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Erschienen in:

24.06.2017

Association Between CD4+, Viral Load, and Pulmonary Function in HIV

verfasst von: Marjan Islam, Navitha Ramesh, Samuel Kolman, Sanjana Koshy, Matthew Frank, Nadim Salomon, Albert Miller, Mary Harris

Erschienen in: Lung | Ausgabe 5/2017

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Abstract

Purpose

The antiretroviral therapy era has shifted the epidemiology of HIV-associated diseases, increasing the recognition of non-infectious pulmonary complications secondary to HIV. We aimed to determine the association between CD4+, viral load, and pulmonary function in individuals with uncontrolled HIV, and determine how changes in these parameters are associated with pulmonary function longitudinally.

Methods

This is a retrospective observational study of individuals with HIV who underwent pulmonary function testing in an urban medical center between August 1997 and November 2015.

Results

Of the 146 participants (mean age 52 ± 10 years), 49% were Hispanic, 56% were men, and 44% were current smokers. CD4+ <200 cells/μl was associated with significant diffusion impairment compared to CD4+ ≥200 cells/μl (DLCO 56 vs. 70%, p = <0.01). VL (viral load) ≥75 copies/ml was associated with significant diffusion impairment compared to VL <75 copies/ml (DLCO 60 vs. 71%, p = <0.01). No difference in FEV1, FEV1/FVC, or TLC was noted between groups. In univariate analysis, CD4+ and VL correlated with DLCO (r = +0.33; p = <0.01; r = −0.26; p = <0.01) and no correlation was noted with FEV1, FEV1/FVC, or TLC. Current smoking and history of AIDS correlated with DLCO (r = −0.20; p = 0.03; r = −0.20; p = 0.04). After adjusting for smoking and other confounders, VL ≥75 copies/ml correlated with a 11.2 (CI 95% [3.03–19.4], p = <0.01) decrease in DLCO. In Spearman’s Rank correlation, there was a negative correlation between change in VL and change in DLCO over time (ρ = −0.47; p = <0.01).

Conclusion

The presence of viremia in individuals with HIV is independently associated with impaired DLCO. Suppression of VL may allow for recovery in diffusing capacity over time, though the degree to which this occurs requires further investigation.
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Metadaten
Titel
Association Between CD4+, Viral Load, and Pulmonary Function in HIV
verfasst von
Marjan Islam
Navitha Ramesh
Samuel Kolman
Sanjana Koshy
Matthew Frank
Nadim Salomon
Albert Miller
Mary Harris
Publikationsdatum
24.06.2017
Verlag
Springer US
Erschienen in
Lung / Ausgabe 5/2017
Print ISSN: 0341-2040
Elektronische ISSN: 1432-1750
DOI
https://doi.org/10.1007/s00408-017-0030-5

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