Erschienen in:
21.12.2019 | Glaucoma
Association between optic nerve head morphology in open-angle glaucoma and corneal biomechanical parameters measured with Corvis ST
verfasst von:
Shuichiro Aoki, Yoshiaki Kiuchi, Kana Tokumo, Yuri Fujino, Masato Matsuura, Hiroshi Murata, Shunsuke Nakakura, Ryo Asaoka
Erschienen in:
Graefe's Archive for Clinical and Experimental Ophthalmology
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Ausgabe 3/2020
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Abstract
Purposes
To investigate associations between Corvis ST-measured corneal biomechanical parameters and glaucomatous optic nerve head (ONH) morphology.
Methods
In total, 118 eyes of 70 patients with open-angle glaucoma were examined in this retrospective cross-sectional study. We measured Heidelberg retina tomograph and Corvis ST values in all eyes. We used the linear mixed model in four sectors (temporal superior, TS; temporal inferior, TI; nasal superior, NS; and nasal inferior, NI) to detect associations between six ONH-related parameters and 14 Corvis ST–related parameters, controlling for age, intraocular pressure, axial length, and central corneal thickness. We calculated the ONH temporal and nasal sector vertical asymmetries (TS-TI and NS-NI asymmetries) and identified the optimal linear mixed models to describe them using model selection with the second-order bias corrected Akaike Information Criterion.
Results
The Corvis ST A2 velocity was negatively associated with the rim volume in the NS sector (p < 0.05). The optimal model for TS-TI asymmetry was TS-TI asymmetry = − 3.22 + 0.15 × HC time + 0.88 × HC deflection amplitude, whereas that for NS-NI asymmetry was 0.49–0.048 × axial length − 2.45 × A2 velocity.
Conclusion
Glaucomatous ONH superior-inferior asymmetries were associated with biomechanical properties measured with Corvis ST. Eyes with superior-dominant rim volume reduction of ONH were associated with small deformations and slow recovery of the cornea.