Association between REM sleep behavior disorder and impulsive–compulsive behaviors in Parkinson’s disease: a systematic review and meta-analysis of observational studies
- 21.10.2019
- Original Communication
Erschienen in:
- Verfasst von
- Hai-tao Lu
- Qiu-yan Shen
- Quan-zhen Zhao
- Hong-yan Huang
- Ping-ping Ning
- Hui Wang
- Dan Xie
- Yan-ming Xu
- Erschienen in
- Journal of Neurology | Ausgabe 2/2020
Abstract
Background
Both REM sleep behavior disorder (RBD) and impulsive–compulsive behaviors (ICBs) are well-recognized non-motor features in patients with Parkinson’s disease (PD). Studies have given contradictory results about the potential association between RBD and ICBs.
Methods
PubMed, Embase (via Ovid), and the Cochrane Central Registry of Controlled Trials (CENTRAL) databases were systematically searched till August 20, 2019 to identify studies that explored the possible correlation between RBD and ICBs in patients with PD. Two authors independently screened records, extracted data and evaluated quality of included studies. Pooled odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated by employing a random or fixed-effects model. We performed subgroup and sensitivity analyses, and we assessed potential publication bias.
Results
A total of 134 references were screened and 10 studies involving 2781 PD patients were included. Overall, RBD was associated with a more than twofold higher risk of developing ICBs (OR 2.12, 95% CI 1.43–3.14, I2 = 56.7%, P < 0.01). Similar results were obtained in sensitivity analyses and in meta-analyses of subgroups stratified based on multivariable adjustment and methods for diagnosing RBD and ICBs. No significant risk of publication bias was found.
Conclusion
RBD in PD is confirmed to be a risk factor for ICBs. Clinicians should be aware of this association to help them improve patient management.
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- Titel
- Association between REM sleep behavior disorder and impulsive–compulsive behaviors in Parkinson’s disease: a systematic review and meta-analysis of observational studies
- Verfasst von
-
Hai-tao Lu
Qiu-yan Shen
Quan-zhen Zhao
Hong-yan Huang
Ping-ping Ning
Hui Wang
Dan Xie
Yan-ming Xu
- Publikationsdatum
- 21.10.2019
- Verlag
- Springer Berlin Heidelberg
- Erschienen in
-
Journal of Neurology / Ausgabe 2/2020
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459 - DOI
- https://doi.org/10.1007/s00415-019-09588-3
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