Association Between Colorectal Cancer and Atherosclerotic Diseases: A Study Using a National Inpatient Database in Japan | springermedizin.de

Springer Medizin

nach oben

Digestive Diseases and Sciences

Erschienen in:

01.02.2016 | Original Article

Association Between Colorectal Cancer and Atherosclerotic Diseases: A Study Using a National Inpatient Database in Japan

verfasst von: Yutaka Yamaji, Hideo Yasunaga, Yoshihiro Hirata, Atsuo Yamada, Shuntaro Yoshida, Hiromasa Horiguchi, Kiyohide Fushimi, Kazuhiko Koike

Erschienen in: Digestive Diseases and Sciences | Ausgabe 6/2016

Einloggen, um Zugang zu erhalten

Abstract

Background

Both colorectal neoplasms and atherosclerosis can be induced by common visceral fat accumulation. However, the association between these diseases at the advanced stage, colorectal cancer and cardiovascular/cerebrovascular diseases, has not been elucidated.

Aims

This study aimed to investigate the association between colorectal cancer and vascular diseases in relation to obesity and metabolic disorders, using a nationwide database of hospitalized patients in Japan. We used non-cardiac gastric cancer patients as a reference, because they were considered to be neutral for obesity or metabolic disorders.

Methods

We identified 54,591 patients with colorectal cancer and 19,565 patients with gastric cancer from the Diagnosis Procedure Combination database. The data collected included: sex; age; body mass index (BMI); smoking status; comorbidity; and medication data, comprising hypertension, diabetes, hyperlipidemia, coronary artery disease, and stroke. We compared these data in a cross-sectional setting by multivariate analyses.

Results

Multivariate logistic regression analyses showed that female sex, increased BMI, hypertension [odds ratio (OR) 1.11; 95 % confidence interval (CI) 1.07–1.15; P < 0.0001], and diabetes (OR 1.17; 95 % CI 1.12–1.23; P < 0.0001) were more associated with colorectal cancer than with gastric cancer. Smoking, aspirin use (OR 0.85; 95 % CI 0.79–0.92; P < 0.0001), and coronary artery disease (OR 0.90; 95 % CI 0.86–0.95; P = 0.0001) were inversely associated with colorectal cancer.

Conclusions

Obesity and metabolic disorders were more associated with colorectal cancer than with non-cardiac gastric cancer, while coronary artery disease (CAD) was inversely associated. Some mechanisms involving separate populations of colorectal cancer and CAD under visceral fat accumulation might be suggested.

Anzeige

Nur mit Berechtigung zugänglich

1.

Joint WHO/FAO Expert Consultation on Diet, Nutrition and the Prevention of Chronic Diseases. Diet, Nutrition and the Prevention of Chronic Diseases: Report of a Joint WHO/FAO Expert Consultation. WHO Technical Report Series 916 ed. Geneva: World Health Organization; 2003.

2.

World Cancer Research Fund/American Institute for Cancer Research. Food, Nutrition, Physical Activity, and the Prevention of Cancer: A Global Perspective. Washington, DC: American Institute for Cancer Research; 2007.

3.

Trevisan M, Liu J, Muti P, et al. Markers of insulin resistance and colorectal cancer mortality. Cancer Epidemiol Biomark Prev. 2001;10:937–941.

4.

Colangelo LA, Gapstur SM, Gann PH, Dyer AR, Liu K. Colorectal cancer mortality and factors related to the insulin resistance syndrome. Cancer Epidemiol Biomark Prev. 2002;11:385–391.

5.

Ahmed RL, Schmitz KH, Anderson KE, Rosamond WD, Folsom AR. The metabolic syndrome and risk of incident colorectal cancer. Cancer. 2006;107:28–36.CrossRefPubMed

6.

Bowers K, Albanes D, Limburg P, et al. A prospective study of anthropometric and clinical measurements associated with insulin resistance syndrome and colorectal cancer in male smokers. Am J Epidemiol. 2006;164:652–664.CrossRefPubMed

7.

Stürmer T, Buring JE, Lee IM, Gaziano JM, Glynn RJ. Metabolic abnormalities and risk for colorectal cancer in the physicians’ health study. Cancer Epidemiol Biomark Prev. 2006;15:2391–2397.CrossRef

8.

Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 2001;285:2486–2497.CrossRef

9.

Grundy SM, Brewer HB Jr, Cleeman JI, et al. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on scientific issues related to definition. Circulation. 2004;109:433–438.CrossRefPubMed

10.

Neugut AI, Lee WC, Garbowski GC, et al. Obesity and colorectal adenomatous polyps. J Natl Cancer Inst. 1991;83:359–361.CrossRefPubMed

11.

Giovannucci E, Ascherio A, Rimm EB, Colditz GA, Stampfer MJ, Willett WC. Physical activity, obesity, and risk for colon cancer and adenoma in men. Ann Intern Med. 1995;122:327–334.CrossRefPubMed

12.

Kono S, Handa K, Hayabuchi H, et al. Obesity, weight gain and risk of colon adenomas in Japanese men. Jpn J Cancer Res. 1999;90:805–811.CrossRefPubMed

13.

Morita T, Tabata S, Mineshita M, Mizoue T, Moore MA, Kono S. The metabolic syndrome is associated with increased risk of colorectal adenoma development: the Self-Defense Forces health study. Asian Pac J Cancer Prev. 2005;6:485–489.PubMed

14.

Yamaji Y, Okamoto M, Yoshida H, et al. The effect of body weight reduction on the incidence of colorectal adenoma. Am J Gastroenterol. 2008;103:2061–2067.CrossRefPubMed

15.

Muto T, Bussey HJ, Morson BC. The evolution of cancer of the colon and rectum. Cancer. 1975;36:2251–2270.CrossRefPubMed

16.

Frezza EE, Wachtel MS, Chiriva-Internati M. Influence of obesity on the risk of developing colon cancer. Gut. 2006;55:285–291.CrossRefPubMedPubMedCentral

17.

Gunter MJ, Leitzmann MF. Obesity and colorectal cancer: epidemiology, mechanisms and candidate genes. J Nutr Biochem. 2006;17:145–156.CrossRefPubMed

18.

Cowey S, Hardy RW. The metabolic syndrome: a high-risk state for cancer? Am J Pathol. 2006;169:1505–1522.CrossRefPubMedPubMedCentral

19.

Correa P. Human gastric carcinogenesis: a multistep and multifactorial process—first American Cancer Society award lecture on cancer epidemiology and prevention. Cancer Res. 1992;52:6735–6740.PubMed

20.

Kumar V, Kato N, Urabe Y, et al. Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma. Nat Genet. 2011;43:455–458.CrossRefPubMed

21.

Chan AOO, Jim MH, Lam KF, et al. Prevalence of colorectal neoplasm among patients with newly diagnosed coronary artery disease. JAMA. 2007;298:1412–1419.CrossRefPubMed

22.

Kim BJ, Kim JY, Chang DK, et al. Coexistence between carotid artery stenosis and colorectal adenomatous polyps in middle-aged men. Digestion. 2010;81:20–26.CrossRefPubMed

23.

Lim YJ, Kwack WG, Lee YS, Hahm KB, Kim YK. Increased pulse wave velocity reflecting arterial stiffness in patients with colorectal adenomas. J Clin Biochem Nutr. 2010;47:261–265.CrossRefPubMedPubMedCentral

24.

Yang SY, Kim YS, Chung SJ, et al. Association between colorectal adenoma and coronary atherosclerosis detected by CT coronary angiography in Korean men; a cross-sectional study. J Gastroenterol Hepatol. 2010;25:1795–1799.CrossRefPubMed

25.

Kim H-B, Lee H-R, Shim J-Y, et al. The association between arterial stiffness and colorectal adenomatous polyp in women. J Womens Health. 2011;20:765–769.CrossRef

26.

Yamaji Y, Mitsushima T, Koike K. Pulse-wave velocity, the ankle-brachial index, and the visceral fat area are highly associated with colorectal adenoma. Dig Liver Dis. 2014;46:943–949.CrossRefPubMed

27.

Kune GA, Kune S, Watson LF. Colorectal cancer risk, chronic illnesses, operations, and medications: case control results from the Melbourne Colorectal Cancer Study. Cancer Res. 1988;48:4399–4404.PubMed

28.

Neugut AI, Jacobson JS, Sherif G, et al. Coronary artery disease and colorectal neoplasia. Dis Colon Rectum. 1995;38:873–877.CrossRefPubMed

29.

Neugut AI, Rosenberg DJ, Ahsan H, et al. Association between coronary heart disease and cancers of the breast, prostate, and colon. Cancer Epidemiol Biomark Prev. 1998;7:869–873.

30.

Reicher-Reiss H, Jonas M, Goldbourt U, Boyko V, Modan B. Selectively increased risk of cancer in men with coronary heart disease. Am J Cardiol. 2001;87:459–462. (A6).CrossRefPubMed

31.

Watanabe Y, Ozasa K, Ito Y, et al. Medical history of circulatory diseases and colorectal cancer death in the JACC Study. J Epidemiol. 2005;15:S168–S172.CrossRefPubMed

32.

Chan AOO, Lam KF, Tong T, et al. Coexistence between colorectal cancer/adenoma and coronary artery disease: results from 1382 patients. Aliment Pharmacol Ther. 2006;24:535–539.CrossRefPubMed

33.

Robertson DJ, Riis AH, Friis S, Pedersen L, Baron JA, Sorensen HT. Neither long-term statin use nor atherosclerotic disease is associated with risk of colorectal cancer. Clin Gastroenterol Hepatol. 2010;8:1056–1061.CrossRefPubMed

34.

Kuwabara K, Matsuda S, Fushimi K, et al. Quantitative assessment of the advantages of laparoscopic gastrectomy and the impact of volume-related hospital characteristics on resource use and outcomes of gastrectomy patients in Japan. Ann Surg. 2011;253:64–70.CrossRefPubMed

35.

Yasunaga H, Horiguchi H, Kuwabara K, et al. Outcomes after laparoscopic or open distal gastrectomy for early-stage gastric cancer: a propensity-matched analysis. Ann Surg. 2013;257:640–646.CrossRefPubMed

36.

Niikura R, Yasunaga H, Yamaji Y, et al. Factors affecting in-hospital mortality in patients with lower gastrointestinal tract bleeding: a retrospective study using a national database in Japan. J Gastroenterol. 2015;50:533–540.CrossRefPubMed

37.

Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med. 2003;348:1625–1638.CrossRefPubMed

38.

Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet. 2008;371:569–578.CrossRefPubMed

39.

Yamaji Y, Watabe H, Yoshida H, et al. High-risk population for gastric cancer development based on serum pepsinogen status and lifestyle factors. Helicobacter. 2009;14:81–86.CrossRefPubMed

40.

Yang P, Zhou Y, Chen B, et al. Overweight, obesity and gastric cancer risk: results from a meta-analysis of cohort studies. Eur J Cancer. 2009;45:2867–2873.CrossRefPubMed

41.

Chen Y, Liu L, Wang X, et al. Body mass index and risk of gastric cancer: a meta-analysis of a population with more than ten million from 24 prospective studies. Cancer Epidemiol Biomark Prev. 2013;22:1395–1408.CrossRef

42.

Lin XJ, Wang CP, Liu XD, et al. Body mass index and risk of gastric cancer: a meta-analysis. Jpn J Clin Oncol. 2014;44:783–791.CrossRefPubMed

43.

Song M, Choi JY, Yang JJ, et al. Obesity at adolescence and gastric cancer risk. Cancer Causes Control. 2015;26:247–256.CrossRefPubMed

44.

Must A, Jacques PF, Dallal GE, Bajema CJ, Dietz WH. Long-term morbidity and mortality of overweight adolescents. A follow-up of the Harvard Growth Study of 1922 to 1935. N Engl J Med. 1992;327:1350–1355.CrossRefPubMed

45.

Russo A, Franceschi S, La Vecchia C, et al. Body size and colorectal-cancer risk. Int J Cancer. 1998;78:161–165.CrossRefPubMed

46.

Bjorge T, Engeland A, Tverdal A, Smith GD. Body mass index in adolescence in relation to cause-specific mortality: a follow-up of 230,000 Norwegian adolescents. Am J Epidemiol. 2008;168:30–37.CrossRefPubMed

47.

Levi Z, Kark JD, Barchana M, et al. Measured body mass index in adolescence and the incidence of colorectal cancer in a cohort of 1.1 million males. Cancer Epidemiol Biomark Prev. 2011;20:2524–2531.CrossRef

48.

Tirosh A, Shai I, Afek A, et al. Adolescent BMI trajectory and risk of diabetes versus coronary disease. N Engl J Med. 2011;364:1315–1325.CrossRefPubMed

49.

de Mutsert R, Sun Q, Willett WC, Hu FB, van Dam RM. Overweight in early adulthood, adult weight change, and risk of type 2 diabetes, cardiovascular diseases, and certain cancers in men: a cohort study. Am J Epidemiol. 2014;179:1353–1365.CrossRefPubMedPubMedCentral

50.

Inoue M, Ito LS, Tajima K, et al. Height, weight, menstrual and reproductive factors and risk of gastric cancer among Japanese postmenopausal women: analysis by subsite and histologic subtype. Int J Cancer. 2002;97:833–838.CrossRefPubMed

51.

Tanaka T, Nagata C, Oba S, Takatsuka N, Shimizu H. Prospective cohort study of body mass index in adolescence and death from stomach cancer in Japan. Cancer Sci. 2007;98:1785–1789.CrossRefPubMed

52.

Ministry of Health, Labour and Welfare. Vital Statistics Japan. http://www.mhlw.go.jp/english/database/db-hw/vs01.html. Accessed October 20, 2015.

53.

Takii T, Yasuda S, Takahashi J, et al. Trends in acute myocardial infarction incidence and mortality over 30 years in Japan. Circ J. 2010;74:93–100.CrossRefPubMed

54.

Slattery ML, Friedman GD, Potter JD, Edwards S, Caan BJ, Samowitz W. A description of age, sex, and site distributions of colon carcinoma in three geographic areas. Cancer. 1996;78:1666–1670.CrossRefPubMed

55.

Okamoto M, Shiratori Y, Yamaji Y, et al. Relationship between age and site of colorectal cancer based on colonoscopy findings. Gastrointest Endosc. 2002;55:548–551.CrossRefPubMed

56.

Samowitz WS, Albertsen H, Herrick J, et al. Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer. Gastroenterology. 2005;129:837–845.CrossRefPubMed

57.

Stocks T, Van Hemelrijck M, Manjer J, et al. Blood pressure and risk of cancer incidence and mortality in the Metabolic Syndrome and Cancer Project. Hypertension. 2012;59:802–810.CrossRefPubMed

58.

Watanabe Y, Yamaji Y, Suzuki H, et al. Association between colorectal polyps and hypertension treatment. J Dig Dis. 2015;16:649–655.CrossRefPubMed

59.

Hansson LE, Nyren O, Hsing AW, et al. The risk of stomach cancer in patients with gastric or duodenal ulcer disease. N Engl J Med. 1996;335:242–249.CrossRefPubMed

60.

Rothwell PM, Wilson M, Elwin C-E, et al. Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials. Lancet. 2010;376:1741–1750.CrossRefPubMed

61.

Pahor M, Guralnik JM, Ferrucci L, et al. Calcium-channel blockade and incidence of cancer in aged populations. Lancet. 1996;348:493–497.CrossRefPubMed

62.

Sipahi I, Debanne SM, Rowland DY, Simon DI, Fang JC. Angiotensin-receptor blockade and risk of cancer: meta-analysis of randomised controlled trials. Lancet Oncol. 2010;11:627–636.CrossRefPubMedPubMedCentral

63.

Lin Y, Totsuka Y, He Y, et al. Epidemiology of esophageal cancer in Japan and China. J Epidemiol. 2013;23:233–242.CrossRefPubMed

64.

Lindkvist B, Johansen D, Stocks T, et al. Metabolic risk factors for esophageal squamous cell carcinoma and adenocarcinoma: a prospective study of 580,000 subjects within the Me-Can project. BMC Cancer. 2014;14:103.CrossRefPubMedPubMedCentral

Titel: Association Between Colorectal Cancer and Atherosclerotic Diseases: A Study Using a National Inpatient Database in Japan
verfasst von: Yutaka Yamaji
Hideo Yasunaga
Yoshihiro Hirata
Atsuo Yamada
Shuntaro Yoshida
Hiromasa Horiguchi
Kiyohide Fushimi
Kazuhiko Koike
Publikationsdatum: 01.02.2016
Verlag: Springer US
Erschienen in: Digestive Diseases and Sciences / Ausgabe 6/2016
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-016-4041-5

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Anzeige

Neu im Fachgebiet Innere Medizin

24.04.2024 | DGIM 2024 | Kongressbericht | Nachrichten

Metformin rückt in den Hintergrund

24.04.2024 | DGIM 2024 | Kongressbericht | Nachrichten

Myokarditis nach Infekt – richtig schwierig wird es bei Profisportlern

24.04.2024 | DGIM 2024 | Kongressbericht | Nachrichten

Thrombophiliescreening – Wenn, dann richtig und nur bei therapeutischer Konsequenz

24.04.2024 | DGIM 2024 | Nachrichten

Bei Senioren mit Prostatakarzinom auf Anämie achten!

weitere anzeigen

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen