Erschienen in:
27.03.2020 | Original Article
Association between the rate of third generation cephalosporin-resistant Escherichia coli and Klebsiella pneumoniae and antibiotic consumption based on 143 Chinese tertiary hospitals data in 2014
verfasst von:
Ping Yang, Yunbo Chen, Saiping Jiang, Ping Shen, Xiaoyang Lu, Yonghong Xiao
Erschienen in:
European Journal of Clinical Microbiology & Infectious Diseases
|
Ausgabe 8/2020
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Abstract
This study sought to discuss the correlation between the third-generation cephalosporins (3GC)-resistant Escherichia coli and Klebsiella pneumoniae and antibiotic consumption intensity from 143 Chinese tertiary hospitals in 2014. With a retrospective design, the correlation between antibiotic consumption and 3GC-resistant E. coli and K. pneumoniae were performed. 3GC-resistant E. coli was significantly correlated with the consumption of all antibiotics (r = 0.252, p < 0.01), β-Lactams antibiotics (r = 0.313, p < 0.01), β-Lactams excluding combinations with β-lactamase inhibitors (r = 0.365, p < 0.01), cephalosporin (r = 0.398, p < 0.01), cephalosporins excluding combinations with β-lactamase inhibitors (r = 0.374, p < 0.01), 3GC (r = 0.321, p < 0.01), and 3GC excluding combinations with β-lactamase inhibitors (r = 0.343, p < 0.01). 3GC-resistant K. pneumoniae was significantly correlated with the consumption of all antibiotics (r = 0.200, p < 0.05), β-Lactams antibiotics (r = 0.232, p < 0.01), cephalosporin (r = 0.215, p < 0.05), 3GC (r = 0.383, p < 0.01), 3GC excluding combinations with β-lactamase inhibitors (r = 0.245, p < 0.01), and β-lactam-β-lactamase inhibitor combinations (r = 0.218, p < 0.05). There was a significant relationship between the antibiotic consumption and the rates of 3GC-resistant E. coli and K. pneumoniae. Clinicians should grasp the indication of antibiotics use to reduce the production of drug-resistant bacteria.