The online version of this article (doi:10.1186/s12894-015-0083-9) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
S.Y. carried out the study design, drafted the manuscript, and analyzed the data. T.W. supervised the study design, manuscript drafting, data collection, data analyses and interpretation. E.G. participated data collection and interpretation, and manuscript revision. B.B. and S.H. helped with data collection, data interpretation and manuscript revision. All authors read and approved the final manuscript.
Existing epidemiological studies of the association between oxidative stress and erectile dysfunction (ED) are sparse and inconclusive, which is likely due to cross-sectional design and small sample size. Therefore, we investigated the association between biomarkers of oxidative stress and ED in prospective setting among a relatively large sample size of men.
We conducted the prospective study among 917 men ages between 47 and 80 years at the time of blood draw, which is a part of nested prospective case–control study of prostate cancer in the Health Professionals Follow-up Study. Plasma fluorescent oxidation products (FlOPs), a global biomarker for oxidative stress, were measured at three excitation/emission wavelengths (360/420 nm named as FlOP_360; 320/420 nm named as FlOP_320 and 400/475 nm named as FlOP_400).
Approximately 35 % of men developed ED during follow-up. We did not find an independent association between FlOP_360, FlOP_320, FlOP_400 and risk of ED in the multivariable adjusted model (Tertile 3 vs. tertile 1: odds ratio [OR] = 0.90, 95 % confidence interval [CI] = 0.61-1.34, Ptrend = 0.54 for FlOP_360; OR = 0.73, 95 % CI = 0.49-1.07, Ptrend = 0.27 for FlOP_320; and OR = 0.98, 95 % CI = 0.66-1.45, Ptrend = 0.72 for FlOP_400). Further analysis of the association between FlOPs and ED in the fasting samples or controls only (free of prostate cancer incidence) did not change the results appreciably.
Plasma FlOPs were not associated with the risk of ED, suggesting oxidative stress may not be an independent risk factor for ED.
Additional file 1: Table S1. Baseline characteristics according to tertiles of plasma fluorescent oxidation products in the Health Professional Follow-up Study in prostate cancer cases (N = 457), 1993–1995. (DOCX 14 kb)12894_2015_83_MOESM1_ESM.docx
Additional file 2: Table S2. Baseline characteristics according to tertiles of plasma fluorescent oxidation products in the Health Professional Follow-up Study in controls (N = 460), 1993–1995. (DOCX 15 kb)12894_2015_83_MOESM2_ESM.docx
Additional file 3: Table S3. Baseline characteristics according to tertiles of plasma fluorescent oxidation products (FlOPs) (N = 1,000): cross-sectional analysis in the Health Professional Follow-up Study, 1993–1995. (DOCX 13 kb)12894_2015_83_MOESM3_ESM.docx
Additional file 4: Table S4. Association between plasma fluorescent oxidation products (FlOPs) and erectile dysfunction (N = 1,000): cross-sectional analysis in the Health Professional Follow-up Study, 1993–1995. (DOCX 15 kb)12894_2015_83_MOESM4_ESM.docx
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