Skip to main content
main-content
Erschienen in: Breast Cancer Research and Treatment 2/2018

29.05.2018 | Epidemiology

Association between sleep disorders and the presence of breast cancer metastases in gynecological practices in Germany: a case–control study of 11,412 women

verfasst von: Louis Jacob, Paulina Christiana Scholten, Karel Kostev, Matthias Kalder

Erschienen in: Breast Cancer Research and Treatment | Ausgabe 2/2018

Einloggen, um Zugang zu erhalten

Abstract

Purpose

The goal of the present study was to analyze the impact of sleep disorders on the development of metastases in women with breast cancer followed in gynecological practices in Germany.

Methods

The study included women who were initially diagnosed with breast cancer in 262 gynecological practices in Germany between January 2000 and December 2015 (index date). Participants were followed for up to 5 years. Women diagnosed with breast cancer metastases within a period of 6 months and before the end of follow-up were matched (1:1) by age, index year, physician, type of hormonal therapy (tamoxifen or aromatase inhibitors) and follow-up time (in months) with women without metastases. Regression analyses were conducted to study the association between sleep disorders and the presence of metastases, and these regression analyses were adjusted for depression.

Results

A total of 11,412 women were included in the present study. The mean age was 59.8 years (SD 11.4 years) and most participants were between 61 and 70 years old (metastases group: 32.6%; no-metastases group: 32.3%). Sleep disorders were associated with a significant increase in the presence of breast cancer metastases in the overall population (odds ratio [OR] 1.31) and in the different age subgroups (ORs between 1.24 and 1.43).

Conclusion

A positive association was found between sleep disorders and the presence of metastases in women diagnosed with breast cancer in gynecological practices in Germany.
Literatur
1.
Zurück zum Zitat Ghoncheh M, Pournamdar Z, Salehiniya H (2016) Incidence and mortality and epidemiology of breast cancer in the world. Asian Pac J Cancer Prev 17:43–46 CrossRefPubMed Ghoncheh M, Pournamdar Z, Salehiniya H (2016) Incidence and mortality and epidemiology of breast cancer in the world. Asian Pac J Cancer Prev 17:43–46 CrossRefPubMed
2.
Zurück zum Zitat Jönsson B, Wilking N (2013) Prevention and the economic burden of breast cancer, GE Healthcare Jönsson B, Wilking N (2013) Prevention and the economic burden of breast cancer, GE Healthcare
3.
Zurück zum Zitat Jacob L, Kostev K, Rathmann W, Kalder M (2016) Impact of metformin on metastases in patients with breast cancer and type 2 diabetes. J Diabetes Complicat 30:1056–1059 CrossRefPubMed Jacob L, Kostev K, Rathmann W, Kalder M (2016) Impact of metformin on metastases in patients with breast cancer and type 2 diabetes. J Diabetes Complicat 30:1056–1059 CrossRefPubMed
4.
Zurück zum Zitat Cappuccio FP, D’Elia L, Strazzullo P, Miller MA (2010) Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies. Sleep 33:585–592 CrossRefPubMedPubMedCentral Cappuccio FP, D’Elia L, Strazzullo P, Miller MA (2010) Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies. Sleep 33:585–592 CrossRefPubMedPubMedCentral
5.
Zurück zum Zitat Shen X, Wu Y, Zhang D (2016) Nighttime sleep duration, 24-hour sleep duration and risk of all-cause mortality among adults: a meta-analysis of prospective cohort studies. Sci Rep 6:21480 CrossRefPubMedPubMedCentral Shen X, Wu Y, Zhang D (2016) Nighttime sleep duration, 24-hour sleep duration and risk of all-cause mortality among adults: a meta-analysis of prospective cohort studies. Sci Rep 6:21480 CrossRefPubMedPubMedCentral
6.
Zurück zum Zitat Liu T-Z, Xu C, Rota M, Cai H, Zhang C, Shi M-J, Yuan R-X, Weng H, Meng X-Y, Kwong JSW, Sun X (2017) Sleep duration and risk of all-cause mortality: A flexible, non-linear, meta-regression of 40 prospective cohort studies. Sleep Med Rev 32:28–36 CrossRefPubMed Liu T-Z, Xu C, Rota M, Cai H, Zhang C, Shi M-J, Yuan R-X, Weng H, Meng X-Y, Kwong JSW, Sun X (2017) Sleep duration and risk of all-cause mortality: A flexible, non-linear, meta-regression of 40 prospective cohort studies. Sleep Med Rev 32:28–36 CrossRefPubMed
7.
Zurück zum Zitat Carpenter JS, Elam JL, Ridner SH, Carney PH, Cherry GJ, Cucullu HL (2004) Sleep, fatigue, and depressive symptoms in breast cancer survivors and matched healthy women experiencing hot flashes. Oncol Nurs Forum 31:591–5598 CrossRefPubMed Carpenter JS, Elam JL, Ridner SH, Carney PH, Cherry GJ, Cucullu HL (2004) Sleep, fatigue, and depressive symptoms in breast cancer survivors and matched healthy women experiencing hot flashes. Oncol Nurs Forum 31:591–5598 CrossRefPubMed
8.
Zurück zum Zitat Colagiuri B, Christensen S, Jensen AB, Price MA, Butow PN, Zachariae R (2011) Prevalence and predictors of sleep difficulty in a national cohort of women with primary breast cancer three to four months postsurgery. J Pain Symptom Manag 42:710–720 CrossRef Colagiuri B, Christensen S, Jensen AB, Price MA, Butow PN, Zachariae R (2011) Prevalence and predictors of sleep difficulty in a national cohort of women with primary breast cancer three to four months postsurgery. J Pain Symptom Manag 42:710–720 CrossRef
9.
Zurück zum Zitat Girschik J, Heyworth J, Fritschi L (2013) Self-reported sleep duration, sleep quality, and breast cancer risk in a population-based case–control study. Am J Epidemiol 177:316–327 CrossRefPubMed Girschik J, Heyworth J, Fritschi L (2013) Self-reported sleep duration, sleep quality, and breast cancer risk in a population-based case–control study. Am J Epidemiol 177:316–327 CrossRefPubMed
10.
Zurück zum Zitat Palesh O, Aldridge-Gerry A, Ulusakarya A, Ortiz-Tudela E, Capuron L, Innominato PF (2013) Sleep disruption in breast cancer patients and survivors. J Natl Compr Cancer Netw 11:1523–1530 CrossRef Palesh O, Aldridge-Gerry A, Ulusakarya A, Ortiz-Tudela E, Capuron L, Innominato PF (2013) Sleep disruption in breast cancer patients and survivors. J Natl Compr Cancer Netw 11:1523–1530 CrossRef
11.
Zurück zum Zitat Vogtmann E, Levitan EB, Hale L, Shikany JM, Shah NA, Endeshaw Y, Lewis CE, Manson JE, Chlebowski RT (2013) Association between sleep and breast cancer incidence among postmenopausal women in the Women’s Health Initiative. Sleep 36:1437–1444 CrossRefPubMedPubMedCentral Vogtmann E, Levitan EB, Hale L, Shikany JM, Shah NA, Endeshaw Y, Lewis CE, Manson JE, Chlebowski RT (2013) Association between sleep and breast cancer incidence among postmenopausal women in the Women’s Health Initiative. Sleep 36:1437–1444 CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Palesh O, Aldridge-Gerry A, Zeitzer JM, Koopman C, Neri E, Giese-Davis J, Jo B, Kraemer H, Nouriani B, Spiegel D (2014) Actigraphy-measured sleep disruption as a predictor of survival among women with advanced breast cancer. Sleep 37:837–842 CrossRefPubMedPubMedCentral Palesh O, Aldridge-Gerry A, Zeitzer JM, Koopman C, Neri E, Giese-Davis J, Jo B, Kraemer H, Nouriani B, Spiegel D (2014) Actigraphy-measured sleep disruption as a predictor of survival among women with advanced breast cancer. Sleep 37:837–842 CrossRefPubMedPubMedCentral
13.
Zurück zum Zitat Fang H-F, Miao N-F, Chen C-D, Sithole T, Chung M-H (2015) Risk of cancer in patients with insomnia, parasomnia, and obstructive sleep apnea: a nationwide nested case–control study. J Cancer 6:1140–1147 CrossRefPubMedPubMedCentral Fang H-F, Miao N-F, Chen C-D, Sithole T, Chung M-H (2015) Risk of cancer in patients with insomnia, parasomnia, and obstructive sleep apnea: a nationwide nested case–control study. J Cancer 6:1140–1147 CrossRefPubMedPubMedCentral
14.
Zurück zum Zitat Lin X, Chen W, Wei F, Ying M, Wei W, Xie X (2015) Night-shift work increases morbidity of breast cancer and all-cause mortality: a meta-analysis of 16 prospective cohort studies. Sleep Med 16:1381–1387 CrossRefPubMed Lin X, Chen W, Wei F, Ying M, Wei W, Xie X (2015) Night-shift work increases morbidity of breast cancer and all-cause mortality: a meta-analysis of 16 prospective cohort studies. Sleep Med 16:1381–1387 CrossRefPubMed
15.
Zurück zum Zitat Otte JL, Carpenter JS, Manchanda S, Rand KL, Skaar TC, Weaver M, Chernyak Y, Zhong X, Igega C, Landis C (2015) Systematic review of sleep disorders in cancer patients: can the prevalence of sleep disorders be ascertained? Cancer Med 4:183–200 CrossRefPubMed Otte JL, Carpenter JS, Manchanda S, Rand KL, Skaar TC, Weaver M, Chernyak Y, Zhong X, Igega C, Landis C (2015) Systematic review of sleep disorders in cancer patients: can the prevalence of sleep disorders be ascertained? Cancer Med 4:183–200 CrossRefPubMed
16.
Zurück zum Zitat Qian X, Brinton LA, Schairer C, Matthews CE (2015) Sleep duration and breast cancer risk in the Breast Cancer Detection Demonstration Project follow-up cohort. Br J Cancer 112:567–571 CrossRefPubMed Qian X, Brinton LA, Schairer C, Matthews CE (2015) Sleep duration and breast cancer risk in the Breast Cancer Detection Demonstration Project follow-up cohort. Br J Cancer 112:567–571 CrossRefPubMed
17.
Zurück zum Zitat Xiao Q, Signorello LB, Brinton LA, Cohen SS, Blot WJ, Matthews CE (2016) Sleep duration and breast cancer risk among black and white women. Sleep Med 20:25–29 CrossRefPubMed Xiao Q, Signorello LB, Brinton LA, Cohen SS, Blot WJ, Matthews CE (2016) Sleep duration and breast cancer risk among black and white women. Sleep Med 20:25–29 CrossRefPubMed
18.
Zurück zum Zitat Soucise A, Vaughn C, Thompson CL, Millen AE, Freudenheim JL, Wactawski-Wende J, Phipps AI, Hale L, Qi L, Ochs-Balcom HM (2017) Sleep quality, duration, and breast cancer aggressiveness. Breast Cancer Res Treat 164:169–178 CrossRefPubMedPubMedCentral Soucise A, Vaughn C, Thompson CL, Millen AE, Freudenheim JL, Wactawski-Wende J, Phipps AI, Hale L, Qi L, Ochs-Balcom HM (2017) Sleep quality, duration, and breast cancer aggressiveness. Breast Cancer Res Treat 164:169–178 CrossRefPubMedPubMedCentral
19.
Zurück zum Zitat Sen A, Opdahl S, Strand LB, Vatten LJ, Laugsand LE, Janszky I (2017) Insomnia and the Risk of Breast Cancer: the HUNT study. Psychosom Med 79:461 CrossRefPubMed Sen A, Opdahl S, Strand LB, Vatten LJ, Laugsand LE, Janszky I (2017) Insomnia and the Risk of Breast Cancer: the HUNT study. Psychosom Med 79:461 CrossRefPubMed
20.
Zurück zum Zitat Trudel-Fitzgerald C, Zhou ES, Poole EM, Zhang X, Michels KB, Eliassen AH, Chen WY, Holmes MD, Tworoger SS, Schernhammer ES (2017) Sleep and survival among women with breast cancer: 30 years of follow-up within the Nurses’ Health Study. Br J Cancer 116:1239–1246 CrossRefPubMedPubMedCentral Trudel-Fitzgerald C, Zhou ES, Poole EM, Zhang X, Michels KB, Eliassen AH, Chen WY, Holmes MD, Tworoger SS, Schernhammer ES (2017) Sleep and survival among women with breast cancer: 30 years of follow-up within the Nurses’ Health Study. Br J Cancer 116:1239–1246 CrossRefPubMedPubMedCentral
22.
Zurück zum Zitat Kuo H-H, Chiu M-J, Liao W-C, Hwang S-L (2006) Quality of sleep and related factors during chemotherapy in patients with stage I/II breast cancer. J Formos Med Assoc 105:64–69 CrossRefPubMed Kuo H-H, Chiu M-J, Liao W-C, Hwang S-L (2006) Quality of sleep and related factors during chemotherapy in patients with stage I/II breast cancer. J Formos Med Assoc 105:64–69 CrossRefPubMed
23.
Zurück zum Zitat Liede A, Jerzak KJ, Hernandez RK, Wade SW, Sun P, Narod SA (2016) The incidence of bone metastasis after early-stage breast cancer in Canada. Breast Cancer Res Treat 156:587–595 CrossRefPubMed Liede A, Jerzak KJ, Hernandez RK, Wade SW, Sun P, Narod SA (2016) The incidence of bone metastasis after early-stage breast cancer in Canada. Breast Cancer Res Treat 156:587–595 CrossRefPubMed
24.
Zurück zum Zitat Khanfir A, Lahiani F, Bouzguenda R, Ayedi I, Daoud J, Frikha M (2013) Prognostic factors and survival in metastatic breast cancer: a single institution experience. Rep Pract Oncol Radiother 18:127–132 CrossRefPubMedPubMedCentral Khanfir A, Lahiani F, Bouzguenda R, Ayedi I, Daoud J, Frikha M (2013) Prognostic factors and survival in metastatic breast cancer: a single institution experience. Rep Pract Oncol Radiother 18:127–132 CrossRefPubMedPubMedCentral
25.
Zurück zum Zitat Dombrowski S, Kostev K (2017) Use of electronic medical records in the epidemiological research. Cuvillier Verlag, Göttingen Dombrowski S, Kostev K (2017) Use of electronic medical records in the epidemiological research. Cuvillier Verlag, Göttingen
26.
Zurück zum Zitat Jacob L, Freyn M, Kalder M, Dinas K, Kostev K (2018) Impact of tobacco smoking on the risk of developing 25 different cancers in the UK: a retrospective study of 422,010 patients followed for up to 30 years. Oncotarget 9:17420–17429 CrossRefPubMedPubMedCentral Jacob L, Freyn M, Kalder M, Dinas K, Kostev K (2018) Impact of tobacco smoking on the risk of developing 25 different cancers in the UK: a retrospective study of 422,010 patients followed for up to 30 years. Oncotarget 9:17420–17429 CrossRefPubMedPubMedCentral
27.
Zurück zum Zitat Chang W-P, Liu M-E, Chang W-C, Yang AC, Ku Y-C, Pai J-T, Lin Y-W, Tsai S-J (2014) Sleep apnea and the subsequent risk of breast cancer in women: a nationwide population-based cohort study. Sleep Med 15:1016–1020 CrossRefPubMed Chang W-P, Liu M-E, Chang W-C, Yang AC, Ku Y-C, Pai J-T, Lin Y-W, Tsai S-J (2014) Sleep apnea and the subsequent risk of breast cancer in women: a nationwide population-based cohort study. Sleep Med 15:1016–1020 CrossRefPubMed
28.
30.
Zurück zum Zitat Allan K, Berger NA, Li L, Thompson CL (2017) Short sleep duration as a contributor to racial disparities in breast cancer tumor grade. Fam Med Community Health 5:149–154 CrossRef Allan K, Berger NA, Li L, Thompson CL (2017) Short sleep duration as a contributor to racial disparities in breast cancer tumor grade. Fam Med Community Health 5:149–154 CrossRef
31.
Zurück zum Zitat Sánchez-Barceló EJ, Cos S, Mediavilla D, Martínez-Campa C, González A, Alonso-González C (2005) Melatonin-estrogen interactions in breast cancer. J Pineal Res 38:217–222 CrossRefPubMed Sánchez-Barceló EJ, Cos S, Mediavilla D, Martínez-Campa C, González A, Alonso-González C (2005) Melatonin-estrogen interactions in breast cancer. J Pineal Res 38:217–222 CrossRefPubMed
32.
Zurück zum Zitat Irwin MR (2015) Why sleep is important for health: a psychoneuroimmunology perspective. Annu Rev Psychol 66:143–172 CrossRefPubMed Irwin MR (2015) Why sleep is important for health: a psychoneuroimmunology perspective. Annu Rev Psychol 66:143–172 CrossRefPubMed
33.
Zurück zum Zitat Irwin MR, Olmstead R, Carroll JE (2016) Sleep disturbance, sleep duration, and inflammation: a systematic review and meta-analysis of cohort studies and experimental sleep deprivation. Biol Psychiatry 80:40–52 CrossRefPubMed Irwin MR, Olmstead R, Carroll JE (2016) Sleep disturbance, sleep duration, and inflammation: a systematic review and meta-analysis of cohort studies and experimental sleep deprivation. Biol Psychiatry 80:40–52 CrossRefPubMed
34.
Zurück zum Zitat Mausbach BT, Schwab RB, Irwin SA (2015) Depression as a predictor of adherence to adjuvant endocrine therapy (AET) in women with breast cancer: a systematic review and meta-analysis. Breast Cancer Res Treat 152:239–246 CrossRefPubMedPubMedCentral Mausbach BT, Schwab RB, Irwin SA (2015) Depression as a predictor of adherence to adjuvant endocrine therapy (AET) in women with breast cancer: a systematic review and meta-analysis. Breast Cancer Res Treat 152:239–246 CrossRefPubMedPubMedCentral
Metadaten
Titel
Association between sleep disorders and the presence of breast cancer metastases in gynecological practices in Germany: a case–control study of 11,412 women
verfasst von
Louis Jacob
Paulina Christiana Scholten
Karel Kostev
Matthias Kalder
Publikationsdatum
29.05.2018
Verlag
Springer US
Erschienen in
Breast Cancer Research and Treatment / Ausgabe 2/2018
Print ISSN: 0167-6806
Elektronische ISSN: 1573-7217
DOI
https://doi.org/10.1007/s10549-018-4831-x

Weitere Artikel der Ausgabe 2/2018

Breast Cancer Research and Treatment 2/2018 Zur Ausgabe

Neu im Fachgebiet Onkologie

Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Onkologie und bleiben Sie gut informiert – ganz bequem per eMail.