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Current Pain and Headache Reports
Erschienen in: Current Pain and Headache Reports 10/2017

01.10.2017 | Migraine and Beyond (R Cowan, Section Editor)

Association Between Obesity and Migraine in Women

verfasst von: Jelena M. Pavlovic, Julio R. Vieira, Richard B. Lipton, Dale S. Bond

Erschienen in: Current Pain and Headache Reports | Ausgabe 10/2017

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Abstract

Purpose of Review

Migraine is a common and highly disabling condition that is particularly prevalent among women and especially women of reproductive age. The tremendous rise in adiposity in the Western world has led to an epidemic of obesity in women. The particular effects of obesity on women with migraine of various ages are the focus of this review.

Recent Findings

Conflicting findings from various studies with different approaches and populations have made challenging definitive conclusions about associations between migraine and obesity. While the association between obesity and migraine frequency has been consistently demonstrated and obesity is considered a risk factor for progression from episodic to chronic migraine, the association between obesity and migraine prevalence is still somewhat debated and appears to be dependent on gender and age, with the most consistent effects observed in women younger than 55 years of age.

Summary

Association between migraine and obesity is most commonly observed in women of reproductive age. The multimodal changes associated with age and hormonal change in women likely play a role in this relationship, as obesity does not appear to be related to migraine in women over 55 years of age. Future studies focusing on the migraine-obesity relationship in women should examine the effects of age, endogenous hormonal state, and exogenous hormones on migraine and obesity.
Literatur
1.
Macgregor EA, Rosenberg JD, Kurth T. Sex-related differences in epidemiological and clinic-based headache studies. Headache. 2011;51(6):843–59.CrossRefPubMed
2.
Buse DC, Loder EW, Gorman JA, et al. Sex differences in the prevalence, symptoms, and associated features of migraine, probable migraine and other severe headache: results of the American Migraine Prevalence and Prevention (AMPP) Study. Headache. 2013;53(8):1278–99.CrossRefPubMed
3.
Lipton RB, Bigal ME, Diamond M, Freitag F, Reed ML, Stewart WF. Migraine prevalence, disease burden, and the need for preventive therapy. Neurology. 2007;68(5):343–9.CrossRefPubMed
4.
Finocchi C, Strada L. Sex-related differences in migraine. Neurol Sci. 2014;35(Suppl 1):207–13.CrossRefPubMed
5.
Maleki N, Linnman C, Brawn J, Burstein R, Becerra L, Borsook D. Her versus his migraine: multiple sex differences in brain function and structure. Brain. 2012;135(Pt 8):2546–59.CrossRefPubMedPubMedCentral
6.
Pavlovic JM, Akcali D, Bolay H, Bernstein C, Maleki N. Sex-related influences in migraine. J Neurosci Res. 2017;95(1–2):587–93.CrossRefPubMed
7.
•• Ornello R, Ripa P, Pistoia F, et al. Migraine and body mass index categories: a systematic review and meta-analysis of observational studies. J Headache Pain. 2015;16(1):27. Examined the recent literature and conducted meta-analyses on association between BMI and migraine using 11 available studies. Suggested an association between migraine and obesity likely mediated by gender and migraine frequency, with the strongest effect in obese women CrossRefPubMedPubMedCentral
8.
Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of childhood and adult obesity in the United States, 2011–2012. JAMA. 2014;311(8):806–14.CrossRefPubMedPubMedCentral
9.
Wildman RP, Sowers MR. Adiposity and the menopausal transition. Obstet Gynecol Clin N Am. 2011;38(3):441–54.CrossRef
10.
McGill A-T. Causes of metabolic syndrome and obesity-related co-morbidities. Part 1: a composite unifying theory review of human-specific co-adaptations to brain energy consumption. Arch Public Heal Arch Belg Santé Publique. 2014;72(1):30.
11.
Rocha VZ, Libby P. Obesity, inflammation, and atherosclerosis. Nat Rev Cardiol. 2009;6(6):399–409.CrossRefPubMed
12.
McCarthy LH, Bigal ME, Katz M, Derby C, Lipton RB. Chronic pain and obesity in elderly people: results from the Einstein aging study. J Am Geriatr Soc. 2009;57(1):115–9.CrossRefPubMed
13.
14.
• Palmer BF, Clegg DJ. The sexual dimorphism of obesity. Mol Cell Endocrinol. 2015;402:113–9. A comprehensive review highlighting the novel ways sex hormones influence body adiposity and the metabolic syndrome CrossRefPubMed
15.
Waraich RS, Mauvais-Jarvis F. Paracrine and intracrine contributions of androgens and estrogens to adipose tissue biology: physiopathological aspects. Horm Mol Biol Clin Investig. 2013;14(2):49–55.PubMed
16.
Wildman RP, Tepper PG, Crawford S, et al. Do changes in sex steroid hormones precede or follow increases in body weight during the menopause transition? Results from the Study of Women’s Health Across the Nation. J Clin Endocrinol Metab. 2012;97(9):E1695–704.CrossRefPubMedPubMedCentral
17.
Ford ES, Li C, Pearson WS, Zhao G, Strine TW, Mokdad AH. Body mass index and headaches: findings from a national sample of US adults. Cephalalgia. 2008;28(12):1270–6.CrossRefPubMed
18.
Peterlin BL, Rosso AL, Rapoport AM, Scher AI. Obesity and migraine: the effect of age, gender and adipose tissue distribution. Headache. 2010;50(1):52–62.CrossRefPubMed
19.
Robberstad L, Dyb G, Hagen K, Stovner LJ, Holmen TL, Zwart J-A. An unfavorable lifestyle and recurrent headaches among adolescents: the HUNT study. Neurology. 2010;75(8):712–7.CrossRefPubMed
20.
Vo M, Ainalem A, Qiu C, Peterlin BL, Aurora SK, Williams MA. Body mass index and adult weight gain among reproductive age women with migraine. Headache. 2011;51(4):559–69.CrossRefPubMedPubMedCentral
21.
Peterlin BL, Rosso AL, Williams MA, et al. Episodic migraine and obesity and the influence of age, race, and sex. Neurology. 2013;81(15):1314–21.CrossRefPubMedPubMedCentral
22.
23.
Bigal ME, Liberman JN, Lipton RB. Obesity and migraine: a population study. Neurology. 2006;66(4):545–50.CrossRefPubMed
24.
Mattsson P. Migraine headache and obesity in women aged 40–74 years: a population-based study. Cephalalgia. 2007;27(8):877–80.CrossRefPubMed
25.
Keith SW, Wang C, Fontaine KR, Cowan CD, Allison DB. BMI and headache among women: results from 11 epidemiologic datasets. Obesity (Silver Spring). 2008;16(2):377–83.CrossRef
26.
Santos IS, Goulart AC, Passos VM, Molina MC, Lotufo PA, Bensenor IM. Obesity, abdominal obesity and migraine: a cross-sectional analysis of ELSA-Brasil baseline data. Cephalalgia. 2015;35(5):426–36.CrossRefPubMed
27.
Bigal ME, Lipton RB. Obesity is a risk factor for transformed migraine but not chronic tension-type headache. Neurology. 2006;67(2):252–7.CrossRefPubMed
28.
Winter AC, Berger K, Buring JE, Kurth T. Body mass index, migraine, migraine frequency and migraine features in women. Cephalalgia. 2009;29(2):269–78.CrossRefPubMedPubMedCentral
29.
Tchernof A, Després J-P. Pathophysiology of human visceral obesity: an update. Physiol Rev. 2013;93(1):359–404.CrossRefPubMed
30.
Stewart WF, Lipton RB, Celentano DD, Reed ML. Prevalence of migraine headache in the United States. Relation to age, income, race, and other sociodemographic factors. JAMA. 1992;267(1):64–9.CrossRefPubMed
31.
Peters SAE, Huxley RR, Woodward M. Women’s reproductive health factors and body adiposity: findings from the UK Biobank. Int J Obes (Lond) [Internet]. 2015.
32.
•• Chai NC, Scher AI, Moghekar A, Bond DS, Peterlin BL. Obesity and headache: part I—a systematic review of the epidemiology of obesity and headache. Headache. 2014;54(2):219–34. An excellent review with comprehensive tables examining the recent work on epidemiology of obesity and headache CrossRefPubMedPubMedCentral
33.
Chai NC, Bond DS, Moghekar A, Scher AI, Peterlin BL. Obesity and headache. Part II—potential mechanism and treatment considerations. Headache. 2014;54(3):459–71.CrossRefPubMedPubMedCentral
34.
Bigal ME, Lipton RB, Holland PR, Goadsby PJ. Obesity, migraine, and chronic migraine: possible mechanisms of interaction. Neurology. 2007;68(21):1851–61.CrossRefPubMed
35.
Bigal ME, Lipton RB, Stewart WF. The epidemiology and impact of migraine. Curr Neurol Neurosci Rep. 2004;4(2):98–104.CrossRefPubMed
36.
Hattori A, Sturm R. The obesity epidemic and changes in self-report biases in BMI. Obesity (Silver Spring). 2013;21(4):856–60.CrossRef
37.
Brown WJ, Mishra G, Kenardy J, Dobson A. Relationships between body mass index and well-being in young Australian women. Int J Obes Relat Metab Disord. 2000;24(10):1360–8.CrossRefPubMed
38.
Winter AC, Wang L, Buring JE, Sesso HD, Kurth T. Migraine, weight gain and the risk of becoming overweight and obese: a prospective cohort study. Cephalalgia. 2012;32(13):963–71.CrossRefPubMedPubMedCentral
39.
Ronti T, Lupattelli G, Mannarino E. The endocrine function of adipose tissue: an update. Clin Endocrinol. 2006;64(4):355–65.
40.
Bigal ME, Lipton RB. Putative mechanisms of the relationship between obesity and migraine progression. Curr Pain Headache Rep. 2008;12(3):207–12.CrossRefPubMed
41.
42.
• Bond DS, O’Leary KC, Thomas JG, Lipton RG, Papandonatos G, Roth J, et al. Can weight loss improve migraine headaches in obese women? Rationale and design of the Women’s Health and Migraine (WHAM) randomized controlled trial. Contemp Clin Trials. 2013;35:133–44. Future results of this randomized clinical trial of behavioral weight loss intervention in reproductive age women with obesity and migraine will help clarify the migraine obesity relationship and role of weight loss in improving migraine in women with obesity CrossRefPubMedPubMedCentral
43.
Bond DS, Thomas JG, O’Leary KC, et al. Objectively measured physical activity in obese women with and without migraine. Cephalalgia. 2015;35(10):886–93.CrossRefPubMed
44.
Cervoni C, Bond DS, Seng EK. Behavioral weight loss treatments for individuals with migraine and obesity. Curr Pain Headache Rep. 2016;20(2):13.CrossRefPubMed
45.
Jette N, Patten S, Williams J, Becker W, Wiebe S. Comorbidity of migraine and psychiatric disorders—a national population-based study. Headache. 2008;48(4):501–16.CrossRefPubMed
46.
Simon GE, Von Korff M, Saunders K, et al. Association between obesity and psychiatric disorders in the US adult population. Arch Gen Psychiatry. 2006;63(7):824–30.CrossRefPubMedPubMedCentral
47.
Tietjen GE, Peterlin BL, Brandes JL, et al. Depression and anxiety: effect on the migraine-obesity relationship. Headache. 2007;47(6):866–75.CrossRefPubMed
48.
Bond DS, Buse DC, Lipton RB, et al. Clinical pain catastrophizing in women with migraine and obesity. Headache. 55(7):923–33.
49.
Simpson ER. Sources of estrogen and their importance. J Steroid Biochem Mol Biol. 2003;86(3–5):225–30.CrossRefPubMed
50.
Szymczak J, Milewicz A, Thijssen JH, Blankenstein MA, Daroszewski J. Concentration of sex steroids in adipose tissue after menopause. Steroids. 63(5–6):319–21.
51.
Bélanger C, Luu-The V, Dupont P, Tchernof A. Adipose tissue intracrinology: potential importance of local androgen/estrogen metabolism in the regulation of adiposity. Horm Metab Res Horm und Stoffwechselforsch Horm Métabolisme. 2015;34(11–12):737–45.
52.
Nelson LR, Bulun SE. Estrogen production and action. J Am Acad Dermatol. 2001;45(3):S116–24.CrossRefPubMed
53.
Chakrabarti M, Haque A, Banik NL, Nagarkatti P, Nagarkatti M, Ray SK. Estrogen receptor agonists for attenuation of neuroinflammation and neurodegeneration. Brain Res Bull. 2014;109:22–31.CrossRefPubMedPubMedCentral
54.
Klein SL, Schiebinger L, Stefanick ML, et al. Opinion: sex inclusion in basic research drives discovery. Proc Natl Acad Sci U S A. 2015;112(17):5257–8.CrossRefPubMedPubMedCentral
55.
56.
Ahtiainen M, Alen M, Pöllänen E, et al. Hormone therapy is associated with better body composition and adipokine/glucose profiles: a study with monozygotic co-twin control design. Menopause. 2012;19(12):1329–35.CrossRefPubMed
57.
Haarbo J, Marslew U, Gotfredsen A, Christiansen C. Postmenopausal hormone replacement therapy prevents central distribution of body fat after menopause. Metabolism. 1991;40(12):1323–6.CrossRefPubMed
58.
Lavie CJ, De Schutter A, Milani RV. Healthy obese versus unhealthy lean: the obesity paradox. Nat Rev Endocrinol. 2015;11(1):55–62.CrossRefPubMed
59.
Artham SM, Lavie CJ, Patel DA, Ventura HO. Obesity paradox in the elderly: is fatter really fitter? Aging Health. 2009;5(2):177–84.CrossRef
60.
DePalma MJ, Ketchum JM, Saullo TR. Multivariable analyses of the relationships between age, gender, and body mass index and the source of chronic low back pain. Pain Med. 2012;13(4):498–506.CrossRefPubMed
61.
Baker JF, Billig E, Michaud K, et al. Weight loss, the obesity paradox, and the risk of death in rheumatoid arthritis. Arthritis Rheumatol (Hoboken, NJ). 2015;67(7):1711–7.CrossRef
62.
Martin VT, Pavlovic J, Fanning KM, Buse DC, Reed ML, Lipton RB. Perimenopause and menopause are associated with high frequency headache in women with migraine: results of the American Migraine Prevalence and Prevention Study. Headache. 2016;56(2):292–305.CrossRefPubMed
Metadaten
Titel
Association Between Obesity and Migraine in Women
verfasst von
Jelena M. Pavlovic
Julio R. Vieira
Richard B. Lipton
Dale S. Bond
Publikationsdatum
01.10.2017
Verlag
Springer US
Erschienen in
Current Pain and Headache Reports / Ausgabe 10/2017
Print ISSN: 1531-3433
Elektronische ISSN: 1534-3081
DOI
https://doi.org/10.1007/s11916-017-0634-8

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