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Erschienen in: Journal of Neural Transmission 12/2019

27.09.2019 | Psychiatry and Preclinical Psychiatric Studies - Short communication

Association between cognitive performance and SYT1-rs2251214 among women with cocaine use disorder

verfasst von: Thiago Wendt Viola, Jaqueline Bohrer Schuch, Diego Luiz Rovaris, Rafael Genovese, Lucca Tondo, Breno Sanvicente-Vieira, Aline Zaparte, Renata Basso Cupertino, Bruna Santos da Silva, Claiton Henrique Dotto Bau, Rodrigo Grassi-Oliveira

Erschienen in: Journal of Neural Transmission | Ausgabe 12/2019

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Abstract

The SNP rs2251214 of the SYT1 gene was recently associated with externalizing phenotypes, including ADHD and cocaine use disorder (CUD). Here, we investigated whether SYT1-rs2251214 could also be implicated with cognitive performance variations among women with CUD. Results showed that G homozygous (n = 146) have lower cognitive performance in the Stroop, Trail Making and Matrix Reasoning tests compared with A-allele carriers (n = 64), suggesting that rs2251214 may influence the severity of cognitive impairments in CUD.
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Metadaten
Titel
Association between cognitive performance and SYT1-rs2251214 among women with cocaine use disorder
verfasst von
Thiago Wendt Viola
Jaqueline Bohrer Schuch
Diego Luiz Rovaris
Rafael Genovese
Lucca Tondo
Breno Sanvicente-Vieira
Aline Zaparte
Renata Basso Cupertino
Bruna Santos da Silva
Claiton Henrique Dotto Bau
Rodrigo Grassi-Oliveira
Publikationsdatum
27.09.2019
Verlag
Springer Vienna
Erschienen in
Journal of Neural Transmission / Ausgabe 12/2019
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI
https://doi.org/10.1007/s00702-019-02086-w

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