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11.12.2015 | Original article

Association between NAD(P)H oxidase p22phox gene variants and acute myocardial infarction in a Han Chinese population

verfasst von: H. Xu, S. Ma, F.-Y. Tang, Y. Chen, H. Zhou, M. Chen, B. Wang, X. Liu, X. Xie

Erschienen in: Herz | Ausgabe 5/2016

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Abstract

Background

We investigated the association between five selected single-nucleotide polymorphisms (rs12933505, rs3180279, rs3794264, rs4673, rs1049255) in the NAD(P)H p22phox gene and acute myocardial infarction (AMI) as well as severity of coronary artery stenosis in a Han Chinese population.

Patients and methods

A total of 168 patients with AMI and 138 healthy controls were recruited. The TaqMan allelic discrimination assay was used to genotype five single-nucleotide polymorphisms.

Results

The frequency of the rs1049255 G allele was significantly lower in patients with AMI than in controls (p = 0.022). Compared with subjects with an AA genotype, subjects with a GG or AG genotype had a lower risk of AMI [multivariate-adjusted odds ratio (OR), 0.53; 95 % CI, 0.29–0.95; p = 0.031). Subjects with the GG and AG genotypes of rs1049255 showed a decreased susceptibility for triple-vessel disease (TVD) as compared with controls (multivariate-adjusted OR, 0.43; 95 % CI, 0.19–0.98; p = 0.042). Multiple logistic regression analysis revealed that the rs1049255G variant was an independent protective factor for AMI/TVD.

Conclusion

The results suggest there is an association between the p22phox rs1049255 polymorphism with the prevalence of AMI and the severity of coronary artery stenosis in the Han Chinese population.

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Titel: Association between NAD(P)H oxidase p22phox gene variants and acute myocardial infarction in a Han Chinese population
verfasst von: H. Xu
S. Ma
F.-Y. Tang
Y. Chen
H. Zhou
M. Chen
B. Wang
X. Liu
X. Xie
Publikationsdatum: 11.12.2015
Verlag: Springer Medizin
Erschienen in: Herz / Ausgabe 5/2016
Print ISSN: 0340-9937
Elektronische ISSN: 1615-6692
DOI: https://doi.org/10.1007/s00059-015-4391-3

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Association between NAD(P)H oxidase p22phox gene variants and acute myocardial infarction in a Han Chinese population

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Conclusion

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