshi, Hisamitsu Omori, Takahiko Katoh

Erschienen in: Environmental Health and Preventive Medicine | Ausgabe 6/2009

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Abstract

Objectives

The aim of this cross-sectional study was to investigate the association between bone mineral density (BMD) and lifestyle factors, as well as the influence of vitamin D receptor (VDR) gene polymorphism, in adult male workers.

Methods

The subjects were 524 male employees aged 23–49 years (37.3 ± 5.4 years, mean ± standard deviation) working at a large-scale integrated manufacturing facility in Japan. BMD was measured at the nondominant radius by dual-energy X-ray absorptiometry. Lifestyle information was obtained by a questionnaire at the same time, and genomic DNA was isolated from peripheral leukocytes.

Results

The genotype frequencies of VDR gene polymorphism detected by Taq I digestion were 81.3%, 17.9%, and 0.8% for TT, Tt, and tt, respectively. BMD was 0.56 ± 0.06 g/cm². Analysis of covariance with adjustment for age and body mass index (BMI) revealed that subjects who had a past history of exercise, current exercise from 3 to 7 days a week or daily alcohol intake showed significantly higher BMD than subjects without these features (0.56 ± 0.06 versus 0.54 ± 0.06, 0.58 ± 0.06 versus 0.55 ± 0.06, and 0.57 ± 0.06 versus 0.55 ± 0.06, respectively) (P < 0.05). Subjects who ate only 2 meals a day or smoked ≥21 cigarettes a day showed significantly lower BMD if they had the Tt or tt genotype than if they had the TT genotype (0.51 ± 0.04 versus 0.56 ± 0.06 and 0.51 ± 0.05 versus 0.57 ± 0.06, respectively) (P < 0.05).

Conclusions

These findings suggest that the influence of lifestyle on BMD differs according to VDR gene polymorphism in adult male workers.

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Titel: Association between bone mineral density and lifestyle factors or vitamin D receptor gene polymorphism in adult male workers: a cross-sectional study
verfasst von: Yayoi Funakoshi
Hisamitsu Omori
Takahiko Katoh
Publikationsdatum: 01.11.2009
Verlag: Springer Japan
Erschienen in: Environmental Health and Preventive Medicine / Ausgabe 6/2009
Print ISSN: 1342-078X
Elektronische ISSN: 1347-4715
DOI: https://doi.org/10.1007/s12199-009-0104-y

Springer Medizin

Abstract

Objectives

Methods

Results

Conclusions

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