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Annals of Surgical Oncology
Erschienen in:

17.08.2024 | Translational Research

Association Between Changes in Skeletal Muscle Quality and Prognosis in Postoperative Patients with Early Gastric Cancer

verfasst von: Shiho Kobayashi, PT, MSc, Kentaro Kamiya, PT, PhD, Takashi Miki, PT, MSc, Masashi Yamashita, PT, PhD, Takumi Noda, PT, PhD, Kensuke Ueno, PT, MSc, Kazuki Hotta, PT, PhD, Mikiko Sakuraya, MD, Masahiro Niihara, MD, PhD, Michinari Fukuda, MD, PhD, Naoki Hiki, MD, PhD

Erschienen in: Annals of Surgical Oncology | Ausgabe 12/2024

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Abstract

Background

Identifying accurate prognostic factors is crucial for postoperative management of early gastric cancer (EGC) patients. Skeletal muscle quality (SMQ), defined by muscle density on computed tomography (CT) images, has been proposed as a novel prognostic factor. This study compared the prognostic significance of SMQ changes with the well-established factor of body weight (BW) loss in the postoperative EGC setting.

Methods

This single-center retrospective study included 297 postoperative EGC patients (median age 69 years, 68.4% male) who had preoperative and 1-year-postoperative gastrectomy CT images. SMQ was defined as the modified intramuscular adipose tissue content (mIMAC = skeletal muscle density—subcutaneous fat density on CT images) and the change as ΔmIMAC. Log-rank test, Kaplan-Meier survival, and Cox proportional hazards regression analyses were used to assess the associations between prognosis and either ΔmIMAC or BW change (ΔBW). Prognosis prediction by ΔmIMAC and ΔBW was compared by using the area under the curve (AUC) of the receiver operating characteristic curve.

Results

ΔmIMAC was significantly associated with prognosis (log-rank test; P = 0.037), but ΔBW was not (P = 0.243). Prognosis was significantly poorer in the severely decreased mIMAC group than in the preserved group (multivariate Cox proportional hazards regression analysis; P = 0.030) but was unaffected by BW changes (P = 0.697). The AUC indicated a higher prognostic value for ΔmIMAC than ΔBW (ΔmIMAC: AUC = 0.697, ΔBW: AUC = 0.542).

Conclusions

One-year post-gastrectomy SMQ changes may be better prognostic EGC predictors than BW changes.
Literatur
1.
Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49.CrossRefPubMed
2.
Japanese Gastric Cancer Treatment Guidelines 2021 (6th ed). Gastric Cancer. 2023;26(1):1–25.
3.
Yanagimoto Y, Kurokawa Y, Doki Y. Essential updates 2021/2022: perioperative and surgical treatments for gastric and esophagogastric junction cancer. Ann Gastroenterol Surg. 2023;7(5):698–708.CrossRefPubMedPubMedCentral
4.
Bales CW, Ritchie CS. Sarcopenia, weight loss, and nutritional frailty in the elderly. Annu Rev Nutr. 2002;22:309–23.CrossRefPubMed
5.
Segami K, Aoyama T, Kano K, et al. Risk factors for severe weight loss at 1 month after gastrectomy for gastric cancer. Asian J Surg. 2018;41(4):349–55.CrossRefPubMed
6.
Aoyama T, Sato T, Segami K, et al. Risk factors for the loss of lean body mass after gastrectomy for gastric cancer. Ann Surg Oncol. 2016;23(6):1963–70.CrossRefPubMed
7.
Abdiev S, Kodera Y, Fujiwara M, et al. Nutritional recovery after open and laparoscopic gastrectomies. Gastric Cancer. 2011;14(2):144–9.CrossRefPubMed
8.
Stojcev Z, Matysiak K, Duszewski M, Banasiewicz T. The role of dietary nutrition in stomach cancer. Contemp Oncol (Pozn). 2013;17(4):343–5.PubMed
9.
Takiguchi S, Takata A, Murakami K, et al. Clinical application of ghrelin administration for gastric cancer patients undergoing gastrectomy. Gastric Cancer. 2014;17(2):200–5.CrossRefPubMed
10.
Kim KW, Lee K, Lee JB, et al. Preoperative nutritional risk index and postoperative one-year skeletal muscle loss can predict the prognosis of patients with gastric adenocarcinoma: a registry-based study. BMC Cancer. 2021;21(1):157.CrossRefPubMedPubMedCentral
11.
Kubo H, Komatsu S, Ichikawa D, et al. Impact of body weight loss on recurrence after curative gastrectomy for gastric cancer. Anticancer Res. 2016;36(2):807–13.PubMed
12.
Ock CY, Oh DY, Lee J, et al. Weight loss at the first month of palliative chemotherapy predicts survival outcomes in patients with advanced gastric cancer. Gastric Cancer. 2016;19(2):597–606.CrossRefPubMed
13.
Yamashita M, Kamiya K, Matsunaga A, et al. Prognostic value of psoas muscle area and density in patients who undergo cardiovascular surgery. Can J Cardiol. 2017;33(12):1652–9.CrossRefPubMed
14.
Antoun S, Lanoy E, Iacovelli R, et al. Skeletal muscle density predicts prognosis in patients with metastatic renal cell carcinoma treated with targeted therapies. Cancer. 2013;119(18):3377–84.CrossRefPubMed
15.
Maurits JSF, Sedelaar JPM, Mulders PFA, Aben KKH, Kiemeney L, Vrieling A. Skeletal muscle radiodensity and visceral adipose tissue index are associated with survival in renal cell cancer—a multicenter population-based cohort study. Clin Nutr. 2022;41(1):131–43.CrossRefPubMed
16.
Hacker UT, Hasenclever D, Linder N, et al. Prognostic role of body composition parameters in gastric/gastroesophageal junction cancer patients from the EXPAND trial. J Cachexia Sarcopenia Muscle. 2020;11(1):135–44.CrossRefPubMed
17.
18.
Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 2010;17(6):1471–4.CrossRefPubMed
19.
Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240(2):205–13.CrossRefPubMedPubMedCentral
20.
Kusunoki Y, Okugawa Y, Toiyama Y, et al. Modified intramuscular adipose tissue content as a feasible surrogate marker for malnutrition in gastrointestinal cancer. Clin Nutr. 2021;40(5):2640–53.CrossRefPubMed
21.
Kanda Y. Investigation of the freely available easy-to-use software “EZR” for medical statistics. Bone Marrow Transplant. 2013;48(3):452–8.CrossRefPubMed
22.
Gibson DJ, Burden ST, Strauss BJ, Todd C, Lal S. The role of computed tomography in evaluating body composition and the influence of reduced muscle mass on clinical outcome in abdominal malignancy: a systematic review. Eur J Clin Nutr. 2015;69(10):1079–86.CrossRefPubMed
23.
Cruz-Jentoft AJ, Baeyens JP, Bauer JM, et al. Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on sarcopenia in older people. Age Ageing. 2010;39(4):412–23.CrossRefPubMedPubMedCentral
24.
Goodpaster BH, Kelley DE, Thaete FL, He J, Ross R. Skeletal muscle attenuation determined by computed tomography is associated with skeletal muscle lipid content. J Appl Physiol (1985). 2000;89(1):104–10.CrossRefPubMed
25.
Aas SN, Breit M, Karsrud S, et al. Musculoskeletal adaptations to strength training in frail elderly: a matter of quantity or quality? J Cachexia Sarcopenia Muscle. 2020;11(3):663–77.CrossRefPubMedPubMedCentral
26.
Piekarski J, Goldberg HI, Royal SA, Axel L, Moss AA. Difference between liver and spleen CT numbers in the normal adult: its usefulness in predicting the presence of diffuse liver disease. Radiology. 1980;137(3):727–9.CrossRefPubMed
27.
Simoneau JA, Colberg SR, Thaete FL, Kelley DE. Skeletal muscle glycolytic and oxidative enzyme capacities are determinants of insulin sensitivity and muscle composition in obese women. Faseb J. 1995;9(2):273–8.CrossRefPubMed
28.
Goodpaster BH, Thaete FL, Simoneau JA, Kelley DE. Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat. Diabetes. 1997;46(10):1579–85.CrossRefPubMed
29.
Visser M, Kritchevsky SB, Goodpaster BH, et al. Leg muscle mass and composition in relation to lower extremity performance in men and women aged 70 to 79: the health, aging and body composition study. J Am Geriatr Soc. 2002;50(5):897–904.CrossRefPubMed
30.
Saadeh S, Younossi ZM, Remer EM, et al. The utility of radiological imaging in nonalcoholic fatty liver disease. Gastroenterology. 2002;123(3):745–50.CrossRefPubMed
31.
Torriani M, Hadigan C, Jensen ME, Grinspoon S. Psoas muscle attenuation measurement with computed tomography indicates intramuscular fat accumulation in patients with the HIV-lipodystrophy syndrome. J Appl Physiol (1985). 2003;95(3):1005–10.CrossRefPubMed
32.
Pigneur F, Luciani A, Ghosn M, Reizine E, Morel A, Stehlé T. Skeletal muscle density is highly dependent on CT instrumentation. Radiology. 2023;307(5):e222839.CrossRefPubMed
33.
Kitajima T, Okugawa Y, Shimura T, et al. Combined assessment of muscle quality and quantity predicts oncological outcome in patients with esophageal cancer. Am J Surg. 2023;225(6):1036–44.CrossRefPubMed
34.
Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48(1):16–31.CrossRefPubMed
35.
Zheng C, Chen X, Zhang Z, et al. Nomogram based on intramuscular adipose tissue content for predicting the prognosis of patients with gallbladder cancer after radical resection. Transl Cancer Res. 2022;11(7):1898–908.CrossRefPubMedPubMedCentral
36.
Liu R, Qiu Z, Zhang L, et al. High intramuscular adipose tissue content associated with prognosis and postoperative complications of cancers. J Cachexia Sarcopenia Muscle. 2023.
37.
Tilg H, Moschen AR. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol. 2006;6(10):772–83.CrossRefPubMed
38.
Dalamaga M. Interplay of adipokines and myokines in cancer pathophysiology: emerging therapeutic implications. World J Exp Med. 2013;3(3):26–33.CrossRefPubMedPubMedCentral
39.
Brown LR, Laird BJA, Wigmore SJ, Skipworth RJE. Understanding cancer cachexia and its implications in upper gastrointestinal cancers. Curr Treat Options Oncol. 2022;23(12):1732–47.CrossRefPubMedPubMedCentral
40.
Nishikawa H, Goto M, Fukunishi S, Asai A, Nishiguchi S, Higuchi K. Cancer cachexia: its mechanism and clinical significance. Int J Mol Sci. 2021;22(16).
Metadaten
Titel
Association Between Changes in Skeletal Muscle Quality and Prognosis in Postoperative Patients with Early Gastric Cancer
verfasst von
Shiho Kobayashi, PT, MSc
Kentaro Kamiya, PT, PhD
Takashi Miki, PT, MSc
Masashi Yamashita, PT, PhD
Takumi Noda, PT, PhD
Kensuke Ueno, PT, MSc
Kazuki Hotta, PT, PhD
Mikiko Sakuraya, MD
Masahiro Niihara, MD, PhD
Michinari Fukuda, MD, PhD
Naoki Hiki, MD, PhD
Publikationsdatum
17.08.2024
Verlag
Springer International Publishing
Erschienen in
Annals of Surgical Oncology / Ausgabe 12/2024
Print ISSN: 1068-9265
Elektronische ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-024-16012-2

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