Background
Methods
Subjects and clinical assessment
Quantitative ultrasound measurements
DXA measurements
Statistical analysis
Results
1997–2006 | 2006–2010 | 1997–2010 | ||
---|---|---|---|---|
M80 | Osteoporosis with pathological fracture | 2 (2.6) | 2 (1.1) | |
S12 | Fracture of neck | 1 (1.3) | 1 (0.6) | |
S22 | Fracture of rib(s), sternum and thoracic spine | 3 (3.1) | 3 (3.9) | 6 (3.4) |
S32 | Fracture of lumbar spine and pelvis | |||
S32.0 | Fracture of lumbar vertebra | 9 (11.8) | 9 (5.2) | |
Other | 3 (3.1) | 4 (5.3) | 7 (4.0) | |
S42 | Fracture of shoulder and upper arm | 11 (11.2) | 6 (7.9) | 17 (9.8) |
S52 | Fracture of forearm | |||
S52.5 | Fracture of lower end of radius | 29 (29.6) | 22 (28.9) | 51 (29.3) |
Other | 5 (5.1) | 1 (1.3) | 6 (3.4) | |
S62 | Fracture at wrist and hand level | 7 (7.1) | 5 (6.6) | 12 (6.9) |
S72 | Fracture of femur | |||
S72.0 | Fracture of neck of femur | 4 (4.1) | 7 (9.2) | 11 (6.3) |
S72.1 | Pertrochanteric fracture | 1 (1.0) | 4 (5.3) | 5 (2.9) |
S72.2 | Subtrochanteric fracture | 4 (4.1) | 4 (2.3) | |
Other | 3 (3.1) | 6 (7.9) | 9 (5.2) | |
S82 | Fracture of lower leg, including ankle | 26 (26.5) | 5 (6.6) | 31 (17.8) |
S92 | Fracture of foot, except ankle | 2 (2.0) | 1 (1.3) | 3 (1.7) |
Total number of fractures | 98 (100) | 76 (100) | 174 (100) |
NF | Fx 1997-2010 | Hip Fx 1997-2010 | ||||
---|---|---|---|---|---|---|
n =360 | n = 130 | n = 20 | ||||
Fx 1997-2006 | Fx 2006-2010 | Hip Fx 1997-2006 | Hip Fx 2006-2010 | |||
n = 81 | n = 61 | n = 9 | n = 11 | |||
Age [years] | 79.9 (1.2) | 80.0 (1.2) | 80.0 (1.3) | |||
79.7 (1.2) | 80.3 (1.1)*
| 79.3 (1.4) | 80.5 (0.9) | |||
Weight [kg] | 67.7 (11.3) | 67.8 (12.2) | 69.8 (15.7) | |||
69.5 (12.3) | 65.8 (12.2) | 75.7 (10.2)*
| 65.0 (18.2) | |||
Height [cm] | 155.2 (5.4) | 155.6 (5.8) | 158.9 (7.2)*
| |||
156.6 (5.4)*
| 154.5 (6.4) | 160.7 (4.4)*
| 157.4 (8.8) | |||
BMI [kg/m2] | 28.1 (4.5) | 28.0 (4.7) | 27.4 (4.6) | |||
28.4 (4.8) | 27.5 (4.6) | 29.3 (3.6) | 25.9 (4.9) | |||
VLF [m/s] | 3583 (193) | 3547 (200) | 3515 (245) | |||
3534 (204)*
| 3564 (203) | 3500 (291) | 3527 (215) | |||
Femoral neck BMD [g/cm2] | 0.654 (0.102) | 0.606 (0.083)*
| 0.589 (0.102)*
| |||
0.609 (0.078)*
| 0.605 (0.096)*
| 0.611 (0.089) | 0.570 (0.112)*
|
NF | Fx 1997–2010 | Hip Fx 1997–2010 | ||
---|---|---|---|---|
(n = 360) | (n = 130) | (n = 20) | ||
VLF
| Highest 25% | 101 (28) | 24 (18) | 5 (25)*
|
25% to 75% | 170 (47) | 69 (53) | 5 (25) | |
Lowest 25% | 89 (25) | 37 (28) | 10 (50) | |
Femoral neck BMD | Normal | 73 (20) | 11 (8)*
| 2 (10)*
|
Osteopenic | 206 (57) | 65 (50) | 8 (40) | |
Osteoporotic | 81 (23) | 54 (42) | 10 (50) |
Fx 1997-2006 | Fx 2006-2010 | Fx 1997-2010 | ||||||
---|---|---|---|---|---|---|---|---|
NF n = 409, Fx n = 81 | NF n = 429, Fx n = 61 | NF n = 334, Fx n = 121* | ||||||
n | OR (95% CI) | p | HR (95% CI) | p | OR (95% CI) | p | ||
VLF
| Moderate or high (25-100%) | 364 | ||||||
Low (0-25%) | 126 | 1.6 (0.9 - 2.6) | 0.088 | 0.8 (0.4 - 1.4) | 0.359 | 1.3 (0.8 - 2.0) | 0.326 | |
Femoral neck BMD | T-score > -2.5 | 355 | ||||||
T-score ≤ -2.5 | 135 | 1.8 (1.1 - 3.0) | 0.019 | 2.4 (1.4 - 3.9) | 0.001 | 2.5 (1.6 - 3.9) | <0.001 |
Hip Fx 1997-2006 | Hip Fx 2006-2010 | Hip Fx 1997-2010 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
NF n = 409, Hip Fx n = 9 | NF n = 429, Hip Fx n = 11 | NF n = 334, Hip Fx n = 19* | ||||||||
n | OR (95% CI) | p | n | HR (95% CI) | p | n | OR (95% CI) | p | ||
VLF
| Moderate or high (25-100%) | 313 | 324 | 260 | ||||||
Low (0-25%) | 105 | 6.3 (1.5 - 25.5) | 0.010 | 116 | 1.7 (0.5 - 5.7) | 0.415 | 93 | 3.3 (1.3 - 8.4) | 0.012 | |
Femoral neck BMD | T-score > -2.5 | 311 | 325 | 267 | ||||||
T-score ≤ -2.5 | 107 | 1.5 (0.4 - 6.0) | 0.593 | 115 | 4.8 (1.4 - 16.6) | 0.013 | 86 | 4.1 (1.6 – 10.5) | 0.003 |
OR | (95% CI) | p-value | |
---|---|---|---|
Lifestyle-related risk factors1
| 0.002*
| ||
TUG ≥ 11 s vs. less (referent) | 3.4 | (1.2 - 9.9) | 0.026 |
Low PA vs. moderate to high (referent) | 2.8 | (1.0 - 7.5) | 0.046 |
Coffee consumption > 3 cups/day vs. less (referent) | 0.3 | (0.1 - 1.0) | 0.051 |
Lifestyle-related risk factors and VLF
2
| 0.001*
| ||
Low VLF (0-25%) vs. Moderate or high (25-100%) (referent) | 3.3 | (1.2 - 9.0) | 0.018 |
Low PA vs. moderate to high (referent) | 3.1 | (1.1 - 8.5) | 0.028 |
TUG ≥ 11 s vs. less (referent) | 3.1 | (1.0 - 8.9) | 0.042 |