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Erschienen in: Journal of Neural Transmission 12/2016

12.08.2016 | Psychiatry and Preclinical Psychiatric Studies - Original Article

Association between prematurity and the evolution of psychotic disorders in 22q11.2 deletion syndrome

verfasst von: Yael Midbari Kufert, Ariela Nachmani, Einat Nativ, Abraham Weizman, Doron Gothelf

Erschienen in: Journal of Neural Transmission | Ausgabe 12/2016

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Abstract

In this study, we report the developmental, physical and psychiatric manifestations of 22q11.2 deletion syndrome (22q11.2DS) in a large Israeli cohort, and search for a possible association between preterm birth and the risk for psychotic disorders. The study population consisted of 128 individuals with 22q11.2DS (77 male, 51 female), aged 1–55 years (mean ± SD 12.9 ± 11.0). All subjects underwent a comprehensive medical evaluation. All subjects older than 5 years (n = 104) were also evaluated psychiatrically. Overall, we found rates of physical manifestations similar to those previously reported in the literature. Psychiatric disorders were very common among our study population, with psychotic disorders occurring in 16.3 % of the psychiatrically evaluated population. We found an association between the presence of psychotic disorders and preterm birth. Our results replicate and extend the findings of a previous work and suggest that the evolution of psychosis in 22q11.2DS is a neurodevelopmental process with early obstetric and medical precursors.
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Metadaten
Titel
Association between prematurity and the evolution of psychotic disorders in 22q11.2 deletion syndrome
verfasst von
Yael Midbari Kufert
Ariela Nachmani
Einat Nativ
Abraham Weizman
Doron Gothelf
Publikationsdatum
12.08.2016
Verlag
Springer Vienna
Erschienen in
Journal of Neural Transmission / Ausgabe 12/2016
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI
https://doi.org/10.1007/s00702-016-1607-5

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