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25.08.2018 | Original Article

Association between the BANK1 rs3733197 polymorphism and polymyositis/dermatomyositis in a Chinese Han population

verfasst von: Si Chen, Xiaoting Wen, Qian Wang, Jing Li, Yuan Li, Liubing Li, Hui Yuan, Fengchun Zhang, Yongzhe Li

Erschienen in: Clinical Rheumatology | Ausgabe 2/2019

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Abstract

The aim of our study was to investigate the association between single nucleotide polymorphisms (SNPs) in the BANK1 gene and polymyositis/dermatomyositis (PM/DM) in a Chinese Han population. In total, 363 PM patients, 654 DM patients, and 1280 healthy controls were recruited and genotyped using the Sequenom MassArray system. A significant allele association was observed in rs3733197 among the PM/DM patients (OR 0.81, 95%CI 0.70–0.94, Pc = 1.83 × 10−2). Notably, rs3733197 was associated with DM and PM/DM patients with ILD involvement (Pc = 0.026; Pc = 6.0 × 10−3, respectively). However, no statistically significant difference was observed in the allele or genotype frequencies of three SNPs (rs4522865, rs17266594, and rs10516487) among the DM, PM, and PM/DM patients and healthy controls (all Pc > 0.05). This study was the first to demonstrate that a BANK1 gene SNP (rs3733197) could confer genetic predisposition in PM/DM patients and PM/DM patients with ILD in a Chinese Han population.
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Metadaten
Titel
Association between the BANK1 rs3733197 polymorphism and polymyositis/dermatomyositis in a Chinese Han population
verfasst von
Si Chen
Xiaoting Wen
Qian Wang
Jing Li
Yuan Li
Liubing Li
Hui Yuan
Fengchun Zhang
Yongzhe Li
Publikationsdatum
25.08.2018
Verlag
Springer London
Erschienen in
Clinical Rheumatology / Ausgabe 2/2019
Print ISSN: 0770-3198
Elektronische ISSN: 1434-9949
DOI
https://doi.org/10.1007/s10067-018-4257-1

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