Introduction
Materials and methods
Subjects, DNA preparation
Study 1
Study 2
Study 3
SNP genotyping
Statistical analyses
Results
Allele frequencies (nephropathy case−control) | |||||||
---|---|---|---|---|---|---|---|
Proteinuria | ESRD | Combined | |||||
Study 1 | Study 2 |
P
| OR (95% CI) | Study 3 |
P
| OR (95% CI) | |
SNP | |||||||
rs12778366a T>C | 0.111/0.103 | 0.125/0.124 | 0.672 | 1.04 (0.86–1.26) | 0.101/0.119 | 0.981 | 0.998 (0.84–1.18) |
rs3740051a A>G | 0.291/0.277 | 0.316/0.301 | 0.299 | 1.07 (0.94–1.22) | 0.310/0.274 | 0.138 | 1.09 (0.97–1.23) |
rs2236318a T>A | 0.121/0.129 | 0.099/0.111 | 0.327 | 0.91 (0.75–1.10) | 0.106/0.119 | 0.236 | 0.90 (0.76–1.07) |
rs2236319 A>G | 0.339/0.317 | 0.358/0.339 | 0.165 | 1.09 (0.96–1.24) | 0.349/0.300 | 0.048 | 1.12 (1.00–1.26) |
rs10823108 G>A | 0.335/0.318 | 0.357/0.335 | 0.169 | 1.09 (0.96–1.24) | 0.351/0.302 | 0.049 | 1.12 (1.00–1.26) |
rs10997868a C>A | 0.187/0.184 | 0.187/0.174 | 0.520 | 1.05 (0.90–1.23) | 0.180/0.173 | 0.482 | 1.05 (0.91–1.21) |
rs2273773 T>C | 0.339/0.325 | 0.361/0.347 | 0.325 | 1.07 (0.94–1.21) | 0.353/0.306 | 0.113 | 1.10 (0.98–1.23) |
rs3818292 A>G | 0.336/0.317 | 0.360/0.335 | 0.134 | 1.10 (0.97–1.25) | 0.352/0.306 | 0.042 | 1.13 (1.00–1.26) |
rs3818291 G>A | 0.111/0.101 | 0.127/0.129 | 0.650 | 1.04 (0.87–1.26) | 0.101/0.124 | 0.927 | 0.99 (0.84–1.17) |
rs4746720a T>C | 0.366/0.394 | 0.331/0.364 | 0.041 | 0.88 (0.77–0.99) | 0.367/0.400 | 0.021 | 0.88 (0.78–0.98) |
rs10823116a A>G | 0.446/0.442 | 0.441/0.448 | 0.905 | 0.99 (0.88–1.12) | 0.459/0.394 | 0.428 | 1.05 (0.94–1.16) |
Haplotype | |||||||
TGTGACCGGTG | 0.294/0.279 | 0.316/0.300 | 0.250 | 1.08 (0.95–1.23) | 0.315/0.273 | 0.095 | 1.10 (0.98–1.24) |
TATAGCTAGCA | 0.255/0.273 | 0.251/0.252 | 0.464 | 0.95 (0.83–1.09) | 0.253/0.304 | 0.143 | 0.91 (0.81–1.03) |
CATAGCTAATA | 0.112/0.103 | 0.124/0.129 | 0.817 | 1.02 (0.85–1.23) | 0.100/0.119 | 0.841 | 0.98 (0.83–1.16) |
TAAAGATAGTA | 0.123/0.128 | 0.104/0.112 | 0.484 | 0.94 (0.78–1.13) | 0.105/0.122 | 0.319 | 0.92 (0.78–1.08) |
TATAGCTAGCG | 0.109/0.123 | 0.085/0.111 | 0.037 | 0.81 (0.67–0.99) | 0.113/0.099 | 0.117 | 0.87 (0.73–1.03) |
TATAGATAGTA | 0.065/0.055 | 0.078/0.059 | 0.051 | 1.27 (0.998–1.61) | 0.077/0.053 | 0.016 | 1.31 (1.05–1.62) |
TATGACCGGTG | 0.042/0.039 | 0.040/0.036 | 0.57 | 1.09 (0.81–1.48) | 0.036/0.028 | 0.421 | 1.12 (0.85–1.48) |
Allele frequencies (nephropathy case−control) | |||||||
---|---|---|---|---|---|---|---|
Proteinuria | ESRD | Combined | |||||
Study 1 | Study 2 |
P
| OR (95% CI) | Study 3 |
P
| OR (95% CI) | |
SNP | |||||||
rs1001413a G>A | 0.381/0.359 | 0.353/0.361 | 0.594 | 1.03 (0.91–1.17) | 0.342/0.389 | 0.837 | 0.99 (0.88–1.11) |
rs892034a C>T | 0.193/0.166 | 0.180/0.169 | 0.099 | 1.14 (0.98–1.34) | 0.164/0.194 | 0.352 | 1.07 (0.93–1.23) |
rs2015a A>C | 0.398/0.400 | 0.389/0.406 | 0.550 | 0.96 (0.85–1.09) | 0.384/0.391 | 0.522 | 0.96 (0.86–1.08) |
rs2241703a G>A | 0.235/0.226 | 0.222/0.215 | 0.534 | 1.05 (0.91–1.21) | 0.219/0.208 | 0.453 | 1.05 (0.92–1.20) |
rs2082435a C>G | 0.247/0.262 | 0.260/0.270 | 0.365 | 0.94 (0.82–1.08) | 0.256/0.231 | 0.678 | 0.97 (0.86–1.10) |
rs11575003a T>C | 0.118/0.115 | 0.126/0.132 | 0.886 | 0.99 (0.82–1.18) | 0.132/0.119 | 0.887 | 1.01 (0.86–1.19) |
rs2053071a G>C | 0.377/0.398 | 0.384/0.396 | 0.260 | 0.93 (0.82–1.05) | 0.426/0.402 | 0.506 | 0.96 (0.86–1.08) |
Haplotype | |||||||
Block 1 | |||||||
CCGG | 0.243/0.258 | 0.245/0.268 | 0.136 | 0.90 (0.79–1.03) | 0.254/0.226 | 0.366 | 0.95 (0.84–1.07) |
CAAC | 0.231/0.222 | 0.227/0.216 | 0.438 | 1.06 (0.92–1.22) | 0.218/0.204 | 0.347 | 1.06 (0.94–1.21) |
CAGC | 0.179/0.212 | 0.207/0.206 | 0.186 | 0.91 (0.78–1.05) | 0.232/0.205 | 0.477 | 0.95 (0.84–1.09) |
TAGC | 0.191/0.165 | 0.191/0.169 | 0.037 | 1.18 (1.01–1.37) | 0.164/0.197 | 0.196 | 1.10 (0.95–1.26) |
CCGC | 0.154/0.142 | 0.127/0.140 | 0.993 | 0.999 (0.84–1.18) | 0.130/0.164 | 0.497 | 0.95 (0.81–1.04) |
Block 2 | |||||||
TG | 0.620/0.597 | 0.614/0.599 | 0.191 | 1.08 (0.96–1.22) | 0.568/0.585 | 0.346 | 1.05 (0.95–1.17) |
TC | 0.262/0.288 | 0.256/0.270 | 0.142 | 0.91 (0.79–1.03) | 0.300/0.295 | 0.121 | 0.91 (0.81–1.02) |
CC | 0.114/0.110 | 0.126/0.127 | 0.850 | 1.02 (0.85–1.22) | 0.127/0.109 | 0.586 | 1.05 (0.89–1.23) |
Allele frequencies (nephropathy case−control) | |||||||
---|---|---|---|---|---|---|---|
Proteinuria | ESRD | Combined | |||||
Study 1 | Study 2 |
P
| OR (95% CI) | Study 3 |
P
| OR (95% CI) | |
SNP | |||||||
rs11246002a G>A | 0.137/0.123 | 0.152/0.137 | 0.169 | 1.13 (0.95–1.34) | 0.122/0.110 | 0.138 | 1.13 (0.96–1.32) |
rs2293168 G>A | 0.356/0.362 | 0.385/0.402 | 0.440 | 0.95 (0.84–1.08) | 0.400/0.372 | 0.776 | 0.98 (0.88–1.10) |
rs3216 C>G | 0.172/0.168 | 0.160/0.155 | 0.742 | 1.03 (0.87–1.21) | 0.152/0.192 | 0.655 | 0.97 (0.84–1.12) |
rs10081a A>G | 0.507/0.515 | 0.464/0.463 | 0.805 | 1.02 (0.90–1.15) | 0.460/0.514 | 0.338 | 0.95 (0.85–1.06) |
rs511744a C>T | 0.488/0.482 | 0.469/0.485 | 0.778 | 0.98 (0.87–1.11) | 0.491/0.487 | 0.853 | 0.99 (0.89–1.10) |
rs6598074 T>C | 0.164/0.161 | 0.126/0.135 | 0.797 | 0.98 (0.82–1.16) | 0.154/0.144 | 0.963 | 0.996 (0.86–1.16) |
rs4758633a G>A | 0.347/0.355 | 0.288/0.294 | 0.599 | 0.97 (0.85–1.10) | 0.319/0.349 | 0.360 | 0.94 (0.84–1.06) |
rs11246007a C>T | 0.143/0.155 | 0.149/0.152 | 0.471 | 0.94 (0.79–1.11) | 0.142/0.143 | 0.512 | 0.95 (0.82–1.11) |
rs3782117a A>G | 0.168/0.171 | 0.160/0.153 | 0.843 | 1.02 (0.86–1.20) | 0.152/0.193 | 0.544 | 0.96 (0.83–1.11) |
rs3782116a G>A | 0.307/0.294 | 0.278/0.272 | 0.507 | 1.05 (0.92–1.19) | 0.292/0.268 | 0.333 | 1.06 (0.94–1.20) |
rs3782115a C>T | 0.283/0.283 | 0.265/0.257 | 0.785 | 1.02 (0.89–1.17) | 0.263/0.241 | 0.964 | 1.04 (0.92–1.17) |
rs1023430a A>G | 0.291/0.302 | 0.325/0.307 | 0.849 | 1.01 (0.89–1.15) | 0.285/0.275 | 0.743 | 1.02 (0.91–1.15) |
rs536715a G>A | 0.367/0.367 | 0.395/0.406 | 0.736 | 0.98 (0.86–1.11) | 0.404/0.389 | 0.939 | 0.996 (0.89–1.11) |
rs3829998a G>A | 0.167/0.167 | 0.124/0.139 | 0.529 | 0.95 (0.80–1.12) | 0.160/0.153 | 0.674 | 0.97 (0.83–1.13) |
Haplotype | |||||||
Block 1 | |||||||
GACT | 0.354/0.362 | 0.378/0.398 | 0.342 | 0.94 (0.83–1.06) | 0.403/0.377 | 0.635 | 0.97 (0.87–1.09) |
GGCC | 0.335/0.346 | 0.310/0.309 | 0.700 | 0.98 (0.86–1.11) | 0.317/0.321 | 0.688 | 0.97 (0.87–1.09) |
GGGC | 0.172/0.168 | 0.159/0.154 | 0.688 | 1.03 (0.88–1.21) | 0.151/0.192 | 0.678 | 0.97 (0.84–1.12) |
AGCT | 0.138/0.123 | 0.151/0.137 | 0.171 | 1.27 (0.95–1.34) | 0.124/0.110 | 0.127 | 1.13 (0.97–1.11) |
Block 2 | |||||||
TGGA | 0.519/0.511 | 0.560/0.556 | 0.710 | 1.02 (0.91–1.15) | 0.550/0.521 | 0.462 | 1.04 (0.94–1.16) |
TAGG | 0.171/0.169 | 0.158/0.153 | 0.765 | 1.02 (0.87–1.20) | 0.151/0.192 | 0.622 | 0.96 (0.84–1.11) |
TGAA | 0.143/0.155 | 0.150/0.152 | 0.49 | 0.94 (0.80–1.11) | 0.142/0.142 | 0.540 | 0.95 (0.82–1.11) |
CAGA | 0.167/0.164 | 0.131/0.136 | 0.952 | 0.99 (0.84–1.17) | 0.157/0.146 | 0.868 | 0.95 (0.82–1.11) |
Block 3 | |||||||
AAG | 0.364/0.363 | 0.383/0.402 | 0.547 | 0.96 (0.85–1.09) | 0.403/0.384 | 0.779 | 0.98 (0.88–1.10) |
GGG | 0.287/0.297 | 0.320/0.303 | 0.801 | 1.02 (0.89–1.16) | 0.281/0.265 | 0.640 | 1.03 (0.92–1.15) |
AGG | 0.177/0.170 | 0.157/0.152 | 0.618 | 1.04 (0.89–1.22) | 0.154/0.191 | 0.809 | 0.98 (0.85–1.13) |
AGA | 0.168/0.166 | 0.133/0.140 | 0.856 | 0.98 (0.84–1.16) | 0.158/0.152 | 0.967 | 0.997 (0.86–1.16) |
Allele frequencies (nephropathy case−control) | |||||||
---|---|---|---|---|---|---|---|
Proteinuria | ESRD | Combined | |||||
Study 1 | Study 2 |
P
| OR (95% CI) | Study 3 |
P
| OR (95% CI) | |
SNP | |||||||
rs6490288 G>C | 0.068/0.076 | 0.076/0.077 | 0.574 | 0.94 (0.74–1.18) | 0.080/0.066 | 0.880 | 0.98 (0.80–1.21) |
rs7298516a T>G | 0.009/0.009 | 0.008/0.011 | 0.608 | 0.85 (0.46–1.58) | 0.017/0.016 | 0.714 | 0.91 (0.54–1.53) |
rs3847968a C>T | 0.187/0.184 | 0.187/0.174 | 0.450 | 0.91 (0.71–1.16) | 0.180/0.173 | 0.806 | 1.03 (0.82–1.28) |
rs12424555 C>T | 0.059/0.069 | 0.065/0.069 | 0.366 | 0.89 (0.70–1.14) | 0.071/0.046 | 0.912 | 0.99 (0.79–1.23) |
rs7137625a C>T | 0.057/0.040 | 0.058/0.056 | 0.141 | 1.23 (0.94–1.60) | 0.045/0.063 | 0.435 | 1.10 (0.87–1.40) |
rs2261612 A>G | 0.473/0.484 | 0.457/0.476 | 0.338 | 0.94 (0.84–1.06) | 0.476/0.459 | 0.532 | 0.97 (0.87–1.08) |
rs2070873a T>G | 0.469/0.476 | 0.457/0.474 | 0.443 | 0.95 (0.85–1.08) | 0.480/0.468 | 0.600 | 0.97 (0.87–1.08) |
Haplotype | |||||||
Block 1 | |||||||
CCCAT | 0.527/0.518 | 0.546/0.520 | 0.245 | 1.07 (0.95–1.21) | 0.517/0.532 | 0.400 | 1.05 (0.94–1.16) |
CCCGG | 0.350/0.368 | 0.326/0.348 | 0.154 | 0.91 (0.81–1.03) | 0.360/0.342 | 0.305 | 0.94 (0.84–1.05) |
TTCGG | 0.058/0.067 | 0.065/0.062 | 0.695 | 0.95 (0.75–1.21) | 0.067/0.052 | 0.932 | 1.01 (0.81–1.26) |
CCTGG | 0.056/0.039 | 0.056/0.056 | 0.181 | 1.20 (0.92–1.56) | 0.046/0.063 | 0.501 | 1.08 (0.86–1.38) |
Allele frequencies (nephropathy case−control) | |||||||
---|---|---|---|---|---|---|---|
Proteinuria | Combined | ||||||
Study 1 | Study 2 |
P
| OR (95% CI) | Study 3 |
P
| OR (95% CI) | |
SNP | |||||||
rs9382227a G>T | 0.188/0.196 | 0.218/0.192 | 0.494 | 1.05 (0.91–1.22) | 0.198/0.210 | 0.688 | 1.03 (0.90–1.18) |
rs2804916a T>C | 0.170/0.166 | 0.157/0.163 | 0.921 | 0.99 (0.84–1.17) | 0.138/0.135 | 0.971 | 0.997 (0.86–1.16) |
rs2804918a A>G | 0.345/0.357 | 0.352/0.333 | 0.847 | 1.01 (0.89–1.15) | 0.318/0.321 | 0.896 | 1.01 (0.90–1.13) |
rs9370232a G>C | 0.361/0.370 | 0.358/0.362 | 0.640 | 0.97 (0.86–1.10) | 0.357/0.346 | 0.797 | 0.99 (0.88–1.10) |
rs4712047a G>A | 0.494/0.477 | 0.448/0.505 | 0.221 | 0.93 (0.82–1.05) | 0.456/0.457 | 0.269 | 0.94 (0.84–1.05) |
rs3734674 G>A | 0.158/0.171 | 0.191/0.149 | 0.252 | 1.10 (0.93–1.29) | 0.176/0.188 | 0.416 | 1.06 (0.92–1.23) |
rs11751539a A>T | 0.309/0.320 | 0.302/0.312 | 0.476 | 0.95 (0.84–1.09) | 0.315/0.276 | 0.955 | 0.997 (0.87–1.12) |
rs3757261a G>A | 0.155/0.165 | 0.184/0.139 | 0.159 | 1.12 (0.95–1.32) | 0.168/0.174 | 0.252 | 1.09 (0.94–1.26) |
rs2253217a A>G | 0.063/0.071 | 0.056/0.068 | 0.210 | 0.85 (0.67–1.09) | 0.045/0.061 | 0.111 | 0.83 (0.67–1.04) |
Haplotype | |||||||
Block 1 | |||||||
GT | 0.641/0.637 | 0.629/0.645 | 0.666 | 0.97 (0.86–1.10) | 0.665/0.655 | 0.796 | 0.99 (0.88–1.10) |
TT | 0.189/0.196 | 0.215/0.192 | 0.519 | 1.05 (0.91–1.22) | 0.198/0.210 | 0.711 | 1.03 (0.90–1.17) |
GC | 0.171/0.167 | 0.156/0.163 | 0.086 | 0.87 (0.74–1.02) | 0.137/0.135 | 0.949 | 0.995 (0.86–1.15) |
Block 2 | |||||||
GAGA | 0.471/0.442 | 0.446/0.478 | 0.904 | 0.99 (0.88–1.12) | 0.468/0.491 | 0.674 | 0.98 (0.88–1.09) |
GTGA | 0.311/0.320 | 0.313/0.312 | 0.758 | 0.98 (0.86–1.11) | 0.313/0.272 | 0.734 | 1.02 (0.91–1.14) |
AAAA | 0.154/0.166 | 0.184/0.139 | 0.150 | 1.12 (0.96–1.32) | 0.169/0.174 | 0.239 | 1.09 (0.94–1.26) |
GAGG | 0.061/0.067 | 0.054/0.061 | 0.353 | 0.89 (0.70–1.14) | 0.042/0.050 | 0.280 | 0.88 (0.70–1.11) |
Allele frequencies (nephropathy case−control) | |||||||
---|---|---|---|---|---|---|---|
Proteinuria | ESRD | Combined | |||||
Study 1 | Study 2 |
P
| OR (95% CI) | Study 3 |
P
| OR (95% CI) | |
SNP | |||||||
rs350852a T>C | 0.313/0.338 | 0.313/0.303 | 0.545 | 0.96 (0.84–1.09) | 0.324/0.348 | 0.367 | 0.95 (0.84–1.06) |
rs7246235a T>G | 0.185/0.186 | 0.168/0.209 | 0.110 | 0.88 (0.75–1.03) | 0.202/0.164 | 0.447 | 0.95 (0.82–1.09) |
rs107251a C>T | 0.296/0.315 | 0.305/0.291 | 0.841 | 0.99 (0.87–1.12) | 0.323/0.328 | 0.799 | 0.98 (0.88–1.11) |
rs350844 G>A | 0.304/0.322 | 0.309/0.291 | 0.936 | 0.99 (0.87–1.13) | 0.336/0.347 | 0.819 | 0.99 (0.88–1.11) |
Haplotype | |||||||
Block 1 | |||||||
TCG | 0.516/0.499 | 0.529/0.500 | 0.122 | 1.10 (0.98–1.24) | 0.517/0.532 | 0.342 | 1.05 (0.95–1.17) |
TTA | 0.299/0.318 | 0.303/0.291 | 0.776 | 0.98 (0.86–1.12) | 0.360/0.342 | 0.713 | 0.98 (0.87–1.10) |
GCG | 0.185/0.183 | 0.168/0.209 | 0.100 | 0.88 (0.76–1.02) | 0.067/0.052 | 0.433 | 0.95 (0.83–1.09) |
Allele frequencies (nephropathy case−control) | Proteinuria (study 1, 2, 4) | Proteinuria + ESRD (study 1, 2, 3, 4) | |||
---|---|---|---|---|---|
Study 4 |
P
| OR (95% CI) |
P
| OR (95% CI) | |
SNP | |||||
rs12778366a T>C | 0.089/0.131 | 0.676 | 0.96 (0.81–1.15) | 0.448 | 0.94 (0.80–1.10) |
rs3740051a A>G | 0.311/0.291 | 0.226 | 1.08 (0.96–1.21) | 0.106 | 1.09 (0.98–1.22) |
rs2236318a T>A | 0.113/0.116 | 0.350 | 0.92 (0.78–1.09) | 0.257 | 0.91 (0.78–1.07) |
rs2236319 A>G | 0.360/0.344 | 0.142 | 1.09 (0.97–1.22) | 0.044 | 1.12 (1.00–1.24) |
rs10823108 G>A | 0.358/0.337 | 0.127 | 1.09 (0.97–1.23) | 0.038 | 1.12 (1.01–1.24) |
rs10997868a C>A | 0.181/0.175 | 0.490 | 1.05 (0.91–1.21) | 0.456 | 1.05 (0.92–1.20) |
rs2273773 T>C | 0.364/0.342 | 0.239 | 1.07 (0.95–1.20) | 0.085 | 1.10 (0.99–1.22) |
rs3818292 A>G | 0.358/0.344 | 0.120 | 1.10 (0.98–1.23) | 0.040 | 1.12 (1.01–1.24) |
rs3818291 G>A | 0.090/0.132 | 0.696 | 0.97 (0.81–1.15) | 0.412 | 0.94 (0.80–1.10) |
rs4746720a T>C | 0.371/0.361 | 0.084 | 0.90 (0.81–1.01) | 0.044 | 0.90 (0.81–0.997) |
rs10823116a A>G | 0.453/0.450 | 0.939 | 0.996 (0.89–1.11) | 0.446 | 1.04 (0.94–1.15) |
Haplotype | |||||
TGTGACCGGTG | 0.306/0.297 | 0.240 | 1.07 (0.95–1.21) | 0.098 | 1.09 (0.98–1.22) |
TATAGCTAGCA | 0.269/0.243 | 0.809 | 0.96 (0.87–1.11) | 0.336 | 0.95 (0.85–1.06) |
CATAGCTAATA | 0.105/0.129 | 0.741 | 0.97 (0.82–1.15) | 0.496 | 0.95 (0.81–1.10) |
TAAAGATAGTA | 0.122/0.116 | 0.621 | 0.96 (0.81–1.13) | 0.430 | 0.94 (0.80–1.09) |
TATAGCTAGCG | 0.095/0.112 | 0.022 | 0.82 (0.69–0.97) | 0.071 | 0.86 (0.74–1.01) |
TATAGATAGTA | 0.072/0.059 | 0.0091 | 1.34 (1.07–1.66) | 0.0028 | 1.36 (1.11–1.66) |
TATGACCGGTG | 0.031/0.044 | 0.942 | 1.01 (0.77–1.33) | 0.746 | 1.04 (0.81–1.35) |