The online version of this article (doi:10.1186/1471-2261-14-26) contains supplementary material, which is available to authorized users.
Li Qin, Zhen Yang contributed equally to this work.
The authors declare that they have no competing interests.
Conceived and designed the experiments: QS. Analyzed the data: LQ, ZY. Contributed reagents/materials/analysis tools: LQ, ZY, HG, SL, QS, YX, XL, RL, GN. Wrote the paper: LQ, ZY. All authors read and approved the final manuscript.
A link between uric acid (UA) levels and cardiovascular diseases has been previously reported. However, its importance as a risk factor is still controversial. This study sought to determine whether elevated serum uric acid levels are associated with cardiovascular disease (CVD) in middle-aged and elderly Chinese individuals.
We conducted a population-based cross-sectional study in Shanghai, with a total of 8510 participants aged ≥40 years. The CVD included diagnosed coronary heart disease (CHD) and stroke. MetS was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian Americans.
Uric acid levels were positively associated with BMI, waist circumference, triglycerides, systolic blood pressure, diastolic blood pressure, glycohemoglobin, fasting plasma glucose, postprandial 2-hour plasma glucose (all P < 0.05), and negatively associated with HDL-cholesterol (P < 0.001). The prevalence of CVD significantly increased with increasing quartiles of UA in those without MetS group (p trend < 0.001), but not necessarily increased in those with MetS. After adjustment for metabolic syndrome and other cardiovascular risk factors, multivariate logistic regression analysis showed that odds ratios (OR) for CHD, stroke, and CVD in those in the fourth quartiles were 2.34 (95% confidence interval [CI] 1.73 to 3.45), 2.18 (95% CI 1.86 to 3.28), and 2.16 (95% CI 1.80 to 3.29), respectively, compared with those in the first quartile of UA.
Elevated serum uric acid level was associated with CVD, independent of conventional cardiovascular disease risk factors and metabolic syndrome.
Yang Z, Wang X, Wen J, Ye Z, Li Q, He M, Lu B, Ling C, Wu S, Hu R: Prevalence of non-alcoholic fatty liver disease and its relation to hypoadiponectinaemia in the middle-aged and elderly Chinese population. Arch Med Sci. 2011, 665-672.
Freedman DS, Williamson DF, Gunter EW, Byers T: Relation of serum uric acid to mortality and ischemic heart disease. The NHANES I Epidemiologic Follow-up Study. Am J Epidemiol. 1995, 141: 637-644. PubMed
Li Q, Yang Z, Lu B, Wen J, Ye Z, Chen L, He M, Tao X, Zhang W, Huang Y, Zhang Z, Qu S, Hu R: Serum uric acid level and its association with metabolic syndrome and carotid atherosclerosis in patients with type 2 diabetes. Cardiovasc Diabetol. 2011, 10: 72-10.1186/1475-2840-10-72. CrossRefPubMedPubMedCentral
Kim SY, Guevara JP, Kim KM, Choi HK, Heitjan DF, Albert DA: Hyperuricemia and coronary heart disease: a systematic review and meta-analysis. Arthritis Care Res (Hoboken). 2010, 62: 170-180.
Brand FN, McGee DL, Kannel WB, Stokes J, Castelli WP: Hyperuricemia as a risk factor of coronary heart disease: The Framingham Study. Am J Epidemiol. 1985, 121: 11-18. PubMed
Guidelines for data processing and analysis of the International Physical Activity Questionnaire (IPAQ). 2006, Available at: http://www.ipaq.ki.se/
WHO/MONICA-Project: Multinational Monitoring of Trends andDeterminants in Cardiovascular Diseases (MONICA Project) and Manual of Operation. 1983, Geneva, Switzerland: World Health Organization, Cardiovascular Disease Unit
Chen L, Yang Z, Lu B, Li Q, Ye Z, He M, Huang Y, Wang X, Zhang Z, Wen J, Liu C, Qu S: Hu R:Serum CXC ligand 5 is a new marker of subclinical atherosclerosis in type 2 diabetes. Clin Endocrinol (Oxf). 2011, 75: 766-770. 10.1111/j.1365-2265.2011.04119.x. CrossRef
Yang Z, Zhang Z, Wen J, Wang X, Lu B, Yang Z, Zhang W, Wang M, Feng X, Ling C, Wu S, Hu R: Elevated serum chemokine CXC ligand 5 levels are associated with hypercholesterolemia but not a worsening of insulin resistance in Chinese people. J Clin Endocrinol Metab. 2010, 95: 3926-3932. 10.1210/jc.2009-2194. CrossRefPubMed
- Association between serum uric acid levels and cardiovascular disease in middle-aged and elderly Chinese individuals
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