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15.04.2019 | Original Article

Association between resting heart rate and incident diabetes risk: a Mendelian randomization study

verfasst von: Tengfei Long, Jing Wang, Xu Han, Fei Wang, Hua Hu, Caizheng Yu, Jing Yuan, Ping Yao, Sheng Wei, Youjie Wang, Yuan Liang, Xiaoping Miao, Xiaomin Zhang, Huan Guo, Dan Zheng, Yuhan Tang, Handong Yang, Suli Huang, Meian He

Erschienen in: Acta Diabetologica | Ausgabe 9/2019

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Abstract

Aims

Observational studies indicated that resting heart rate (RHR) was associated with diabetes mellitus (DM) risk; however, it remains unclear whether the association between RHR and DM is causal. We aimed to examine whether there was causal association of RHR with DM risk.

Methods

A prospective study including 16,201 middle-aged and older Chinese (7031 males and 9170 females) derived from the Dongfeng-Tongji cohort was performed. Cox proportional hazard regression models were conducted to estimate the associations between RHR and incident DM risk. In 7481 participants, 65 single nucleotide polymorphisms related to RHR were genotyped. A genetic risk score (GRS) of RHR was calculated based on the RHR-associated variants. The causal associations of RHR with DM risk were investigated by Mendelian randomization analysis.

Results

During a mean (SD) follow-up of 4.5 (0.5) years, 1110 diabetes were identified. Compared with the referential RHR group (≤ 60 beats per minute [bpm]), individuals with RHR > 80 bpm have a higher incident diabetes risk, with a hazard ratio of 1.40 (95% confidence interval [CI], 1.05–1.88). With per SD increase in the weighted genetic risk score, the resting heart rate increased by 0.71 bpm (95% CI 0.49–0.93). By using the GRS to estimate the unconfounded effect, we found that higher resting heart rate did not have a causal effect on diabetes risk (OR 1.00 [95% CI 0.95–1.05]).

Conclusions

The present study supported a positive but not a causal association of RHR with incident diabetes risk. More studies are needed to verify our findings.

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Titel: Association between resting heart rate and incident diabetes risk: a Mendelian randomization study
verfasst von: Tengfei Long
Jing Wang
Xu Han
Fei Wang
Hua Hu
Caizheng Yu
Jing Yuan
Ping Yao
Sheng Wei
Youjie Wang
Yuan Liang
Xiaoping Miao
Xiaomin Zhang
Huan Guo
Dan Zheng
Yuhan Tang
Handong Yang
Suli Huang
Meian He
Publikationsdatum: 15.04.2019
Verlag: Springer Milan
Erschienen in: Acta Diabetologica / Ausgabe 9/2019
Print ISSN: 0940-5429
Elektronische ISSN: 1432-5233
DOI: https://doi.org/10.1007/s00592-019-01344-3

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Association between resting heart rate and incident diabetes risk: a Mendelian randomization study

Abstract

Aims

Methods

Results

Conclusions

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