01.12.2017 | Research article | Ausgabe 1/2017 Open Access

Association between telomere length and the risk of colorectal cancer: a meta-analysis of observational studies
- Zeitschrift:
- BMC Cancer > Ausgabe 1/2017
Electronic supplementary material
Background
Methods
Study search
Study selection
Data extraction
Methodological assessments
Statistical analysis
Results
Study characteristics
Author, publication yr, [Ref no]
|
Country
|
Site
|
Study year
|
Design
|
Pros/retro
|
Case selection
|
Control selection
|
Sample size_case/control
|
Matching
|
Male%
|
Mean age ± SD
b
|
DNA source
|
Measurement technique
|
Adjusted factors
d
|
Estimate of risks
|
Remarks
|
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Zee, 2009 [
22]
|
USA
|
78.8% colon; 21.2%:rectum
|
1982
|
nested
|
pros
|
Ca (PHS cohort)
|
healthy men
|
191/306
|
age ±2years, smk, follow-up length
|
all males
|
60.5 ± 8.66
|
PBL
|
qPCR
|
BMI, al, ex
|
0.8 (0.55–1.16)
|
50.3%: with aspirin use
|
Lee, 2010 [
23]
|
USA
|
76.3% colon; 23.7%:rectum
|
Dec 2005
|
nested
|
pros
|
Ca (WHS cohort)
|
healthy women
|
134/357
|
age ±2years,smk, follow-up length
|
all females
|
60.1 ± 8.68
|
PBL
|
qPCR
|
age, smk, BMI, colorectal polyp, al, ex, pmp, HRT
|
0.94 (0.65–1.37)
|
35.1% with HRT
|
Pooley, 2010 [
24]
|
UK
|
CRC/ADC
|
Jan 1998 -Dec 2003
|
nested
|
pros
|
Ca
c (EPIC)
|
healthy
|
185/406
|
age, gender
|
female control
|
45–75
|
PBL
|
qPCR
|
study plate
|
1.13 (0.54–2.36)
|
|
Pooley, 2010 [
24]
|
UK
|
CRC/ADC
|
March 2001-Feb 2004
|
CC
|
retro
|
Ca registry (SEARCH)
|
healthy
|
2249/2161
|
age, gender
|
female control
|
18–69
|
PBL
|
qPCR
|
study plate
|
3.14 (1.77–2.58)
|
|
Cui, 2012 [
25]
|
China
|
CRC
|
Dec 1996- May 2000
|
nested
|
pros
|
Ca (SWHS)
|
healthy
|
441/549
|
age, date, time
a, meal, antibiotic, mp
|
all females
|
58.5 ± 8.7
|
PBL
|
qPCR
|
age, date, time
|
1.56 (0.92–2.64)
|
part of 74942 cohort
|
Pellat, 2013 [
26]
|
USA (Utah)
|
CRC
|
1991-94
|
CC (DALS)
|
retro
|
Ca (DALS)
|
driver license & social security lists
|
249/374 (1991-94) (colon) 276/372 (1997–2002) (rectal)
|
age, sex
|
54%
|
30–79
|
Cell line (colon), PBL (rectal)
|
qPCR
|
age, sex, BMI, smk, aspirin/NSAID, trans-fatty acid intake
|
0.96 (0.82–1.0)
|
44% on HRT, h/o aspirin, smk
|
Boardman, 2014 [
27]
|
USA
|
colon polyps & CRC
|
2000+
|
CC
|
retro
|
Ca registry & Ca (Mayo biobank)
|
healthy
f
|
598/2212
|
age, gender, location.
|
47% (colon); 58% (Mayo)
|
48 (19–69)
|
PBL
|
qPCR
|
multiple
|
3.53 (1.35–9.24)
|
chemoradio Rx; naive Ca
|
Qin, 2014 [
28]
|
China
|
CRC
|
Jan 2007- Dec 2010
|
CC
|
retro
|
Ca, hospitalised
|
unrelated healthy
e
|
628/1256
|
age ± 5 years, gender
|
54.1%
|
58,8 ± 11.8
|
PBL
|
qPCR
|
smk, Al, age, sex.
|
1.47 (1.09–1.99)
|
chemo-radio Rx & radio Rx; naive Ca
|