Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Konkret geht es um den Diabetes-Patienten mit kardiovaskulären Erkrankungen oder Risiken, die Herzinsuffizienz sowie die kardiovaskuläre Primär- und Sekundärprävention. Sind Sie hier schon auf dem neuesten Stand? Unsere Experten beleuchten, wo und warum das bisherige Procedere geändert werden soll und was in der Praxis sinnvoll ist. Holen Sie sich Ihr Update und 2 CME-Punkte beim MMW-Webinar am 24. April von 17.30 bis 19 Uhr. 
Erweiterte Suche
Anmelden
nach oben
Current Oral Health Reports
Erschienen in: Current Oral Health Reports 2/2020

21.03.2020 | Systemic Diseases (N Buduneli, Section Editor)

Association Between Rheumatoid Arthritis and Periodontitis: Recent Progress

verfasst von: Nazurah Nik Eezammuddeen, Rathna Devi Vaithilingam, Norul Husna Mohamad Hassan, Peter Mark Bartold

Erschienen in: Current Oral Health Reports | Ausgabe 2/2020

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

While a number of reviews have been published in recent years covering all aspects of the relationship between rheumatoid arthritis and periodontitis, this review considers only the very most recent advances in the field by reporting on studies published from January 2018 to August 2019.

Recent Findings

The number of published studies that have investigated this relationship has increased dramatically in recent years. These studies have established a number of important biochemical, cellular, genetic and microbiological processes that link these two conditions at the clinical level.

Summary

There is now very good evidence to support a relationship between RA and periodontitis. It is clear that very good progress is being made but there is need for continuing investigations to better identify the defining mechanism(s) that drive this intriguing relationship.
Literatur
1.
2.
Snyderman R, McCarty GA. Analogous mechanisms of tissue destruction in rheumatoid arthritis and periodontal disease. In: Genco RJ, Mergenhagen SE, editors. Host-parasite interaction in periodontal diseases. Washington, DC: American Society of Microbiology; 1982. p. 354–62.
3.
Moen K, Brun J, Valen M, Skartveit L, Eribe E, Olsen I, et al. Synovial inflammation in active rheumatoid arthritis and psoriatic arthritis facilitates trapping of a variety of oral bacterial DNAs. Clin Exp Rheumatol. 2006;24(6):656–63.PubMed
4.
Rosenstein ED, Greenwald RA, Kushner LJ, Weissmann G. Hypothesis: the humoral immune response to oral bacteria provides a stimulus for the development of rheumatoid arthritis. Inflammation. 2004;28(6):311–8.PubMedCrossRef
5.
Golub L, Payne J, Reinhardt R, Nieman G. Can systemic diseases co-induce (not just exacerbate) periodontitis? A hypothetical “two-hit” model. J Dent Res. 2006;85(2):102–5.PubMedCrossRef
6.
Bartold PM, Marshall R, Haynes D. Periodontitis and rheumatoid arthritis: a review. J Periodontol. 2005;76:2066–74.PubMedCrossRef
7.
Linden GJ, Herzberg MC. Workshop periodontitis and systemic diseases: a record of discussions of working group 4 of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases. J Clin Periodontol. 2013;40:S20–S3.PubMedCrossRef
8.
Bartold PM, Lopez-Oliva I. Rheumatoid arthritis and periodontitis: an update 2012-2017. Periodontol 2000. In Press 2020.
9.
Mobini M, Maboudi A, Mohammadpour RA. Periodontitis in rheumatoid arthritis patients, abundance and association with disease activity. Med J Islam Repub Iran. 2017;31:44.PubMedPubMedCentralCrossRef
10.
11.
Nik-Azis N-M, Mohd-fadzilah F, Mohd-Shahrir M-S, Baharin B, Mohd N. Impact of rheumatoid arthritis functional status on oral and periodontal health in a multi-ethnic population. Sains Malays. 2019;48(3):645–52.CrossRef
12.
Jung ES, Choi YY, Lee KH. Relationship between rheumatoid arthritis and periodontal disease in Korean adults: data from the Sixth Korea National Health and Nutrition Examination Survey, 2013 to 2015. J Periodontol. 2019;90(4):350–7.PubMedCrossRef
13.
Wan-Mohamad WM, Jia SK, Ghazali WSW, Taib H. Anti-cyclic citrullinated peptide antibody and periodontal status in rheumatoid arthritis patients. Pak J Med Sci. 2018;34(4):907.CrossRef
14.
Kim J-W, Park J-B, Yim HW, Lee J, Kwok S-K, Ju JH, et al. Rheumatoid arthritis is associated with early tooth loss: results from Korea National Health and Nutrition Examination Survey V to VI. Korean J Intern Med. 2018;34(6):1381.PubMedPubMedCentralCrossRef
15.
Kim J-H, Choi IA, Lee JY, Kim K-H, Kim S, Koo K-T, et al. Periodontal pathogens and the association between periodontitis and rheumatoid arthritis in Korean adults. J Periodontal Implant Sci. 2018;48(6):347–59.PubMedPubMedCentralCrossRef
16.
Antal M, Battancs E, Bocskai M, Braunitzer G, Kovács L. An observation on the severity of periodontal disease in past cigarette smokers suffering from rheumatoid arthritis- evidence for a long-term effect of cigarette smoke exposure? BMC Oral Health. 2018;18(1):82.PubMedPubMedCentralCrossRef
17.
Rodríguez-Lozano B, González-Febles J, Garnier-Rodríguez JL, Dadlani S, Bustabad-Reyes S, Sanz M, et al. Association between severity of periodontitis and clinical activity in rheumatoid arthritis patients: a case–control study. Arthritis Res Ther. 2019;21(1):27.PubMedPubMedCentralCrossRef
18.
Zhao R, Gu C, Zhang Q, Zhou W, Feng G, Feng X, et al. Periodontal disease in Chinese patients with rheumatoid arthritis: a case control study. Oral Dis. 2019;00:1–7.
19.
Sacks JJ, Luo YH, Helmick CG. Prevalence of specific types of arthritis and other rheumatic conditions in the ambulatory health care system in the United States, 2001–2005. Arthritis Care Res (Hoboken). 2010;62(4):460–4.CrossRef
20.
21.
de Pablo P, Dietrich T, McAlindon TE. Association of periodontal disease and tooth loss with rheumatoid arthritis in the US population. J Rheumatol. 2008;35(1):70–6.PubMed
22.
Chen H-H, Huang N, Chen Y-M, Chen T-J, Chou P, Lee Y-L, et al. Association between a history of periodontitis and the risk of rheumatoid arthritis: a nationwide, population-based, case–control study. Ann Rheum Dis. 2013;72(7):1206–11.PubMedCrossRef
23.
de Oliveira FR, de Brito SR, Magno MB, Carvalho Almeida APCPS, Fagundes NCF, Maia LC, et al. Does periodontitis represent a risk factor for rheumatoid arthritis? A systematic review and meta-analysis. Ther Adv Musculoskelet Dis. 2019;11:1–16.
24.
Kobayashi T, Kido J-I, Ishihara Y, Omori K, Ito S, Matsuura T, et al. The KCNQ1 gene polymorphism as a shared genetic risk for rheumatoid arthritis and chronic periodontitis in Japanese adults: a pilot case-control study. J Periodontol. 2018;89(3):315–24.PubMedCrossRef
25.
26.
Jeong SH, Nam Y, Jung H, Kim J, Rim YA, Park N, et al. Interrupting oral infection of Porphyromonas gingivalis with anti-FimA antibody attenuates bacterial dissemination to the arthritic joint and improves experimental arthritis. Exp Mol Med. 2018;50:e460.PubMedPubMedCentralCrossRef
27.
Courbon G, Rinaudo-Gaujous M, Blasco-Baque V, Auger I, Caire R, Mijola L, et al. Porphyromonas gingivalis experimentally induces periodontitis and an anti-CCP2-associated arthritis in the rat. Ann Rheum Dis. 2019;78(5):594–9.PubMedCrossRef
28.
29.
Lübcke PM, Ebbers MN, Volzke J, Bull J, Kneitz S, Engelmann R, et al. Periodontal treatment prevents arthritis in mice and methotrexate ameliorates periodontal bone loss. Sci Rep. 2019;9(1):8128.PubMedPubMedCentralCrossRef
30.
Ogrendik M. Rheumatoid arthritis is linked to oral bacteria: etiological association. Mod Rheumatol. 2009;19(5):453–6.PubMedCrossRef
31.
Martinez-Martinez RE, Abud-Mendoza C, Patiño-Marin N, Rizo-Rodríguez JC, Little JW, Loyola-Rodríguez JP. Detection of periodontal bacterial DNA in serum and synovial fluid in refractory rheumatoid arthritis patients. J Clin Periodontol. 2009;36(12):1004–10.PubMedCrossRef
32.
Reichert S, Haffner M, Keyßer G, Schäfer C, Stein JM, Schaller HG, et al. Detection of oral bacterial DNA in synovial fluid. J Clin Periodontol. 2013;40(6):591–8.PubMedCrossRef
33.
Totaro MC, Cattani P, Ria F, Tolusso B, Gremese E, Fedele AL, et al. Porphyromonas gingivalis and the pathogenesis of rheumatoid arthritis: analysis of various compartments including the synovial tissue. Arthritis Res Ther. 2013;15(3):R66.PubMedPubMedCentralCrossRef
34.
McGraw WT, Potempa J, Farley D, Travis J. Purification, characterization, and sequence analysis of a potential virulence factor from Porphyromonas gingivalis, peptidylarginine deiminase. Infect Immun. 1999;67(7):3248–56.PubMedPubMedCentralCrossRef
35.
Mikuls TR, Thiele GM, Deane KD, Payne JB, O'Dell JR, Yu F, et al. Porphyromonas gingivalis and disease-related autoantibodies in individuals at increased risk of rheumatoid arthritis. Arthritis Rheum. 2012;64(11):3522–30.PubMedCrossRef
36.
Liao F, Li Z, Wang Y, Shi B, Gong Z, Cheng X. Porphyromonas gingivalis may play an important role in the pathogenesis of periodontitis-associated rheumatoid arthritis. Med Hypotheses. 2009;72(6):732–5.PubMedCrossRef
37.
Potempa J, Mydel P, Koziel J. The case for periodontitis in the pathogenesis of rheumatoid arthritis. Nat Rev Rheumatol. 2017;13(10):606–20.PubMedCrossRef
38.
Konig MF, Abusleme L, Reinholdt J, Palmer RJ, Teles RP, Sampson K, et al. Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis. Sci Transl Med. 2016;8(369):369ra176.PubMedPubMedCentralCrossRef
39.
Kriauciunas A, Gleiznys A, Gleiznys D, Janužis G. The influence of Porphyromonas gingivalis bacterium causing periodontal disease on the pathogenesis of rheumatoid arthritis: systematic review of literature. Cureus. 2019;11(5).
40.
Ayala-Herrera JL, Abud-Mendoza C, Gonzalez-Amaro RF, Espinosa-Cristobal LF, Martínez-Martínez RE. Distribution of Porphyromonas gingivalis fimA genotypes in patients affected by rheumatoid arthritis and periodontitis. Acta Odontol Scand. 2018;76(7):520–4.PubMedCrossRef
41.
Bender P, Egger A, Westermann M, Taudte N, Sculean A, Potempa J, et al. Expression of human and Porphyromonas gingivalis glutaminyl cyclases in periodontitis and rheumatoid arthritis—a pilot study. Arch Oral Biol. 2019;97:223–30.PubMedCrossRef
42.
Mankia K, Cheng Z, Do N, Hunt L, Meade J, Kang J, et al. An increased prevalence of periodontal disease and Porphyromonas gingivalis in anti-CCP positive individuals at-risk of rheumatoid arthritis: a target for prevention? JAMA Netw Open. In Press 2019.
43.
Corrêa JD, Fernandes GR, Calderaro DC, Mendonça SMS, Silva JM, Albiero ML, et al. Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients. Sci Rep. 2019;9(1):8379.PubMedPubMedCentralCrossRef
44.
Eriksson K, Fei G, Lundmark A, Benchimol D, Lee L, Hu YOO, et al. Periodontal health and oral microbiota in patients with rheumatoid arthritis. J Clin Med. 2019;8(5):630.PubMedCentralCrossRef
45.
Herrera JLA, Patrón LA, Martínez REM, Pérez RAD, Mendoza CA, Castro BH. Filifactor alocis and Dialister pneumosintes in a Mexican population affected by periodontitis and rheumatoid arthritis: an exploratory study. Microbiol Immunol. 2019;63:392–5.CrossRef
46.
Beyer K, Zaura E, Brandt BW, Buijs MJ, Brun JG, Crielaard W, et al. Subgingival microbiome of rheumatoid arthritis patients in relation to their disease status and periodontal health. PLoS One. 2018;13(9):e0202278.PubMedPubMedCentralCrossRef
47.
Lopez-Oliva I, Paropkari AD, Saraswat S, Serban S, Yonel Z, Sharma P, et al. Dysbiotic subgingival microbial communities in periodontally healthy patients with rheumatoid arthritis. Arthritis Rheumatol. 2018;70(7):1008–13.PubMedPubMedCentralCrossRef
48.
Wegner N, Lundberg K, Kinloch A, Fisher B, Malmström V, Feldmann M, et al. Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis. Immunol Rev. 2010;233(1):34–54.PubMedCrossRef
49.
van Gaalen FA, Visser H, Huizinga TW. A comparison of the diagnostic accuracy and prognostic value of the first and second anti-cyclic citrullinated peptides (CCP1 and CCP2) autoantibody tests for rheumatoid arthritis. Ann Rheum Dis. 2005;64(10):1510–2.PubMedPubMedCentralCrossRef
50.
Schellekens GA, De Jong B, Van den Hoogen F, Van de Putte L, van Venrooij WJ. Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies. J Clin Invest. 1998;101(1):273–81.PubMedPubMedCentralCrossRef
51.
Schellekens GA, Visser H, De Jong BA, Van Den Hoogen FH, Hazes JM, Breedveld FC, et al. The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum. 2000;43(1):155–63.PubMedCrossRef
52.
György B, Tóth E, Tarcsa E, Falus A, Buzás EI. Citrullination: a posttranslational modification in health and disease. Int J Biochem Cell Biol. 2006;38(10):1662–77.PubMedCrossRef
53.
Koziel J, Mydel P, Potempa J. The link between periodontal disease and rheumatoid arthritis: an updated review. Curr Rheumatol Rep. 2014;16(3):408.PubMedPubMedCentralCrossRef
54.
Mangat P, Wegner N, Venables PJ, Potempa J. Bacterial and human peptidylarginine deiminases: targets for inhibiting the autoimmune response in rheumatoid arthritis? Arthritis Res Ther. 2010;12(3):209.PubMedPubMedCentralCrossRef
55.
Nesse W, Westra J, van der Wal JE, Abbas F, Nicholas AP, Vissink A, et al. The periodontium of periodontitis patients contains citrullinated proteins which may play a role in ACPA (anti-citrullinated protein antibody) formation. J Clin Periodontol. 2012;39(7):599–607.PubMedCrossRef
56.
Harvey G, Fitzsimmons T, Dhamarpatni A, Marchant C, Haynes D, Bartold P. Expression of peptidylarginine deiminase-2 and-4, citrullinated proteins and anti-citrullinated protein antibodies in human gingiva. J Periodontal Res. 2013;48(2):252–61.PubMedCrossRef
57.
Loutan L, Alpizar-Rodriguez D, Courvoisier DS, Finckh A, Mombelli A, Giannopoulou C. Periodontal status correlates with anti-citrullinated protein antibodies in first-degree relatives of individuals with rheumatoid arthritis. J Clin Periodontol. 2019;46(7):690–8.PubMed
58.
Shi J, van Veelen PA, Mahler M, Janssen GM, Drijfhout JW, Huizinga TW, et al. Carbamylation and antibodies against carbamylated proteins in autoimmunity and other pathologies. Autoimmun Rev. 2014;13(3):225–30.PubMedCrossRef
59.
Bright R, Proudman S, Rosenstein E, Bartold P. Is there a link between carbamylation and citrullination in periodontal disease and rheumatoid arthritis? Med Hypotheses. 2015;84(6):570–6.PubMedCrossRef
60.
Mydel P, Wang Z, Brisslert M, Hellvard A, Dahlberg LE, Hazen SL, et al. Carbamylation-dependent activation of T cells: a novel mechanism in the pathogenesis of autoimmune arthritis. J Immunol. 2010;184(12):6882–90.PubMedCrossRef
61.
Steinbrecher UP, Fisher M, Witztum JL, Curtiss LK. Immunogenicity of homologous low density lipoprotein after methylation, ethylation, acetylation, or carbamylation: generation of antibodies specific for derivatized lysine. J Lipid Res. 1984;25(10):1109–16.PubMed
62.
Verheul MK, Vierboom MP, Bert A, Toes RE, Trouw LA. Anti-carbamylated protein antibodies precede disease onset in monkeys with collagen-induced arthritis. Arthritis Res Ther. 2017;19(1):246.PubMedPubMedCentralCrossRef
63.
Bright R, Thiele GM, Manavis J, Mikuls TR, Payne JB, Bartold P. Gingival tissue, an extrasynovial source of malondialdehyde-acetaldehyde adducts, citrullinated and carbamylated proteins. J Periodontal Res. 2018;53(1):139–43.PubMedCrossRef
64.
Kaneko C, Kobayashi T, Ito S, Sugita N, Murasawa A, Nakazono K, et al. Circulating levels of carbamylated protein and neutrophil extracellular traps are associated with periodontitis severity in patients with rheumatoid arthritis: a pilot case-control study. PLoS One. 2018;13(2):e0192365.PubMedPubMedCentralCrossRef
65.
McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. New Engl J Med. 2011;365(23):2205–19.PubMedCrossRef
66.
Kinane DF, Preshaw PM, Loos BG, Periodontology. Host-response: understanding the cellular and molecular mechanisms of host-microbial interactions—Consensus of the Seventh European Workshop on Periodontology. J Clin Periodontol. 2011;38:44–8.PubMedCrossRef
67.
Kaur S, White S, Bartold P. Periodontal disease and rheumatoid arthritis: a systematic review. J Dent Res. 2013;92(5):399–408.PubMedCrossRef
68.
Javed F, Ahmed HB, Mikami T, Almas K, Romanos GE, Al-Hezaimi K. Cytokine profile in the gingival crevicular fluid of rheumatoid arthritis patients with chronic periodontitis. J Investig Clin Dent. 2014;5(1):1–8.PubMedCrossRef
69.
Preshaw PM, Taylor JJ. How has research into cytokine interactions and their role in driving immune responses impacted our understanding of periodontitis? J Clin Periodontol. 2011;38:60–84.PubMedCrossRef
70.
Choy EH, Panayi GS. Cytokine pathways and joint inflammation in rheumatoid arthritis. New Engl J Med. 2001;344(12):907–16.PubMedCrossRef
71.
Thilagar S, Theyagarajan R, Sudhakar U, Suresh S, Saketharaman P, Ahamed N. Comparison of serum tumor necrosis factor-α levels in rheumatoid arthritis individuals with and without chronic periodontitis: a biochemical study. J Indian Soc Periodontol. 2018;22(2):116.PubMedPubMedCentralCrossRef
72.
•• Cosgarea R, Tristiu R, Dumitru RB, Arweiler NB, Rednic S, Sirbu CI, et al. Effects of non-surgical periodontal therapy on periodontal laboratory and clinical data as well as on disease activity in patients with rheumatoid arthritis. Clin Oral Investig. 2019;23(1):141–51. In patients with RA and CP, non-surgical periodontal therapy is a relevant modality not only to improve the periodontal condition but also to decrease RA activity. PubMedCrossRef
73.
•• Äyräväinen L, Heikkinen AM, Kuuliala A, Ahola K, Koivuniemi R, Laasonen L, et al. Inflammatory biomarkers in saliva and serum of patients with rheumatoid arthritis with respect to periodontal status. Ann Med. 2018;50(4):333–44. Concentrations of inflammatory biomarkers in serum and saliva are different between patients with RA and healthy controls. Concentrations of MMP-8 and of IL-6 in serum were elevated in patients with chronic RA reflecting joint inflammation and the burden of established RA. Concentrations of MMP-8 in saliva were elevated already at early stage RA. Level of salivary MMP-8 was associated with poor periodontal health both in patients with early and chronic RA. PubMedCrossRef
74.
Schmalz G, Davarpanah I, Jager J, Mausberg RF, Krohn-Grimberghe B, Schmidt J, et al. MMP-8 and TIMP-1 are associated to periodontal inflammation in patients with rheumatoid arthritis under methotrexate immunosuppression—first results of a cross-sectional study. J Microbiol Immunol Infect. 2019;52(3):386–94.PubMedCrossRef
75.
Panezai J, Ghaffar A, Altamash M, Engström P-E, Larsson A. Periodontal disease influences osteoclastogenic bone markers in subjects with and without rheumatoid arthritis. PLoS One. 2018;13(6):e0197235.PubMedPubMedCentralCrossRef
76.
Kindstedt E, Johansson L, Palmqvist P, Koskinen Holm C, Kokkonen H, Johansson I, et al. Association between marginal jawbone loss and onset of rheumatoid arthritis and relationship to plasma levels of RANKL. Arthritis Rheumatol. 2018;70(4):508–15.PubMedCrossRef
77.
Beyer K, Lie SA, Kjellevold M, Dahl L, Brun JG, Bolstad AI. Marine ω-3, vitamin D levels, disease outcome and periodontal status in rheumatoid arthritis outpatients. Nutrition. 2018;55:116–24.PubMedCrossRef
78.
•• Ziebolz D, Rupprecht A, Schmickler J, Bothmann L, Krämer J, Patschan D, et al. Association of different immunosuppressive medications with periodontal condition in patients with rheumatoid arthritis: results from a cross-sectional study. J Periodontol. 2018;89(11):1310–7. RA medication is associated with periodontal inflammation, without differences in periodontal disease severity. Thereby, combination of MTX + TNF-α shows an increased potential to periodontal inflammation. Additionally, several differences in prevalence of selected bacteria were detected. PubMedCrossRef
79.
Cobb CM. Clinical significance of non-surgical periodontal therapy: an evidence-based perspective of scaling and root planing. J Clin Periodontol. 2002;29:22–32.CrossRef
80.
Zhao X, Liu Z, Shu D, Xiong Y, He M, Xu S, et al. Association of periodontitis with rheumatoid arthritis and the effect of non-surgical periodontal treatment on disease activity in patients with rheumatoid arthritis. Med Sci Monit. 2018;24:5802.PubMedPubMedCentralCrossRef
81.
Kaushal S, Singh AK, Lal N, Das SK, Mahdi AA. Effect of periodontal therapy on disease activity in patients of rheumatoid arthritis with chronic periodontitis. J Oral Biol Craniofac Res. 2019;9(2):128–32.PubMedPubMedCentralCrossRef
82.
Monsarrat P, Fernandez de Grado G, Constantin A, Willmann C, Nabet C, Sixou M, et al. The effect of periodontal treatment on patients with rheumatoid arthritis: ESPERA randomised controlled trial. Joint Bone Spine. 2019;86(5):600–9.PubMedCrossRef
83.
84.
Hashimoto H, Hashimoto S, Muto A, Dewake N, Shimazaki Y. Influence of plaque control on the relationship between rheumatoid arthritis and periodontal health status among Japanese rheumatoid arthritis patients. J Periodontol. 2018;89(9):1033–42.PubMedCrossRef
85.
Chapple IL, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, et al. Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol. 2018;89:S74–84.PubMedCrossRef
86.
Khare N, Vanza B, Sagar D, Saurav K, Chauhan R, Mishra S. Nonsurgical periodontal therapy decreases the severity of rheumatoid arthritis: a case-control study. J Contemp Dent Pract. 2016;17(6):484–8.PubMedCrossRef
87.
Al-Katma MK, Bissada NF, Bordeaux JM, Sue J, Askari AD. Control of periodontal infection reduces the severity of active rheumatoid arthritis. J Clin Rheumatol. 2007;13(3):134–7.PubMedCrossRef
88.
Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO III, et al. 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 2010;62(9):2569–81.PubMedCrossRef
89.
90.
Han JY, Reynolds MA. Effect of anti-rheumatic agents on periodontal parameters and biomarkers of inflammation: a systematic review and meta-analysis. J Periodontal Implant Sci. 2012;42(1):3–12.PubMedPubMedCentralCrossRef
91.
Kadkhoda Z, Amirzargar A, Esmaili Z, Vojdanian M, Akbari S. Effect of TNF-α blockade in gingival crevicular fluid on periodontal condition of patients with rheumatoid arthritis. Iran J Immunol. 2016;13(3):197–203.PubMed
92.
Kobayashi T, Yoshie H. Host responses in the link between periodontitis and rheumatoid arthritis. Curr Oral Health Rep. 2015;2(1):1–8.PubMedCrossRef
93.
Coat J, Demoersman J, Beuzit S, Cornec D, Devauchelle-Pensec V, Saraux A, et al. Anti-B lymphocyte immunotherapy is associated with improvement of periodontal status in subjects with rheumatoid arthritis. J Clin Periodontol. 2015;42(9):817–23.PubMedCrossRef
94.
Jung G-U, Han J-Y, Hwang K-G, Park C-J, Stathopoulou PG, Fiorellini JP. Effects of conventional synthetic disease-modifying antirheumatic drugs on response to periodontal treatment in patients with rheumatoid arthritis. Biomed Res Int. 2018;2018:1465402. https://​doi.​org/​10.​1155/​2018/​1465402.
95.
Rinaudo-Gaujous M, Blasco-Baque V, Miossec P, Gaudin P, Farge P, Roblin X, et al. Infliximab induced a dissociated response of severe periodontal biomarkers in rheumatoid arthritis patients. J Clin Med. 2019;8(5):751.PubMedCentralCrossRef
96.
Savioli C, Ribeiro ACM, Fabri GMC, Calich AL, Carvalho J, Silva CA, et al. Persistent periodontal disease hampers anti-tumor necrosis factor treatment response in rheumatoid arthritis. J Clin Rheumatol. 2012;18(4):180–4.PubMed
97.
Lee YH, Lew PH, Cheah CW, Rahman MT, Baharuddin NA, Vaithilingam RD. Potential mechanisms linking periodontitis to rheumatoid arthritis. J Int Acad Periodontol. 2019;21(3):99–110.PubMed
Metadaten
Titel
Association Between Rheumatoid Arthritis and Periodontitis: Recent Progress
verfasst von
Nazurah Nik Eezammuddeen
Rathna Devi Vaithilingam
Norul Husna Mohamad Hassan
Peter Mark Bartold
Publikationsdatum
21.03.2020
Verlag
Springer International Publishing
Erschienen in
Current Oral Health Reports / Ausgabe 2/2020
Elektronische ISSN: 2196-3002
DOI
https://doi.org/10.1007/s40496-020-00264-4

Weitere Artikel der Ausgabe 2/2020

Current Oral Health Reports 2/2020 Zur Ausgabe

Oral Disease and Nutrition (F Nishimura, Section Editor)

Nutritional Supplements and Periodontal Disease Prevention—Current Understanding

Oral Disease and Nutrition (F Nishimura, Section Editor)

Periodontal Health and Nutritional Status in the Elderly: Systematic Review

Oral Disease and Nutrition (F Nishimura, Section Editor)

Sarcopenia and Mastication

Oral Disease and Nutrition (F Nishimura, Section Editor)

What Are the Major Causes of Dry Mouth in Elderly Adults?

Oral Disease and Nutrition (F Nishimura, Section Editor)

Insulin Function in Peripheral Taste Organ Homeostasis

Systemic Diseases (N Buduneli, Section Editor)

Associations Between Periodontal Health/Treatment and Cognitive Impairment: Latest Evidence From Epidemiological Studies

Neu im Fachgebiet Zahnmedizin

19.04.2024 | Vorhofflimmern | Nachrichten

Parodontalbehandlung verbessert Prognose bei Katheterablation

11.04.2024 | Endokarditis | Nachrichten

Invasive Zahnbehandlung: Wann eine Antibiotikaprophylaxe vor infektiöser Endokarditis schützt

08.04.2024 | Zahnmedizin | Nachrichten

Zell-Organisatoren unter Druck: Mechanismen des embryonalen Zahnwachstums aufgedeckt

11.03.2024 | Kinderzahnmedizin | Nachrichten

Die Oralprophylaxe & Kinderzahnheilkunde umbenannt
weitere anzeigen

Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Zahnmedizin und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen
Bildnachweise