Skip to main content

01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Endocrine Disorders 1/2015

Association between lipids profile and thyroid parameters in euthyroid diabetic subjects: a cross-sectional study

BMC Endocrine Disorders > Ausgabe 1/2015
Yun Zhang, Ping Lu, Ling Zhang, Xinhua Xiao
Wichtige Hinweise

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

YZ and XX wrote the study protocol and designed the study. YZ, PL and LZ collected data and carried out the statistical analysis. YZ wrote the manuscript. XX contributed to the data interpretation and reviewed and edited the manuscript. All authors read and approved the final manuscript.



The concept is now emerging that higher thyroid-stimulating hormone (TSH) and lower thyroid hormone levels within the euthyroid range may adversely affect atherosclerosis. The aim of this study was to investigate the potential association between thyroid parameters and lipids profile in a cohort of euthyroid diabetic subjects.


Four hundred and sixty-two euthyroid type 2 diabetes subjects (302 males and 160 females) were consecutively recruited. Clinical and anthropometric data was collected from all participants. Whole blood samples were drawn in the morning after an overnight fasting for the measurement of serum TSH, free thyroxine (FT4), free triiothyronine (FT3), anti-thyroid peroxidase antibody (TPO-Ab) levels, as well as lipid concentrations and glucose.


TSH was higher in females than males. Stratified by TSH, high-density lipoprotein cholesterol (HDL-c) level increased in subjects with TSH ≥2.5uIU/mL (P = 0.004). And TSH was associated with HDL-c in a Pearson correlation test, however, the association failed to attain significance in partial correlation analyses, adjusted for age, sex, duration of diabetes, fasting glucose and BMI. In females, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-c) level was significant lower in subjects with TSH <2.5uIU/mL. TSH was significantly associated with TC and LDL-c, even in a partial correlation analysis (P = 0.006 and 0.011, respectively). In a multiple linear regression analysis (stepwise), TSH was positive associated with TC (β = 0.202, P = 0.005) and LDL-c (β = 0.144, P = 0.010). In one hundred and six patients having TPO antibody assays, 6 (5.66%) were positive. The blood pressure and lipid levels were lower in TPO-Ab positive patients, however, the differences were not significantly.


In conclusion, we identified TSH was positively associated with serum TC and LDL-c in euthyroid diabetic women. Our analysis in the subgroup having TPO antibody assays demonstrating non-significantly lower TC levels among seropositive subjects was consistent with the above stated consideration for women as a whole. Further investigations are needed to understand the intimate mechanisms of lipid metabolism in type 2 diabetes with respect to thyroid function.
Über diesen Artikel

Weitere Artikel der Ausgabe 1/2015

BMC Endocrine Disorders 1/2015 Zur Ausgabe

Neu im Fachgebiet Innere Medizin

Meistgelesene Bücher aus der Inneren Medizin

2017 | Buch

Rheumatologie aus der Praxis

Entzündliche Gelenkerkrankungen – mit Fallbeispielen

Dieses Fachbuch macht mit den wichtigsten chronisch entzündlichen Gelenk- und Wirbelsäulenerkrankungen vertraut. Anhand von über 40 instruktiven Fallbeispielen werden anschaulich diagnostisches Vorgehen, therapeutisches Ansprechen und der Verlauf …

Rudolf Puchner

2016 | Buch

Ambulant erworbene Pneumonie

Was, wann, warum – Dieses Buch bietet differenzierte Diagnostik und Therapie der ambulant erworbenen Pneumonie zur sofortigen sicheren Anwendung. Entsprechend der neuesten Studien und Leitlinien aller wichtigen Fachgesellschaften.

Santiago Ewig

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Innere Medizin und bleiben Sie gut informiert – ganz bequem per eMail.

© Springer Medizin